{"context":{"query":">>uniprot>>signor","source_dataset":"uniprot","target_dataset":"signor"},"stats":{"queried":1,"total":44,"mapped":1},"pagination":{"has_next":false},"schema":"id|entity_a|entity_b|effect|mechanism|direct|score","mappings":[{"input":"P09874","source":"P09874|Poly [ADP-ribose] polymerase 1","targets":["SIGNOR-111680|PARP1|Apoptosis|down-regulates||false|0.70","SIGNOR-116178|CASP3|PARP1|down-regulates activity|cleavage|true|0.78","SIGNOR-146220|MAPK1|PARP1|up-regulates|phosphorylation|true|0.52","SIGNOR-146224|MAPK1|PARP1|up-regulates|phosphorylation|true|0.52","SIGNOR-189183|veliparib|PARP1|down-regulates|chemical inhibition|true|0.80","SIGNOR-189394|LSM-1988|PARP1|down-regulates|chemical inhibition|true|0.80","SIGNOR-193474|4-Iodo-3-nitrobenzamide|PARP1|down-regulates|chemical inhibition|true|0.80","SIGNOR-194399|1038915-60-4|PARP1|down-regulates|chemical inhibition|true|0.80","SIGNOR-195016|olaparib|PARP1|down-regulates|chemical inhibition|true|0.80","SIGNOR-205698|A-966492|PARP1|down-regulates|chemical inhibition|true|0.80","SIGNOR-244669|ERK1/2|PARP1|up-regulates|phosphorylation|true|0.20","SIGNOR-244673|ERK1/2|PARP1|up-regulates|phosphorylation|true|0.20","SIGNOR-254528|PARP1|SNAIL/RELA/PARP1|form complex|binding|true|0.48","SIGNOR-254891|PARP1|SERPINF1|down-regulates quantity by repression|transcriptional regulation|false|0.20","SIGNOR-254892|PARP1|THBD|up-regulates quantity by expression|transcriptional regulation|false|0.20","SIGNOR-254893|PARP1|THBD|down-regulates quantity by repression|transcriptional regulation|false|0.20","SIGNOR-256465|Caspase 3 complex|PARP1|down-regulates activity|cleavage|true|0.78","SIGNOR-256470|Caspase 7 complex|PARP1|down-regulates|cleavage|true|0.72","SIGNOR-260065|DNA_damage|PARP1|up-regulates||false|0.70","SIGNOR-261270|PARP1|POLA1|up-regulates activity|binding|true|0.34","SIGNOR-261321|PARP1|TP53|up-regulates activity|relocalization|true|0.56","SIGNOR-261554|FLT3|PARP1|up-regulates quantity by expression|transcriptional regulation|false|0.25","SIGNOR-264526|PARP1|CHD2|up-regulates quantity|binding|true|0.20","SIGNOR-271470|CHFR|PARP1|down-regulates quantity by destabilization|polyubiquitination|true|0.43","SIGNOR-271574|PARP1|KDM5B|up-regulates activity|relocalization|true|0.35","SIGNOR-272477|ZNF365|PARP1|up-regulates activity|binding|true|0.20","SIGNOR-272478|PARP1|MRE11|up-regulates activity|relocalization|true|0.20","SIGNOR-273715|NAT10|PARP1|up-regulates quantity by stabilization|acetylation|true|0.20","SIGNOR-276357|CDK5|PARP1|down-regulates activity|phosphorylation|true|0.26","SIGNOR-276358|CDK5|PARP1|down-regulates activity|phosphorylation|true|0.26","SIGNOR-276359|CDK5|PARP1|down-regulates activity|phosphorylation|true|0.26","SIGNOR-276651|PRKACA|PARP1|up-regulates activity|phosphorylation|true|0.20","SIGNOR-276652|PRKACA|PARP1|up-regulates activity|phosphorylation|true|0.20","SIGNOR-276653|PRKACA|PARP1|up-regulates activity|phosphorylation|true|0.20","SIGNOR-277551|ATR|PARP1|down-regulates activity|phosphorylation|true|0.36","SIGNOR-278506|ATR|PARP1|down-regulates|phosphorylation|true|0.36","SIGNOR-278774|PHRF1|PARP1|down-regulates quantity by destabilization|ubiquitination|true|0.20","SIGNOR-278776|RNF144A|PARP1|down-regulates quantity by destabilization|ubiquitination|true|0.20","SIGNOR-279146|CDK2|PARP1|up-regulates activity|phosphorylation|true|0.36","SIGNOR-279169|EGFR|PARP1|up-regulates activity|phosphorylation|true|0.39","SIGNOR-279470|MET|PARP1|up-regulates activity|phosphorylation|true|0.39","SIGNOR-280085|PRKCD|PARP1|down-regulates activity|phosphorylation|true|0.20","SIGNOR-280093|PRKDC|PARP1|down-regulates activity|phosphorylation|true|0.53","SIGNOR-83703|CASP7|PARP1|down-regulates|cleavage|true|0.72"]}]}