{"context":{"query":">>uniprot>>string","source_dataset":"uniprot","target_dataset":"string"},"stats":{"queried":6,"total":6,"mapped":6},"pagination":{"has_next":false},"schema":"id|preferred_name|protein_size|interaction_count|annotation","mappings":[{"input":"P29474","source":"P29474|Nitric oxide synthase 3","targets":["9606.ENSP00000297494|NOS3|1203|3276|Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets; Belongs to the NOS family."]},{"input":"P08588","source":"P08588|Beta-1 adrenergic receptor","targets":["9606.ENSP00000358301|ADRB1|477|1524|Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors ; Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily."]},{"input":"P06213","source":"P06213|Insulin receptor","targets":["9606.ENSP00000303830|INSR|1382|3742|Insulin receptor subunit alpha; Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lea [...] "]},{"input":"P41240","source":"P41240|Tyrosine-protein kinase CSK","targets":["9606.ENSP00000220003|CSK|450|3002|Tyrosine-protein kinase CSK; Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C- terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins  [...] "]},{"input":"P01019","source":"P01019|Angiotensinogen","targets":["9606.ENSP00000355627|AGT|485|4988|Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release."]},{"input":"P05093","source":"P05093|Steroid 17-alpha-hydroxylase/17,20 lyase","targets":["9606.ENSP00000358903|CYP17A1|508|2688|Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol  (Probable). Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C1 [...] "]}]}