{"context":{"query":">>uniprot>>pdb","source_dataset":"uniprot","target_dataset":"pdb"},"stats":{"queried":4,"total":171,"mapped":4},"pagination":{"has_next":true,"next_token":"-1[]P05067,1,P05067,111,2]["},"schema":"id|title|method|resolution|source_organism|chain_count|header","mappings":[{"input":"P05067","source":"P05067|Amyloid-beta precursor protein","targets":["1AAP|X-RAY CRYSTAL STRUCTURE OF THE PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR|X-RAY DIFFRACTION|1.5|Homo sapiens|0|PROTEINASE INHIBITOR (TRYPSIN)","1AMB|SOLUTION STRUCTURE OF RESIDUES 1-28 OF THE AMYLOID BETA-PEPTIDE|SOLUTION NMR||Homo sapiens|0|PROTEINASE INHIBITOR(TRYPSIN)","1AMC|SOLUTION STRUCTURE OF RESIDUES 1-28 OF THE AMYLOID BETA-PEPTIDE|SOLUTION NMR||Homo sapiens|0|PROTEINASE INHIBITOR(TRYPSIN)","1AML|THE ALZHEIMER`S DISEASE AMYLOID A4 PEPTIDE (RESIDUES 1-40)|SOLUTION NMR||Homo sapiens|0|SERINE PROTEASE INHIBITOR","1BA4|THE SOLUTION STRUCTURE OF AMYLOID BETA-PEPTIDE (1-40) IN A WATER-MICELLE ENVIRONMENT. IS THE MEMBRANE-SPANNING DOMAIN WHERE WE THINK IT IS? NMR, 10 STRUCTURES|SOLUTION NMR||Homo sapiens|0|GLYCOPROTEIN","1BA6|SOLUTION STRUCTURE OF THE METHIONINE-OXIDIZED AMYLOID BETA-PEPTIDE (1-40). DOES OXIDATION AFFECT CONFORMATIONAL SWITCHING? NMR, 10 STRUCTURES|SOLUTION NMR||Homo sapiens|0|GLYCOPROTEIN","1BJB|SOLUTION NMR STRUCTURE OF AMYLOID BETA[E16], RESIDUES 1-28, 14 STRUCTURES|SOLUTION NMR||Homo sapiens|0|GLYCOPROTEIN","1BJC|SOLUTION NMR STRUCTURE OF AMYLOID BETA[F16], RESIDUES 1-28, 15 STRUCTURES|SOLUTION NMR||Homo sapiens|0|GLYCOPROTEIN","1BRC|RELOCATING A NEGATIVE CHARGE IN THE BINDING POCKET OF TRYPSIN|X-RAY DIFFRACTION|2.5|Rattus norvegicus|0|HYDROLASE/HYDROLASE INHIBITOR","1CA0|BOVINE CHYMOTRYPSIN COMPLEXED TO APPI|X-RAY DIFFRACTION|2.1|Bos taurus; Homo sapiens|0|COMPLEX (SERINE PROTEASE/INHIBITOR)","1HZ3|ALZHEIMER'S DISEASE AMYLOID-BETA PEPTIDE (RESIDUES 10-35)|SOLUTION NMR|||0|SUGAR BINDING PROTEIN","1IYT|Solution structure of the Alzheimer's disease amyloid beta-peptide (1-42)|SOLUTION NMR|||0|PROTEIN BINDING","1MWP|N-TERMINAL DOMAIN OF THE AMYLOID PRECURSOR PROTEIN|X-RAY DIFFRACTION|1.8|Homo sapiens|0|SUGAR BINDING PROTEIN","1OWT|Structure of the Alzheimer's disease amyloid precursor protein copper binding domain|SOLUTION NMR||Homo sapiens|0|APOPTOSIS","1QCM|AMYLOID BETA PEPTIDE (25-35), NMR, 20 STRUCTURES|SOLUTION NMR||Homo sapiens|0|AMYLOID","1QWP|NMR analysis of 25-35 fragment of beta amyloid peptide|SOLUTION NMR|||0|PROTEIN BINDING","1QXC|NMR structure of the fragment 25-35 of beta amyloid peptide in 20/80 v:v hexafluoroisopropanol/water mixture|SOLUTION NMR|||0|PROTEIN BINDING","1QYT|Solution structure of fragment (25-35) of beta amyloid peptide in SDS micellar solution|SOLUTION NMR|||0|PROTEIN BINDING","1TAW|BOVINE TRYPSIN COMPLEXED TO APPI|X-RAY DIFFRACTION|1.8|Bos taurus; Homo sapiens|0|COMPLEX (SERINE PROTEASE/INHIBITOR)","1TKN|Solution structure of CAPPD*, an independently folded extracellular domain of human Amyloid-beta Precursor Protein|SOLUTION NMR||Homo sapiens|0|MEMBRANE PROTEIN","1X11|X11 PTB DOMAIN|X-RAY DIFFRACTION|2.5|Homo sapiens|0|COMPLEX (PEPTIDE BINDING MODULE/PEPTIDE)","1Z0Q|Aqueous Solution Structure of the Alzheimer's Disease Abeta Peptide (1-42)|SOLUTION NMR|||0|PROTEIN BINDING","1ZE7|Zinc-binding domain of Alzheimer's disease amyloid beta-peptide in water solution at pH 6.5|SOLUTION NMR|||0|METAL BINDING PROTEIN","1ZE9|Zinc-binding domain of Alzheimer's disease amyloid beta-peptide complexed with a zinc (II) cation|SOLUTION NMR|||0|METAL BINDING PROTEIN","1ZJD|Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with Kunitz Protease Inhibitor Domain of Protease Nexin II|X-RAY DIFFRACTION|2.6|Homo sapiens|0|HYDROLASE, BLOOD CLOTTING","21FB|Structure of minor species of Abeta fibrils from AppNL-FPsen1P117L mice|ELECTRON MICROSCOPY|3.4|Homo sapiens|0|PROTEIN FIBRIL","2BEG|3D Structure of Alzheimer's Abeta(1-42) fibrils|SOLUTION NMR||Homo sapiens|0|PROTEIN FIBRIL","2BP4|Zinc-binding domain of Alzheimer's disease amyloid beta-peptide in TFE-water (80-20) solution|SOLUTION NMR|||0|AMYLOID PEPTIDE","2FJZ|Structure of the Alzheimer's Amyloid Precursor Protein (APP) copper binding domain (residues 133 to 189) in 'small unit cell' form, metal-free|X-RAY DIFFRACTION|1.61|Homo sapiens|0|METAL BINDING PROTEIN","2FK1|Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'small unit cell' form, Cu(II)-bound|X-RAY DIFFRACTION|1.6|Homo sapiens|0|METAL BINDING PROTEIN","2FK2|Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'small unit cell' form, Cu(I)-bound|X-RAY DIFFRACTION|1.65|Homo sapiens|0|APOPTOSIS","2FK3|Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'large unit cell' form|X-RAY DIFFRACTION|2.4|Homo sapiens|0|METAL BINDING PROTEIN","2FKL|Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain (Residues 126- 189 of APP)|X-RAY DIFFRACTION|2.5|Homo sapiens|0|METAL BINDING PROTEIN","2FMA|Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'small unit cell' form, atomic resolution|X-RAY DIFFRACTION|0.85|Homo sapiens|0|METAL BINDING PROTEIN","2G47|Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-40)|X-RAY DIFFRACTION|2.1|Homo sapiens; SYNTHETIC CONSTRUCT|0|HYDROLASE","2IPU|PFA1 Fab fragment complexed with Abeta 1-8 peptide|X-RAY DIFFRACTION|1.65|Mus musculus; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","2LFM|A partially folded structure of amyloid-beta(1 40) in an aqueous environment|SOLUTION NMR|||0|PROTEIN FIBRIL","2LLM|Structure of amyloid precursor protein's transmembrane domain|SOLUTION NMR||Homo sapiens|0|PROTEIN FIBRIL","2LMN|Structural Model for a 40-Residue Beta-Amyloid Fibril with Two-Fold Symmetry, Positive Stagger|SOLID-STATE NMR|||0|PROTEIN FIBRIL","2LMO|Structural Model for a 40-Residue Beta-Amyloid Fibril with Two-Fold Symmetry, Negative Stagger|SOLID-STATE NMR|||0|PROTEIN FIBRIL","2LMP|Structural Model for a 40-residue Beta-Amyloid Fibril with Three-Fold Symmetry, Positive Stagger|SOLID-STATE NMR|||0|PROTEIN FIBRIL","2LMQ|Structural Model for a 40-residue Beta-Amyloid Fibril with Three-Fold Symmetry, Negative Stagger|SOLID-STATE NMR|||0|PROTEIN FIBRIL","2LNQ|40-residue D23N beta amyloid fibril|SOLID-STATE NMR|||0|PROTEIN FIBRIL","2LOH|Dimeric structure of transmembrane domain of amyloid precursor protein in micellar environment|SOLUTION NMR||Homo sapiens|0|NEUROPEPTIDE","2LP1|The solution NMR structure of the transmembrane C-terminal domain of the amyloid precursor protein (C99)|SOLUTION NMR||Homo sapiens|0|MEMBRANE PROTEIN","2LZ3|Solution NMR structure of transmembrane domain of amyloid precursor protein WT|SOLUTION NMR||Homo sapiens|0|MEMBRANE PROTEIN","2LZ4|Solution NMR structure of transmembrane domain of amyloid precursor protein V44M|SOLUTION NMR||Homo sapiens|0|MEMBRANE PROTEIN","2M4J|40-residue beta-amyloid fibril derived from Alzheimer's disease brain|SOLID-STATE NMR||Homo sapiens|0|PROTEIN FIBRIL","2M9R|3D NMR structure of a complex between the amyloid beta peptide (1-40) and the polyphenol epsilon-viniferin glucoside|SOLUTION NMR|||0|PROTEIN FIBRIL","2M9S|3D NMR structure of a complex between the amyloid beta peptide (1-40) and the polyphenol epsilon-viniferin glucoside|SOLUTION NMR|||0|PROTEIN FIBRIL","2MGT|Zinc induced dimer of the metal binding domain 1-16 of human amyloid beta-peptide with Alzheimer's disease pathogenic English mutation H6R|SOLUTION NMR|||0|PROTEIN FIBRIL, METAL BINDING PROTEIN","2MJ1|NMR structure of the soluble A beta 17-34 peptide|SOLUTION NMR|||0|HYDROLASE INHIBITOR","2MPZ|Atomic model of the Abeta D23N \"\"Iowa\"\" mutant using solid-state NMR, EM and Rosetta modeling|SOLID-STATE NMR||Homo sapiens|0|PROTEIN FIBRIL","2MVX|Atomic-resolution 3D structure of amyloid-beta fibrils: the Osaka mutation|SOLID-STATE NMR||Homo sapiens|0|PROTEIN FIBRIL","2MXU|42-Residue Beta Amyloid Fibril|SOLID-STATE NMR|||0|PROTEIN FIBRIL","2NAO|Atomic resolution structure of a disease-relevant Abeta(1-42) amyloid fibril|SOLUTION NMR||Homo sapiens|0|PROTEIN FIBRIL","2OTK|Structure of Alzheimer Ab peptide in complex with an engineered binding protein|SOLUTION NMR||engineered binding protein; Homo sapiens|0|DE NOVO PROTEIN, PEPTIDE BINDING PROTEIN","2R0W|PFA2 FAB complexed with Abeta1-8|X-RAY DIFFRACTION|2.503|Mus musculus; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","2WK3|Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-42)|X-RAY DIFFRACTION|2.59|HOMO SAPIENS|0|HYDROLASE","2Y29|Structure of segment KLVFFA from the amyloid-beta peptide (Ab, residues 16-21), alternate polymorph III|X-RAY DIFFRACTION|2.3||0|PROTEIN FIBRIL","2Y2A|Structure of segment KLVFFA from the amyloid-beta peptide (Ab, residues 16-21), alternate polymorph I|X-RAY DIFFRACTION|1.91||0|PROTEIN FIBRIL","2Y3J|Structure of segment AIIGLM from the amyloid-beta peptide (Ab, residues 30-35)|X-RAY DIFFRACTION|1.99||0|PROTEIN FIBRIL","2Y3K|Structure of segment MVGGVVIA from the amyloid-beta peptide (Ab, residues 35-42), alternate polymorph 1|X-RAY DIFFRACTION|1.9||0|PROTEIN FIBRIL","2Y3L|Structure of segment MVGGVVIA from the amyloid-beta peptide (Ab, residues 35-42), alternate polymorph 2|X-RAY DIFFRACTION|2.1||0|PROTEIN FIBRIL","3AYU|Crystal structure of MMP-2 active site mutant in complex with APP-drived decapeptide inhibitor|X-RAY DIFFRACTION|2|Homo sapiens; SYNTHETIC CONSTRUCT|0|HYDROLASE/HYDROLASE INHIBITOR","3BAE|Crystal structure of Fab WO2 bound to the N terminal domain of Amyloid beta peptide (1-28)|X-RAY DIFFRACTION|1.593|Mus musculus; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","3BKJ|Crystal structure of Fab wo2 bound to the n terminal domain of amyloid beta peptide (1-16)|X-RAY DIFFRACTION|1.59|Mus musculus; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","3DXC|Crystal structure of the intracellular domain of human APP in complex with Fe65-PTB2|X-RAY DIFFRACTION|2.1|Homo sapiens|0|PROTEIN BINDING","3DXD|Crystal structure of the intracellular domain of human APP (T668E mutant) in complex with Fe65-PTB2|X-RAY DIFFRACTION|2.2|Homo sapiens|0|PROTEIN BINDING","3DXE|Crystal structure of the intracellular domain of human APP (T668A mutant) in complex with Fe65-PTB2|X-RAY DIFFRACTION|2|Homo sapiens|0|PROTEIN BINDING","3GCI|Crystal Structure of the Complex Formed Between a New Isoform of Phospholipase A2 with C-terminal Amyloid Beta Heptapeptide at 2 A Resolution|X-RAY DIFFRACTION|2.04|Naja sagittifera; SYNTHETIC CONSTRUCT|0|HYDROLASE","3IFL|X-ray structure of amyloid beta peptide:antibody (Abeta1-7:12A11) complex|X-RAY DIFFRACTION|1.5|Mus musculus; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","3IFN|X-ray structure of amyloid beta peptide:antibody (Abeta1-40:12A11) complex|X-RAY DIFFRACTION|1.5|Mus musculus; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","3IFO|X-ray structure of amyloid beta peptide:antibody (Abeta1-7:10D5) complex|X-RAY DIFFRACTION|2.15|Mus musculus; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","3IFP|X-ray structure of amyloid beta peptide:antibody (Abeta1-7:12B4) complex|X-RAY DIFFRACTION|2.95|Mus musculus; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","3JQ5|Phospholipase A2 Prevents the Aggregation of Amyloid Beta Peptides: Crystal Structure of the Complex of Phospholipase A2 with Octapeptide Fragment of Amyloid Beta Peptide, Asp-Ala-Glu-Phe-Arg-His-Asp-Ser at 2 A Resolution|X-RAY DIFFRACTION|2.03|Naja sagittifera; SYNTHETIC CONSTRUCT|0|HYDROLASE","3JQL|Crystal Structure of the Complex Formed Between Phospholipase A2 and a Hexapeptide Fragment of Amyloid Beta Peptide, Lys-Leu-Val-Phe-Phe-Ala at 1.2 A Resolution|X-RAY DIFFRACTION|1.2|Naja sagittifera; SYNTHETIC CONSTRUCT|0|HYDROLASE","3JTI|Crystal structure of the complex formed between Phospholipase A2 with beta-amyloid fragment, Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met at 1.8 A resolution|X-RAY DIFFRACTION|1.8|Naja sagittifera; SYNTHETIC CONSTRUCT|0|HYDROLASE","3KTM|Structure of the Heparin-induced E1-Dimer of the Amyloid Precursor Protein (APP)|X-RAY DIFFRACTION|2.7|Homo sapiens|0|CELL ADHESION, SIGNALING PROTEIN","3L33|Human mesotrypsin complexed with amyloid precursor protein inhibitor(APPI)|X-RAY DIFFRACTION|2.48|Homo sapiens|0|Hydrolase/Cell Adhesion","3L81|Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain, in complex with a sorting peptide from the amyloid precursor protein (APP)|X-RAY DIFFRACTION|1.6|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSPORT PROTEIN","3MOQ|Amyloid beta(18-41) peptide fusion with new antigen receptor variable domain from sharks|X-RAY DIFFRACTION|2.054|Homo sapiens; Orectolobus maculatus|0|NEUROPEPTIDE, IMMUNE SYSTEM","3MXC|Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications.|X-RAY DIFFRACTION|2|Homo sapiens; SYNTHETIC CONSTRUCT|0|PROTEIN BINDING","3MXY|Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications.|X-RAY DIFFRACTION|2.3|Homo sapiens; SYNTHETIC CONSTRUCT|0|PROTEIN BINDING","3NYJ|Crystal Structure Analysis of APP E2 domain|X-RAY DIFFRACTION|3.2|Homo sapiens|0|PROTEIN FIBRIL","3NYL|The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain|X-RAY DIFFRACTION|2.8|Homo sapiens|0|CELL ADHESION","3OVJ|Structure of an amyloid forming peptide KLVFFA from amyloid beta in complex with orange G|X-RAY DIFFRACTION|1.8||0|PROTEIN FIBRIL","3OW9|Structure of an amyloid forming peptide KLVFFA from amyloid beta, alternate polymorph II|X-RAY DIFFRACTION|1.8||0|PROTEIN FIBRIL","3PZZ|Structure of an amyloid forming peptide GAIIGL (29-34) from amyloid beta|X-RAY DIFFRACTION|1.29||0|PROTEIN FIBRIL","3Q2X|Structure of an amyloid forming peptide NKGAII (residues 27-32) from amyloid beta|X-RAY DIFFRACTION|1.451||0|PROTEIN FIBRIL","3SV1|Crystal structure of APP peptide bound rat Mint2 PARM|X-RAY DIFFRACTION|3.3|Rattus norvegicus; SYNTHETIC CONSTRUCT|0|PROTEIN BINDING","3U0T|Fab-antibody complex|X-RAY DIFFRACTION|2.5|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","3UMH|X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with cadmium|X-RAY DIFFRACTION|2|Homo sapiens|0|METAL BINDING PROTEIN","3UMI|X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with zinc|X-RAY DIFFRACTION|2.4|Homo sapiens|0|METAL BINDING PROTEIN","3UMK|X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with copper|X-RAY DIFFRACTION|2.6|Homo sapiens|0|METAL BINDING PROTEIN","4HIX|Crystal structure of a humanised 3D6 Fab bound to amyloid beta peptide|X-RAY DIFFRACTION|2.204|homo Sapiens, Mus musculus; SYNTHETIC CONSTRUCT|0|PROTEIN FIBRIL/Immune System","4JFN|Crystal structure of the N-terminal, growth factor-like domain of the amyloid precursor protein bound to copper|X-RAY DIFFRACTION|1.75|Homo sapiens|0|METAL BINDING PROTEIN","4M1C|Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Amyloid-Beta (1-40)|X-RAY DIFFRACTION|3.5007|Homo sapiens; SYNTHETIC CONSTRUCT|0|HYDROLASE","4MDR|Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain D190A mutant, in complex with a sorting peptide from the amyloid precursor protein (APP)|X-RAY DIFFRACTION|1.85|Homo sapiens; SYNTHETIC CONSTRUCT|0|PROTEIN TRANSPORT/PROTEIN BINDING","4MVI|Crystal structure of an engineered lipocalin (Anticalin US7) in complex with the Alzheimer amyloid peptide Abeta(1-40)|X-RAY DIFFRACTION|1.7|Homo sapiens; SYNTHETIC CONSTRUCT|0|PROTEIN BINDING/PROTEIN FIBRIL"]},{"input":"Q9NZC2","source":"Q9NZC2|Triggering receptor expressed on myeloid cells 2","targets":["5ELI|Triggering receptor expressed on myeloid cells 2|X-RAY DIFFRACTION|3.0977|Homo sapiens|0|IMMUNE SYSTEM","5UD7|Crystal Structure of Wild-Type Ig-like Domain|X-RAY DIFFRACTION|2.20002|Homo sapiens|0|SIGNALING PROTEIN","5UD8|Crystal Structure of Mutant Ig-like Domain|X-RAY DIFFRACTION|1.8|Homo sapiens|0|IMMUNE SYSTEM","6B8O|WT Ig-like V Domain with Phosphatidylserine|X-RAY DIFFRACTION|2.2|Homo sapiens|0|SIGNALING PROTEIN","6XDS|Crystal structure of MBP-TREM2 Ig domain fusion with fragment, 2-((4-bromophenyl)amino)ethan-1-ol|X-RAY DIFFRACTION|1.466|Homo sapiens; Methanosarcina mazei|0|SIGNALING PROTEIN","6Y6C|TREM2 extracellular domain (19-174) in complex with single-chain variable fragment (scFv-4)|X-RAY DIFFRACTION|2.26|Homo sapiens|0|IMMUNE SYSTEM","6YMQ|TREM2 extracellular domain (19-131) in complex with single-chain variable 4 (scFv-4)|X-RAY DIFFRACTION|3.07|Homo sapiens|0|IMMUNE SYSTEM","6YYE|TREM2 extracellular domain (19-131) in complex with single-chain variable fragment (scFv-2)|X-RAY DIFFRACTION|3.36|Homo sapiens|0|IMMUNE SYSTEM","6Z0G|Structure of TREM2 transmembrane helix in DPC micelles|SOLUTION NMR||Homo sapiens|0|MEMBRANE PROTEIN","6Z0H|Structure of TREM2 transmembrane helix K186A variant in DPC micelles|SOLUTION NMR||Homo sapiens|0|MEMBRANE PROTEIN","6Z0I|Structure of the TREM2 transmembrane helix in complex with DAP12 in DPC micelles|SOLUTION NMR||Homo sapiens|0|MEMBRANE PROTEIN","8T51|Crystal structure of Fab 3.10C2 bound to TREM2|X-RAY DIFFRACTION|1.9|Homo sapiens; SYNTHETIC CONSTRUCT|0|PEPTIDE BINDING PROTEIN","8T59|Crystal structure of Para.09 bound to TREM2|X-RAY DIFFRACTION|2|synthetic construct; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM/PEPTIDE BINDING PROTEIN","9PWN|Crystal structure of Fabs 7411 in complex with TREM2 peptide|X-RAY DIFFRACTION|1.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","9PX5|Crystal structure of Fab 7268 in complex with MBP-TREM2 Ig domain fusion|X-RAY DIFFRACTION|3.7|Escherichia coli; Homo sapiens|0|IMMUNE SYSTEM"]},{"input":"P02649","source":"P02649|Apolipoprotein E","targets":["1B68|APOLIPOPROTEIN E4 (APOE4), 22K FRAGMENT|X-RAY DIFFRACTION|2|Homo sapiens|0|LIPID TRANSPORT","1BZ4|APOLIPOPROTEIN E3 (APO-E3), TRUNCATION MUTANT 165|X-RAY DIFFRACTION|1.85|Homo sapiens|0|LIPID BINDING PROTEIN","1EA8|Apolipoprotein E3 22kD fragment LYS146GLU mutant|X-RAY DIFFRACTION|1.95|HOMO SAPIENS|0|LIPID BINDING PROTEIN","1GS9|Apolipoprotein E4, 22k domain|X-RAY DIFFRACTION|1.7|HOMO SAPIENS|0|LIPID BINDING PROTEIN","1H7I|Apolipoprotein E3 22kD fragment LYS146GLN mutant|X-RAY DIFFRACTION|1.9|HOMO SAPIENS|0|LIPID BINDING PROTEIN","1LE2|STRUCTURAL BASIS FOR ALTERED FUNCTION IN THE COMMON MUTANTS OF HUMAN APOLIPOPROTEIN-E|X-RAY DIFFRACTION|3|Homo sapiens|0|LIPOPROTEIN","1LE4|STRUCTURAL BASIS FOR ALTERED FUNCTION IN THE COMMON MUTANTS OF HUMAN APOLIPOPROTEIN-E|X-RAY DIFFRACTION|2.5|Homo sapiens|0|LIPOPROTEIN","1LPE|THREE-DIMENSIONAL STRUCTURE OF THE LDL RECEPTOR-BINDING DOMAIN OF HUMAN APOLIPOPROTEIN E|X-RAY DIFFRACTION|2.25|Homo sapiens|0|LIPOPROTEIN","1NFN|APOLIPOPROTEIN E3 (APOE3)|X-RAY DIFFRACTION|1.8|Homo sapiens|0|LIPID TRANSPORT","1NFO|APOLIPOPROTEIN E2 (APOE2, D154A MUTATION)|X-RAY DIFFRACTION|2|Homo sapiens|0|LIPID TRANSPORT","1OEF|PEPTIDE OF HUMAN APOE RESIDUES 263-286, NMR, 5 STRUCTURES AT PH 4.8, 37 DEGREES CELSIUS AND PEPTIDE:SDS MOLE RATIO OF 1:90|SOLUTION NMR||Homo sapiens|0|APOLIPOPROTEIN","1OEG|PEPTIDE OF HUMAN APOE RESIDUES 267-289, NMR, 5 STRUCTURES AT PH 6.0, 37 DEGREES CELSIUS AND PEPTIDE:SDS MOLE RATIO OF 1:90|SOLUTION NMR||Homo sapiens|0|APOLIPOPROTEIN","1OR2|APOLIPOPROTEIN E3 (APOE3) TRUNCATION MUTANT 165|X-RAY DIFFRACTION|2.5|Homo sapiens|0|LIPID BINDING PROTEIN","1OR3|APOLIPOPROTEIN E3 (APOE3), TRIGONAL TRUNCATION MUTANT 165|X-RAY DIFFRACTION|1.73|Homo sapiens|0|LIPID BINDING PROTEIN","2KC3|NMR solution structure of complete receptor binding domain of human apolipoprotein E|SOLUTION NMR||Homo sapiens|0|LIPOPROTEIN","2KNY|Fusion construct of CR17 from LRP-1 and ApoE residues 130-149|SOLUTION NMR||Homo sapiens|0|METAL BINDING PROTEIN","2L7B|NMR Structure of full length apoE3|SOLUTION NMR||Homo sapiens|0|LIPID TRANSPORT","6IWB|Crystal structure of a computationally designed protein (LD3) in complex with BCL-2|X-RAY DIFFRACTION|2.5|Homo sapiens|0|APOPTOSIS","6NCN|Fragment-based Discovery of an apoE4 Stabilizer|X-RAY DIFFRACTION|1.82|Homo sapiens|0|LIPID TRANSPORT","6NCO|Fragment-based Discovery of an apoE4 Stabilizer|X-RAY DIFFRACTION|1.707|Homo sapiens|0|LIPID TRANSPORT","6V7M|Crystal structure of a proteolytically cleaved, amino terminal domain of apolipoprotein E3|X-RAY DIFFRACTION|2|Homo sapiens|0|LIPID TRANSPORT","7FCR|Crystal structure of the N-terminal domain of mutants of Human Apolipoprotein-E (ApoE)|X-RAY DIFFRACTION|1.4|Homo sapiens|0|LIPID TRANSPORT","7FCS|Crystal structure of the N-terminal domain of mutants of Human Apolipoprotein-E (ApoE)|X-RAY DIFFRACTION|1.6|Homo sapiens|0|LIPID TRANSPORT","7UVJ|Rationally Designed ED1 Epitope-Scaffold Immunogen for SARS-CoV-2|X-RAY DIFFRACTION|1.99|Escherichia coli|0|DE NOVO PROTEIN","8AX8|Human Apolipoprotein E4 (ApoE4) N-terminal domain (space group P3121)|X-RAY DIFFRACTION|1.551|Homo sapiens|0|LIPID BINDING PROTEIN","8AX9|Human Apolipoprotein E4 (ApoE4) N-terminal domain (space group P212121)|X-RAY DIFFRACTION|1.549|Homo sapiens|0|LIPID BINDING PROTEIN","8CDY|N-terminal domain of human apolipoprotein E|X-RAY DIFFRACTION|1.9|Escherichia coli; Homo sapiens|0|LIPID TRANSPORT","8CE0|N-terminal domain of human apolipoprotein E|X-RAY DIFFRACTION|1.75|Escherichia coli; Homo sapiens|0|LIPID TRANSPORT","8GRX|APOE4 receptor in complex with APOE4 NTD|ELECTRON MICROSCOPY|3.0|Homo sapiens|0|IMMUNE SYSTEM"]},{"input":"P49768","source":"P49768|Presenilin-1","targets":["2KR6|Solution structure of presenilin-1 CTF subunit|SOLUTION NMR||Homo sapiens|0|HYDROLASE","4UIS|The cryoEM structure of human gamma-Secretase complex|ELECTRON MICROSCOPY|4.4|HOMO SAPIENS|0|HYDROLASE","5A63|Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution.|ELECTRON MICROSCOPY|3.4|Homo sapiens|0|HYDROLASE","5FN2|Cryo-EM structure of gamma secretase in complex with a drug DAPT|ELECTRON MICROSCOPY|4.2|Homo sapiens|0|HYDROLASE","5FN3|Cryo-EM structure of gamma secretase in class 1 of the apo- state ensemble|ELECTRON MICROSCOPY|4.1|Homo sapiens|0|HYDROLASE","5FN4|Cryo-EM structure of gamma secretase in class 2 of the apo- state ensemble|ELECTRON MICROSCOPY|4.0|Homo sapiens|0|HYDROLASE","5FN5|Cryo-EM structure of gamma secretase in class 3 of the apo- state ensemble|ELECTRON MICROSCOPY|4.3|Homo sapiens|0|HYDROLASE","6IDF|Cryo-EM structure of gamma secretase in complex with a Notch fragment|ELECTRON MICROSCOPY|2.7|Homo sapiens|0|MEMBRANE PROTEIN","6IYC|Recognition of the Amyloid Precursor Protein by Human gamma-secretase|ELECTRON MICROSCOPY|2.6|Homo sapiens|0|MEMBRANE PROTEIN","6LQG|Human gamma-secretase in complex with small molecule Avagacestat|ELECTRON MICROSCOPY|3.1|Homo sapiens|0|MEMBRANE PROTEIN/HYDROLASE","6LR4|Molecular basis for inhibition of human gamma-secretase by small molecule|ELECTRON MICROSCOPY|3.0|Homo sapiens|0|MEMBRANE PROTEIN","7C9I|Human gamma-secretase in complex with small molecule L-685,458|ELECTRON MICROSCOPY|3.1|Homo sapiens|0|HYDROLASE","7D8X|CryoEM structure of human gamma-secretase in complex with E2012 and L685458|ELECTRON MICROSCOPY|2.6|Homo sapiens|0|HYDROLASE","7Y5T|CryoEM structure of PS1-containing gamma-secretase in complex with MRK-560|ELECTRON MICROSCOPY|2.9|Homo sapiens|0|MEMBRANE PROTEIN/HYDROLASE","8IM7|Human gamma-secretase treated with ganglioside GM1|ELECTRON MICROSCOPY|3.4|Homo sapiens|0|MEMBRANE PROTEIN","8K8E|Human gamma-secretase in complex with a substrate mimetic|ELECTRON MICROSCOPY|2.6|Homo sapiens; SYNTHETIC CONSTRUCT|0|MEMBRANE PROTEIN","8KCO|Cryo-EM structure of human gamma-secretase in complex with RO4929097|ELECTRON MICROSCOPY|2.8|Homo sapiens|0|MEMBRANE PROTEIN","8KCP|Cryo-EM structure of human gamma-secretase in complex with Crenigacestat|ELECTRON MICROSCOPY|3.0|Homo sapiens|0|MEMBRANE PROTEIN","8KCS|Cryo-EM structure of human gamma-secretase in complex with BMS906024|ELECTRON MICROSCOPY|2.4|Homo sapiens|0|MEMBRANE PROTEIN","8KCT|Cryo-EM structure of human gamma-secretase in complex with Nirogacestat|ELECTRON MICROSCOPY|2.6|Homo sapiens|0|MEMBRANE PROTEIN","8KCU|Cryo-EM structure of human gamma-secretase in complex with MK-0752|ELECTRON MICROSCOPY|2.7|Homo sapiens|0|MEMBRANE PROTEIN","8OQY|Structure of apo form of human gamma-secretase PSEN1 APH-1B isoform reconstituted into lipid nanodisc|ELECTRON MICROSCOPY|3.3|Homo sapiens|0|MEMBRANE PROTEIN","8OQZ|Structure of human gamma-secretase PSEN1 APH-1B isoform reconstituted into lipid nanodisc in complex with Ab46|ELECTRON MICROSCOPY|3.4|Homo sapiens|0|MEMBRANE PROTEIN","8X52|Cryo-EM structure of human gamma-secretase in complex with Abeta49|ELECTRON MICROSCOPY|2.9|Homo sapiens|0|MEMBRANE PROTEIN","8X53|Cryo-EM structure of human gamma-secretase in complex with Abeta46|ELECTRON MICROSCOPY|3.0|Homo sapiens; SYNTHETIC CONSTRUCT|0|MEMBRANE PROTEIN","8X54|Cryo-EM structure of human gamma-secretase in complex with APP-C99|ELECTRON MICROSCOPY|2.9|Homo sapiens|0|MEMBRANE PROTEIN","9K95|Cryo-EM structure of human gamma-secretase in complex with compound E|ELECTRON MICROSCOPY|2.9|Homo sapiens|0|MEMBRANE PROTEIN"]}]}