{"context":{"query":">>uniprot>>reactome","source_dataset":"uniprot","target_dataset":"reactome"},"stats":{"queried":8,"total":82,"mapped":8},"pagination":{"has_next":false},"schema":"id|name|tax_id|is_disease_pathway","mappings":[{"input":"P29597","source":"P29597|Non-receptor tyrosine-protein kinase TYK2","targets":["R-HSA-1059683|Interleukin-6 signaling|9606|false","R-HSA-110056|MAPK3 (ERK1) activation|9606|false","R-HSA-112411|MAPK1 (ERK2) activation|9606|false","R-HSA-449836|Other interleukin signaling|9606|false","R-HSA-6783783|Interleukin-10 signaling|9606|false","R-HSA-6785807|Interleukin-4 and Interleukin-13 signaling|9606|false","R-HSA-6788467|IL-6-type cytokine receptor ligand interactions|9606|false","R-HSA-8854691|Interleukin-20 family signaling|9606|false","R-HSA-8984722|Interleukin-35 Signalling|9606|false","R-HSA-9020591|Interleukin-12 signaling|9606|false","R-HSA-9020933|Interleukin-23 signaling|9606|false","R-HSA-9020956|Interleukin-27 signaling|9606|false","R-HSA-909733|Interferon alpha/beta signaling|9606|false","R-HSA-912694|Regulation of IFNA/IFNB signaling|9606|false","R-HSA-9674555|Signaling by CSF3 (G-CSF)|9606|false","R-HSA-9679191|Potential therapeutics for SARS|9606|true","R-HSA-9705462|Inactivation of CSF3 (G-CSF) signaling|9606|false","R-HSA-9705671|SARS-CoV-2 activates/modulates innate and adaptive immune responses|9606|true","R-HSA-9725370|Signaling by ALK fusions and activated point mutants|9606|true","R-HSA-9833109|Evasion by RSV of host interferon responses|9606|true"]},{"input":"P05771","source":"P05771|Protein kinase C beta type","targets":["R-HSA-114516|Disinhibition of SNARE formation|9606|false","R-HSA-1169091|Activation of NF-kappaB in B cells|9606|false","R-HSA-416993|Trafficking of GluR2-containing AMPA receptors|9606|false","R-HSA-418597|G alpha (z) signalling events|9606|false","R-HSA-4419969|Depolymerization of the Nuclear Lamina|9606|false","R-HSA-5099900|WNT5A-dependent internalization of FZD4|9606|false","R-HSA-5218921|VEGFR2 mediated cell proliferation|9606|false","R-HSA-5668599|RHO GTPases Activate NADPH Oxidases|9606|false","R-HSA-76005|Response to elevated platelet cytosolic Ca2+|9606|false","R-HSA-8939246|RUNX1 regulates transcription of genes involved in differentiation of myeloid cells|9606|false"]},{"input":"P19838","source":"P19838|Nuclear factor NF-kappa-B p105 subunit","targets":["R-HSA-1169091|Activation of NF-kappaB in B cells|9606|false","R-HSA-1810476|RIP-mediated NFkB activation via ZBP1|9606|false","R-HSA-193692|Regulated proteolysis of p75NTR|9606|false","R-HSA-202424|Downstream TCR signaling|9606|false","R-HSA-209560|NF-kB is activated and signals survival|9606|false","R-HSA-2559582|Senescence-Associated Secretory Phenotype (SASP)|9606|false","R-HSA-2871837|FCERI mediated NF-kB activation|9606|false","R-HSA-3134963|DEx/H-box helicases activate type I IFN and inflammatory cytokines production |9606|false","R-HSA-3214841|PKMTs methylate histone lysines|9606|false","R-HSA-381340|Transcriptional regulation of white adipocyte differentiation|9606|false","R-HSA-445989|TAK1-dependent IKK and NF-kappa-B activation  |9606|false","R-HSA-448706|Interleukin-1 processing|9606|false","R-HSA-5603029|IkBA variant leads to EDA-ID|9606|true","R-HSA-5607764|CLEC7A (Dectin-1) signaling|9606|false","R-HSA-5621575|CD209 (DC-SIGN) signaling|9606|false","R-HSA-5660668|CLEC7A/inflammasome pathway|9606|false","R-HSA-5684264|MAP3K8 (TPL2)-dependent MAPK1/3 activation|9606|false","R-HSA-6798695|Neutrophil degranulation|9606|false","R-HSA-844456|The NLRP3 inflammasome|9606|false","R-HSA-8853884|Transcriptional Regulation by VENTX|9606|false","R-HSA-9020702|Interleukin-1 signaling|9606|false","R-HSA-933542|TRAF6 mediated NF-kB activation|9606|false","R-HSA-9609690|HCMV Early Events|9606|true","R-HSA-9660826|Purinergic signaling in leishmaniasis infection|9606|true","R-HSA-9692916|SARS-CoV-1 activates/modulates innate immune responses|9606|true","R-HSA-9818749|Regulation of NFE2L2 gene expression|9606|false","R-HSA-9860927|Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells|9606|false","R-HSA-9909649|Regulation of PD-L1(CD274) transcription|9606|false"]},{"input":"P19438","source":"P19438|Tumor necrosis factor receptor superfamily member 1A","targets":["R-HSA-5357786|TNFR1-induced proapoptotic signaling|9606|false","R-HSA-5357905|Regulation of TNFR1 signaling|9606|false","R-HSA-5357956|TNFR1-induced NF-kappa-B signaling pathway|9606|false","R-HSA-5626978|TNFR1-mediated ceramide production|9606|false","R-HSA-5669034|TNFs bind their physiological receptors|9606|false","R-HSA-6783783|Interleukin-10 signaling|9606|false","R-HSA-75893|TNF signaling|9606|false"]},{"input":"Q14765","source":"Q14765|Signal transducer and activator of transcription 4","targets":["R-HSA-8854691|Interleukin-20 family signaling|9606|false","R-HSA-8950505|Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation|9606|false","R-HSA-8984722|Interleukin-35 Signalling|9606|false","R-HSA-9020591|Interleukin-12 signaling|9606|false","R-HSA-9020933|Interleukin-23 signaling|9606|false","R-HSA-9020958|Interleukin-21 signaling|9606|false","R-HSA-9942503|Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)|9606|false"]},{"input":"Q13568","source":"Q13568|Interferon regulatory factor 5","targets":["R-HSA-877300|Interferon gamma signaling|9606|false","R-HSA-909733|Interferon alpha/beta signaling|9606|false","R-HSA-9860276|SLC15A4:TASL-dependent IRF5 activation|9606|false"]},{"input":"P29459","source":"P29459|Interleukin-12 subunit alpha","targets":["R-HSA-6783783|Interleukin-10 signaling|9606|false","R-HSA-6785807|Interleukin-4 and Interleukin-13 signaling|9606|false","R-HSA-8984722|Interleukin-35 Signalling|9606|false","R-HSA-9020591|Interleukin-12 signaling|9606|false"]},{"input":"P16871","source":"P16871|Interleukin-7 receptor subunit alpha","targets":["R-HSA-1266695|Interleukin-7 signaling|9606|false","R-HSA-8856825|Cargo recognition for clathrin-mediated endocytosis|9606|false","R-HSA-8856828|Clathrin-mediated endocytosis|9606|false"]}]}