{"context":{"query":">>uniprot>>signor","source_dataset":"uniprot","target_dataset":"signor"},"stats":{"queried":1,"total":73,"mapped":1},"pagination":{"has_next":false},"schema":"id|entity_a|entity_b|effect|mechanism|direct|score","mappings":[{"input":"P11802","source":"P11802|Cyclin-dependent kinase 4","targets":["SIGNOR-102734|MYC|CDK4|up-regulates quantity by expression|transcriptional regulation|true|0.57","SIGNOR-135181|CDK4|RB1|down-regulates|phosphorylation|true|0.93","SIGNOR-135185|CDK4|RB1|down-regulates|phosphorylation|true|0.93","SIGNOR-140409|CDKN2A|CDK4|down-regulates|binding|true|0.91","SIGNOR-153450|CDK4|BRCA1|down-regulates|phosphorylation|true|0.67","SIGNOR-159849|CDK4|RASSF1|down-regulates|phosphorylation|true|0.41","SIGNOR-167770|CDK4|PELP1|up-regulates|phosphorylation|true|0.35","SIGNOR-167774|CDK4|PELP1|up-regulates|phosphorylation|true|0.35","SIGNOR-176515|CDK4|MEF2A|down-regulates|binding|true|0.28","SIGNOR-176518|CDK4|MEF2C|down-regulates|binding|true|0.28","SIGNOR-176521|CDK4|MEF2C|down-regulates||true|0.28","SIGNOR-176524|CDK4|MEF2D|down-regulates|binding|true|0.28","SIGNOR-176527|CDK4|MYOD1|down-regulates|binding|true|0.51","SIGNOR-176530|CDK4|MYOG|down-regulates|binding|true|0.33","SIGNOR-177251|CDK4|FOXM1|up-regulates|phosphorylation|true|0.62","SIGNOR-177255|CDK4|FOXM1|up-regulates|phosphorylation|true|0.62","SIGNOR-177259|CDK4|FOXM1|up-regulates|phosphorylation|true|0.62","SIGNOR-177263|CDK4|FOXM1|up-regulates|phosphorylation|true|0.62","SIGNOR-177266|CDK4|FOXM1|up-regulates|phosphorylation|true|0.62","SIGNOR-178624|YES1|CDK4|down-regulates|phosphorylation|true|0.25","SIGNOR-182822|CDK4|SMAD3|down-regulates activity|phosphorylation|true|0.76","SIGNOR-182979|CDK4|SMAD3|down-regulates|phosphorylation|true|0.76","SIGNOR-182983|CDK4|SMAD3|down-regulates|phosphorylation|true|0.76","SIGNOR-185120|CDK4|RUNX3|down-regulates|phosphorylation|true|0.40","SIGNOR-189990|4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-pyrazole-3-carboxamide|CDK4|down-regulates|chemical inhibition|true|0.80","SIGNOR-192038|alvocidib|CDK4|down-regulates|chemical inhibition|true|0.80","SIGNOR-192464|alvocidib hydrochloride|CDK4|down-regulates|chemical inhibition|true|0.80","SIGNOR-200483|CDK4|RB1|down-regulates|phosphorylation|true|0.93","SIGNOR-200487|CDK4|RB1|down-regulates|phosphorylation|true|0.93","SIGNOR-201666|CCND1|CDK4|up-regulates|binding|true|0.96","SIGNOR-205704|palbociclib|CDK4|down-regulates|chemical inhibition|true|0.80","SIGNOR-206130|N-[6,6-dimethyl-5-[(1-methyl-4-piperidinyl)-oxomethyl]-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-methylbutanamide|CDK4|down-regulates|chemical inhibition|true|0.80","SIGNOR-206364|R547|CDK4|down-regulates|chemical inhibition|true|0.80","SIGNOR-232138|CDK4|SMAD3|down-regulates activity|phosphorylation|true|0.76","SIGNOR-232142|CDK4|SMAD3|down-regulates activity|phosphorylation|true|0.76","SIGNOR-232146|CDK4|SMAD3|down-regulates activity|phosphorylation|true|0.76","SIGNOR-250763|CDK4|RBL1|up-regulates activity|phosphorylation|true|0.81","SIGNOR-250764|CDK4|RBL1|up-regulates activity|phosphorylation|true|0.81","SIGNOR-250765|CDK4|RBL1|up-regulates activity|phosphorylation|true|0.81","SIGNOR-250766|CDK4|SMAD3|unknown|phosphorylation|true|0.76","SIGNOR-250767|CDK4|SMAD3|unknown|phosphorylation|true|0.76","SIGNOR-258172|alvocidib|CDK4|down-regulates activity|chemical inhibition|true|0.80","SIGNOR-258274|R547|CDK4|down-regulates activity|chemical inhibition|true|0.80","SIGNOR-259794|R547|CDK4|down-regulates activity|chemical inhibition|true|0.80","SIGNOR-262220|4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-pyrazole-3-carboxamide|CDK4|down-regulates activity|chemical inhibition|true|0.80","SIGNOR-262221|4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-pyrazole-3-carboxamide|CDK4|down-regulates activity|chemical inhibition|true|0.80","SIGNOR-262735|CDK4|CELF1|up-regulates activity|phosphorylation|true|0.40","SIGNOR-264059|LRRC4|CDK4|down-regulates quantity by repression|transcriptional regulation|false|0.20","SIGNOR-267568|CDC25A|CDK4|up-regulates activity|dephosphorylation|true|0.70","SIGNOR-269329|CAK complex|CDK4|up-regulates|phosphorylation|true|0.58","SIGNOR-273602|CDK4|TOB2|up-regulates activity|phosphorylation|true|0.20","SIGNOR-275494|CDK4|KAT2A|up-regulates activity|phosphorylation|true|0.36","SIGNOR-275495|CDK4|KAT2A|up-regulates activity|phosphorylation|true|0.36","SIGNOR-276317|CDK4|GATA4|down-regulates quantity by destabilization|phosphorylation|true|0.36","SIGNOR-277138|CDC25A|CDK4|up-regulates activity|dephosphorylation|true|0.70","SIGNOR-278377|CDK4|FOXO1|up-regulates activity|phosphorylation|true|0.46","SIGNOR-278512|CDK4|PAX3|up-regulates activity|phosphorylation|true|0.30","SIGNOR-279018|CDK4|KAT2A|up-regulates activity|phosphorylation|true|0.36","SIGNOR-279019|CDK4|WDR77|up-regulates activity|phosphorylation|true|0.70","SIGNOR-279148|CDK4|GATA4|up-regulates activity|phosphorylation|true|0.36","SIGNOR-279450|CDK4|TFEB|up-regulates activity|phosphorylation|true|0.20","SIGNOR-279514|CDK4|TFE3|up-regulates activity|phosphorylation|true|0.20","SIGNOR-280214|CDK4|APP|down-regulates quantity by destabilization|phosphorylation|true|0.26","SIGNOR-29957|CDKN1A|CDK4|down-regulates|binding|true|0.94","SIGNOR-32295|CCND1|CDK4|up-regulates|binding|true|0.96","SIGNOR-32301|CDK4|CyclinD/CDK4|form complex|binding|true|0.96","SIGNOR-36549|CDK7|CDK4|up-regulates|phosphorylation|true|0.59","SIGNOR-39045|TGFB1|CDK4|down-regulates quantity by repression|transcriptional regulation|false|0.28","SIGNOR-44554|CDKN2A|CDK4|down-regulates|binding|true|0.91","SIGNOR-44598|CDKN2C|CDK4|down-regulates|binding|true|0.87","SIGNOR-46758|CDKN2B|CDK4|down-regulates|binding|true|0.88","SIGNOR-47899|CDK4|RB1|down-regulates|phosphorylation|true|0.93","SIGNOR-87105|CDK4|PRDX1|down-regulates|phosphorylation|true|0.23"]}]}