{"context":{"query":">>uniprot>>reactome","source_dataset":"uniprot","target_dataset":"reactome"},"stats":{"queried":5,"total":71,"mapped":5},"pagination":{"has_next":false},"schema":"id|name|tax_id|is_disease_pathway","mappings":[{"input":"P04626","source":"P04626|Receptor tyrosine-protein kinase erbB-2","targets":["R-HSA-1227986|Signaling by ERBB2|9606|false","R-HSA-1250196|SHC1 events in ERBB2 signaling|9606|false","R-HSA-1251932|PLCG1 events in ERBB2 signaling|9606|false","R-HSA-1257604|PIP3 activates AKT signaling|9606|false","R-HSA-1306955|GRB7 events in ERBB2 signaling|9606|false","R-HSA-1358803|Downregulation of ERBB2:ERBB3 signaling|9606|false","R-HSA-1963640|GRB2 events in ERBB2 signaling|9606|false","R-HSA-1963642|PI3K events in ERBB2 signaling|9606|false","R-HSA-2219530|Constitutive Signaling by Aberrant PI3K in Cancer|9606|true","R-HSA-416572|Sema4D induced cell migration and growth-cone collapse|9606|false","R-HSA-5673001|RAF/MAP kinase cascade|9606|false","R-HSA-6785631|ERBB2 Regulates Cell Motility|9606|false","R-HSA-6811558|PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling|9606|false","R-HSA-8847993|ERBB2 Activates PTK6 Signaling|9606|false","R-HSA-8863795|Downregulation of ERBB2 signaling|9606|false","R-HSA-8866910|TFAP2 (AP-2) family regulates transcription of growth factors and their receptors|9606|false","R-HSA-9634285|Constitutive Signaling by Overexpressed ERBB2|9606|true","R-HSA-9652282|Drug-mediated inhibition of ERBB2 signaling|9606|false","R-HSA-9664565|Signaling by ERBB2 KD Mutants|9606|true","R-HSA-9665233|Resistance of ERBB2 KD mutants to trastuzumab|9606|true","R-HSA-9665244|Resistance of ERBB2 KD mutants to sapitinib|9606|true","R-HSA-9665245|Resistance of ERBB2 KD mutants to tesevatinib|9606|true","R-HSA-9665246|Resistance of ERBB2 KD mutants to neratinib|9606|true","R-HSA-9665247|Resistance of ERBB2 KD mutants to osimertinib|9606|true","R-HSA-9665249|Resistance of ERBB2 KD mutants to afatinib|9606|true","R-HSA-9665250|Resistance of ERBB2 KD mutants to AEE788|9606|true","R-HSA-9665251|Resistance of ERBB2 KD mutants to lapatinib|9606|true","R-HSA-9665348|Signaling by ERBB2 ECD mutants|9606|true","R-HSA-9665686|Signaling by ERBB2 TMD/JMD mutants|9606|true","R-HSA-9665737|Drug resistance in ERBB2 TMD/JMD mutants|9606|true","R-HSA-9927418|Developmental Lineage of Mammary Gland Luminal Epithelial Cells|9606|false","R-HSA-9927432|Developmental Lineage of Mammary Gland Myoepithelial Cells|9606|false","R-HSA-9938206|Developmental Lineage of Mammary Stem Cells|9606|false"]},{"input":"P21802","source":"P21802|Fibroblast growth factor receptor 2","targets":["R-HSA-2023837|Signaling by FGFR2 amplification mutants|9606|true","R-HSA-2033519|Activated point mutants of FGFR2|9606|true","R-HSA-5655253|Signaling by FGFR2 in disease|9606|true","R-HSA-8851708|Signaling by FGFR2 IIIa TM|9606|true","R-HSA-8853333|Signaling by FGFR2 fusions|9606|true","R-HSA-109704|PI3K Cascade|9606|false","R-HSA-1257604|PIP3 activates AKT signaling|9606|false","R-HSA-190375|FGFR2c ligand binding and activation|9606|false","R-HSA-190377|FGFR2b ligand binding and activation|9606|false","R-HSA-2219530|Constitutive Signaling by Aberrant PI3K in Cancer|9606|true","R-HSA-5654221|Phospholipase C-mediated cascade; FGFR2|9606|false","R-HSA-5654695|PI-3K cascade:FGFR2|9606|false","R-HSA-5654699|SHC-mediated cascade:FGFR2|9606|false","R-HSA-5654700|FRS-mediated FGFR2 signaling|9606|false","R-HSA-5654727|Negative regulation of FGFR2 signaling|9606|false","R-HSA-5673001|RAF/MAP kinase cascade|9606|false","R-HSA-6811558|PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling|9606|false"]},{"input":"O96017","source":"O96017|Serine/threonine-protein kinase Chk2","targets":["R-HSA-5693565|Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks|9606|false","R-HSA-6804756|Regulation of TP53 Activity through Phosphorylation|9606|false","R-HSA-6804757|Regulation of TP53 Degradation|9606|false","R-HSA-6804760|Regulation of TP53 Activity through Methylation|9606|false","R-HSA-69473|G2/M DNA damage checkpoint|9606|false","R-HSA-69541|Stabilization of p53|9606|false","R-HSA-69601|Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A|9606|false","R-HSA-75035|Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex|9606|false"]},{"input":"Q08499","source":"Q08499|3',5'-cyclic-AMP phosphodiesterase 4D","targets":["R-HSA-180024|DARPP-32 events|9606|false","R-HSA-418555|G alpha (s) signalling events|9606|false","R-HSA-9860927|Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells|9606|false"]},{"input":"P37173","source":"P37173|TGF-beta receptor type-2","targets":["R-HSA-2173788|Downregulation of TGF-beta receptor signaling|9606|false","R-HSA-2173789|TGF-beta receptor signaling activates SMADs|9606|false","R-HSA-2173791|TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)|9606|false","R-HSA-3304356|SMAD2/3 Phosphorylation Motif Mutants in Cancer|9606|true","R-HSA-3642279|TGFBR2 MSI Frameshift Mutants in Cancer|9606|true","R-HSA-3645790|TGFBR2 Kinase Domain Mutants in Cancer|9606|true","R-HSA-3656532|TGFBR1 KD Mutants in Cancer|9606|true","R-HSA-3656535|TGFBR1 LBD Mutants in Cancer|9606|true","R-HSA-5689603|UCH proteinases|9606|false","R-HSA-9839389|TGFBR3 regulates TGF-beta signaling|9606|false"]}]}