{"context":{"query":">>uniprot>>reactome","source_dataset":"uniprot","target_dataset":"reactome"},"stats":{"queried":3,"total":77,"mapped":3},"pagination":{"has_next":false},"schema":"id|name|tax_id|is_disease_pathway","mappings":[{"input":"P04637","source":"P04637|Cellular tumor antigen p53","targets":["R-HSA-111448|Activation of NOXA and translocation to mitochondria|9606|false","R-HSA-139915|Activation of PUMA and translocation to mitochondria|9606|false","R-HSA-1912408|Pre-NOTCH Transcription and Translation|9606|false","R-HSA-2559580|Oxidative Stress Induced Senescence|9606|false","R-HSA-2559584|Formation of Senescence-Associated Heterochromatin Foci (SAHF)|9606|false","R-HSA-2559585|Oncogene Induced Senescence|9606|false","R-HSA-2559586|DNA Damage/Telomere Stress Induced Senescence|9606|false","R-HSA-3232118|SUMOylation of transcription factors|9606|false","R-HSA-349425|Autodegradation of the E3 ubiquitin ligase COP1|9606|false","R-HSA-390471|Association of TriC/CCT with target proteins during biosynthesis|9606|false","R-HSA-5620971|Pyroptosis|9606|false","R-HSA-5628897|TP53 Regulates Metabolic Genes|9606|false","R-HSA-5689880|Ub-specific processing proteases|9606|false","R-HSA-5689896|Ovarian tumor domain proteases|9606|false","R-HSA-5693565|Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks|9606|false","R-HSA-6785807|Interleukin-4 and Interleukin-13 signaling|9606|false","R-HSA-6796648|TP53 Regulates Transcription of DNA Repair Genes|9606|false","R-HSA-6803204|TP53 Regulates Transcription of Genes Involved in Cytochrome C Release|9606|false","R-HSA-6803205|TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain|9606|false","R-HSA-6803207|TP53 Regulates Transcription of Caspase Activators and Caspases|9606|false","R-HSA-6803211|TP53 Regulates Transcription of Death Receptors and Ligands|9606|false","R-HSA-6804114|TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest|9606|false","R-HSA-6804115|TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain|9606|false","R-HSA-6804116|TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest|9606|false","R-HSA-6804754|Regulation of TP53 Expression|9606|false","R-HSA-6804756|Regulation of TP53 Activity through Phosphorylation|9606|false","R-HSA-6804757|Regulation of TP53 Degradation|9606|false","R-HSA-6804758|Regulation of TP53 Activity through Acetylation|9606|false","R-HSA-6804759|Regulation of TP53 Activity through Association with Co-factors|9606|false","R-HSA-6804760|Regulation of TP53 Activity through Methylation|9606|false","R-HSA-6811555|PI5P Regulates TP53 Acetylation|9606|false","R-HSA-69473|G2/M DNA damage checkpoint|9606|false","R-HSA-69481|G2/M Checkpoints|9606|false","R-HSA-69541|Stabilization of p53|9606|false","R-HSA-69895|Transcriptional  activation of  cell cycle inhibitor p21 |9606|false","R-HSA-70635|Urea cycle|9606|false","R-HSA-8852276|The role of GTSE1 in G2/M progression after G2 checkpoint|9606|false","R-HSA-8853884|Transcriptional Regulation by VENTX|9606|false","R-HSA-8941855|RUNX3 regulates CDKN1A transcription|9606|false","R-HSA-8943724|Regulation of PTEN gene transcription|9606|false","R-HSA-9723905|Loss of function of TP53 in cancer due to loss of tetramerization ability|9606|true","R-HSA-9725370|Signaling by ALK fusions and activated point mutants|9606|true","R-HSA-9758274|Regulation of NF-kappa B signaling|9606|false","R-HSA-9819196|Zygotic genome activation (ZGA)|9606|false","R-HSA-983231|Factors involved in megakaryocyte development and platelet production|9606|false","R-HSA-9833482|PKR-mediated signaling|9606|false"]},{"input":"O14746","source":"O14746|Telomerase reverse transcriptase","targets":["R-HSA-171319|Telomere Extension By Telomerase|9606|false","R-HSA-201722|Formation of the beta-catenin:TCF transactivating complex|9606|false","R-HSA-9825895|Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence|9606|false"]},{"input":"Q13315","source":"Q13315|Serine-protein kinase ATM","targets":["R-HSA-2559586|DNA Damage/Telomere Stress Induced Senescence|9606|false","R-HSA-3371453|Regulation of HSF1-mediated heat shock response|9606|false","R-HSA-349425|Autodegradation of the E3 ubiquitin ligase COP1|9606|false","R-HSA-5685938|HDR through Single Strand Annealing (SSA)|9606|false","R-HSA-5685942|HDR through Homologous Recombination (HRR)|9606|false","R-HSA-5693548|Sensing of DNA Double Strand Breaks|9606|false","R-HSA-5693554|Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)|9606|false","R-HSA-5693565|Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks|9606|false","R-HSA-5693568|Resolution of D-loop Structures through Holliday Junction Intermediates|9606|false","R-HSA-5693571|Nonhomologous End-Joining (NHEJ)|9606|false","R-HSA-5693579|Homologous DNA Pairing and Strand Exchange|9606|false","R-HSA-5693607|Processing of DNA double-strand break ends|9606|false","R-HSA-5693616|Presynaptic phase of homologous DNA pairing and strand exchange|9606|false","R-HSA-6796648|TP53 Regulates Transcription of DNA Repair Genes|9606|false","R-HSA-6803204|TP53 Regulates Transcription of Genes Involved in Cytochrome C Release|9606|false","R-HSA-6803207|TP53 Regulates Transcription of Caspase Activators and Caspases|9606|false","R-HSA-6804756|Regulation of TP53 Activity through Phosphorylation|9606|false","R-HSA-6804757|Regulation of TP53 Degradation|9606|false","R-HSA-6804760|Regulation of TP53 Activity through Methylation|9606|false","R-HSA-69473|G2/M DNA damage checkpoint|9606|false","R-HSA-69541|Stabilization of p53|9606|false","R-HSA-912446|Meiotic recombination|9606|false","R-HSA-9664873|Pexophagy|9606|false","R-HSA-9701192|Defective homologous recombination repair (HRR) due to BRCA1 loss of function|9606|true","R-HSA-9704331|Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function|9606|true","R-HSA-9704646|Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function|9606|true","R-HSA-9709570|Impaired BRCA2 binding to RAD51|9606|true","R-HSA-9709603|Impaired BRCA2 binding to PALB2|9606|true"]}]}