{"context":{"query":">>uniprot>>pdb","source_dataset":"uniprot","target_dataset":"pdb"},"stats":{"queried":5,"total":311,"mapped":5},"pagination":{"has_next":true,"next_token":"-1[]P42336,1,P42336,76,1]["},"schema":"id|title|method|resolution|source_organism|chain_count|header","mappings":[{"input":"P21802","source":"P21802|Fibroblast growth factor receptor 2","targets":["1DJS|LIGAND-BINDING PORTION OF FIBROBLAST GROWTH FACTOR RECEPTOR 2 IN COMPLEX WITH FGF1|X-RAY DIFFRACTION|2.4|Homo sapiens|0|HORMONE/GROWTH FACTOR/RECEPTOR","1E0O|CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX|X-RAY DIFFRACTION|2.8|HOMO SAPIENS|0|GROWTH FACTOR","1EV2|CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2)|X-RAY DIFFRACTION|2.2|Homo sapiens|0|GROWTH FACTOR/GROWTH FACTOR RECEPTOR","1GJO|The FGFr2 tyrosine kinase domain|X-RAY DIFFRACTION|2.4|HOMO SAPIENS|0|TRANSFERASE","1II4|CRYSTAL STRUCTURE OF SER252TRP APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2|X-RAY DIFFRACTION|2.7|Homo sapiens|0|GROWTH FACTOR/GROWTH FACTOR RECEPTOR","1IIL|CRYSTAL STRUCTURE OF PRO253ARG APERT MUTANT FGF RECEPTOR 2 (FGFR2) IN COMPLEX WITH FGF2|X-RAY DIFFRACTION|2.3|Homo sapiens|0|GROWTH FACTOR/GROWTH FACTOR RECEPTOR","1NUN|Crystal Structure Analysis of the FGF10-FGFR2b Complex|X-RAY DIFFRACTION|2.9|Homo sapiens|0|HORMONE/GROWTH FACTOR/MEMBRANE PROTEIN","1OEC|FGFr2 kinase domain|X-RAY DIFFRACTION|2.4|HOMO SAPIENS|0|TRANSFERASE","1WVZ|Solution Structure of the D2 Domain of the Fibroblast Growth Factor|SOLUTION NMR||Homo sapiens|0|TRANSFERASE","2FDB|Crystal Structure of Fibroblast growth factor (FGF)8b in complex with FGF Receptor (FGFR) 2c|X-RAY DIFFRACTION|2.28|Homo sapiens|0|HORMONE/GROWTH FACTOR/TRANSFERASE","2PSQ|Crystal Structure of Unphosphorylated Unactivated Wild Type FGF Receptor 2 (FGFR2) Kinase Domain|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE","2PVF|Crystal Structure of Tyrosine Phosphorylated Activated FGF Receptor 2 (FGFR2) Kinase Domain in Complex with ATP Analog and Substrate Peptide|X-RAY DIFFRACTION|1.8|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE","2PVY|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome.|X-RAY DIFFRACTION|2.2|Homo sapiens|0|TRANSFERASE","2PWL|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549H Mutation Responsible for Crouzon Syndrome.|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE","2PY3|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565G Mutation Responsible for Pfeiffer Syndrome|X-RAY DIFFRACTION|2.3|Homo sapiens|0|TRANSFERASE","2PZ5|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible for Pfeiffer Syndrome|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE","2PZP|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation Responsible for Crouzon Syndrome|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE","2PZR|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K641R Mutation Responsible for Pfeiffer Syndrome|X-RAY DIFFRACTION|3|Homo sapiens|0|TRANSFERASE","2Q0B|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565A Mutation Responsible for Pfeiffer Syndrome|X-RAY DIFFRACTION|2.9|Homo sapiens|0|TRANSFERASE","3B2T|Structure of phosphotransferase|X-RAY DIFFRACTION|1.8|Homo sapiens|0|TRANSFERASE","3CAF|Crystal Structure of hFGFR2 D2 Domain|X-RAY DIFFRACTION|1.96|Homo sapiens|0|TRANSFERASE","3CLY|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domains Trapped in Trans-Phosphorylation Reaction|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSFERASE","3CU1|Crystal Structure of 2:2:2 FGFR2D2:FGF1:SOS complex|X-RAY DIFFRACTION|2.6|Homo sapiens|0|Transferase/Hormone","3DAR|Crystal structure of D2 domain from human FGFR2|X-RAY DIFFRACTION|2.2|Homo sapiens|0|TRANSFERASE","3EUU|Crystal structure of the FGFR2 D2 domain|X-RAY DIFFRACTION|2.34|Homo sapiens|0|TRANSFERASE","3OJ2|Crystal structure of FGF1 complexed with the ectodomain of FGFR2b harboring the A172F Pfeiffer syndrome mutation|X-RAY DIFFRACTION|2.2|Homo sapiens|0|Cytokine/Signaling Protein","3OJM|Crystal Structure of FGF1 complexed with the ectodomain of FGFR2b harboring P253R Apert mutation|X-RAY DIFFRACTION|2.1|Homo sapiens|0|Cytokine/Signaling Protein","3RI1|Crystal structure of the catalytic domain of FGFR2 kinase in complex with ARQ 069|X-RAY DIFFRACTION|2.1|Homo sapiens|0|Transferase/Transferase Inhibitor","4J23|Low resolution crystal structure of the FGFR2D2D3/FGF1/SR128545 complex|X-RAY DIFFRACTION|3.882|Homo sapiens|0|SIGNALING PROTEIN/transferase","4J95|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome in Space Group C2.|X-RAY DIFFRACTION|2.3767|Homo sapiens|0|TRANSFERASE","4J96|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic Gain-of-Function K659M Mutation Identified in Cervical Cancer.|X-RAY DIFFRACTION|2.2972|Homo sapiens|0|TRANSFERASE","4J97|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic Gain-of-Function K659E Mutation Identified in Endometrial Cancer.|X-RAY DIFFRACTION|2.5482|Homo sapiens|0|TRANSFERASE","4J98|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Gain-of-Function K659Q Mutation.|X-RAY DIFFRACTION|2.3067|Homo sapiens|0|TRANSFERASE","4J99|Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Gain-of-Function K659T Mutation.|X-RAY DIFFRACTION|1.8474|Homo sapiens|0|TRANSFERASE","4WV1|Crystal structure of the FGFR2 D2 domain in complex with Fab 2B.1.3|X-RAY DIFFRACTION|2.362|Homo sapiens|0|TRANSFERASE/IMMUNE SYSTEM","5EG3|Crystal Structure of the Activated FGF Receptor 2 (FGFR2) Kinase Domain in complex with the cSH2 domain of Phospholipase C gamma (PLCgamma)|X-RAY DIFFRACTION|2.606|Homo sapiens; Rattus norvegicus|0|Transferase/Hydrolase","5UGL|Crystal Structure of FGF Receptor 2 Tyrosine Kinase Domain Harboring the D650V Activating Mutation|X-RAY DIFFRACTION|1.861|Homo sapiens|0|TRANSFERASE","5UGX|Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 Harboring a E565A/D650V double Gain-of-Function Mutation|X-RAY DIFFRACTION|2.349|Homo sapiens|0|TRANSFERASE","5UHN|Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 harboring a N549H/E565A Double Gain-of-Function Mutation|X-RAY DIFFRACTION|2.909|Homo sapiens|0|TRANSFERASE","5UI0|Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 harboring an E565A/K659M Double Gain-of-Function Mutation|X-RAY DIFFRACTION|2.05|Homo sapiens|0|TRANSFERASE","6AGX|The cocrystal structure of FGFR2 bound with compound 14 harboring 5H-pyrrolo[2,3-b]pyrazine scaffold|X-RAY DIFFRACTION|2.95|Homo sapiens|0|TRANSFERASE/INHIBITOR","6LVK|Crystal structure of FGFR2 in complex with 1,3,5-triazine derivative|X-RAY DIFFRACTION|2.29|Homo sapiens|0|TRANSFERASE","6LVL|Crystal structure of FGFR2 in complex with 1,3,5-triazine derivative|X-RAY DIFFRACTION|2.98|Homo sapiens|0|TRANSFERASE","6V6Q|Crystal Structure of Monophosphorylated FGF Receptor 2 isoform IIIb with PTR657|X-RAY DIFFRACTION|2.46|Homo sapiens|0|TRANSFERASE","7KIA|Crystal structure of FGFR2 kinase domain gatekeeper mutant V564F in complex with covalent compound 19|X-RAY DIFFRACTION|2.22|Homo sapiens|0|SIGNALING PROTEIN","7KIE|Crystal structure of FGFR2 kinase domain gatekeeper mutant V564F in complex with covalent compound 3|X-RAY DIFFRACTION|2.47|Homo sapiens|0|SIGNALING PROTEIN","7OZY|FGFR2 kinase domain (residues 461-763) in complex with 38.|X-RAY DIFFRACTION|2.28|Homo sapiens|0|TRANSFERASE","8E1X|FGFR2 kinase domain in complex with a Pyrazolo[1,5-a]pyrimidine analog (Compound 29)|X-RAY DIFFRACTION|2.68|Homo sapiens|0|STRUCTURAL PROTEIN","8H75|FGFR2 in complex with YJ001|X-RAY DIFFRACTION|3.75|Homo sapiens|0|TRANSFERASE","8STG|Discovery and clinical validation of RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations|X-RAY DIFFRACTION|3.79|Homo sapiens|0|TRANSFERASE/INHIBITOR","8SWE|FGFR2 Kinase Domain Bound to Reversible Inhibitor Cmpd 3|X-RAY DIFFRACTION|2.24|Homo sapiens|0|ONCOPROTEIN","8U1F|FGFR2 Kinase Domain Bound to Irreversible Inhibitor Cmpd 10|X-RAY DIFFRACTION|3.33|Homo sapiens|0|Transferase/Inhibitor","8W2X|TAS-120 covalent structure with FGFR2|X-RAY DIFFRACTION|2.98|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","8W38|TAS-120 covalent structure with FGFR2 molecular brake mutant|X-RAY DIFFRACTION|2.6|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","8W3B|TAS-120 covalent structure with FGFR2 molecular brake mutant|X-RAY DIFFRACTION|2.23|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","8W3D|TAS-120 covalent structure with FGFR2 molecular brake mutant|X-RAY DIFFRACTION|2.04|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","9U3N|Crystal structure of FGFR2 kinase domain gatekeeper mutant V564F in complex with compound LC-F2-01|X-RAY DIFFRACTION|3.25|Homo sapiens|0|TRANSFERASE","9U7E|FGFR2 kinase domain with a macrocyclic compound 8g|X-RAY DIFFRACTION|2.2|Homo sapiens|0|TRANSFERASE","9U7S|FGFR2 kinase domain with a macrocyclic compound 8r|X-RAY DIFFRACTION|1.99|Homo sapiens|0|TRANSFERASE"]},{"input":"P04626","source":"P04626|Receptor tyrosine-protein kinase erbB-2","targets":["1MFG|The Structure of ERBIN PDZ domain bound to the Carboxy-terminal tail of the ErbB2 Receptor|X-RAY DIFFRACTION|1.25|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","1MFL|The Structure of ERBIN PDZ domain bound to the Carboxy-terminal tail of the ErbB2 Receptor|X-RAY DIFFRACTION|1.88|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","1MW4|Solution structure of the human Grb7-SH2 domain in complex with a 10 amino acid peptide pY1139|SOLUTION NMR||Homo sapiens; SYNTHETIC CONSTRUCT|0|HORMONE/GROWTH FACTOR/TRANSFERASE","1N8Z|Crystal structure of extracellular domain of human HER2 complexed with Herceptin Fab|X-RAY DIFFRACTION|2.52|Homo sapiens; Mus musculus, Homo sapiens|0|TRANSFERASE","1QR1|POOR BINDING OF A HER-2/NEU EPITOPE (GP2) TO HLA-A2.1 IS DUE TO A LACK OF INTERACTIONS IN THE CENTER OF THE PEPTIDE|X-RAY DIFFRACTION|2.4|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","1S78|Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex|X-RAY DIFFRACTION|3.25|Homo sapiens; Mus musculus|0|TRANSFERASE","2A91|Crystal structure of ErbB2 domains 1-3|X-RAY DIFFRACTION|2.5|Homo sapiens|0|SIGNALING PROTEIN,TRANSFERASE,MEMBRANE PROTEIN","2JWA|ErbB2 transmembrane segment dimer spatial structure|SOLUTION NMR||Homo sapiens|0|TRANSFERASE","2KS1|Heterodimeric association of Transmembrane domains of ErbB1 and ErbB2 receptors Enabling Kinase Activation|SOLUTION NMR||Homo sapiens|0|TRANSFERASE","2L4K|Water refined solution structure of the human Grb7-SH2 domain in complex with the 10 amino acid peptide pY1139|SOLUTION NMR||Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","2N2A|Spatial structure of HER2/ErbB2 dimeric transmembrane domain in the presence of cytoplasmic juxtamembrane domains|SOLUTION NMR||Homo sapiens|0|MEMBRANE PROTEIN","3BE1|Dual specific bH1 Fab in complex with the extracellular domain of HER2/ErbB-2|X-RAY DIFFRACTION|2.9|Homo sapiens|0|TRANSFERASE","3H3B|Crystal structure of the single-chain Fv (scFv) fragment of an anti-ErbB2 antibody chA21 in complex with residues 1-192 of ErbB2 extracellular domain|X-RAY DIFFRACTION|2.45|Homo sapiens; Mus musculus|0|IMMUNE SYSTEM","3MZW|HER2 extracelluar region with affinity matured 3-helix affibody ZHER2:342|X-RAY DIFFRACTION|2.9|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE","3N85|Crystallographic trimer of HER2 extracellular regions in complex with tryptophan-rich antibody fragment|X-RAY DIFFRACTION|3.2|Homo sapiens|0|Transferase/immune system","3PP0|Crystal Structure of the Kinase domain of Human HER2 (erbB2).|X-RAY DIFFRACTION|2.25|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3RCD|HER2 Kinase Domain Complexed with TAK-285|X-RAY DIFFRACTION|3.21|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3WLW|Molecular Architecture of the ErbB2 Extracellular Domain Homodimer|X-RAY DIFFRACTION|3.088|Homo sapiens|0|HYDROLASE/IMMUNE SYSTEM","3WSQ|Structure of HER2 with an Fab|X-RAY DIFFRACTION|3.5|Homo sapiens|0|TRANSFERASE/IMMUNE SYSTEM","4GFU|PTPN18 in complex with HER2-pY1248 phosphor-peptides|X-RAY DIFFRACTION|2|Homo sapiens; SYNTHETIC CONSTRUCT|0|HYDROLASE/Peptide","4HRL|Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2|X-RAY DIFFRACTION|2.55|Homo sapiens; synthetic|0|TRANSFERASE/DE NOVO PROTEIN","4HRM|Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2|X-RAY DIFFRACTION|3.2|Homo sapiens; synthetic|0|TRANSFERASE/DE NOVO PROTEIN","4HRN|Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2|X-RAY DIFFRACTION|2.65|Homo sapiens; synthetic|0|TRANSFERASE/DE NOVO PROTEIN","4NND|Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites|X-RAY DIFFRACTION|2.502|Homo sapiens; SYNTHETIC CONSTRUCT|0|HYDROLASE","5K33|Crystal structure of extracellular domain of HER2 in complex with Fcab STAB19|X-RAY DIFFRACTION|3.3|Homo sapiens|0|IMMUNE SYSTEM","5KWG|Crystal structure of extracellular domain of HER2 in complex with Fcab H10-03-6|X-RAY DIFFRACTION|4.3|Homo sapiens|0|IMMUNE SYSTEM","5MY6|Crystal structure of a HER2-Nb complex|X-RAY DIFFRACTION|2.246|Camelus dromedarius; Homo sapiens|0|TRANSFERASE","5O4G|HER2 in complex with Fab MF3958|X-RAY DIFFRACTION|3|Homo sapiens|0|ONCOPROTEIN","5OB4|NMR spatial structure of HER2 TM domain dimer in DPC micelles.|SOLUTION NMR||Homo sapiens|0|MEMBRANE PROTEIN","5TQS|Phospholipase C gamma-1 C-terminal SH2 domain bound to a phosphopeptide derived from the receptor tyrosine kinase ErbB2|X-RAY DIFFRACTION|1.876|Bos taurus; SYNTHETIC CONSTRUCT|0|HYDROLASE","6ATT|39S Fab bound to HER2 ecd|X-RAY DIFFRACTION|3.77|Homo sapiens|0|IMMUNE SYSTEM","6BGT|Structure of Trastuzumab Fab mutant in complex with Her2 extracellular domain|X-RAY DIFFRACTION|2.7|Homo sapiens|0|TRANSFERASE/IMMUNE SYSTEM","6J71|HuA21-scFv in complex with the extracellular domain(ECD) of HER2|X-RAY DIFFRACTION|2.918|Homo sapiens|0|SIGNALING PROTEIN","6LBX|Crystal structure of HER2 Domain IV and Rb-H2|X-RAY DIFFRACTION|2.03|Cyclostomata; Homo sapiens|0|PROTEIN BINDING","6OGE|Cryo-EM structure of Her2 extracellular domain-Trastuzumab Fab-Pertuzumab Fab complex|ELECTRON MICROSCOPY|4.36|Homo sapiens|0|transferase/immune system","7JXH|HER2 in complex with JBJ-08-178-01|X-RAY DIFFRACTION|3.27|Homo sapiens|0|TRANSFERASE/TRANSFERASE Inhibitor","7MN5|Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain|ELECTRON MICROSCOPY|2.93|Escherichia coli; Homo sapiens|0|SIGNALING PROTEIN","7MN6|Structure of the HER2 S310F/HER3/NRG1b Heterodimer Extracellular Domain|ELECTRON MICROSCOPY|3.09|Escherichia coli; Homo sapiens|0|SIGNALING PROTEIN","7MN8|Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain bound to Trastuzumab Fab|ELECTRON MICROSCOPY|3.45|Escherichia coli; Homo sapiens|0|SIGNALING PROTEIN/IMMUNE SYSTEM","7PCD|HER2 IN COMPLEX WITH A COVALENT INHIBITOR|X-RAY DIFFRACTION|1.77|Homo sapiens|0|TRANSFERASE","7QVK|NM-02 in complex with HER2-ECD|X-RAY DIFFRACTION|3.1|Camelus bactrianus; Homo sapiens|0|ONCOPROTEIN","8FFJ|Structure of Zanidatamab bound to HER2|ELECTRON MICROSCOPY|7.5|Homo sapiens|0|TRANSFERASE/IMMUNE SYSTEM","8HGO|The EGF-bound EGFR/HER2 ectodomain complex|ELECTRON MICROSCOPY|3.31|Homo sapiens|0|MEMBRANE PROTEIN","8HGP|The EREG-bound EGFR/HER2 ectodomain complex|ELECTRON MICROSCOPY|4.53|Homo sapiens|0|MEMBRANE PROTEIN","8JYQ|Crystal structure of cancer-specific anti-HER2 antibody H2Mab-214 in complex with epitope peptide|X-RAY DIFFRACTION|1.75|Homo sapiens; Mus musculus; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","8JYR|Crystal structure of anti-HER2 antibody H2Mab-119 in complex with HER2 domain I|X-RAY DIFFRACTION|1.69|Homo sapiens; Mus musculus|0|IMMUNE SYSTEM","8PWH|Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex|ELECTRON MICROSCOPY|3.17|Homo sapiens|0|STRUCTURAL PROTEIN","8Q6J|Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex|ELECTRON MICROSCOPY|3.3|Homo sapiens|0|STRUCTURAL PROTEIN","8U4K|Structure of the HER2/HER4/BTC Heterodimer Extracellular Domain|ELECTRON MICROSCOPY|4.27|Homo sapiens|0|MEMBRANE PROTEIN, TRANSFERASE","8U4L|Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain|ELECTRON MICROSCOPY|3.31|Homo sapiens|0|MEMBRANE PROTEIN, TRANSFERASE","8U8X|crystal structure of the receptor tyrosine kinase Human HER2 (ERBB2) YVMA mutant kinase domain in complex with inhibitor compound 27|X-RAY DIFFRACTION|1.69|Homo sapiens|0|SIGNALING PROTEIN,TRANSFERASE/INHIBITOR","8VB5|Crystal structure of kinase domain of HER2 Exon 20 insertion mutant in complex with tucatinib|X-RAY DIFFRACTION|1.48|Homo sapiens|0|TRANSFERASE","8VQD|HER2 S310F in complex with TL1 Fab|ELECTRON MICROSCOPY|2.61|Homo sapiens|0|SIGNALING PROTEIN","8VQE|Homodimeric structure of HER2 S310F extracellular region|ELECTRON MICROSCOPY|2.67|Homo sapiens|0|SIGNALING PROTEIN","9IUT|Crystal structure of cancer-specific anti-HER2 antibody H2Mab-250 in complex with epitope peptide|X-RAY DIFFRACTION|2.09|Mus musculus; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","9L1S|Structure of the HER2 (S310F) - pertuzumab (T30S/D31A) complex|ELECTRON MICROSCOPY|3.0|Homo sapiens|0|IMMUNE SYSTEM","9MTE|CryoEM structure of extracellular domain of human HER2 complexed with two nano-bodies 27A05 and 47D05|ELECTRON MICROSCOPY|2.66|Homo sapiens; Lama glama|0|TRANSFERASE/IMMUNE SYSTEM","9MTX|CryoEM structure of extracellular domain of human HER2 complexed with nano-bodies 29E09|ELECTRON MICROSCOPY|3.06|Homo sapiens; Lama glama|0|TRANSFERASE","9QBF|HER2/ErbB2 extracellular domain (ECD) in compact conformation in complex with trastuzumab (TZB) antibody|ELECTRON MICROSCOPY|3.8|Aequorea victoria; Homo sapiens|0|SIGNALING PROTEIN","9QBG|HER2/ErbB2 extracellular domain (ECD) in extended conformation in complex with trastuzumab (TZB) antibody|ELECTRON MICROSCOPY|3.6|Aequorea victoria; Homo sapiens|0|SIGNALING PROTEIN","9QBH|HER2/ErbB2 extracellular domain (ECD) from a near full-length construct solubilized in amphipols.|ELECTRON MICROSCOPY|3.77|Aequorea victoria; Homo sapiens|0|SIGNALING PROTEIN"]},{"input":"Q9UM73","source":"Q9UM73|ALK tyrosine kinase receptor","targets":["2KUP|Solution structure of the complex of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589) of HALK|SOLUTION NMR||Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN/ONCOPROTEIN","2KUQ|Solution structure of the chimera of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589) of HALK|SOLUTION NMR||Homo sapiens; synthetic construct|0|SIGNALING PROTEIN","2XB7|Structure of Human Anaplastic Lymphoma Kinase in complex with NVP- TAE684|X-RAY DIFFRACTION|2.5|HOMO SAPIENS|0|TRANSFERASE","2XBA|Structure of Human Anaplastic Lymphoma Kinase in complex with PHA- E429|X-RAY DIFFRACTION|1.95|HOMO SAPIENS|0|TRANSFERASE","2XP2|Structure of the Human Anaplastic Lymphoma Kinase in Complex with Crizotinib (PF-02341066)|X-RAY DIFFRACTION|1.9|HOMO SAPIENS|0|TRANSFERASE","2YFX|Structure of L1196M Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib|X-RAY DIFFRACTION|1.7|HOMO SAPIENS|0|TRANSFERASE","2YHV|Structure of L1196M Mutant Anaplastic Lymphoma Kinase|X-RAY DIFFRACTION|1.9|HOMO SAPIENS|0|TRANSFERASE","2YJR|Structure of F1174L Mutant Anaplastic Lymphoma Kinase|X-RAY DIFFRACTION|1.9|HOMO SAPIENS|0|TRANSFERASE","2YJS|Structure of C1156Y Mutant Anaplastic Lymphoma Kinase|X-RAY DIFFRACTION|1.9|HOMO SAPIENS|0|TRANSFERASE","2YS5|Solution structure of the complex of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589) of hALK|SOLUTION NMR||Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","2YT2|Solution structure of the chimera of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589) of hALK|SOLUTION NMR||Homo sapiens|0|SIGNALING PROTEIN","3AOX|X-ray crystal structure of human anaplastic lymphoma kinase in complex with CH5424802|X-RAY DIFFRACTION|1.75|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3L9P|Crystal Structure of the Anaplastic Lymphoma Kinase Catalytic Domain|X-RAY DIFFRACTION|1.8|Homo sapiens|0|TRANSFERASE","3LCS|Crystal Structure of the Anaplastic Lymphoma Kinase Catalytic Domain|X-RAY DIFFRACTION|1.95|Homo sapiens|0|TRANSFERASE","3LCT|Crystal Structure of the Anaplastic Lymphoma Kinase Catalytic Domain|X-RAY DIFFRACTION|2.1|Homo sapiens|0|TRANSFERASE","4ANL|Structure of G1269A Mutant Anaplastic Lymphoma Kinase|X-RAY DIFFRACTION|1.7|HOMO SAPIENS|0|TRANSFERASE","4ANQ|Structure of G1269A Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib|X-RAY DIFFRACTION|1.76|HOMO SAPIENS|0|TRANSFERASE","4ANS|Structure of L1196M,G1269A Double Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib|X-RAY DIFFRACTION|1.85|HOMO SAPIENS|0|TRANSFERASE","4CCB|Structure of the Human Anaplastic Lymphoma Kinase in Complex with 3-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)ethoxy)-5-(5-methyl-1H- pyrazol-4-yl)pyridin-2-amine|X-RAY DIFFRACTION|2.03|HOMO SAPIENS|0|TRANSFERASE","4CCU|Structure of the Human Anaplastic Lymphoma Kinase in Complex with 2-(5-(6-amino-5-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)ethoxy) pyridin-3-yl)-4-methylthiazol-2-yl)propan-2-ol|X-RAY DIFFRACTION|2|HOMO SAPIENS|0|TRANSFERASE","4CD0|Structure of L1196M Mutant Human Anaplastic Lymphoma Kinase in Complex with 2-(5-(6-amino-5-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2- yl)phenyl)ethoxy)pyridin-3-yl)-4-methylthiazol-2-yl)propane-1,2-diol|X-RAY DIFFRACTION|2.23|HOMO SAPIENS|0|TRANSFERASE","4CLI|Structure of the Human Anaplastic Lymphoma Kinase in Complex with PF- 06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16, 17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).|X-RAY DIFFRACTION|2.05|HOMO SAPIENS|0|TRANSFERASE","4CLJ|Structure of L1196M Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).|X-RAY DIFFRACTION|1.66|HOMO SAPIENS|0|TRANSFERASE","4CMO|Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 2-((1R)-1-((3-amino-6-(2-methoxypyridin-3-yl)pyrazin-2-yl) oxy)ethyl)-4-fluoro-N-methylbenzamide|X-RAY DIFFRACTION|2.05|HOMO SAPIENS|0|TRANSFERASE","4CMT|Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 3-((1R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)ethoxy)- 5-(3-(methylsulfonyl)phenyl)pyridin-2-amine|X-RAY DIFFRACTION|1.73|HOMO SAPIENS|0|TRANSFERASE","4CMU|Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor (10R)-7-amino-12-fluoro-1,3,10,16-tetramethyl-16,17-dihydro- 1H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11)benzoxadiazacyclotetradecin-15(10H)-one|X-RAY DIFFRACTION|1.8|HOMO SAPIENS|0|TRANSFERASE","4CNH|Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 3-((1R)-1-(5-fluoro-2-methoxyphenyl)ethoxy)-5-(1-methyl-1H- 1,2,3-triazol-5-yl)pyridin-2-amine|X-RAY DIFFRACTION|1.9|HOMO SAPIENS|0|TRANSFERASE","4CTB|Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor (5R)-8-amino-3-fluoro-5,19-dimethyl-20-oxo-5,18,19,20- tetrahydro-7,11-(azeno)pyrido(2',1':2,3)imidazo(4,5-h)(2,5,11) benzoxadiazacyclotetradecine-14-carbonitrile|X-RAY DIFFRACTION|1.79|HOMO SAPIENS|0|TRANSFERASE","4CTC|Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 7-amino-3-cyclopropyl-12-fluoro-1,10,16-trimethyl-16,17- dihydro-1H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecin-15(10H)-one|X-RAY DIFFRACTION|2.03|HOMO SAPIENS|0|TRANSFERASE","4DCE|Crystal structure of human anaplastic lymphoma kinase in complex with a piperidine-carboxamide inhibitor|X-RAY DIFFRACTION|2.03|Homo sapiens|0|Transferase/Inhibitor","4FNW|Crystal structure of the apo F1174L anaplastic lymphoma kinase catalytic domain|X-RAY DIFFRACTION|1.75|Homo sapiens|0|TRANSFERASE","4FNX|Crystal structure of the apo R1275Q anaplastic lymphoma kinase catalytic domain|X-RAY DIFFRACTION|1.7|Homo sapiens|0|TRANSFERASE","4FNY|Crystal structure of the R1275Q anaplastic lymphoma kinase catalytic domain in complex with a benzoxazole inhibitor|X-RAY DIFFRACTION|2.45|Homo sapiens|0|Transferase/Inhibitor","4FNZ|Crystal structure of human anaplastic lymphoma kinase in complex with piperidine-carboxamide inhibitor 2|X-RAY DIFFRACTION|2.6|Homo sapiens|0|Transferase/Inhibitor","4FOB|Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 1|X-RAY DIFFRACTION|1.9|Homo sapiens|0|Transferase/Inhibitor","4FOC|Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 2|X-RAY DIFFRACTION|1.7|Homo sapiens|0|Transferase/Inhibitor","4FOD|Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 36|X-RAY DIFFRACTION|2|Homo sapiens|0|Transferase/Inhibitor","4JOA|Crystal Structure of Human Anaplastic Lymphoma Kinase in complex with 7-azaindole based inhibitor|X-RAY DIFFRACTION|2.7|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4MKC|Crystal Structure of Anaplastic Lymphoma Kinase Complexed with LDK378|X-RAY DIFFRACTION|2.01|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4TT7|Crystal structure of human ALK with a covalent modification|X-RAY DIFFRACTION|2.1|Homo sapiens|0|TRANSFERASE","4Z55|Anaplastic lymphoma kinase catalytic domain complexed with pyrazolopyrimidine derivative of LDK378|X-RAY DIFFRACTION|1.55|Homo sapiens|0|Transferase/Transferase Inhibitor","5A9U|Structure of C1156Y Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).|X-RAY DIFFRACTION|1.6|HOMO SAPIENS|0|TRANSFERASE","5AA8|Structure of C1156Y,L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).|X-RAY DIFFRACTION|1.86|HOMO SAPIENS|0|TRANSFERASE","5AA9|Structure of L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).|X-RAY DIFFRACTION|1.93|HOMO SAPIENS|0|TRANSFERASE","5AAA|Structure of L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib|X-RAY DIFFRACTION|1.73|HOMO SAPIENS|0|TRANSFERASE","5AAB|Structure of C1156Y,L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib|X-RAY DIFFRACTION|2.2|HOMO SAPIENS|0|TRANSFERASE","5AAC|Structure of C1156Y Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib|X-RAY DIFFRACTION|1.7|HOMO SAPIENS|0|TRANSFERASE","5FTO|Crystal structure of the ALK kinase domain in complex with Entrectinib|X-RAY DIFFRACTION|2.22|HOMO SAPIENS|0|TRANSFERASE","5FTQ|Crystal structure of the ALK kinase domain in complex with Cmpd 17|X-RAY DIFFRACTION|1.7|HOMO SAPIENS|0|TRANSFERASE","5IMX|Anaplastic lymphoma kinase (ALK) catalytic domain complexed with novel inhibitor 3-sulfonylpyrazol-4-amino pyrimidine|X-RAY DIFFRACTION|2.12|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5IUG|Crystal Structure of Anaplastic Lymphoma Kinase (ALK) in complex with 5a|X-RAY DIFFRACTION|1.93|Homo sapiens|0|TRANSFERASE","5IUH|Crystal Structure of the Anaplastic Lymphoma Kinase (ALK) in complex with 5d|X-RAY DIFFRACTION|2.1|Homo sapiens|0|TRANSFERASE","5IUI|Crystal Structure of Anaplastic Lyphoma Kinase (ALK) in complex with 4|X-RAY DIFFRACTION|1.88|Homo sapiens|0|TRANSFERASE","5KZ0|Structure of Human Anaplastic Lymphoma Kinase in Complex With 2-[(1R)-1-{[2-amino-5-(1,3-dimethyl-1H-pyrazol-4-yl)pyridin-3-yl]oxy}ethyl]-4-fluoro-N,N-dimethylbenzamide|X-RAY DIFFRACTION|2.3|Homo sapiens|0|Transferase/Transferase Inhibitor","5VZ5|Crystal structure of an anaplastic lymphoma kinase-derived neuroblastoma tumor antigen bound to the Human Major Histocompatibility Complex Class I molecule HLA-B*1501|X-RAY DIFFRACTION|2.5901|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","6AT9|Crystal structure of an anaplastic lymphoma kinase-derived neuroblastoma tumor antigen bound to the Human Major Histocompatibility Complex Class I molecule HLA-A*0101|X-RAY DIFFRACTION|2.9503|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","6CDT|Structure of Human Anaplastic Lymphoma Kinase Domain|X-RAY DIFFRACTION|1.8|Homo sapiens|0|TRANSFERASE","6E0R|hALK in complex with compound 7 N-((1S)-1-(5-fluoropyridin-2-yl)ethyl)-1-(5-methyl-1H-pyrazol-3-yl)-3-(oxetan-3-ylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-6-amine|X-RAY DIFFRACTION|2.303|Homo sapiens|0|PROTEIN BINDING","6EBW|hALK in complex with compound 9 (6-(((1S)-1-(5-Fluoropyridin-2-yl)ethyl)amino)-1-(3-methyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)(morpholin-4-yl)methanone|X-RAY DIFFRACTION|2.455|Homo sapiens|0|TRANSFERASE/INHIBITOR","6EDL|hALK in complex with compound 1 (S)-N-(1-(2,4-difluorophenyl)ethyl)-3-(3-methyl-1H-pyrazol-5-yl)imidazo[1,2-b]pyridazin-6-amine|X-RAY DIFFRACTION|2.799|Homo sapiens|0|TRANSFERASE/INHIBITOR","6MX8|Crystal structure of anaplastic lymphoma kinase (ALK) bound by Brigatinib|X-RAY DIFFRACTION|1.96|Homo sapiens|0|TRANSFERASE","7BTT|A X-ray cocrystal structure of XMU-MP-5 bound to the ALK kinase domain|X-RAY DIFFRACTION|1.86|Homo sapiens|0|TRANSFERASE","7JY4|hALK in complex with ((1S,2S)-1-(2,4-difluorophenyl)-2-(2-(3-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenoxy)cyclopropyl)methanamine|X-RAY DIFFRACTION|2.42|Homo sapiens|0|TRANSFERASE","7JYR|hALK in complex with 1-[(1R,2R)-1-(2,4-difluorophenyl)-2-[2-(5-methyl-1H-pyrazol-3-yl)-4-(trifluoromethyl)phenoxy]cyclopropyl]methanamine|X-RAY DIFFRACTION|2.32|Homo sapiens|0|TRANSFERASE","7JYS|hALK in complex with 3-(3-chlorophenyl)-5-methyl-1H-pyrazole|X-RAY DIFFRACTION|2.22|Homo sapiens|0|TRANSFERASE","7JYT|hALK in complex with 3-(3-methyl-1H-pyrazol-5-yl)pyridine|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSFERASE","7LRZ|Structure of the Human ALK GRD|X-RAY DIFFRACTION|1.91|Homo sapiens|0|TRANSFERASE","7LS0|Structure of the Human ALK GRD bound to AUG|X-RAY DIFFRACTION|3.05|Homo sapiens|0|TRANSFERASE/TRANSFERASE ACTIVATOR","7MZW|Anaplastic lymphoma kinase (ALK) extracellular ligand binding region 673-1025|SOLUTION NMR||Homo sapiens|0|TRANSFERASE","7MZY|Anaplastic lymphoma kinase (ALK) extracellular fragment of ligand binding region 673-986|X-RAY DIFFRACTION|1.5|Homo sapiens|0|TRANSFERASE","7N00|Anaplastic lymphoma kinase (ALK) extracellular fragment of ligand binding region 648-1025 in complex with AUG-alpha|ELECTRON MICROSCOPY|2.27|Homo sapiens|0|TRANSFERASE","7NWZ|ALK:ALKAL2 complex|X-RAY DIFFRACTION|4.17|Homo sapiens|0|PROTEIN BINDING","7NX3|Crystal structure of ALK in complex with Fab324|X-RAY DIFFRACTION|2.81|Homo sapiens; Mus musculus|0|PROTEIN BINDING","7NX4|Crystal structure of the TG and EGF-like domains of ALK|X-RAY DIFFRACTION|3|Homo sapiens|0|PROTEIN BINDING","7R7K|Structure of Human Anaplastic Lymphoma Kinase Domain in complex with (4-[6-amino-5-[(1~{R})-1-[5-fluoro-2-(triazol-2-yl)phenyl]ethoxy]-3-pyridyl]isoindolin-1-one)|X-RAY DIFFRACTION|1.831|Homo sapiens|0|TRANSFERASE","7R7R|Structure of Human Anaplastic Lymphoma Kinase Domain in complex with ((2~{R})-2-[5-[6-amino-5-[(1~{R})-1-[5-fluoro-2-(triazol-2-yl)phenyl]ethoxy]-3-pyridyl]-4-methyl-thiazol-2-yl]propane-1,2-diol)|X-RAY DIFFRACTION|1.935|Homo sapiens|0|TRANSFERASE","8ARJ|Anaplastic Lymphoma Kinase with a novel carboline inhibitor|X-RAY DIFFRACTION|1.645|Homo sapiens|0|ANTITUMOR PROTEIN","9G5I|Cryo-EM structure of a 2:1 ALK:ALKAL2 complex obtained after re-processing of EMPIAR-10930 data|ELECTRON MICROSCOPY|3.2|Homo sapiens|0|CYTOKINE","9GBE|Structure of Human Anaplastic Lymphoma Kinase (ALK) harboring the G1202R/L1196M Compound Mutation in Complex with NVL-655|X-RAY DIFFRACTION|1.58|Homo sapiens|0|ONCOPROTEIN"]},{"input":"P42336","source":"P42336|Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform","targets":["2ENQ|Solution structure of the C2 domain from human PI3-kinase p110 subunit alpha|SOLUTION NMR||Homo sapiens|0|TRANSFERASE","2RD0|Structure of a human p110alpha/p85alpha complex|X-RAY DIFFRACTION|3.05|Homo sapiens|0|Transferase/Oncoprotein","3HHM|Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE/ONCOPROTEIN","3HIZ|Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha|X-RAY DIFFRACTION|3.3|Homo sapiens|0|TRANSFERASE/ONCOPROTEIN","3ZIM|Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Kalpha|X-RAY DIFFRACTION|2.85|HOMO SAPIENS|0|TRANSFERASE","4JPS|Co-crystal Structures of the Lipid Kinase PI3K alpha with Pan and Isoform Selective Inhibitors|X-RAY DIFFRACTION|2.2|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4L1B|Crystal Structure of p110alpha complexed with niSH2 of p85alpha|X-RAY DIFFRACTION|2.586|Homo sapiens|0|signaling Protein/transferase/Inhibitor","4L23|Crystal Structure of p110alpha complexed with niSH2 of p85alpha and PI-103|X-RAY DIFFRACTION|2.501|Homo sapiens|0|signaling Protein/transferase/Inhibitor","4L2Y|Crystal Structure of p110alpha complexed with niSH2 of p85alpha and compound 9d|X-RAY DIFFRACTION|2.8|Homo sapiens|0|signaling Protein/transferase/Inhibitor","4OVU|Crystal Structure of p110alpha in complex with niSH2 of p85alpha|X-RAY DIFFRACTION|2.96|Homo sapiens|0|TRANSFERASE/TRANSFERASE REGULATOR","4OVV|Crystal Structure of PI3Kalpha in complex with diC4-PIP2|X-RAY DIFFRACTION|3.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE REGULATOR","4TUU|Isolated p110a subunit of PI3Ka provides a platform for structure-based drug design|X-RAY DIFFRACTION|2.64|Homo sapiens|0|TRANSFERASE","4TV3|Isolated p110a subunit of PI3Ka provides a platform for structure-based drug design|X-RAY DIFFRACTION|2.85|Homo sapiens|0|TRANSFERASE/TRANSFERASE Inhibitor","4WAF|Crystal Structure of a novel tetrahydropyrazolo[1,5-a]pyrazine in an engineered PI3K alpha|X-RAY DIFFRACTION|2.39|Homo sapiens|0|transferase/transferase inhibitor","4YKN|Pi3K alpha lipid kinase with Active Site Inhibitor|X-RAY DIFFRACTION|2.9|Homo sapiens|0|Transferase/Transferase Inhibitor","4ZOP|Co-crystal Structure of Lipid Kinase PI3K alpha with a selective phosphatidylinositol-3 kinase alpha inhibitor|X-RAY DIFFRACTION|2.62|Homo sapiens|0|transferase/transferase inhibitor","5DXH|p110alpha/p85alpha with compound 5|X-RAY DIFFRACTION|3|Bos taurus; Homo sapiens|0|Transferase/Transferase Inhibitor","5DXT|p110alpha with GDC-0326|X-RAY DIFFRACTION|2.25|Homo sapiens|0|Transferase/Inhibitor","5FI4|Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5ITD|Crystal structure of PI3K alpha with PI3K delta inhibitor|X-RAY DIFFRACTION|3.02|Homo sapiens|0|Transferase/Protein Transport/Inhibitor","5SW8|Crystal structure of PI3Kalpha in complex with fragments 7 and 11|X-RAY DIFFRACTION|3.3|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SWG|Crystal Structure of PI3Kalpha in complex with fragments 5 and 21|X-RAY DIFFRACTION|3.11|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SWO|Crystal Structure of PI3Kalpha in complex with fragments 4 and 19|X-RAY DIFFRACTION|3.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SWP|Crystal Structure of PI3Kalpha in complex with fragments 6 and 24|X-RAY DIFFRACTION|3.41|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SWR|Crystal Structure of PI3Kalpha in complex with fragments 20 and 26|X-RAY DIFFRACTION|3.31|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SWT|Crystal Structure of PI3Kalpha in complex with fragments 17 and 27|X-RAY DIFFRACTION|3.49|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SX8|Crystal Structure of PI3Kalpha in complex with fragments 12 and 15|X-RAY DIFFRACTION|3.47|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SX9|Crystal Structure of PI3Kalpha in complex with fragment 14|X-RAY DIFFRACTION|3.52|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXA|Crystal Structure of PI3Kalpha in complex with fragment 10|X-RAY DIFFRACTION|3.35|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXB|Crystal Structure of PI3Kalpha in complex with fragment 23|X-RAY DIFFRACTION|3.3|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXC|Crystal Structure of PI3Kalpha in complex with fragment 8|X-RAY DIFFRACTION|3.55|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXD|Crystal Structure of PI3Kalpha in complex with fragment 22|X-RAY DIFFRACTION|3.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXE|Crystal Structure of PI3Kalpha in complex with fragments 19 and 28|X-RAY DIFFRACTION|3.51|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXF|Crystal Structure of PI3Kalpha in complex with fragment 9|X-RAY DIFFRACTION|3.46|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXI|Crystal Structure of PI3Kalpha in complex with fragment 13|X-RAY DIFFRACTION|3.4|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXJ|Crystal Structure of PI3Kalpha in complex with fragment 29|X-RAY DIFFRACTION|3.42|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXK|Crystal Structure of PI3Kalpha in complex with fragment 18|X-RAY DIFFRACTION|3.55|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5UBR|CRYSTAL STRUCTURE OF PI3K ALPHA IN COMPLEX WITH A 7-(3-(PIPERAZIN-1-YL)PHENYL)PYRROLO[2,1-F][1,2,4] TRIAZIN-4-AMINE DERIVIATINE|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE/TRANSFERASE REGULATOR","5UK8|The co-structure of (R)-4-(6-(1-(cyclopropylsulfonyl)cyclopropyl)-2-(1H-indol-4-yl)pyrimidin-4-yl)-3-methylmorpholine and a rationally designed PI3K-alpha mutant that mimics ATR|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE/SIGNALING PROTEIN/INHIBITOR","5UKJ|The co-structure of N,N-dimethyl-4-[(6R)-6-methyl-5-(1H-pyrrolo[2,3- b]pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5- a]pyrazin-3-yl]benzenesulfonamide and a rationally designed PI3K-alpha mutant that mimics ATR|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE/SIGNALING PROTEIN/INHIBITOR","5UL1|The co-structure of 3-amino-6-(4-((1-(dimethylamino)propan-2-yl)sulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide and a rationally designed PI3K-alpha mutant that mimics ATR|X-RAY DIFFRACTION|3|Homo sapiens|0|TRANSFERASE/SIGNALING PROTEIN/INHIBITOR","5XGH|Crystal structure of PI3K complex with an inhibitor|X-RAY DIFFRACTION|2.97|Homo sapiens|0|TRANSFERASE/INHIBITOR","5XGI|Crystal structure of PI3K complex with an inhibitor|X-RAY DIFFRACTION|2.56|Homo sapiens|0|TRANSFERASE/INHIBITOR","5XGJ|Crystal structure of PI3K complex with an inhibitor|X-RAY DIFFRACTION|2.97|Homo sapiens|0|TRANSFERASE/INHIBITOR","6GVF|Crystal structure of PI3K alpha in complex with 3-(2-Amino-benzooxazol-5-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE","6GVG|Crystal structure of PI3K alpha in complex with 3-(2-Amino-benzooxazol-5-yl)-1-isopropyl-4-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine|X-RAY DIFFRACTION|3|Homo sapiens|0|TRANSFERASE","6GVH|Crystal structure of PI3K alpha in complex with 3-(2-Amino-benzooxazol-5-yl)-4-chloro-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine|X-RAY DIFFRACTION|2.74|Homo sapiens|0|TRANSFERASE","6GVI|Crystal structure of PI3K alpha in complex with 3-(2-Amino-benzooxazol-5-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine|X-RAY DIFFRACTION|2.9|Homo sapiens|0|TRANSFERASE","6NCT|Structure of p110alpha/niSH2 - vector data collection|X-RAY DIFFRACTION|3.35|Homo sapiens|0|TRANSFERASE","6OAC|PQR530 [(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine] bound to the PI3Ka catalytic subunit p110alpha|X-RAY DIFFRACTION|3.15|Homo sapiens|0|TRANSFERASE","6PYS|Human PI3Kalpha in complex with Compound 2-10 ((3S)-3-benzyl-3-methyl-5-[5-(2-methylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1,3-dihydro-2H-indol-2-one)|X-RAY DIFFRACTION|2.19|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","6VO7|Crystal structure of PI3K-alpha Ras Binding Domain (RBD)|X-RAY DIFFRACTION|2.31|Homo sapiens|0|ONCOPROTEIN","7JIU|HUMAN PI3KDELTA IN COMPLEX WITH COMPOUND 2F|X-RAY DIFFRACTION|2.12||0|TRANSFERASE/TRANSFERASE INHIBITOR","7K6M|Crystal structure of PI3Kalpha selective Inhibitor PF-06843195|X-RAY DIFFRACTION|2.413|Homo sapiens|0|SIGNALING PROTEIN, Transferase","7K6N|Crystal structure of PI3Kalpha selective Inhibitor 11-1575|X-RAY DIFFRACTION|2.77|Homo sapiens|0|SIGNALING PROTEIN, Transferase","7K6O|Crystal structure of PI3Kalpha inhibitor 10-5429|X-RAY DIFFRACTION|2.738|Homo sapiens|0|SIGNALING PROTEIN, Transferase","7K71|Crystal structure of PI3Kalpha inhibitor 4-0686|X-RAY DIFFRACTION|2.9|Homo sapiens|0|SIGNALING PROTEIN, Transferase","7L1B|Crystal structure of HLA-A*03:01 in complex with a wild-type PIK3CA peptide|X-RAY DIFFRACTION|2.04|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","7L1C|Crystal structure of HLA-A*03:01 in complex with a mutant PIK3CA peptide|X-RAY DIFFRACTION|1.96|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","7L1D|Crystal structure of human 21LT2-2 TCR bound to HLA-A*03:01 in complex with a mutant PIK3CA peptide|X-RAY DIFFRACTION|3.11|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","7MLK|Crystal structure of human PI3Ka (p110a subunit) with MMV085400 bound to the active site determined at 2.9 angstroms resolution|X-RAY DIFFRACTION|2.91|Homo sapiens|0|TRANSFERASE/INHIBITOR","7MYN|Cryo-EM Structure of p110alpha in complex with p85alpha|ELECTRON MICROSCOPY|2.79|Homo sapiens|0|TRANSFERASE","7MYO|Cryo-EM structure of p110alpha in complex with p85alpha inhibited by BYL-719|ELECTRON MICROSCOPY|2.92|Homo sapiens|0|TRANSFERASE","7PG5|Crystal Structure of PI3Kalpha|X-RAY DIFFRACTION|2.20029|Homo sapiens|0|TRANSFERASE","7PG6|Crystal Structure of PI3Kalpha in complex with the inhibitor NVP-BYL719|X-RAY DIFFRACTION|2.49944|Homo sapiens|0|TRANSFERASE","7R9V|Structure of PIK3CA with covalent inhibitor 19|X-RAY DIFFRACTION|2.69|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","7R9Y|Structure of PIK3CA with covalent inhibitor 22|X-RAY DIFFRACTION|2.85|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","7RRG|Crystal structure of human 0606T1-2 TCR bound to HLA-A*03:01 in complex with a mutant PIK3CA peptide|X-RAY DIFFRACTION|2.12|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","7TZ7|PI3K alpha in complex with an inhibitor|X-RAY DIFFRACTION|2.41|Homo sapiens|0|transferase/inhibitor","8AM0|Crystal structure of human T1061E PI3Kalpha in complex with its regulatory subunit and the inhibitor GDC-0077 (Inavolisib)|X-RAY DIFFRACTION|2.818|Homo sapiens|0|TRANSFERASE","8BFU|Crystal structure of the apo p110alpha catalytic subunit from homo sapiens|X-RAY DIFFRACTION|2.41|Homo sapiens|0|TRANSFERASE","8DCP|PI 3-kinase alpha with nanobody 3-126|ELECTRON MICROSCOPY|2.41|Homo sapiens|0|TRANSFERASE","8DCX|PI 3-kinase alpha with nanobody 3-159|ELECTRON MICROSCOPY|2.8|Homo sapiens|0|TRANSFERASE","8DD4|PI 3-kinase alpha with nanobody 3-142|ELECTRON MICROSCOPY|3.1|Homo sapiens|0|TRANSFERASE","8DD8|PI 3-kinase alpha with nanobody 3-142, crosslinked with DSG|ELECTRON MICROSCOPY|3.4|Homo sapiens|0|TRANSFERASE","8EXL|Crystal structure of PI3K-alpha in complex with taselisib|X-RAY DIFFRACTION|1.989|Homo sapiens|0|CELL CYCLE","8EXO|Crystal structure of PI3K-alpha in complex with compound 19|X-RAY DIFFRACTION|2.46|Homo sapiens|0|CELL CYCLE","8EXU|Crystal structure of PI3K-alpha in complex with compound 30|X-RAY DIFFRACTION|2.68|Homo sapiens|0|CELL CYCLE","8EXV|Crystal structure of PI3K-alpha in complex with compound 32|X-RAY DIFFRACTION|2.48|Homo sapiens|0|CELL CYCLE","8GUA|Cryo-EM structure of cancer-specific PI3Kalpha mutant E542K in complex with BYL-719|ELECTRON MICROSCOPY|2.77|Homo sapiens|0|STRUCTURAL PROTEIN","8GUB|Cryo-EM structure of cancer-specific PI3Kalpha mutant H1047R in complex with BYL-719|ELECTRON MICROSCOPY|2.73|Homo sapiens|0|STRUCTURAL PROTEIN","8GUD|Cryo-EM structure of cancer-specific PI3Kalpha mutant E545K in complex with BYL-719|ELECTRON MICROSCOPY|2.62|Homo sapiens|0|STRUCTURAL PROTEIN","8ILR|Cryo-EM structure of PI3Kalpha in complex with compound 16|ELECTRON MICROSCOPY|3.05|Homo sapiens|0|STRUCTURAL PROTEIN","8ILS|Cryo-EM structure of PI3Kalpha in complex with compound 17|ELECTRON MICROSCOPY|3.1|Homo sapiens|0|STRUCTURAL PROTEIN","8ILV|Cryo-EM structure of PI3Kalpha in complex with compound 18|ELECTRON MICROSCOPY|3.19|Homo sapiens|0|STRUCTURAL PROTEIN","8OW2|Crystal structure of the p110alpha catalytic subunit from homo sapiens in complex with activator 1938|X-RAY DIFFRACTION|2.57|Homo sapiens|0|TRANSFERASE","8SBC|Co-structure of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform and brain penetrant inhibitors|X-RAY DIFFRACTION|2.3|Homo sapiens|0|TRANSFERASE","8SBJ|Co-structure Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform complexed with brain penetrant inhibitors|X-RAY DIFFRACTION|3.1|Homo sapiens|0|TRANSFERASE","8TDU|STX-478, a Mutant-Selective, Allosteric Inhibitor bound to PI3Kalpha|X-RAY DIFFRACTION|3.11|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","8TGD|STX-478, a Mutant-Selective, Allosteric Inhibitor bound to H1047R PI3Kalpha|X-RAY DIFFRACTION|2.928|Homo sapiens|0|TRANSFERASE/TRANSFERSE INHIBITOR","8TS7|Human PI3K p85alpha/p110alpha|X-RAY DIFFRACTION|2.71|Homo sapiens|0|SIGNALING PROTEIN","8TS8|p85alpha/p110alpha heterodimer H1047R mutant|X-RAY DIFFRACTION|2.72|Homo sapiens|0|SIGNALING PROTEIN","8TS9|Human PI3K p85alpha/p110alpha H1047R bound to compound 1|X-RAY DIFFRACTION|2.83|Homo sapiens|0|SIGNALING PROTEIN/INHIBITOR","8TSA|Human PI3K p85alpha/p110alpha H1047R bound to compound 2|X-RAY DIFFRACTION|2.51|Homo sapiens|0|SIGNALING PROTEIN/INHIBITOR","8TSB|Human PI3K p85alpha/p110alpha bound to compound 2|X-RAY DIFFRACTION|3.53|Homo sapiens|0|SIGNALING PROTEIN/INHIBITOR","8TSC|Human PI3K p85alpha/p110alpha H1047R bound to compound 3|X-RAY DIFFRACTION|3.62|Homo sapiens|0|SIGNALING PROTEIN/INHIBITOR","8TSD|Human PI3K p85alpha/p110alpha bound to RLY-2608|X-RAY DIFFRACTION|2.7|Homo sapiens|0|SIGNALING PROTEIN,TRANSFERASE/INHIBITOR","8TU6|CryoEM structure of PI3Kalpha|ELECTRON MICROSCOPY|3.12|Homo sapiens|0|CYTOSOLIC PROTEIN","8TWY|Structure of p110 alpha bound to (S)-1-(4-((2-(4-(4-(2-amino-4-(difluoromethyl)pyrimidin-5-yl)-6-(3-methylmorpholino)-1,3,5- triazin-2-yl)piperazin-1-yl)-2-oxoethoxy)methyl)piperidin-1-yl)prop-2-en-1-one (compound 9)|X-RAY DIFFRACTION|2.67|Homo sapiens|0|TRANSFERASE/Inhibitor","8V8H|PI3Ka H1047R co-crystal structure with inhibitor in cryptic pocket near H1047R (compound 4).|X-RAY DIFFRACTION|3.58|Homo sapiens|0|SIGNALING PROTEIN"]},{"input":"Q13131","source":"Q13131|5'-AMP-activated protein kinase catalytic subunit alpha-1","targets":["4RED|Crystal structure of human AMPK alpha1 KD-AID with K43A mutation|X-RAY DIFFRACTION|2.95|Homo sapiens|0|TRANSFERASE","4RER|Crystal structure of the phosphorylated human alpha1 beta2 gamma1 holo-AMPK complex bound to AMP and cyclodextrin|X-RAY DIFFRACTION|4.047|Homo sapiens|0|TRANSFERASE","4REW|Crystal structure of the non-phosphorylated human alpha1 beta2 gamma1 holo-AMPK complex|X-RAY DIFFRACTION|4.58|Homo sapiens|0|TRANSFERASE","5EZV|X-ray crystal structure of AMP-activated protein kinase alpha-2/alpha-1 RIM chimaera (alpha-2(1-347)/alpha-1(349-401)/alpha-2(397-end) beta-1 gamma-1) co-crystallized with C2 (5-(5-hydroxyl-isoxazol-3-yl)-furan-2-phosphonic acid)|X-RAY DIFFRACTION|2.99|Homo sapiens|0|TRANSFERASE","6C9F|AMP-activated protein kinase bound to pharmacological activator R734|X-RAY DIFFRACTION|2.924|Homo sapiens|0|TRANSFERASE","6C9G|AMP-activated protein kinase bound to pharmacological activator R739|X-RAY DIFFRACTION|2.7|Homo sapiens|0|TRANSFERASE","6C9H|non-phosphorylated AMP-activated protein kinase bound to pharmacological activator R734|X-RAY DIFFRACTION|2.65|Homo sapiens|0|TRANSFERASE","6C9J|AMP-activated protein kinase bound to pharmacological activator R734|X-RAY DIFFRACTION|3.05|Homo sapiens|0|TRANSFERASE","7JHG|Cryo-EM structure of ATP-bound fully inactive AMPK in complex with Dorsomorphin (Compound C) and Fab-nanobody|ELECTRON MICROSCOPY|3.47|Escherichia coli K-12; Homo sapiens; synthetic construct|0|TRANSFERASE/IMMUNE SYSTEM","7JHH|Cryo-EM structure of ATP-bound fully inactive AMPK in complex with Fab and nanobody|ELECTRON MICROSCOPY|3.92|Escherichia coli K-12; Homo sapiens; synthetic construct|0|TRANSFERASE/IMMUNE SYSTEM","7JIJ|ATP-bound AMP-activated protein kinase|X-RAY DIFFRACTION|5.5|Escherichia coli; Homo sapiens|0|SIGNALING PROTEIN","7M74|ATP-bound AMP-activated protein kinase|ELECTRON MICROSCOPY|3.93|Escherichia coli; Homo sapiens; Lama glama|0|SIGNALING PROTEIN"]}]}