{"context":{"query":">>uniprot>>pdb","source_dataset":"uniprot","target_dataset":"pdb"},"stats":{"queried":8,"total":76,"mapped":6},"pagination":{"has_next":false},"schema":"id|title|method|resolution|source_organism|chain_count|header","mappings":[{"input":"P29597","source":"P29597|Non-receptor tyrosine-protein kinase TYK2","targets":["3LXN|Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE","3LXP|Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6|X-RAY DIFFRACTION|1.65|Homo sapiens|0|TRANSFERASE","3NYX|Non-phosphorylated TYK2 JH1 domain with Quinoline-Thiadiazole-Thiophene Inhibitor|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3NZ0|Non-phosphorylated TYK2 kinase with CMP6|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSFERASE","3ZON|Human TYK2 pseudokinase domain bound to a kinase inhibitor|X-RAY DIFFRACTION|2.15|HOMO SAPIENS|0|TRANSFERASE","4GFO|TYK2 kinase (JH1 domain) with 2,6-DICHLORO-N-(2-OXO-2,5-DIHYDROPYRIDIN-4-YL)BENZAMIDE|X-RAY DIFFRACTION|2.3|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4GIH|Tyk2 (JH1) in complex with 2,6-DICHLORO-N-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}BENZAMIDE|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4GII|Tyk2 (JH1) in complex with 2,6-dichloro-4-cyano-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide|X-RAY DIFFRACTION|2.31|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4GJ2|Tyk2 (JH1) in complex with 2,6-dichloro-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4GJ3|Tyk2 (JH1) in complex with 2,6-dichloro-4-cyano-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4GVJ|Tyk2 (JH1) in complex with adenosine di-phosphate|X-RAY DIFFRACTION|2.03|Homo sapiens|0|HYDROLASE","4OLI|The pseudokinase/kinase protein from JAK-family member TYK2|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE","4PO6|Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular peptide|X-RAY DIFFRACTION|1.99|Homo sapiens|0|TRANSFERASE","4PY1|Crystal structure of Tyk2 in complex with compound 15, 6-((2,5-dimethoxyphenyl)thio)-3-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazine|X-RAY DIFFRACTION|2.16|Homo sapiens|0|TRANSFERASE","4WOV|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH BMS-066 AKA 2-METHOXY-N-({6-[3-METHYL-7-(METHYLAMINO)-3,5,8,10-TETRAAZATRICYCLO[7.3.0.0, 6]DODECA-1(9),2(6),4,7,11-PENTAEN-11-YL]PYRIDIN-2-YL}METHY L)ACETAMIDE|X-RAY DIFFRACTION|1.8|Homo sapiens|0|TRANSFERASE/INHIBITOR","5C01|Crystal Structure of kinase|X-RAY DIFFRACTION|2.15|Homo sapiens|0|TRANSFERASE","5C03|Crystal Structure of kinase|X-RAY DIFFRACTION|1.9|Homo sapiens|0|TRANSFERASE","5F1Z|Structure of TYK2 with inhibitor 16: 3-azanyl-5-[(2~{S})-3-methylbutan-2-yl]-7-[1-methyl-5-(2-oxidanylpropan-2-yl)pyrazol-3-yl]-1~{H}-pyrazolo[4,3-c]pyridin-4-one|X-RAY DIFFRACTION|2.65|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5F20|Structure of TYK2 with inhibitor 4: 3-azanyl-5-(2-methylphenyl)-7-(1-methylpyrazol-3-yl)-1~{H}-pyrazolo[4,3-c]pyridin-4-one|X-RAY DIFFRACTION|2.91|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5TKD|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH 6-[(3,5-DIMETHYLPHE NYL)AMINO]-8- (METHYLAMINO)IMIDAZO[1,2-B]PYRIDAZINE-3-CARBO XAMIDE|X-RAY DIFFRACTION|1.92|Homo sapiens|0|TRANSFERASE","5WAL|Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model|X-RAY DIFFRACTION|2.45|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","6AAM|Crystal structure of TYK2 in complex with peficitinib|X-RAY DIFFRACTION|1.98|Homo sapiens|0|TRANSFERASE/INHIBITOR","6DBK|Tyk2 with compound 8|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSFERASE","6DBM|Tyk2 with compound 23|X-RAY DIFFRACTION|2.368|Homo sapiens|0|TRANSFERASE","6NSL|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound-6c AKA 6-((1-(4-CYANOPHENY L)-2-OXO-1,2-DIHYDRO-3-PYRIDINYL)AMINO)-N-CYCLOPROPYL-8-(M ETHYLAMINO)IMIDAZO[1,2-B]PYRIDAZINE-3-CARBOXAMIDE|X-RAY DIFFRACTION|2.15|Homo sapiens|0|TRANSFERASE","6NZE|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_5 AKA 4-[(2-CARBAMOYLPHEN YL)AMINO]-6-[(5-FLUOROPYRIDIN-2-YL)AMINO]-N-METHYLPYRIDINE -3-CARBOXAMIDE|X-RAY DIFFRACTION|1.96|Homo sapiens|0|TRANSFERASE","6NZF|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_5 AKA 4-[(2-CARBAMOYLPHEN YL)AMINO]-6-[(5-FLUOROPYRIDIN-2-YL)AMINO]-N-METHYLPYRIDINE -3-CARBOXAMIDE|X-RAY DIFFRACTION|2.39|Homo sapiens|0|TRANSFERASE","6NZH|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_40 AKA 6-cyclopropaneamido-4-[(2-methanesulfonylphenyl)amino]-N-methylpyridine-3-carboxamide|X-RAY DIFFRACTION|2.73|Homo sapiens|0|TRANSFERASE","6NZP|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH COMPOUND-11 AKA 6-CYCLOPROPANEAMIDO-4-{[2-METHOXY-3-(1-METHYL-1H-1,2,4-TRI AZOL-3-YL)PHENYL]AMINO}-N-(?H?)METHYLPYRIDAZINE-3-CARBOXAMIDE|X-RAY DIFFRACTION|2.35|Homo sapiens|0|TRANSFERASE","6NZQ|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_29 AKA 6-[(5-FLUORO-4-METH YLPYRIDIN-2-YL)AMINO]-4-({2-METHOXY-3-[(PYRIDIN-2-YLMETHYL )CARBAMOYL]PHENYL}AMINO)-N-METHYLPYRIDINE-3-CARBOXAMIDE|X-RAY DIFFRACTION|2.11|Homo sapiens|0|TRANSFERASE","6NZR|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_12 AKA 4-[(2-methanesulfonylphenyl)amino]-N-(H3)methyl-6-[(pyridin-2- yl)amino]pyridazine-3-carboxamide|X-RAY DIFFRACTION|2.56|Homo sapiens|0|TRANSFERASE","6OVA|Crystal Structure of TYK2 with novel pyrrolidinone inhibitor|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","6VNS|Crystal structure of TYK2 kinase with compound 13|X-RAY DIFFRACTION|2.09|Homo sapiens|0|TRANSFERASE/INHIBITOR","6VNV|Crystal structure of TYK2 kinase with compound 14|X-RAY DIFFRACTION|2.15|Homo sapiens|0|TRANSFERASE/INHIBITOR","6VNX|Crystal structure of TYK2 kinase with compound 19|X-RAY DIFFRACTION|2.18|Homo sapiens|0|TRANSFERASE/INHIBITOR","6VNY|Crystal structure of TYK2 kinase with compound 10|X-RAY DIFFRACTION|2.3|Homo sapiens|0|TRANSFERASE/INHIBITOR","6X8F|Crystal structure of TYK2 with Compound 11|X-RAY DIFFRACTION|2.15|Homo sapiens|0|TRANSFERASE","6X8G|Crystal structure of TYK2 with Compound 22|X-RAY DIFFRACTION|2.21|Homo sapiens|0|TRANSFERASE","7AX4|Human TYK2 pseudokinase domain (575-869) in complex with 5-(4-Fluoro-phenyl)-2-ureido-thiophene-3-carboxylic acid amide.|X-RAY DIFFRACTION|2.12|Homo sapiens|0|SIGNALING PROTEIN","7K7O|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH COMPOUND-12 AKA:6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(pyrimidin-2-yl)phenyl]amino}-N-methylpyridazine-3-carboxamide|X-RAY DIFFRACTION|2.82|Homo sapiens|0|TRANSFERASE","7K7Q|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH COMPOUND-12 AKA:6-[(cyclopropanecarbonyl)amino]-4-({3-[6-(dimethylcarbamoyl)pyridazin-3-yl]-2-methoxyphenyl}amino)-N-methylpyridazine-3-carboxamide|X-RAY DIFFRACTION|2.27|Homo sapiens|0|TRANSFERASE","7UYR|Crystal structure of TYK2 kinase domain in complex with compound 12|X-RAY DIFFRACTION|2.15|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","7UYS|Crystal structure of TYK2 kinase domain in complex with compound 16|X-RAY DIFFRACTION|2.15|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","7UYT|Crystal structure of TYK2 kinase domain in complex with compound 25|X-RAY DIFFRACTION|2.14|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","7UYU|Crystal structure of TYK2 kinase domain in complex with compound 30|X-RAY DIFFRACTION|2.05|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","8EXN|Crystal structure of PTP1B D181A/Q262A phosphatase domain with TYK2 activation loop phosphopeptide|X-RAY DIFFRACTION|2.151|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","8EYC|Crystal structure of PTP1B D181A/Q262A/C215A phosphatase domain with TYK2 activation loop phosphopeptide|X-RAY DIFFRACTION|2.99|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","8S98|Crystal structure of the TYK2 pseudokinase domain in complex with compound 8|X-RAY DIFFRACTION|1.87|Homo sapiens|0|TRANSFERASE","8S99|Crystal structure of the TYK2 pseudokinase domain in complex with compound 11|X-RAY DIFFRACTION|1.71|Homo sapiens|0|TRANSFERASE","8S9A|Crystal structure of the TYK2 pseudokinase domain in complex with TAK-279|X-RAY DIFFRACTION|1.83|Homo sapiens|0|TRANSFERASE","8TB5|TYK2 JH2 bound to Compound7|X-RAY DIFFRACTION|2.32|Homo sapiens|0|SIGNALING PROTEIN","8TB6|TYK2 JH2 bound to Compound14|X-RAY DIFFRACTION|1.96|Homo sapiens|0|SIGNALING PROTEIN"]},{"input":"P05771","source":"P05771|Protein kinase C beta type","targets":["2I0E|Structure of catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor|X-RAY DIFFRACTION|2.6|Homo sapiens|0|TRANSFERASE","8SE1|Structure of Full-length Human Protein Kinase C Beta 2 (PKCBII) in the Inactive Conformation|X-RAY DIFFRACTION|3.32|Homo sapiens|0|SIGNALING PROTEIN","8SE2|Structure of Full-length Human Protein Kinase C Beta 1 (PKCBI) in the Active and Inactive Conformation Soaked in Manganese Chloride|X-RAY DIFFRACTION|2.95|Homo sapiens|0|SIGNALING PROTEIN,TRANSFERASE","8SE3|Structure of Full-length Human Protein Kinase C Beta 1 (PKCBI) in the Active Conformation|X-RAY DIFFRACTION|2.6|Homo sapiens|0|SIGNALING PROTEIN,TRANSFERASE","8SE4|Structure of Full-length Human Protein Kinase C Beta 1 (PKCBI) in the Active and Inactive Conformation|X-RAY DIFFRACTION|2.68|Homo sapiens|0|SIGNALING PROTEIN, TRANSFERASE","8SG2|BIVALENT INTERACTIONS OF PIN1 WITH THE C-TERMINAL TAIL OF PKC|SOLUTION NMR||Homo sapiens; SYNTHETIC CONSTRUCT|0|ISOMERASE","9C5F|Crystal Structure Analysis of human PRKCB|X-RAY DIFFRACTION|2.41|Homo sapiens|0|TRANSFERASE","9S9T|Structure of human PKCBeta Kinase domain with Ruboxistaurin, D427N mutant|X-RAY DIFFRACTION|3.425|Homo sapiens|0|TRANSFERASE"]},{"input":"P51684","source":"P51684|C-C chemokine receptor type 6","targets":["6WWZ|Cryo-EM structure of the human chemokine receptor CCR6 in complex with CCL20 and a Go protein|ELECTRON MICROSCOPY|3.34|Homo sapiens; Mus musculus; Rattus norvegicus|0|MEMBRANE PROTEIN"]},{"input":"Q13698","source":"Q13698|Voltage-dependent L-type calcium channel subunit alpha-1S","targets":["2VAY|Calmodulin complexed with CaV1.1 IQ peptide|X-RAY DIFFRACTION|1.94|HOMO SAPIENS; SYNTHETIC CONSTRUCT|0|METAL TRANSPORT","6B27|Crystal structure of human STAC2 Tandem SH3 Domains (296-411) in complex with a CaV1.1 II-III loop peptide|X-RAY DIFFRACTION|1.73|Homo sapiens; SYNTHETIC CONSTRUCT|0|PROTEIN BINDING"]},{"input":"P10826","source":"P10826|Retinoic acid receptor beta","targets":["1HRA|THE SOLUTION STRUCTURE OF THE HUMAN RETINOIC ACID RECEPTOR-BETA DNA-BINDING DOMAIN|SOLUTION NMR||Homo sapiens|0|DNA-BINDING RECEPTOR","1XAP|Structure of the ligand binding domain of the Retinoic Acid Receptor beta|X-RAY DIFFRACTION|2.1|Homo sapiens|0|TRANSCRIPTION","4DM6|Crystal structure of RARb LBD homodimer in complex with TTNPB|X-RAY DIFFRACTION|1.9|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION/protein binding","4DM8|Crystal structure of RARb LBD in complex with 9cis retinoic acid|X-RAY DIFFRACTION|2.3|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION/protein binding","4JYG|Crystal structure of RARbeta LBD in complex with agonist BMS411 [4-{[(5,5-dimethyl-8-phenyl-5,6-dihydronaphthalen-2-yl)carbonyl]amino}benzoic acid]|X-RAY DIFFRACTION|2.35|Homo sapiens; SYNTHETIC CONSTRUCT|0|Transcription/Agonist","4JYH|Crystal structure of RARbeta LBD in complex with selective agonist BMS948 [4-{[(8-phenylnaphthalen-2-yl)carbonyl]amino}benzoic acid]|X-RAY DIFFRACTION|2.6|Homo sapiens; SYNTHETIC CONSTRUCT|0|Transcription/Agonist","4JYI|Crystal structure of RARbeta LBD in complex with selective partial agonist BMS641 [3-chloro-4-[(E)-2-(5,5-dimethyl-8-phenyl-5,6-dihydronaphthalen-2-yl)ethenyl]benzoic acid]|X-RAY DIFFRACTION|1.9|Homo sapiens; SYNTHETIC CONSTRUCT|0|Transcription/Agonist","5UAN|Crystal structure of multi-domain RAR-beta-RXR-alpha heterodimer on DNA|X-RAY DIFFRACTION|3.508|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION/DNA","6SSQ|Crystal structure of RARbeta LBD in complex with LG 100754|X-RAY DIFFRACTION|2.3|Homo sapiens|0|TRANSCRIPTION"]},{"input":"P29459","source":"P29459|Interleukin-12 subunit alpha","targets":["1F45|HUMAN INTERLEUKIN-12|X-RAY DIFFRACTION|2.8|Homo sapiens|0|CYTOKINE/CYTOKINE","3HMX|Crystal structure of ustekinumab FAB/IL-12 complex|X-RAY DIFFRACTION|3|Homo sapiens|0|Cytokine/IMMUNE SYSTEM","8XRP|The Cryo-EM structure of IL-12, receptor subunit beta-1 and receptor subunit beta-2 complex|ELECTRON MICROSCOPY|3.75|Homo sapiens|0|CYTOKINE","8YI7|The Cryo-EM structure of IL-12, receptor subunit beta-1 and receptor subunit beta-2 complex, local refinement|ELECTRON MICROSCOPY|3.57|Homo sapiens|0|CYTOKINE"]}],"not_found":["P32302","Q14765"]}