{"context":{"query":">>uniprot>>reactome","source_dataset":"uniprot","target_dataset":"reactome"},"stats":{"queried":5,"total":65,"mapped":5},"pagination":{"has_next":false},"schema":"id|name|tax_id|is_disease_pathway","mappings":[{"input":"P21802","source":"P21802|Fibroblast growth factor receptor 2","targets":["R-HSA-2023837|Signaling by FGFR2 amplification mutants|9606|true","R-HSA-2033519|Activated point mutants of FGFR2|9606|true","R-HSA-5655253|Signaling by FGFR2 in disease|9606|true","R-HSA-8851708|Signaling by FGFR2 IIIa TM|9606|true","R-HSA-8853333|Signaling by FGFR2 fusions|9606|true","R-HSA-109704|PI3K Cascade|9606|false","R-HSA-1257604|PIP3 activates AKT signaling|9606|false","R-HSA-190375|FGFR2c ligand binding and activation|9606|false","R-HSA-190377|FGFR2b ligand binding and activation|9606|false","R-HSA-2219530|Constitutive Signaling by Aberrant PI3K in Cancer|9606|true","R-HSA-5654221|Phospholipase C-mediated cascade; FGFR2|9606|false","R-HSA-5654695|PI-3K cascade:FGFR2|9606|false","R-HSA-5654699|SHC-mediated cascade:FGFR2|9606|false","R-HSA-5654700|FRS-mediated FGFR2 signaling|9606|false","R-HSA-5654727|Negative regulation of FGFR2 signaling|9606|false","R-HSA-5673001|RAF/MAP kinase cascade|9606|false","R-HSA-6811558|PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling|9606|false"]},{"input":"P03372","source":"P03372|Estrogen receptor","targets":["R-HSA-1251985|Nuclear signaling by ERBB4|9606|false","R-HSA-1257604|PIP3 activates AKT signaling|9606|false","R-HSA-2219530|Constitutive Signaling by Aberrant PI3K in Cancer|9606|true","R-HSA-383280|Nuclear Receptor transcription pathway|9606|false","R-HSA-4090294|SUMOylation of intracellular receptors|9606|false","R-HSA-5689896|Ovarian tumor domain proteases|9606|false","R-HSA-6811558|PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling|9606|false","R-HSA-8866910|TFAP2 (AP-2) family regulates transcription of growth factors and their receptors|9606|false","R-HSA-8931987|RUNX1 regulates estrogen receptor mediated transcription|9606|false","R-HSA-8939211|ESR-mediated signaling|9606|false","R-HSA-8939256|RUNX1 regulates transcription of genes involved in WNT signaling|9606|false","R-HSA-8939902|Regulation of RUNX2 expression and activity|9606|false","R-HSA-9009391|Extra-nuclear estrogen signaling|9606|false","R-HSA-9018519|Estrogen-dependent gene expression|9606|false","R-HSA-9841251|Mitochondrial unfolded protein response (UPRmt)|9606|false","R-HSA-9927418|Developmental Lineage of Mammary Gland Luminal Epithelial Cells|9606|false","R-HSA-9927426|Developmental Lineage of Mammary Gland Alveolar Cells|9606|false"]},{"input":"O14746","source":"O14746|Telomerase reverse transcriptase","targets":["R-HSA-171319|Telomere Extension By Telomerase|9606|false","R-HSA-201722|Formation of the beta-catenin:TCF transactivating complex|9606|false","R-HSA-9825895|Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence|9606|false"]},{"input":"Q15303","source":"Q15303|Receptor tyrosine-protein kinase erbB-4","targets":["R-HSA-1227986|Signaling by ERBB2|9606|false","R-HSA-1236394|Signaling by ERBB4|9606|false","R-HSA-1250196|SHC1 events in ERBB2 signaling|9606|false","R-HSA-1250342|PI3K events in ERBB4 signaling|9606|false","R-HSA-1250347|SHC1 events in ERBB4 signaling|9606|false","R-HSA-1251985|Nuclear signaling by ERBB4|9606|false","R-HSA-1253288|Downregulation of ERBB4 signaling|9606|false","R-HSA-1257604|PIP3 activates AKT signaling|9606|false","R-HSA-1963640|GRB2 events in ERBB2 signaling|9606|false","R-HSA-1963642|PI3K events in ERBB2 signaling|9606|false","R-HSA-2219530|Constitutive Signaling by Aberrant PI3K in Cancer|9606|true","R-HSA-5673001|RAF/MAP kinase cascade|9606|false","R-HSA-6785631|ERBB2 Regulates Cell Motility|9606|false","R-HSA-6811558|PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling|9606|false","R-HSA-8847993|ERBB2 Activates PTK6 Signaling|9606|false","R-HSA-8863795|Downregulation of ERBB2 signaling|9606|false","R-HSA-9018519|Estrogen-dependent gene expression|9606|false","R-HSA-9620244|Long-term potentiation|9606|false","R-HSA-9664565|Signaling by ERBB2 KD Mutants|9606|true","R-HSA-9665686|Signaling by ERBB2 TMD/JMD mutants|9606|true"]},{"input":"O14965","source":"O14965|Aurora kinase A","targets":["R-HSA-174178|APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1|9606|false","R-HSA-2565942|Regulation of PLK1 Activity at G2/M Transition|9606|false","R-HSA-4615885|SUMOylation of DNA replication proteins|9606|false","R-HSA-6804114|TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest|9606|false","R-HSA-6804756|Regulation of TP53 Activity through Phosphorylation|9606|false","R-HSA-8854050|FBXL7 down-regulates AURKA during mitotic entry and in early mitosis|9606|false","R-HSA-8854518|AURKA Activation by TPX2|9606|false","R-HSA-8854521|Interaction between PHLDA1 and AURKA|9606|false"]}]}