{"context":{"query":">>uniprot>>pdb","source_dataset":"uniprot","target_dataset":"pdb"},"stats":{"queried":8,"total":467,"mapped":8},"pagination":{"has_next":true,"next_token":"-1[]P03372,1,P03372,121,1][O14965,1,O14965,192,1][P04637,1,P04637,143,1]["},"schema":"id|title|method|resolution|source_organism|chain_count|header","mappings":[{"input":"P21802","source":"P21802|Fibroblast growth factor receptor 2","targets":["1DJS|LIGAND-BINDING PORTION OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 IN COMPLEX WITH FGF1|X-RAY DIFFRACTION|2.4|Homo sapiens|0|HORMONE/GROWTH FACTOR/RECEPTOR","1E0O|CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX|X-RAY DIFFRACTION|2.8|HOMO SAPIENS|0|GROWTH FACTOR","1EV2|CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2)|X-RAY DIFFRACTION|2.2|Homo sapiens|0|GROWTH FACTOR/GROWTH FACTOR RECEPTOR","1GJO|The FGFr2 tyrosine kinase domain|X-RAY DIFFRACTION|2.4|HOMO SAPIENS|0|TRANSFERASE","1II4|CRYSTAL STRUCTURE OF SER252TRP APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2|X-RAY DIFFRACTION|2.7|Homo sapiens|0|GROWTH FACTOR/GROWTH FACTOR RECEPTOR","1IIL|CRYSTAL STRUCTURE OF PRO253ARG APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2|X-RAY DIFFRACTION|2.3|Homo sapiens|0|GROWTH FACTOR/GROWTH FACTOR RECEPTOR","1NUN|Crystal Structure Analysis of the FGF10-FGFR2b Complex|X-RAY DIFFRACTION|2.9|Homo sapiens|0|HORMONE/GROWTH FACTOR/MEMBRANE PROTEIN","1OEC|FGFr2 kinase domain|X-RAY DIFFRACTION|2.4|HOMO SAPIENS|0|TRANSFERASE","1WVZ|Solution Structure of the D2 Domain of the Fibroblast Growth Factor|SOLUTION NMR||Homo sapiens|0|TRANSFERASE","2FDB|Crystal Structure of Fibroblast growth factor (FGF)8b in complex with FGF Receptor (FGFR) 2c|X-RAY DIFFRACTION|2.28|Homo sapiens|0|HORMONE/GROWTH FACTOR/TRANSFERASE","2PSQ|Crystal Structure of Unphosphorylated Unactivated Wild Type FGF Receptor 2 (FGFR2) Kinase Domain|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE","2PVF|Crystal Structure of Tyrosine Phosphorylated Activated FGF Receptor 2 (FGFR2) Kinase Domain in Complex with ATP Analog and Substrate Peptide|X-RAY DIFFRACTION|1.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE","2PVY|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome.|X-RAY DIFFRACTION|2.2|Homo sapiens|0|TRANSFERASE","2PWL|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549H Mutation Responsible for Crouzon Syndrome.|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE","2PY3|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565G Mutation Responsible for Pfeiffer Syndrome|X-RAY DIFFRACTION|2.3|Homo sapiens|0|TRANSFERASE","2PZ5|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible for Pfeiffer Syndrome|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE","2PZP|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation Responsible for Crouzon Syndrome|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE","2PZR|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K641R Mutation Responsible for Pfeiffer Syndrome|X-RAY DIFFRACTION|3|Homo sapiens|0|TRANSFERASE","2Q0B|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565A Mutation Responsible for Pfeiffer Syndrome|X-RAY DIFFRACTION|2.9|Homo sapiens|0|TRANSFERASE","3B2T|Structure of phosphotransferase|X-RAY DIFFRACTION|1.8|Homo sapiens|0|TRANSFERASE","3CAF|Crystal Structure of hFGFR2 D2 Domain|X-RAY DIFFRACTION|1.96|Homo sapiens|0|TRANSFERASE","3CLY|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domains Trapped in Trans-Phosphorylation Reaction|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSFERASE","3CU1|Crystal Structure of 2:2:2 FGFR2D2:FGF1:SOS complex|X-RAY DIFFRACTION|2.6|Homo sapiens|0|Transferase/Hormone","3DAR|Crystal structure of D2 domain from human FGFR2|X-RAY DIFFRACTION|2.2|Homo sapiens|0|TRANSFERASE","3EUU|Crystal structure of the FGFR2 D2 domain|X-RAY DIFFRACTION|2.34|Homo sapiens|0|TRANSFERASE","3OJ2|Crystal structure of FGF1 complexed with the ectodomain of FGFR2b harboring the A172F Pfeiffer syndrome mutation|X-RAY DIFFRACTION|2.2|Homo sapiens|0|Cytokine/Signaling Protein","3OJM|Crystal Structure of FGF1 complexed with the ectodomain of FGFR2b harboring P253R Apert mutation|X-RAY DIFFRACTION|2.1|Homo sapiens|0|Cytokine/Signaling Protein","3RI1|Crystal structure of the catalytic domain of FGFR2 kinase in complex with ARQ 069|X-RAY DIFFRACTION|2.1|Homo sapiens|0|Transferase/Transferase Inhibitor","4J23|Low resolution crystal structure of the FGFR2D2D3/FGF1/SR128545 complex|X-RAY DIFFRACTION|3.882|Homo sapiens|0|SIGNALING PROTEIN/transferase","4J95|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome in Space Group C2.|X-RAY DIFFRACTION|2.3767|Homo sapiens|0|TRANSFERASE","4J96|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic Gain-of-Function K659M Mutation Identified in Cervical Cancer.|X-RAY DIFFRACTION|2.2972|Homo sapiens|0|TRANSFERASE","4J97|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic Gain-of-Function K659E Mutation Identified in Endometrial Cancer.|X-RAY DIFFRACTION|2.5482|Homo sapiens|0|TRANSFERASE","4J98|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Gain-of-Function K659Q Mutation.|X-RAY DIFFRACTION|2.3067|Homo sapiens|0|TRANSFERASE","4J99|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Gain-of-Function K659T Mutation.|X-RAY DIFFRACTION|1.8474|Homo sapiens|0|TRANSFERASE","4WV1|Crystal structure of the FGFR2 D2 domain in complex with Fab 2B.1.3|X-RAY DIFFRACTION|2.362|Homo sapiens|0|TRANSFERASE/IMMUNE SYSTEM","5EG3|Crystal Structure of the Activated FGF Receptor 2 (FGFR2) Kinase Domain in complex with the cSH2 domain of Phospholipase C gamma (PLCgamma)|X-RAY DIFFRACTION|2.606|Homo sapiens; Rattus norvegicus|0|Transferase/Hydrolase","5UGL|Crystal Structure of FGF Receptor 2 Tyrosine Kinase Domain Harboring the D650V Activating Mutation|X-RAY DIFFRACTION|1.861|Homo sapiens|0|TRANSFERASE","5UGX|Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 Harboring a E565A/D650V double Gain-of-Function Mutation|X-RAY DIFFRACTION|2.349|Homo sapiens|0|TRANSFERASE","5UHN|Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 harboring a N549H/E565A Double Gain-of-Function Mutation|X-RAY DIFFRACTION|2.909|Homo sapiens|0|TRANSFERASE","5UI0|Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 harboring an E565A/K659M Double Gain-of-Function Mutation|X-RAY DIFFRACTION|2.05|Homo sapiens|0|TRANSFERASE","6AGX|The cocrystal structure of FGFR2 bound with compound 14 harboring 5H-pyrrolo[2,3-b]pyrazine scaffold|X-RAY DIFFRACTION|2.95|Homo sapiens|0|TRANSFERASE/INHIBITOR","6LVK|Crystal structure of FGFR2 in complex with 1,3,5-triazine derivative|X-RAY DIFFRACTION|2.29|Homo sapiens|0|TRANSFERASE","6LVL|Crystal structure of FGFR2 in complex with 1,3,5-triazine derivative|X-RAY DIFFRACTION|2.98|Homo sapiens|0|TRANSFERASE","6V6Q|Crystal Structure of Monophosphorylated FGF Receptor 2 isoform IIIb with PTR657|X-RAY DIFFRACTION|2.46|Homo sapiens|0|TRANSFERASE","7KIA|Crystal structure of FGFR2 kinase domain gatekeeper mutant V564F in complex with covalent compound 19|X-RAY DIFFRACTION|2.22|Homo sapiens|0|SIGNALING PROTEIN","7KIE|Crystal structure of FGFR2 kinase domain gatekeeper mutant V564F in complex with covalent compound 3|X-RAY DIFFRACTION|2.47|Homo sapiens|0|SIGNALING PROTEIN","7OZY|FGFR2 kinase domain (residues 461-763) in complex with 38.|X-RAY DIFFRACTION|2.28|Homo sapiens|0|TRANSFERASE","8E1X|FGFR2 kinase domain in complex with a Pyrazolo[1,5-a]pyrimidine analog (Compound 29)|X-RAY DIFFRACTION|2.68|Homo sapiens|0|STRUCTURAL PROTEIN","8H75|FGFR2 in complex with YJ001|X-RAY DIFFRACTION|3.75|Homo sapiens|0|TRANSFERASE","8STG|Discovery and clinical validation of RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations|X-RAY DIFFRACTION|3.79|Homo sapiens|0|TRANSFERASE/INHIBITOR","8SWE|FGFR2 Kinase Domain Bound to Reversible Inhibitor Cmpd 3|X-RAY DIFFRACTION|2.24|Homo sapiens|0|ONCOPROTEIN","8U1F|FGFR2 Kinase Domain Bound to Irreversible Inhibitor Cmpd 10|X-RAY DIFFRACTION|3.33|Homo sapiens|0|Transferase/Inhibitor","8W2X|TAS-120 covalent structure with FGFR2|X-RAY DIFFRACTION|2.98|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","8W38|TAS-120 covalent structure with FGFR2 molecular brake mutant|X-RAY DIFFRACTION|2.6|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","8W3B|TAS-120 covalent structure with FGFR2 molecular brake mutant|X-RAY DIFFRACTION|2.23|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","8W3D|TAS-120 covalent structure with FGFR2 molecular brake mutant|X-RAY DIFFRACTION|2.04|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","9U3N|Crystal structure of FGFR2 kinase domain gatekeeper mutant V564F in complex with compound LC-F2-01|X-RAY DIFFRACTION|3.25|Homo sapiens|0|TRANSFERASE","9U7E|FGFR2 kinase domain with a macrocyclic compound 8g|X-RAY DIFFRACTION|2.2|Homo sapiens|0|TRANSFERASE","9U7S|FGFR2 kinase domain with a macrocyclic compound 8r|X-RAY DIFFRACTION|1.99|Homo sapiens|0|TRANSFERASE"]},{"input":"P03372","source":"P03372|Estrogen receptor","targets":["1A52|ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN COMPLEXED TO ESTRADIOL|X-RAY DIFFRACTION|2.8|Homo sapiens|0|RECEPTOR","1ERE|HUMAN ESTROGEN RECEPTOR LIGAND-BINDING DOMAIN IN COMPLEX WITH 17BETA-ESTRADIOL|X-RAY DIFFRACTION|3.1|Homo sapiens|0|NUCLEAR RECEPTOR","1ERR|HUMAN ESTROGEN RECEPTOR LIGAND-BINDING DOMAIN IN COMPLEX WITH RALOXIFENE|X-RAY DIFFRACTION|2.6|Homo sapiens|0|NUCLEAR RECEPTOR","1G50|CRYSTAL STRUCTURE OF A WILD TYPE HER ALPHA LBD AT 2.9 ANGSTROM RESOLUTION|X-RAY DIFFRACTION|2.9|Homo sapiens|0|DNA BINDING PROTEIN","1GWQ|HUMAN OESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH RALOXIFENE CORE AND TIF2 NRBOX2 PEPTIDE|X-RAY DIFFRACTION|2.45|HOMO SAPIENS; SYNTHETIC CONSTRUCT|0|NUCLEAR RECEPTOR","1GWR|HUMAN OESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH 17BETA-OESTRADIOL AND TIF2 NRBOX3 PEPTIDE|X-RAY DIFFRACTION|2.4|HOMO SAPIENS; SYNTHETIC CONSTRUCT|0|NUCLEAR RECEPTOR","1HCP|DNA RECOGNITION BY THE OESTROGEN RECEPTOR: FROM SOLUTION TO THE CRYSTAL|SOLUTION NMR||Homo sapiens|0|TRANSCRIPTION REGULATION","1HCQ|THE CRYSTAL STRUCTURE OF THE ESTROGEN RECEPTOR DNA-BINDING DOMAIN BOUND TO DNA: HOW RECEPTORS DISCRIMINATE BETWEEN THEIR RESPONSE ELEMENTS|X-RAY DIFFRACTION|2.4|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION/DNA","1L2I|Human Estrogen Receptor alpha Ligand-binding Domain in Complex with (R,R)-5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol and a Glucocorticoid Receptor Interacting Protein 1 NR box II Peptide|X-RAY DIFFRACTION|1.95|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION RECEPTOR/COACTIVATOR","1PCG|Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions|X-RAY DIFFRACTION|2.7|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION/INHIBITOR","1QKT|MUTANT ESTROGEN NUCLEAR RECEPTOR LIGAND BINDING DOMAIN COMPLEXED WITH ESTRADIOL|X-RAY DIFFRACTION|2.2|HOMO SAPIENS|0|NUCLEAR RECEPTOR","1QKU|WILD TYPE ESTROGEN NUCLEAR RECEPTOR LIGAND BINDING DOMAIN COMPLEXED WITH ESTRADIOL|X-RAY DIFFRACTION|3.2|HOMO SAPIENS|0|NUCLEAR RECEPTOR","1R5K|Human Estrogen Receptor alpha Ligand-Binding Domain In Complex With GW5638|X-RAY DIFFRACTION|2.7|Homo sapiens|0|DNA BINDING PROTEIN","1SJ0|Human Estrogen Receptor Alpha Ligand-binding Domain in Complex with the Antagonist Ligand 4-D|X-RAY DIFFRACTION|1.9|Homo sapiens|0|HORMONE/GROWTH FACTOR RECEPTOR","1UOM|The Structure of Estrogen Receptor in Complex with a Selective and Potent Tetrahydroisochiolin Ligand.|X-RAY DIFFRACTION|2.28|HOMO SAPIENS|0|NUCLEAR PROTEIN","1X7E|CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR ALPHA COMPLEXED WITH WAY-244|X-RAY DIFFRACTION|2.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","1X7R|CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR ALPHA COMPLEXED WITH GENISTEIN|X-RAY DIFFRACTION|2|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","1XP1|HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 15|X-RAY DIFFRACTION|1.8|Homo sapiens|0|HORMONE/GROWTH FACTOR RECEPTOR","1XP6|HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 16|X-RAY DIFFRACTION|1.7|Homo sapiens|0|HORMONE/GROWTH FACTOR RECEPTOR","1XP9|HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 18|X-RAY DIFFRACTION|1.8|Homo sapiens|0|HORMONE/GROWTH FACTOR RECEPTOR","1XPC|HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 19|X-RAY DIFFRACTION|1.6|Homo sapiens|0|HORMONE/GROWTH FACTOR RECEPTOR","1XQC|X-ray structure of ERalpha LBD bound to a tetrahydroisoquinoline SERM ligand at 2.05A resolution|X-RAY DIFFRACTION|2.05|Homo sapiens|0|HORMONE receptor","1YIM|Human estrogen receptor alpha ligand-binding domain in complex with compound 4|X-RAY DIFFRACTION|1.9|Homo sapiens|0|HORMONE/GROWTH FACTOR RECEPTOR","1YIN|Human estrogen receptor alpha ligand-binding domain in complex with compound 3F|X-RAY DIFFRACTION|2.2|Homo sapiens|0|HORMONE/GROWTH FACTOR RECEPTOR","1ZKY|Human Estrogen Receptor Alpha Ligand-Binding Domain In Complex With OBCP-3M and A Glucocorticoid Receptor Interacting Protein 1 Nr Box II Peptide|X-RAY DIFFRACTION|2.25|Homo sapiens; SYNTHETIC CONSTRUCT|0|HORMONE/GROWTH FACTOR RECEPTOR","2AYR|A SERM Designed for the Treatment of Uterine Leiomyoma with Unique Tissue Specificity for Uterus and Ovaries in Rats|X-RAY DIFFRACTION|1.9|Homo sapiens|0|TRANSCRIPTION","2B1V|Human estrogen receptor alpha ligand-binding domain in complex with OBCP-1M and a glucocorticoid receptor interacting protein 1 NR box II peptide|X-RAY DIFFRACTION|1.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|HORMONE/GROWTH FACTOR RECEPTOR","2B1Z|Human estrogen receptor alpha ligand-binding domain in complex with 17methyl-17alpha-dihydroequilenin and a glucoc interacting protein 1 NR box II peptide|X-RAY DIFFRACTION|1.78|Homo sapiens; SYNTHETIC CONSTRUCT|0|HORMONE/GROWTH FACTOR RECEPTOR","2B23|Human estrogen receptor alpha ligand-binding domain and a glucocorticoid receptor-interacting protein 1 NR box II peptide|X-RAY DIFFRACTION|2.1|Homo sapiens; SYNTHETIC CONSTRUCT|0|HORMONE/GROWTH FACTOR RECEPTOR","2BJ4|ESTROGEN RECEPTOR ALPHA LBD IN COMPLEX WITH A PHAGE-DISPLAY DERIVED PEPTIDE ANTAGONIST|X-RAY DIFFRACTION|2|HOMO SAPIENS; SYNTHETIC CONSTRUCT|0|NUCLEAR RECEPTOR","2FAI|Human Estrogen Receptor Alpha Ligand-Binding Domain In Complex With OBCP-2M and A Glucocorticoid Receptor Interacting Protein 1 NR Box II Peptide|X-RAY DIFFRACTION|2.1|Homo sapiens; SYNTHETIC CONSTRUCT|0|HORMONE/GROWTH FACTOR RECEPTOR","2G44|Human Estrogen Receptor Alpha Ligand-Binding Domain In Complex With OBCP-1M-G and A Glucocorticoid Receptor Interacting Protein 1 NR Box II Peptide|X-RAY DIFFRACTION|2.65|Homo sapiens; SYNTHETIC CONSTRUCT|0|HORMONE/GROWTH FACTOR RECEPTOR","2G5O|Human estrogen receptor alpha ligand-binding domain in complex with 2-(but-1-enyl)-17beta-estradiol and a glucocorticoid receptor interacting protein 1 NR BOX II Peptide|X-RAY DIFFRACTION|2.3|Homo sapiens; SYNTHETIC CONSTRUCT|0|HORMONE/GROWTH FACTOR RECEPTOR","2I0J|Benzopyrans are Selective Estrogen Receptor beta Agonists (SERBAs) with Novel Activity in Models of Benign Prostatic Hyperplasia|X-RAY DIFFRACTION|2.9|Homo sapiens|0|TRANSCRIPTION","2IOG|Human estrogen receptor alpha ligand-binding domain in complex with compound 11F|X-RAY DIFFRACTION|1.6|Homo sapiens|0|HORMONE","2IOK|Human estrogen receptor alpha ligand-binding domain in complex with compound 1D|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSCRIPTION","2JF9|ESTROGEN RECEPTOR ALPHA LBD IN COMPLEX WITH A TAMOXIFEN-SPECIFIC PEPTIDE ANTAGONIST|X-RAY DIFFRACTION|2.1|HOMO SAPIENS; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","2JFA|ESTROGEN RECEPTOR ALPHA LBD IN COMPLEX WITH AN AFFINITY-SELECTED COREPRESSOR PEPTIDE|X-RAY DIFFRACTION|2.55|HOMO SAPIENS; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","2LLO|Solution NMR-derived structure of calmodulin N-lobe bound with ER alpha peptide|SOLUTION NMR||Xenopus laevis; SYNTHETIC CONSTRUCT|0|METAL BINDING PROTEIN/HORMONE RECEPTOR","2LLQ|Solution nmr-derived structure of calmodulin c-lobe bound with er alpha peptide|SOLUTION NMR||Xenopus laevis; SYNTHETIC CONSTRUCT|0|METAL BINDING PROTEIN/HORMONE RECEPTOR","2OCF|Human estrogen receptor alpha ligand-binding domain in complex with estradiol and the E2#23 FN3 monobody|X-RAY DIFFRACTION|2.95|Homo sapiens|0|HORMONE/GROWTH FACTOR","2OUZ|Crystal Structure of Estrogen Receptor alpha-lasofoxifene complex|X-RAY DIFFRACTION|2|Homo sapiens|0|HORMONE/GROWTH FACTOR","2P15|Crystal structure of the ER alpha ligand binding domain with the agonist ortho-trifluoromethylphenylvinyl estradiol|X-RAY DIFFRACTION|1.94|Homo sapiens; SYNTHETIC CONSTRUCT|0|HORMONE RECEPTOR","2POG|Benzopyrans as Selective Estrogen Receptor b Agonists (SERBAs). Part 2: Structure Activity Relationship Studies on the Benzopyran Scaffold.|X-RAY DIFFRACTION|1.84|Homo sapiens|0|LIPID BINDING PROTEIN","2Q6J|Crystal Structure of Estrogen Receptor alpha Complexed to a B-N Substituted Ligand|X-RAY DIFFRACTION|2.7|Homo sapiens; Mus musculus|0|TRANSCRIPTION","2Q70|Estrogen receptor alpha ligand-binding domain complxed to a benzopyran ligand|X-RAY DIFFRACTION|1.95|Homo sapiens|0|TRANSCRIPTION","2QA6|Crystal Structure of Estrogen Receptor Alpha mutant 537S Complexed with 4-(6-hydroxy-1H-indazol-3-yl)benzene-1,3-diol|X-RAY DIFFRACTION|2.6|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","2QA8|Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain Mutant 537S Complexed with Genistein|X-RAY DIFFRACTION|1.85|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","2QAB|Crystal Structure of Estrogen Receptor Alpha Ligand Binding Domain Mutant 537S Complexed with an Ethyl Indazole Compound|X-RAY DIFFRACTION|1.89|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","2QE4|Estrogen receptor alpha ligand-binding domain in complex with a benzopyran agonist|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSCRIPTION","2QGT|Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain Complexed to an Ether Estradiol Compound|X-RAY DIFFRACTION|2.15|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","2QGW|Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain Complexed with a Chloro-Indazole Compound|X-RAY DIFFRACTION|2.39|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","2QH6|Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain Complexed with an Oxabicyclic diarylethylene Compound|X-RAY DIFFRACTION|2.7|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","2QR9|Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain Complexed with an Oxabicyclic Derivative Compound|X-RAY DIFFRACTION|2|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","2QSE|Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain complexed with Burned Meat Compound 4-OH-PhIP|X-RAY DIFFRACTION|1.85|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","2QXM|Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain Complexed to Burned Meat Compound PhIP|X-RAY DIFFRACTION|2.3|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","2QXS|Crystal Structure of Antagonizing Mutant 536S of the Estrogen Receptor Alpha Ligand Binding Domain Complexed to Raloxifene|X-RAY DIFFRACTION|1.7|Homo sapiens|0|TRANSCRIPTION","2QZO|Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain Complexed with WAY-169916|X-RAY DIFFRACTION|1.72|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","2R6W|Estrogen receptor alpha ligand-binding domain complexed to a SERM|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSCRIPTION","2R6Y|Estrogen receptor alpha ligand-binding domain in complex with a SERM|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSCRIPTION","2YAT|Crystal structure of estradiol derived metal chelate and estrogen receptor-ligand binding domain complex|X-RAY DIFFRACTION|2.602|HOMO SAPIENS|0|TRANSCRIPTION","2YJA|Stapled Peptides binding to Estrogen Receptor alpha.|X-RAY DIFFRACTION|1.82|HOMO SAPIENS; SYNTHETIC CONSTRUCT|0|HORMONE RECEPTOR/PEPTIDE","3CBM|SET7/9-ER-AdoMet complex|X-RAY DIFFRACTION|1.69|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE/TRANSFERASE RECEPTOR","3CBO|SET7/9-ER-AdoHcy complex|X-RAY DIFFRACTION|1.65|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE/TRANSFERASE RECEPTOR","3CBP|Set7/9-ER-Sinefungin complex|X-RAY DIFFRACTION|1.42|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE/TRANSFERASE RECEPTOR","3DT3|Human Estrogen receptor alpha LBD with GW368|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSCRIPTION","3ERD|HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH DIETHYLSTILBESTROL AND A GLUCOCORTICOID RECEPTOR INTERACTING PROTEIN 1 NR BOX II PEPTIDE|X-RAY DIFFRACTION|2.03|Homo sapiens|0|NUCLEAR RECEPTOR","3ERT|HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH 4-HYDROXYTAMOXIFEN|X-RAY DIFFRACTION|1.9|Homo sapiens|0|NUCLEAR RECEPTOR","3HLV|Crystal structure of human Estrogen Receptor Alpha Ligand-Binding Domain in complex with a Glucocorticoid Receptor Interacting Protein 1 Nr Box II Peptide and 16-alpha-hydroxy-estrone ((8S,9R,13S,14R,16R)-3,16-dihydroxy-13-methyl-7,8,9,11,12,14,15, 16-octahydro-6H-cyclopenta[a]phenanthren-17-one|X-RAY DIFFRACTION|3|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","3HM1|Crystal structure of human Estrogen Receptor Alpha Ligand-Binding Domain in complex with a Glucocorticoid Receptor Interacting Protein 1 Nr Box II Peptide and estrone ((8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one)|X-RAY DIFFRACTION|2.33|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","3L03|Crystal Structure of human Estrogen Receptor alpha Ligand-Binding Domain in complex with a Glucocorticoid Receptor Interacting Protein 1 Nr Box II peptide and Estetrol (Estra-1,3,5(10)-triene-3,15 alpha,16alpha,17beta-tetrol)|X-RAY DIFFRACTION|1.896|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","3OS8|Estrogen Receptor|X-RAY DIFFRACTION|2.031|Homo sapiens|0|SIGNALING PROTEIN","3OS9|Estrogen Receptor|X-RAY DIFFRACTION|2.303|Homo sapiens|0|SIGNALING PROTEIN","3OSA|Estrogen Receptor|X-RAY DIFFRACTION|2.296|Homo sapiens|0|SIGNALING PROTEIN","3Q95|Crystal structure of human estrogen receptor alpha LBD in complex with GRIP peptide and estriol|X-RAY DIFFRACTION|2.05|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION REGULATOR","3UU7|Crystal structure of hERa-LBD (Y537S) in complex with bisphenol-A|X-RAY DIFFRACTION|2.196|Homo sapiens; SYNTHETIC CONSTRUCT|0|HORMONE RECEPTOR","3UUA|Crystal structure of hERa-LBD (Y537S) in complex with bisphenol-AF|X-RAY DIFFRACTION|2.05|Homo sapiens; SYNTHETIC CONSTRUCT|0|HORMONE RECEPTOR","3UUC|Crystal structure of hERa-LBD (wt) in complex with bisphenol-C|X-RAY DIFFRACTION|2.1|Homo sapiens|0|HORMONE RECEPTOR","3UUD|Crystal structure of hERa-LBD (Y537S) in complex with estradiol|X-RAY DIFFRACTION|1.6|Homo sapiens; SYNTHETIC CONSTRUCT|0|HORMONE RECEPTOR","4AA6|The oestrogen receptor recognizes an imperfectly palindromic response element through an alternative side-chain conformation|X-RAY DIFFRACTION|2.6|HOMO SAPIENS; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION/DNA","4DMA|Crystal structure of ERa LBD in complex with RU100132|X-RAY DIFFRACTION|2.3|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION/protein binding/agonist","4IU7|Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with Constrained WAY-derivative, 2b|X-RAY DIFFRACTION|2.29|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","4IUI|Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with Dynamic WAY derivative, 4a|X-RAY DIFFRACTION|2.3|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","4IV2|Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with Dynamic WAY-derivative, 5a|X-RAY DIFFRACTION|2.14|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","4IV4|Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with Constrained WAY-derivative, 5b|X-RAY DIFFRACTION|2.3|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","4IVW|Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with Constrained WAY-derivative, 6b|X-RAY DIFFRACTION|2.06|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","4IVY|Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with Dynamic WAY-derivative, 7a|X-RAY DIFFRACTION|1.95|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","4IW6|Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with Constrained WAY-derivative, 7b|X-RAY DIFFRACTION|1.98|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","4IW8|Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with Dynamic WAY-derivative, 9a|X-RAY DIFFRACTION|2.0375|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","4IWC|Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with a Dynamic Thiophene-derivative|X-RAY DIFFRACTION|2.24|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","4IWF|Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with a Dynamic Oxime-derivative|X-RAY DIFFRACTION|1.932|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","4JC3|14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface|X-RAY DIFFRACTION|2.05|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN/Peptide","4JDD|14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface|X-RAY DIFFRACTION|2.1|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN/Peptide","4MG5|Crystal structure of hERa-LBD (Y537S) in complex with chlordecone|X-RAY DIFFRACTION|2.05|Homo sapiens; SYNTHETIC CONSTRUCT|0|HORMONE RECEPTOR","4MG6|Crystal structure of hERa-LBD (Y537S) in complex with benzylbutylphtalate|X-RAY DIFFRACTION|2.1|Homo sapiens; SYNTHETIC CONSTRUCT|0|HORMONE RECEPTOR","4MG7|Crystal structure of hERa-LBD (Y537S) in complex with ferutinine|X-RAY DIFFRACTION|2.15|Homo sapiens; SYNTHETIC CONSTRUCT|0|HORMONE RECEPTOR","4MG8|Crystal structure of hERa-LBD (Y537S) in complex with alpha-zearalanol|X-RAY DIFFRACTION|1.85|Homo sapiens; SYNTHETIC CONSTRUCT|0|HORMONE RECEPTOR","4MG9|Crystal structure of hERa-LBD (Y537S) in complex with butylparaben|X-RAY DIFFRACTION|2|Homo sapiens; SYNTHETIC CONSTRUCT|0|HORMONE RECEPTOR","4MGA|Crystal structure of hERa-LBD (Y537S) in complex with 4-tert-octylphenol|X-RAY DIFFRACTION|1.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|HORMONE RECEPTOR","4MGB|Crystal structure of hERa-LBD (Y537S) in complex with TCBPA|X-RAY DIFFRACTION|1.85|Homo sapiens; SYNTHETIC CONSTRUCT|0|HORMONE RECEPTOR"]},{"input":"O14746","source":"O14746|Telomerase reverse transcriptase","targets":["2BCK|Crystal Structure of HLA-A*2402 Complexed with a telomerase peptide|X-RAY DIFFRACTION|2.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","4B18|The crystal structure of human Importin alpha 5 with TERT NLS peptide|X-RAY DIFFRACTION|2.52|HOMO SAPIENS; SYNTHETIC CONSTRUCT|0|TRANSPORT PROTEIN / PEPTIDE","4MNQ|TCR-peptide specificity overrides affinity enhancing TCR-MHC interactions|X-RAY DIFFRACTION|2.742|Homo sapiens; Pan troglodytes; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","5MEN|Human Leukocyte Antigen A02 presenting ILAKFLHWL, in complex with cognate T-Cell Receptor|X-RAY DIFFRACTION|2.81|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","5MEO|Human Leukocyte Antigen presenting ILGKFLHRL|X-RAY DIFFRACTION|1.772|Homo sapiens|0|IMMUNE SYSTEM","5MEP|Human Leukocyte Antigen A02 presenting ILGKFLHWL|X-RAY DIFFRACTION|2.71|Homo sapiens|0|IMMUNE SYSTEM","5MEQ|Human Leukocyte Antigen A02 presenting ILAKFLHTL|X-RAY DIFFRACTION|2.27|Homo sapiens|0|IMMUNE SYSTEM","5MER|Human Leukocyte Antigen A02 presenting ILAKFLHEL|X-RAY DIFFRACTION|1.88|Homo sapiens|0|IMMUNE SYSTEM","5UGW|STRUCTURE OF THE HUMAN TELOMERASE THUMB DOMAIN|X-RAY DIFFRACTION|2.31|Homo sapiens|0|TRANSFERASE","7BG9|The catalytic core lobe of human telomerase in complex with a telomeric DNA substrate|ELECTRON MICROSCOPY|3.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|RNA BINDING PROTEIN","7QXA|Cryo-EM map of human telomerase-DNA-TPP1 complex (sharpened)|ELECTRON MICROSCOPY|3.2|Homo sapiens; SYNTHETIC CONSTRUCT|0|RNA BINDING PROTEIN","7QXB|Cryo-EM map of human telomerase-DNA-TPP1-POT1 complex (sharpened map)|ELECTRON MICROSCOPY|3.9|Homo sapiens; SYNTHETIC CONSTRUCT|0|RNA BINDING PROTEIN","7QXS|Cryo-EM structure of human telomerase-DNA-TPP1-POT1 complex (with POT1 side chains)|ELECTRON MICROSCOPY|3.9|Homo sapiens; SYNTHETIC CONSTRUCT|0|RNA BINDING PROTEIN","7TRD|Human telomerase catalytic core structure at 3.3 Angstrom|ELECTRON MICROSCOPY|3.3|Homo sapiens; SYNTHETIC CONSTRUCT|0|REPLICATION","7TRE|Human telomerase catalytic core with shelterin protein TPP1|ELECTRON MICROSCOPY|3.5|Homo sapiens; SYNTHETIC CONSTRUCT|0|REPLICATION","7TRF|Human telomerase catalytic core RNP with H2A/H2B|ELECTRON MICROSCOPY|3.7|Homo sapiens; SYNTHETIC CONSTRUCT|0|REPLICATION","7V99|catalytic core of human telomerase holoenzyme|ELECTRON MICROSCOPY|3.54|Homo sapiens; SYNTHETIC CONSTRUCT|0|REPLICATION","9QAX|The catalytic core with C2 symmetry of human telomerase dimer|ELECTRON MICROSCOPY|3.3|Homo sapiens; SYNTHETIC CONSTRUCT|0|RNA BINDING PROTEIN","9QAY|Catalytic core 1 of dimeric human telomerase|ELECTRON MICROSCOPY|3.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|DNA BINDING PROTEIN","9QAZ|Catalytic core 2 of dimeric human telomerase|ELECTRON MICROSCOPY|3.6|Homo sapiens; SYNTHETIC CONSTRUCT|0|DNA BINDING PROTEIN","9SHY|Cryo-EM structure of the catalytic core of human telomerase at the initiation state of the repeat addition cycle|ELECTRON MICROSCOPY|3.53|Homo sapiens; SYNTHETIC CONSTRUCT|0|RNA BINDING PROTEIN","9SHZ|Cryo-EM structure of the catalytic core of human telomerase at the elongation state of the repeat addition cycle|ELECTRON MICROSCOPY|3.2|Homo sapiens; SYNTHETIC CONSTRUCT|0|RNA BINDING PROTEIN","9SI0|Cryo-EM structure of the catalytic core of human telomerase at the pre-termination state of the repeat addition cycle|ELECTRON MICROSCOPY|3.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|RNA BINDING PROTEIN"]},{"input":"Q15303","source":"Q15303|Receptor tyrosine-protein kinase erbB-4","targets":["2AHX|Crystal structure of ErbB4/HER4 extracellular domain|X-RAY DIFFRACTION|2.396|Homo sapiens|0|CELL CYCLE,SIGNALING PROTEIN","2L2T|Solution NMR structure of the ErbB4 dimeric membrane domain|SOLUTION NMR||Homo sapiens|0|MEMBRANE PROTEIN","2LCX|Spatial Structure of the ErbB4 dimeric TM domain|SOLUTION NMR||Homo sapiens|0|TRANSFERASE","2R4B|ErbB4 kinase domain complexed with a thienopyrimidine inhibitor|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE","3BBT|crystal structure of the ErbB4 kinase in complex with lapatinib|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE","3BBW|crystal structure of the ErbB4 kinase in its inactive conformation|X-RAY DIFFRACTION|4|Homo sapiens|0|TRANSFERASE","3BCE|Crystal structure of the ErbB4 kinase|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE","3U2P|Crystal structure of N-terminal three extracellular domains of ErbB4/Her4|X-RAY DIFFRACTION|2.57|Homo sapiens|0|Transferase, Signaling protein","3U7U|Crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta|X-RAY DIFFRACTION|3.03|Homo sapiens|0|TRANSFERASE/TRANSFERASE REGULATOR","3U9U|Crystal Structure of Extracellular Domain of Human ErbB4/Her4 in complex with the Fab fragment of mAb1479|X-RAY DIFFRACTION|3.42|Homo sapiens; Mus musculus|0|TRANSFERASE","8U4I|Structure of the HER4/NRG1b Homodimer Extracellular Domain|ELECTRON MICROSCOPY|3.38|Homo sapiens|0|MEMBRANE PROTEIN, TRANSFERASE","8U4J|Structure of the HER4/BTC Homodimer Extracellular Domain|ELECTRON MICROSCOPY|3.7|Homo sapiens|0|MEMBRANE PROTEIN, TRANSFERASE","8U4K|Structure of the HER2/HER4/BTC Heterodimer Extracellular Domain|ELECTRON MICROSCOPY|4.27|Homo sapiens|0|MEMBRANE PROTEIN, TRANSFERASE","8U4L|Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain|ELECTRON MICROSCOPY|3.31|Homo sapiens|0|MEMBRANE PROTEIN, TRANSFERASE"]},{"input":"O14965","source":"O14965|Aurora kinase A","targets":["1MQ4|Crystal Structure of Aurora-A Protein Kinase|X-RAY DIFFRACTION|1.9|Homo sapiens|0|TRANSFERASE","1MUO|CRYSTAL STRUCTURE OF AURORA-2, AN ONCOGENIC SERINE-THREONINE KINASE|X-RAY DIFFRACTION|2.9|Homo sapiens|0|TRANSFERASE","1OL5|Structure of Aurora-A 122-403, phosphorylated on Thr287, Thr288 and bound to TPX2 1-43|X-RAY DIFFRACTION|2.5|HOMO SAPIENS|0|TRANSFERASE/CELL CYCLE","1OL6|Structure of unphosphorylated D274N mutant of Aurora-A|X-RAY DIFFRACTION|3|HOMO SAPIENS|0|TRANSFERASE","1OL7|Structure of Human Aurora-A 122-403 phosphorylated on Thr287, Thr288|X-RAY DIFFRACTION|2.75|HOMO SAPIENS|0|KINASE","2BMC|Aurora-2 T287D T288D complexed with PHA-680632|X-RAY DIFFRACTION|2.6|HOMO SAPIENS|0|TRANSFERASE","2C6D|Aurora A kinase activated mutant (T287D) in complex with ADPNP|X-RAY DIFFRACTION|2.2|HOMO SAPIENS|0|TRANSFERASE","2C6E|Aurora A kinase activated mutant (T287D) in complex with a 5- aminopyrimidinyl quinazoline inhibitor|X-RAY DIFFRACTION|2.1|HOMO SAPIENS|0|TRANSFERASE/INHIBITOR","2DWB|Aurora-A kinase complexed with AMPPNP|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE","2J4Z|Structure of Aurora-2 in complex with PHA-680626|X-RAY DIFFRACTION|2|HOMO SAPIENS|0|TRANSFERASE","2J50|Structure of Aurora-2 in complex with PHA-739358|X-RAY DIFFRACTION|3|HOMO SAPIENS|0|TRANSFERASE","2NP8|Structural Basis for the Inhibition of Aurora A Kinase by a Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors|X-RAY DIFFRACTION|2.25|Homo sapiens|0|TRANSFERASE","2W1C|Structure determination of Aurora Kinase in complex with inhibitor|X-RAY DIFFRACTION|3.24|HOMO SAPIENS|0|TRANSFERASE","2W1D|Structure determination of Aurora Kinase in complex with inhibitor|X-RAY DIFFRACTION|2.97|HOMO SAPIENS|0|TRANSFERASE","2W1E|Structure determination of Aurora Kinase in complex with inhibitor|X-RAY DIFFRACTION|2.93|HOMO SAPIENS|0|TRANSFERASE","2W1F|Structure determination of Aurora Kinase in complex with inhibitor|X-RAY DIFFRACTION|2.85|HOMO SAPIENS|0|TRANSFERASE","2W1G|Structure determination of Aurora Kinase in complex with inhibitor|X-RAY DIFFRACTION|2.71|HOMO SAPIENS|0|TRANSFERASE","2WQE|Structure of S155R Aurora-A somatic mutant|X-RAY DIFFRACTION|2.5|HOMO SAPIENS|0|TRANSFERASE","2WTV|Aurora-A Inhibitor Structure|X-RAY DIFFRACTION|2.4|HOMO SAPIENS|0|TRANSFERASE","2WTW|Aurora-A Inhibitor Structure (2nd crystal form)|X-RAY DIFFRACTION|3.302|HOMO SAPIENS|0|TRANSFERASE","2X6D|Aurora-A bound to an inhibitor|X-RAY DIFFRACTION|2.796|HOMO SAPIENS|0|TRANSFERASE","2X6E|Aurora-A bound to an inhibitor|X-RAY DIFFRACTION|3.35|HOMO SAPIENS|0|TRANSFERASE","2X81|STRUCTURE OF AURORA A IN COMPLEX WITH MLN8054|X-RAY DIFFRACTION|2.91|HOMO SAPIENS|0|TRANSFERASE","2XNE|Structure of Aurora-A bound to an imidazopyrazine inhibitor|X-RAY DIFFRACTION|2.8|HOMO SAPIENS|0|TRANSFERASE","2XNG|Structure of Aurora-A bound to a selective imidazopyrazine inhibitor|X-RAY DIFFRACTION|2.605|HOMO SAPIENS|0|TRANSFERASE","2XRU|AURORA-A T288E COMPLEXED WITH PHA-828300|X-RAY DIFFRACTION|2.9|HOMO SAPIENS|0|TRANSFERASE","3COH|Crystal structure of Aurora-A in complex with a pentacyclic inhibitor|X-RAY DIFFRACTION|2.7|Homo sapiens|0|TRANSFERASE","3E5A|Crystal structure of Aurora A in complex with VX-680 and TPX2|X-RAY DIFFRACTION|2.3|Homo sapiens|0|TRANSFERASE","3EFW|Structure of AuroraA with pyridyl-pyrimidine urea inhibitor|X-RAY DIFFRACTION|2.29|Homo sapiens|0|Transferase/Inhibitor","3FDN|Structure-based drug design of novel Aurora kinase A inhibitors: Structure basis for potency and specificity|X-RAY DIFFRACTION|1.9|Homo sapiens|0|TRANSFERASE","3H0Y|Aurora A in complex with a bisanilinopyrimidine|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE","3H0Z|Aurora A in complex with a bisanilinopyrimidine|X-RAY DIFFRACTION|2.92|Homo sapiens|0|TRANSFERASE","3H10|Aurora A inhibitor complex|X-RAY DIFFRACTION|2.2|Homo sapiens|0|TRANSFERASE","3HA6|Crystal structure of aurora A in complex with TPX2 and compound 10|X-RAY DIFFRACTION|2.36|Homo sapiens|0|TRANSFERASE","3K5U|Identification, SAR Studies and X-ray Cocrystal Analysis of a Novel Furano-pyrimidine Aurora Kinase A Inhibitor|X-RAY DIFFRACTION|2.35|Homo sapiens|0|TRANSFERASE","3LAU|Crystal Structure of Aurora2 kinase in complex with a GSK3beta inhibitor|X-RAY DIFFRACTION|2.1|Homo sapiens|0|TRANSFERASE","3M11|Crystal Structure of Aurora A Kinase complexed with inhibitor|X-RAY DIFFRACTION|2.75|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3MYG|Aurora A Kinase complexed with SCH 1473759|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE","3NRM|Imidazo[1,2-a]pyrazine-based Aurora Kinase Inhibitors|X-RAY DIFFRACTION|3.05|Homo sapiens|0|TRANSFERASE","3O50|Crystal structure of benzamide 9 bound to AuroraA|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSFERASE","3O51|Crystal structure of anthranilamide 10 bound to AuroraA|X-RAY DIFFRACTION|3.2|Homo sapiens|0|TRANSFERASE","3P9J|Aurora A kinase domain with phthalazinone pyrazole inhibitor|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3QBN|Structure of Human Aurora A in Complex with a diaminopyrimidine|X-RAY DIFFRACTION|3.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3R21|Design, synthesis, and biological evaluation of pyrazolopyridine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (Part I)|X-RAY DIFFRACTION|2.9|Homo sapiens|0|transferase/transferase inhibitor","3R22|Design, synthesis, and biological evaluation of pyrazolopyridine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (Part I)|X-RAY DIFFRACTION|2.9|Homo sapiens|0|transferase/transferase inhibitor","3UNZ|Aurora A in Complex with RPM1679|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3UO4|Aurora A in complex with RPM1680|X-RAY DIFFRACTION|2.45|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3UO5|Aurora A in complex with YL1-038-31|X-RAY DIFFRACTION|2.7012|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3UO6|Aurora A in complex with YL5-083|X-RAY DIFFRACTION|2.8002|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3UOD|Aurora A in complex with RPM1693|X-RAY DIFFRACTION|2.5002|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3UOH|Aurora A in complex with RPM1722|X-RAY DIFFRACTION|2.8002|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3UOJ|Aurora A in complex with RPM1715|X-RAY DIFFRACTION|2.9003|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3UOK|Aurora A in complex with YL5-81-1|X-RAY DIFFRACTION|2.9506|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3UOL|Aurora A in complex with SO2-162|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3UP2|Aurora A in complex with RPM1686|X-RAY DIFFRACTION|2.3001|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3UP7|Aurora A in complex with YL1-038-09|X-RAY DIFFRACTION|3.05|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3VAP|Synthesis and SAR Studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off target kinase selectivity|X-RAY DIFFRACTION|2.66|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3W10|Aurora kinase A complexed to pyrazole aminoquinoline I|X-RAY DIFFRACTION|2.7|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3W16|Structure of Aurora kinase A complexed to pyrazole-aminoquinoline inhibitor III|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3W18|Structure of Aurora kinase A complexed to benzoimidazole-indazole inhibitor XIII|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3W2C|Structure of Aurora kinase A complexed to benzoimidazole-indazole inhibitor XV|X-RAY DIFFRACTION|2.45|Homo sapiens|0|TRANSFERASE","4B0G|Complex of Aurora-A bound to an Imidazopyridine-based inhibitor|X-RAY DIFFRACTION|2.5|HOMO SAPIENS|0|TRANSFERASE","4BN1|Crystal structure of V174M mutant of Aurora-A kinase|X-RAY DIFFRACTION|2.499|HOMO SAPIENS|0|TRANSFERASE","4BYI|Aurora A kinase bound to a highly selective imidazopyridine inhibitor|X-RAY DIFFRACTION|2.6|HOMO SAPIENS|0|TRANSFERASE","4BYJ|Aurora A kinase bound to a highly selective imidazopyridine inhibitor|X-RAY DIFFRACTION|2.75|HOMO SAPIENS|0|TRANSFERASE","4C3P|Structure of dephosphorylated Aurora A (122-403) bound to TPX2 and AMPPCP|X-RAY DIFFRACTION|2.69|HOMO SAPIENS|0|TRANSFERASE","4C3R|Structure of dephosphorylated Aurora A (122-403) bound to AMPPCP|X-RAY DIFFRACTION|2.79|HOMO SAPIENS|0|TRANSFERASE","4CEG|Crystal structure of Aurora A 122-403 C290A, C393A bound to ADP|X-RAY DIFFRACTION|2.1|HOMO SAPIENS|0|TRANSFERASE","4DEA|Aurora A in complex with YL1-038-18|X-RAY DIFFRACTION|2.45|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4DEB|Aurora A in complex with RK2-17-01|X-RAY DIFFRACTION|3.05|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4DED|Aurora A in complex with YL1-038-21|X-RAY DIFFRACTION|3.05|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4DEE|Aurora A in complex with ADP|X-RAY DIFFRACTION|2.3|Homo sapiens|0|TRANSFERASE","4DHF|Structure of Aurora A mutant bound to Biogenidec cpd 15|X-RAY DIFFRACTION|2.8|Homo sapiens|0|transferase/transferase inhibitor","4J8M|Aurora A in complex with CD532|X-RAY DIFFRACTION|1.853|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4J8N|Aurora A Kinase Apo|X-RAY DIFFRACTION|3.135|Homo sapiens|0|TRANSFERASE","4JAI|Crystal Structure of Aurora Kinase A in complex with N-{4-[(6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridin-1-yl)amino]phenyl}benzamide|X-RAY DIFFRACTION|3.2|Homo sapiens|0|transferase/transferase inhibitor","4JAJ|Crystal Structure of Aurora Kinase A in complex with BENZO[C][1,8]NAPHTHYRIDIN-6(5H)-ONE|X-RAY DIFFRACTION|2.7|Homo sapiens|0|transferase/transferase inhibitor","4JBO|Novel Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules|X-RAY DIFFRACTION|2.493|Homo sapiens|0|TRANSFERASE","4JBP|Novel Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules|X-RAY DIFFRACTION|2.45|Homo sapiens|0|TRANSFERASE","4JBQ|Novel Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules|X-RAY DIFFRACTION|2.3|Homo sapiens|0|TRANSFERASE","4O0S|Crystal structures of human kinase Aurora A|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE","4O0U|Crystal structures of human kinase Aurora A|X-RAY DIFFRACTION|2.6|Homo sapiens|0|TRANSFERASE","4O0W|Crystal structures of human kinase Aurora A|X-RAY DIFFRACTION|2.6|Homo sapiens|0|TRANSFERASE","4PRJ|Aurora A kinase domain with compound 2 (N-[1-(3-cyanobenzyl)-1H-pyrazol-4-yl]-6-(1H-pyrazol-4-yl)-1H-indazole-3-carboxamide)|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4UYN|SAR156497 an exquisitely selective inhibitor of Aurora kinases|X-RAY DIFFRACTION|1.9|HOMO SAPIENS|0|TRANSFERASE","4UZD|SAR156497 an exquisitely selective inhibitor of Aurora kinases|X-RAY DIFFRACTION|3.2|HOMO SAPIENS|0|TRANSFERASE","4UZH|SAR156497 an exquisitely selective inhibitor of Aurora kinases|X-RAY DIFFRACTION|2|HOMO SAPIENS|0|TRANSFERASE","4ZS0|Human Aurora A catalytic domain bound to SB-6-OH|X-RAY DIFFRACTION|3|Homo sapiens|0|TRANSFERASE","4ZTQ|Human Aurora A catalytic domain bound to FK932|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE","4ZTR|Human Aurora A catalytic domain bound to FK1141|X-RAY DIFFRACTION|2.85|Homo sapiens|0|TRANSFERASE","4ZTS|Human Aurora A catalytic domain bound to FK1142|X-RAY DIFFRACTION|2.9|Homo sapiens|0|TRANSFERASE","5AAD|Aurora A kinase bound to an imidazopyridine inhibitor (7a)|X-RAY DIFFRACTION|3.1|HOMO SAPIENS|0|TRANSFERASE","5AAE|Aurora A kinase bound to an imidazopyridine inhibitor (14d)|X-RAY DIFFRACTION|3.11|HOMO SAPIENS|0|TRANSFERASE","5AAF|Aurora A kinase bound to an imidazopyridine inhibitor (14a)|X-RAY DIFFRACTION|2.78|HOMO SAPIENS|0|TRANSFERASE","5AAG|Aurora A kinase bound to an imidazopyridine inhibitor (14b)|X-RAY DIFFRACTION|2.85|HOMO SAPIENS|0|TRANSFERASE","5DN3|Aurora A in complex with ATP and AA35.|X-RAY DIFFRACTION|2.05|Homo sapiens|0|TRANSFERASE","5DNR|Aurora A Kinase in complex with ATP in space group P41212|X-RAY DIFFRACTION|1.95|Homo sapiens|0|TRANSFERASE","5DOS|Aurora A Kinase in Complex with AA35 and ATP in Space Group P6122|X-RAY DIFFRACTION|2.98|Homo sapiens|0|TRANSFERASE","5DPV|Aurora A Kinase in Complex with AA35 and JNJ-7706621 in Space Group P6122|X-RAY DIFFRACTION|2.285|Homo sapiens|0|TRANSFERASE","5DR2|Aurora A Kinase in Complex with AA30 and ATP in Space Group P6122|X-RAY DIFFRACTION|2.46|Homo sapiens|0|TRANSFERASE"]},{"input":"P38398","source":"P38398|Breast cancer type 1 susceptibility protein","targets":["1JM7|Solution structure of the BRCA1/BARD1 RING-domain heterodimer|SOLUTION NMR||Homo sapiens|0|ANTITUMOR","1JNX|Crystal structure of the BRCT repeat region from the breast cancer associated protein, BRCA1|X-RAY DIFFRACTION|2.5|Homo sapiens|0|GENE REGULATION","1N5O|Structural consequences of a cancer-causing BRCA1-BRCT missense mutation|X-RAY DIFFRACTION|2.8|Homo sapiens|0|ANTITUMOR PROTEIN","1OQA|Solution structure of the BRCT-c domain from human BRCA1|SOLUTION NMR||Homo sapiens|0|GENE REGULATION","1T15|Crystal Structure of the Brca1 BRCT Domains in Complex with the Phosphorylated Interacting Region from Bach1 Helicase|X-RAY DIFFRACTION|1.85|Homo sapiens; SYNTHETIC CONSTRUCT|0|ANTITUMOR PROTEIN","1T29|Crystal structure of the BRCA1 BRCT repeats bound to a phosphorylated BACH1 peptide|X-RAY DIFFRACTION|2.3|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","1T2U|Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1: structure of BRCA1 missense variant V1809F|X-RAY DIFFRACTION|2.8|Homo sapiens|0|ANTITUMOR PROTEIN","1T2V|Structural basis of phospho-peptide recognition by the BRCT domain of BRCA1, structure with phosphopeptide|X-RAY DIFFRACTION|3.3|Homo sapiens; SYNTHETIC CONSTRUCT|0|ANTITUMOR PROTEIN","1Y98|Structure of the BRCT repeats of BRCA1 bound to a CtIP phosphopeptide.|X-RAY DIFFRACTION|2.5|Homo sapiens; SYNTHETIC CONSTRUCT|0|ANTITUMOR PROTEIN","2ING|X-ray Structure of the BRCA1 BRCT mutant M1775K|X-RAY DIFFRACTION|3.6|Homo sapiens|0|DNA BINDING PROTEIN","3COJ|Crystal Structure of the BRCT Domains of Human BRCA1 in Complex with a Phosphorylated Peptide from Human Acetyl-CoA Carboxylase 1|X-RAY DIFFRACTION|3.21|Homo sapiens; SYNTHETIC CONSTRUCT|0|ANTITUMOR PROTEIN/LIGASE","3K0H|The crystal structure of BRCA1 BRCT in complex with a minimal recognition tetrapeptide with an amidated C-terminus|X-RAY DIFFRACTION|2.7|Homo sapiens; SYNTHETIC CONSTRUCT|0|PROTEIN BINDING","3K0K|Crystal Structure of BRCA1 BRCT in complex with a minimal recognition tetrapeptide with a free carboxy C-terminus.|X-RAY DIFFRACTION|2.7|Homo sapiens; SYNTHETIC CONSTRUCT|0|PROTEIN BINDING","3K15|Crystal Structure of BRCA1 BRCT D1840T in complex with a minimal recognition tetrapeptide with an amidated C-terminus|X-RAY DIFFRACTION|2.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|PROTEIN BINDING","3K16|Crystal Structure of BRCA1 BRCT D1840T in complex with a minimal recognition tetrapeptide with a free carboxy C-terminus|X-RAY DIFFRACTION|3|Homo sapiens; SYNTHETIC CONSTRUCT|0|ISOMERASE","3PXA|Impact of BRCA1 BRCT domain missense substitutions on phospho-peptide recognition: G1656D|X-RAY DIFFRACTION|2.55|Homo sapiens|0|PROTEIN BINDING","3PXB|Impact of BRCA1 BRCT domain missense substitutions on phospho-peptide recognition: T1700A|X-RAY DIFFRACTION|2.5|Homo sapiens|0|PROTEIN BINDING","3PXC|Impact of BRCA1 BRCT domain missense substitutions on phospho-peptide recognition: R1699Q|X-RAY DIFFRACTION|2.8|Homo sapiens|0|PROTEIN BINDING","3PXD|Impact of BRCA1 BRCT domain missense substitutions on phospho-peptide recognition: R1835P|X-RAY DIFFRACTION|2.8|Homo sapiens|0|PROTEIN BINDING","3PXE|Impact of BRCA1 BRCT domain missense substitutions on phospho-peptide recognition: E1836K|X-RAY DIFFRACTION|2.85|Homo sapiens; SYNTHETIC CONSTRUCT|0|PROTEIN BINDING","4IFI|Structure of human BRCA1 BRCT in complex with BAAT peptide|X-RAY DIFFRACTION|2.2|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","4IGK|Structure of human BRCA1 BRCT in complex with ATRIP peptide|X-RAY DIFFRACTION|1.75|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","4JLU|Crystal structure of BRCA1 BRCT with doubly phosphorylated Abraxas|X-RAY DIFFRACTION|3.5|Homo sapiens; SYNTHETIC CONSTRUCT|0|ANTITUMOR PROTEIN/SIGNALING PROTEIN","4OFB|Crystal structure of human BRCA1 BRCT in complex with nonphosphopeptide inhibitor|X-RAY DIFFRACTION|3.05|Homo sapiens; SYNTHETIC CONSTRUCT|0|PROTEIN BINDING","4U4A|Complex Structure of BRCA1 BRCT with singly phospho Abraxas|X-RAY DIFFRACTION|3.51|Homo sapiens; SYNTHETIC CONSTRUCT|0|ANTITUMOR PROTEIN/SIGNALING PROTEIN","4Y18|Structure of BRCA1 BRCT domains in complex with Abraxas double phosphorylated peptide|X-RAY DIFFRACTION|3.5|Homo sapiens; SYNTHETIC CONSTRUCT|0|ANTITUMOR PROTEIN","4Y2G|Structure of BRCA1 BRCT domains in complex with Abraxas single phosphorylated peptide|X-RAY DIFFRACTION|2.5|Homo sapiens; SYNTHETIC CONSTRUCT|0|ANTITUMOR PROTEIN","6G2I|Filament of acetyl-CoA carboxylase and BRCT domains of BRCA1 (ACC-BRCT) at 5.9 A resolution|ELECTRON MICROSCOPY|5.9|Homo sapiens|0|LIGASE","7JZV|Cryo-EM structure of the BRCA1-UbcH5c/BARD1 E3-E2 module bound to a nucleosome|ELECTRON MICROSCOPY|3.9|Homo sapiens; synthetic construct|0|LIGASE/DNA","7LYB|Cryo-EM structure of the human nucleosome core particle in complex with BRCA1-BARD1-UbcH5c|ELECTRON MICROSCOPY|3.28|Homo sapiens|0|STRUCTURAL PROTEIN/DNA","8GRQ|Cryo-EM structure of BRCA1/BARD1 bound to H2AK127-UbcH5c-Ub nucleosome|ELECTRON MICROSCOPY|3.87|Homo sapiens|0|NUCLEAR PROTEIN","8RS8|Crystal structure of BRCA1 BRCTs in complex with a RIF1 phosphopeptide|X-RAY DIFFRACTION|1.31|Homo sapiens; SYNTHETIC CONSTRUCT|0|PEPTIDE BINDING PROTEIN","9QPX|BRCA1 BRCT tandem repeat with RNA polymerase II pSer5-CTD peptide|X-RAY DIFFRACTION|3|Homo sapiens; SYNTHETIC CONSTRUCT|0|PROTEIN BINDING"]},{"input":"P04637","source":"P04637|Cellular tumor antigen p53","targets":["1A1U|SOLUTION STRUCTURE DETERMINATION OF A P53 MUTANT DIMERIZATION DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE|SOLUTION NMR||Homo sapiens|0|ANTI-ONCOGENE","1AIE|P53 TETRAMERIZATION DOMAIN CRYSTAL STRUCTURE|X-RAY DIFFRACTION|1.5|Homo sapiens|0|P53 TETRAMERIZATION","1C26|CRYSTAL STRUCTURE OF P53 TETRAMERIZATION DOMAIN|X-RAY DIFFRACTION|1.7|Homo sapiens|0|GENE REGULATION","1DT7|SOLUTION STRUCTURE OF THE C-TERMINAL NEGATIVE REGULATORY DOMAIN OF P53 IN A COMPLEX WITH CA2+-BOUND S100B(BB)|SOLUTION NMR||Rattus norvegicus; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","1GZH|Crystal structure of the BRCT domains of human 53BP1 bound to the p53 tumor supressor|X-RAY DIFFRACTION|2.6|HOMO SAPIENS|0|GENE REGULATION","1H26|CDK2/CyclinA in complex with an 11-residue recruitment peptide from p53|X-RAY DIFFRACTION|2.24|HOMO SAPIENS; SYNTHETIC CONSTRUCT|0|CELL CYCLE","1HS5|NMR SOLUTION STRUCTURE OF DESIGNED P53 DIMER|SOLUTION NMR||Homo sapiens|0|GENE REGULATION","1JSP|NMR Structure of CBP Bromodomain in complex with p53 peptide|SOLUTION NMR||Homo sapiens; SYNTHETIC CONSTRUCT|0|DNA BINDING PROTEIN","1KZY|Crystal Structure of the 53bp1 BRCT Region Complexed to Tumor Suppressor P53|X-RAY DIFFRACTION|2.5|Homo sapiens|0|DNA BINDING PROTEIN, PROTEIN BINDING","1MA3|Structure of a Sir2 enzyme bound to an acetylated p53 peptide|X-RAY DIFFRACTION|2|Archaeoglobus fulgidus; SYNTHETIC CONSTRUCT|0|PROTEIN BINDING, TRANSCRIPTION","1OLG|HIGH-RESOLUTION SOLUTION STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR|SOLUTION NMR||Homo sapiens|0|ANTI-ONCOGENE","1OLH|HIGH-RESOLUTION SOLUTION STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR|SOLUTION NMR||Homo sapiens|0|ANTI-ONCOGENE PROTEIN","1PES|NMR SOLUTION STRUCTURE OF THE TETRAMERIC MINIMUM TRANSFORMING DOMAIN OF P53|SOLUTION NMR||Homo sapiens|0|DNA-BINDING","1PET|NMR SOLUTION STRUCTURE OF THE TETRAMERIC MINIMUM TRANSFORMING DOMAIN OF P53|SOLUTION NMR||Homo sapiens|0|DNA-BINDING","1SAE|HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAC STRUCTURES)|SOLUTION NMR||Homo sapiens|0|ANTI-ONCOGENE","1SAF|HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAD STRUCTURES)|SOLUTION NMR||Homo sapiens|0|ANTI-ONCOGENE","1SAK|HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAC STRUCTURES)|SOLUTION NMR||Homo sapiens|0|ANTI-ONCOGENE","1SAL|HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAD STRUCTURES)|SOLUTION NMR||Homo sapiens|0|ANTI-ONCOGENE","1TSR|P53 CORE DOMAIN IN COMPLEX WITH DNA|X-RAY DIFFRACTION|2.2|Homo sapiens; SYNTHETIC CONSTRUCT|0|ANTITUMOR PROTEIN/DNA","1TUP|TUMOR SUPPRESSOR P53 COMPLEXED WITH DNA|X-RAY DIFFRACTION|2.2|Homo sapiens; SYNTHETIC CONSTRUCT|0|ANTITUMOR PROTEIN/DNA","1UOL|Crystal structure of the human p53 core domain mutant M133L/V203A/N239Y/N268D at 1.9 A resolution.|X-RAY DIFFRACTION|1.9|HOMO SAPIENS|0|DNA BINDING PROTEIN","1XQH|Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH|X-RAY DIFFRACTION|1.75|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE","1YC5|Sir2-p53 peptide-nicotinamide|X-RAY DIFFRACTION|1.4|Thermotoga maritima; SYNTHETIC CONSTRUCT|0|HYDROLASE","1YCQ|XENOPUS LAEVIS MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF HUMAN P53|X-RAY DIFFRACTION|2.3|Xenopus laevis|0|COMPLEX (ONCOGENE PROTEIN/PEPTIDE)","1YCR|MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF P53|X-RAY DIFFRACTION|2.6|Homo sapiens|0|COMPLEX (ONCOGENE PROTEIN/PEPTIDE)","1YCS|P53-53BP2 COMPLEX|X-RAY DIFFRACTION|2.2|Homo sapiens|0|COMPLEX (ANTI-ONCOGENE/ANKYRIN REPEATS)","2AC0|Structural Basis of DNA Recognition by p53 Tetramers (complex I)|X-RAY DIFFRACTION|1.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|APOPTOSIS/DNA","2ADY|Structural Basis of DNA Recognition by p53 Tetramers (complex IV)|X-RAY DIFFRACTION|2.5|Homo sapiens; SYNTHETIC CONSTRUCT|0|APOPTOSIS/DNA","2AHI|Structural Basis of DNA Recognition by p53 Tetramers (complex III)|X-RAY DIFFRACTION|1.85|Homo sapiens; SYNTHETIC CONSTRUCT|0|APOPTOSIS/DNA","2ATA|Structural Basis of DNA Recognition by p53 Tetramers (complex II)|X-RAY DIFFRACTION|2.2|Homo sapiens; SYNTHETIC CONSTRUCT|0|APOPTOSIS/DNA","2B3G|p53N (fragment 33-60) bound to RPA70N|X-RAY DIFFRACTION|1.6|Homo sapiens|0|REPLICATION","2BIM|human p53 core domain mutant M133L-V203A-N239Y-N268D-R273H|X-RAY DIFFRACTION|1.98|HOMO SAPIENS|0|DNA BINDING PROTEIN","2BIN|human p53 core domain mutant M133L-H168R-V203A-N239Y-N268D|X-RAY DIFFRACTION|1.9|HOMO SAPIENS|0|DNA BINDING PROTEIN","2BIO|human p53 core domain mutant M133L-V203A-N239Y-R249S-N268D|X-RAY DIFFRACTION|1.9|HOMO SAPIENS|0|DNA BINDING PROTEIN","2BIP|human p53 core domain mutant M133L-H168R-V203A-N239Y-R249S-N268D|X-RAY DIFFRACTION|1.8|HOMO SAPIENS|0|DNA BINDING PROTEIN","2BIQ|human p53 core domain mutant T123A-M133L-H168R-V203A-N239Y-R249S- N268D|X-RAY DIFFRACTION|1.8|HOMO SAPIENS|0|DNA BINDING PROTEIN","2FEJ|Solution structure of human p53 DNA binding domain.|SOLUTION NMR||Homo sapiens|0|TRANSCRIPTION","2FOJ|The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with p53 peptide 364-367|X-RAY DIFFRACTION|1.6|Homo sapiens; SYNTHETIC CONSTRUCT|0|HYDROLASE","2FOO|The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with p53 peptide 359-362|X-RAY DIFFRACTION|2.2|Homo sapiens; SYNTHETIC CONSTRUCT|0|HYDROLASE","2GS0|NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and the activation domain of p53|SOLUTION NMR||Homo sapiens; Saccharomyces cerevisiae|0|TRANSCRIPTION","2H1L|The Structure of the Oncoprotein SV40 Large T Antigen and p53 Tumor Suppressor Complex|X-RAY DIFFRACTION|3.16|Homo sapiens; Simian virus 40|0|VIRAL PROTEIN","2H2D|The Structural Basis for Sirtuin Substrate Affinity|X-RAY DIFFRACTION|1.7|Thermotoga maritima; SYNTHETIC CONSTRUCT|0|HYDROLASE","2H2F|The Structural basis for Sirtuin Substrate affinity|X-RAY DIFFRACTION|2.2|Thermotoga maritima; SYNTHETIC CONSTRUCT|0|HYDROLASE","2H4F|Sir2-p53 peptide-NAD+|X-RAY DIFFRACTION|2|Thermotoga maritima; SYNTHETIC CONSTRUCT|0|HYDROLASE","2H4H|Sir2 H116Y mutant-p53 peptide-NAD|X-RAY DIFFRACTION|1.99|Thermotoga maritima; SYNTHETIC CONSTRUCT|0|HYDROLASE","2H4J|Sir2-deacetylated peptide (from enzymatic turnover in crystal)|X-RAY DIFFRACTION|2.1|Thermotoga maritima; SYNTHETIC CONSTRUCT|0|HYDROLASE","2H59|Sir2 H116A-deacetylated p53 peptide-3'-o-acetyl ADP ribose|X-RAY DIFFRACTION|1.9|Thermotoga maritima; SYNTHETIC CONSTRUCT|0|HYDROLASE","2J0Z|p53 tetramerization domain wild type|SOLUTION NMR|||0|TRANSCRIPTION","2J10|p53 tetramerization domain mutant T329F Q331K|SOLUTION NMR|||0|TRANSCRIPTION","2J11|p53 tetramerization domain mutant Y327S T329G Q331G|SOLUTION NMR|||0|TRANSCRIPTION","2J1W|Human p53 core domain mutant M133L-V143A-V203A-N239Y-N268D|X-RAY DIFFRACTION|1.8|HOMO SAPIENS|0|NUCLEAR PROTEIN","2J1X|Human p53 core domain mutant M133L-V203A-Y220C-N239Y-N268D|X-RAY DIFFRACTION|1.65|HOMO SAPIENS|0|NUCLEAR PROTEIN","2J1Y|Human p53 core domain mutant M133L-V203A-N239Y-G245S-N268D|X-RAY DIFFRACTION|1.69|HOMO SAPIENS|0|NUCLEAR PROTEIN","2J1Z|Human p53 core domain mutant M133L-V203A-N239Y-N268D-F270L|X-RAY DIFFRACTION|1.8|HOMO SAPIENS|0|NUCLEAR PROTEIN","2J20|Human p53 core domain mutant M133L-V203A-N239Y-N268D-R273C|X-RAY DIFFRACTION|1.8|HOMO SAPIENS|0|NUCLEAR PROTEIN","2J21|Human p53 core domain mutant M133L-V203A-N239Y-N268D-R282W|X-RAY DIFFRACTION|1.6|HOMO SAPIENS|0|NUCLEAR PROTEIN","2K8F|Structural Basis for the Regulation of p53 Function by p300|SOLUTION NMR||Homo sapiens|0|Transferase/Transcription","2L14|Structure of CBP nuclear coactivator binding domain in complex with p53 TAD|SOLUTION NMR||Homo sapiens; Mus musculus|0|PROTEIN BINDING","2LY4|HMGB1-facilitated p53 DNA binding occurs via HMG-box/p53 transactivation domain interaction and is regulated by the acidic tail|SOLUTION NMR||Homo sapiens|0|NUCLEAR PROTEIN/ANTITUMOUR PROTEIN","2MEJ|Solution Structure of the Complex Between BCL-xL and the p53 Core Domain determined with PRE restraints|SOLUTION NMR||Homo sapiens|0|APOPTOSIS","2MWO|Solution structure of 53BP1 tandem Tudor domains in complex with a p53K370me2 peptide|SOLUTION NMR||Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION/ANTITUMOR PROTEIN","2MWP|Solution structure of 53BP1 tandem Tudor domains in complex with a p53K382me2 peptide|SOLUTION NMR||Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION/ANTITUMOR PROTEIN","2MWY|Mdmx-p53|SOLUTION NMR||Homo sapiens; SYNTHETIC CONSTRUCT|0|Cell Cycle/Antitumor Protein","2MZD|Characterization of the p300 Taz2-p53 TAD2 Complex and Comparison with the p300 Taz2-p53 TAD1 Complex|SOLUTION NMR||Homo sapiens|0|PROTEIN BINDING","2OCJ|Human p53 core domain in the absence of DNA|X-RAY DIFFRACTION|2.05|Homo sapiens|0|DNA BINDING PROTEIN","2PCX|Crystal structure of p53DBD(R282Q) at 1.54-angstrom Resolution|X-RAY DIFFRACTION|1.54|Homo sapiens|0|TRANSCRIPTION","2RUK|Solution structure of the complex between p53 transactivation domain 2 and TFIIH p62 PH domain|SOLUTION NMR||Homo sapiens|0|TRANSCRIPTION","2V5W|Crystal structure of HDAC8-substrate complex|X-RAY DIFFRACTION|2|HOMO SAPIENS; SYNTHETIC CONSTRUCT|0|HYDROLASE/HYDROLASE SUBSTRATE","2VUK|Structure of the p53 core domain mutant Y220C bound to the stabilizing small-molecule drug PhiKan083|X-RAY DIFFRACTION|1.5|HOMO SAPIENS|0|TRANSCRIPTION","2WGX|HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-Y236F-N239Y-T253I-N268D|X-RAY DIFFRACTION|1.75|HOMO SAPIENS|0|CELL CYCLE","2X0U|STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO A 2-amino substituted benzothiazole scaffold|X-RAY DIFFRACTION|1.6|HOMO SAPIENS|0|CELL CYCLE","2X0V|STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 4-(trifluoromethyl)benzene-1,2-diamine|X-RAY DIFFRACTION|1.8|HOMO SAPIENS|0|CELL CYCLE","2X0W|STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 5,6-dimethoxy- 2-methylbenzothiazole|X-RAY DIFFRACTION|2.1|HOMO SAPIENS|0|CELL CYCLE","2XWR|Crystal structure of the DNA-binding domain of human p53 with extended N terminus|X-RAY DIFFRACTION|1.68|HOMO SAPIENS|0|CELL CYCLE","2YBG|Structure of Lys120-acetylated p53 core domain|X-RAY DIFFRACTION|1.9|HOMO SAPIENS|0|CELL CYCLE","2YDR|CpOGA D298N in complex with p53-derived O-GlcNAc peptide|X-RAY DIFFRACTION|2.75|CLOSTRIDIUM PERFRINGENS; SYNTHETIC CONSTRUCT|0|HYDROLASE/PEPTIDE","2Z5S|Molecular basis for the inhibition of p53 by Mdmx|X-RAY DIFFRACTION|2.3|Danio rerio; SYNTHETIC CONSTRUCT|0|CELL CYCLE","2Z5T|Molecular basis for the inhibition of p53 by Mdmx|X-RAY DIFFRACTION|2.3|Danio rerio; SYNTHETIC CONSTRUCT|0|CELL CYCLE","3D05|Human p53 core domain with hot spot mutation R249S (II)|X-RAY DIFFRACTION|1.7|Homo sapiens|0|TRANSCRIPTION","3D06|Human p53 core domain with hot spot mutation R249S (I)|X-RAY DIFFRACTION|1.2|Homo sapiens|0|TRANSCRIPTION","3D07|Human p53 core domain with hot spot mutation R249S (III)|X-RAY DIFFRACTION|2.2|Homo sapiens|0|TRANSCRIPTION","3D08|Human p53 core domain with hot spot mutation R249S and second-site suppressor mutation H168R|X-RAY DIFFRACTION|1.4|Homo sapiens|0|TRANSCRIPTION","3D09|Human p53 core domain with hot spot mutation R249S and second-site suppressor mutations H168R and T123A|X-RAY DIFFRACTION|1.9|Homo sapiens|0|TRANSCRIPTION","3D0A|Human p53 core domain with hot spot mutation R249S and second site suppressor mutation H168R in sequence-specific complex with DNA|X-RAY DIFFRACTION|1.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION/DNA","3DAB|Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain|X-RAY DIFFRACTION|1.9|Homo sapiens; SYNTHETIC CONSTRUCT|0|CELL CYCLE","3DAC|Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain|X-RAY DIFFRACTION|1.8|Danio rerio; SYNTHETIC CONSTRUCT|0|CELL CYCLE","3IGK|Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 2)|X-RAY DIFFRACTION|1.7|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION/DNA","3IGL|Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 1)|X-RAY DIFFRACTION|1.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION/DNA","3KMD|Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer|X-RAY DIFFRACTION|2.15|Homo sapiens; SYNTHETIC CONSTRUCT|0|DNA BINDING PROTEIN/DNA","3KZ8|Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 3)|X-RAY DIFFRACTION|1.91|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION/DNA","3LW1|Binary complex of 14-3-3 sigma and p53 pT387-peptide|X-RAY DIFFRACTION|1.28|Homo sapiens; SYNTHETIC CONSTRUCT|0|PEPTIDE BINDING PROTEIN","3OQ5|Crystal structure of the 3-MBT domain from human L3MBTL1 in complex with p53K382me1|X-RAY DIFFRACTION|2.5005|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","3PDH|Structure of Sir2Tm bound to a propionylated peptide|X-RAY DIFFRACTION|1.8|Thermotoga maritima; SYNTHETIC CONSTRUCT|0|HYDROLASE","3Q01|An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity|X-RAY DIFFRACTION|2.1|Homo sapiens|0|ANTITUMOR PROTEIN","3Q05|An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity|X-RAY DIFFRACTION|2.4|Homo sapiens; SYNTHETIC CONSTRUCT|0|ANTITUMOR PROTEIN/DNA","3Q06|An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity|X-RAY DIFFRACTION|3.2|Homo sapiens; SYNTHETIC CONSTRUCT|0|CELL CYCLE/DNA","3SAK|HIGH RESOLUTION SOLUTION NMR STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF P53 BY MULTI-DIMENSIONAL NMR (SAC STRUCTURES)|SOLUTION NMR||Homo sapiens|0|APOPTOSIS/CELL CYCLE/GENE REGULATION","3TG5|Structure of SMYD2 in complex with p53 and SAH|X-RAY DIFFRACTION|2.3|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE","3TS8|Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element|X-RAY DIFFRACTION|2.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|ANTITUMOR PROTEIN/DNA","3ZME|Structure of the p53 core domain mutant Y220C bound to the small molecule PhiKan7242|X-RAY DIFFRACTION|1.35|Homo sapiens|0|CELL CYCLE"]},{"input":"O96017","source":"O96017|Serine/threonine-protein kinase Chk2","targets":["1GXC|FHA domain from human Chk2 kinase in complex with a synthetic phosphopeptide|X-RAY DIFFRACTION|2.7|HOMO SAPIENS; SYNTHETIC CONSTRUCT|0|PHOSPHOPROTEIN-BINDING DOMAIN","2CN5|Crystal structure of human Chk2 in complex with ADP|X-RAY DIFFRACTION|2.25|HOMO SAPIENS|0|TRANSFERASE","2CN8|Crystal structure of human Chk2 in complex with debromohymenialdisine|X-RAY DIFFRACTION|2.7|HOMO SAPIENS|0|TRANSFERASE","2W0J|Crystal structure of Chk2 in complex with NSC 109555, a specific inhibitor|X-RAY DIFFRACTION|2.05|HOMO SAPIENS|0|TRANSFERASE","2W7X|Cellular inhibition of checkpoint kinase 2 and potentiation of cytotoxic drugs by novel Chk2 inhibitor PV1019|X-RAY DIFFRACTION|2.07|HOMO SAPIENS|0|TRANSFERASE","2WTC|CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR|X-RAY DIFFRACTION|3|HOMO SAPIENS|0|TRANSFERASE","2WTD|Crystal structure of Chk2 in complex with an inhibitor|X-RAY DIFFRACTION|2.75|HOMO SAPIENS|0|TRANSFERASE","2WTI|CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR|X-RAY DIFFRACTION|2.5|HOMO SAPIENS|0|TRANSFERASE","2WTJ|CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR|X-RAY DIFFRACTION|2.1|HOMO SAPIENS|0|TRANSFERASE","2XBJ|Crystal Structure of Chk2 in complex with an inhibitor|X-RAY DIFFRACTION|2.3|HOMO SAPIENS|0|TRANSFERASE","2XK9|Structural analysis of checkpoint kinase 2 (Chk2) in complex with inhibitor PV1533|X-RAY DIFFRACTION|2.35|HOMO SAPIENS|0|TRANSFERASE","2XM8|Co-crystal structure of a small molecule inhibitor bound to the kinase domain of Chk2|X-RAY DIFFRACTION|3.4|HOMO SAPIENS|0|TRANSFERASE","2XM9|Structure of a small molecule inhibitor with the kinase domain of Chk2|X-RAY DIFFRACTION|2.5|HOMO SAPIENS|0|TRANSFERASE","2YCF|Crystal Structure of Checkpoint Kinase 2 in complex with Inhibitor PV1531|X-RAY DIFFRACTION|1.77|HOMO SAPIENS|0|TRANSFERASE","2YCQ|Crystal structure of checkpoint kinase 2 in complex with inhibitor PV1115|X-RAY DIFFRACTION|2.05|HOMO SAPIENS|0|TRANSFERASE","2YCR|Crystal structure of checkpoint kinase 2 in complex with inhibitor PV976|X-RAY DIFFRACTION|2.2|HOMO SAPIENS|0|TRANSFERASE","2YCS|Crystal structure of checkpoint kinase 2 in complex with PV788|X-RAY DIFFRACTION|2.35|HOMO SAPIENS|0|TRANSFERASE","2YIQ|Structural analysis of checkpoint kinase 2 in complex with inhibitor PV1322|X-RAY DIFFRACTION|1.89|HOMO SAPIENS|0|TRANSFERASE","2YIR|Structural analysis of checkpoint kinase 2 in complex with inhibitor PV1352|X-RAY DIFFRACTION|2.1|HOMO SAPIENS|0|TRANSFERASE","2YIT|Structural analysis of checkpoint kinase 2 in complex with PV1162, a novel inhibitor|X-RAY DIFFRACTION|2.2|HOMO SAPIENS|0|TRANSFERASE","3I6U|Structure and Activation Mechanism of the CHK2 DNA-Damage Checkpoint Kinase|X-RAY DIFFRACTION|3|Homo sapiens|0|TRANSFERASE","3I6W|Structure and Activation Mechanism of the CHK2 DNA-Damage Checkpoint Kinase|X-RAY DIFFRACTION|3.25|Homo sapiens|0|TRANSFERASE","3VA4|Crystal structure of the mammalian MDC1 FHA domain complexed with CHK2 pThr68 peptide|X-RAY DIFFRACTION|1.54|Mus musculus; SYNTHETIC CONSTRUCT|0|CELL CYCLE","4A9R|CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH BENZIMIDAZOLE CARBOXAMIDE INHIBITOR|X-RAY DIFFRACTION|2.85|HOMO SAPIENS|0|TRANSFERASE","4A9S|CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH BENZIMIDAZOLE CARBOXAMIDE INHIBITOR|X-RAY DIFFRACTION|2.66|HOMO SAPIENS|0|TRANSFERASE","4A9T|CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH BENZIMIDAZOLE CARBOXAMIDE INHIBITOR|X-RAY DIFFRACTION|2.7|HOMO SAPIENS|0|TRANSFERASE","4A9U|CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH BENZIMIDAZOLE CARBOXAMIDE INHIBITOR|X-RAY DIFFRACTION|2.48|HOMO SAPIENS|0|TRANSFERASE","4BDA|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|2.6|HOMO SAPIENS|0|TRANSFERASE","4BDB|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|2.5|HOMO SAPIENS|0|TRANSFERASE","4BDC|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|3|HOMO SAPIENS|0|TRANSFERASE","4BDD|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|2.67|HOMO SAPIENS|0|TRANSFERASE","4BDE|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|2.55|HOMO SAPIENS|0|TRANSFERASE","4BDF|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|2.7|HOMO SAPIENS|0|TRANSFERASE","4BDG|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|2.84|HOMO SAPIENS|0|TRANSFERASE","4BDH|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|2.7|HOMO SAPIENS|0|TRANSFERASE","4BDI|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|2.32|HOMO SAPIENS|0|TRANSFERASE","4BDJ|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|3.01|HOMO SAPIENS|0|TRANSFERASE","4BDK|Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)|X-RAY DIFFRACTION|3.3|HOMO SAPIENS|0|TRANSFERASE"]}]}