{"context":{"query":">>uniprot>>reactome","source_dataset":"uniprot","target_dataset":"reactome"},"stats":{"queried":5,"total":87,"mapped":5},"pagination":{"has_next":false},"schema":"id|name|tax_id|is_disease_pathway","mappings":[{"input":"P11511","source":"P11511|Aromatase","targets":["R-HSA-193144|Estrogen biosynthesis|9606|false","R-HSA-211976|Endogenous sterols|9606|false","R-HSA-5579030|Defective CYP19A1 causes AEXS|9606|true"]},{"input":"P21802","source":"P21802|Fibroblast growth factor receptor 2","targets":["R-HSA-2023837|Signaling by FGFR2 amplification mutants|9606|true","R-HSA-2033519|Activated point mutants of FGFR2|9606|true","R-HSA-5655253|Signaling by FGFR2 in disease|9606|true","R-HSA-8851708|Signaling by FGFR2 IIIa TM|9606|true","R-HSA-8853333|Signaling by FGFR2 fusions|9606|true","R-HSA-109704|PI3K Cascade|9606|false","R-HSA-1257604|PIP3 activates AKT signaling|9606|false","R-HSA-190375|FGFR2c ligand binding and activation|9606|false","R-HSA-190377|FGFR2b ligand binding and activation|9606|false","R-HSA-2219530|Constitutive Signaling by Aberrant PI3K in Cancer|9606|true","R-HSA-5654221|Phospholipase C-mediated cascade; FGFR2|9606|false","R-HSA-5654695|PI-3K cascade:FGFR2|9606|false","R-HSA-5654699|SHC-mediated cascade:FGFR2|9606|false","R-HSA-5654700|FRS-mediated FGFR2 signaling|9606|false","R-HSA-5654727|Negative regulation of FGFR2 signaling|9606|false","R-HSA-5673001|RAF/MAP kinase cascade|9606|false","R-HSA-6811558|PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling|9606|false"]},{"input":"P31749","source":"P31749|RAC-alpha serine/threonine-protein kinase","targets":["R-HSA-111447|Activation of BAD and translocation to mitochondria |9606|false","R-HSA-1257604|PIP3 activates AKT signaling|9606|false","R-HSA-1358803|Downregulation of ERBB2:ERBB3 signaling|9606|false","R-HSA-1445148|Translocation of SLC2A4 (GLUT4) to the plasma membrane|9606|false","R-HSA-1474151|Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation|9606|false","R-HSA-165159|MTOR signalling|9606|false","R-HSA-198323|AKT phosphorylates targets in the cytosol|9606|false","R-HSA-198693|AKT phosphorylates targets in the nucleus|9606|false","R-HSA-199418|Negative regulation of the PI3K/AKT network|9606|false","R-HSA-203615|eNOS activation|9606|false","R-HSA-211163|AKT-mediated inactivation of FOXO1A|9606|false","R-HSA-354192|Integrin signaling|9606|false","R-HSA-3769402|Deactivation of the beta-catenin transactivating complex|9606|false","R-HSA-389357|CD28 dependent PI3K/Akt signaling|9606|false","R-HSA-389513|Co-inhibition by CTLA4|9606|false","R-HSA-392451|G beta:gamma signalling through PI3Kgamma|9606|false","R-HSA-450385|Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA|9606|false","R-HSA-450604|KSRP (KHSRP) binds and destabilizes mRNA|9606|false","R-HSA-5218920|VEGFR2 mediated vascular permeability|9606|false","R-HSA-5628897|TP53 Regulates Metabolic Genes|9606|false","R-HSA-5674400|Constitutive Signaling by AKT1 E17K in Cancer|9606|true","R-HSA-6785807|Interleukin-4 and Interleukin-13 signaling|9606|false","R-HSA-6804757|Regulation of TP53 Degradation|9606|false","R-HSA-6804758|Regulation of TP53 Activity through Acetylation|9606|false","R-HSA-6804759|Regulation of TP53 Activity through Association with Co-factors|9606|false","R-HSA-6811558|PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling|9606|false","R-HSA-69202|Cyclin E associated events during G1/S transition |9606|false","R-HSA-69656|Cyclin A:Cdk2-associated events at S phase entry|9606|false","R-HSA-8849469|PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1|9606|false","R-HSA-8876198|RAB GEFs exchange GTP for GDP on RABs|9606|false","R-HSA-8941332|RUNX2 regulates genes involved in cell migration|9606|false","R-HSA-8948751|Regulation of PTEN stability and activity|9606|false","R-HSA-9009391|Extra-nuclear estrogen signaling|9606|false","R-HSA-9604323|Negative regulation of NOTCH4 signaling|9606|false","R-HSA-9607240|FLT3 Signaling|9606|false","R-HSA-9614399|Regulation of localization of FOXO transcription factors|9606|false","R-HSA-9634638|Estrogen-dependent nuclear events downstream of ESR-membrane signaling|9606|false","R-HSA-9755511|KEAP1-NFE2L2 pathway|9606|false","R-HSA-9755779|SARS-CoV-2 targets host intracellular signalling and regulatory pathways|9606|true","R-HSA-9841251|Mitochondrial unfolded protein response (UPRmt)|9606|false","R-HSA-9856530|High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells|9606|false","R-HSA-9856532|Mechanical load activates signaling by PIEZO1 and integrins in osteocytes|9606|false"]},{"input":"P37231","source":"P37231|Peroxisome proliferator-activated receptor gamma","targets":["R-HSA-1989781|PPARA activates gene expression|9606|false","R-HSA-381340|Transcriptional regulation of white adipocyte differentiation|9606|false","R-HSA-383280|Nuclear Receptor transcription pathway|9606|false","R-HSA-4090294|SUMOylation of intracellular receptors|9606|false","R-HSA-8943724|Regulation of PTEN gene transcription|9606|false","R-HSA-9022707|MECP2 regulates transcription factors|9606|false","R-HSA-9844594|Transcriptional regulation of brown and beige adipocyte differentiation by EBF2|9606|false","R-HSA-9841922|MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis|9606|false"]},{"input":"P03372","source":"P03372|Estrogen receptor","targets":["R-HSA-1251985|Nuclear signaling by ERBB4|9606|false","R-HSA-1257604|PIP3 activates AKT signaling|9606|false","R-HSA-2219530|Constitutive Signaling by Aberrant PI3K in Cancer|9606|true","R-HSA-383280|Nuclear Receptor transcription pathway|9606|false","R-HSA-4090294|SUMOylation of intracellular receptors|9606|false","R-HSA-5689896|Ovarian tumor domain proteases|9606|false","R-HSA-6811558|PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling|9606|false","R-HSA-8866910|TFAP2 (AP-2) family regulates transcription of growth factors and their receptors|9606|false","R-HSA-8931987|RUNX1 regulates estrogen receptor mediated transcription|9606|false","R-HSA-8939211|ESR-mediated signaling|9606|false","R-HSA-8939256|RUNX1 regulates transcription of genes involved in WNT signaling|9606|false","R-HSA-8939902|Regulation of RUNX2 expression and activity|9606|false","R-HSA-9009391|Extra-nuclear estrogen signaling|9606|false","R-HSA-9018519|Estrogen-dependent gene expression|9606|false","R-HSA-9841251|Mitochondrial unfolded protein response (UPRmt)|9606|false","R-HSA-9927418|Developmental Lineage of Mammary Gland Luminal Epithelial Cells|9606|false","R-HSA-9927426|Developmental Lineage of Mammary Gland Alveolar Cells|9606|false"]}]}