{"context":{"query":">>uniprot>>pdb","source_dataset":"uniprot","target_dataset":"pdb"},"stats":{"queried":4,"total":151,"mapped":4},"pagination":{"has_next":false},"schema":"id|title|method|resolution|source_organism|chain_count|header","mappings":[{"input":"P29597","source":"P29597|Non-receptor tyrosine-protein kinase TYK2","targets":["3LXN|Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE","3LXP|Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6|X-RAY DIFFRACTION|1.65|Homo sapiens|0|TRANSFERASE","3NYX|Non-phosphorylated TYK2 JH1 domain with Quinoline-Thiadiazole-Thiophene Inhibitor|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3NZ0|Non-phosphorylated TYK2 kinase with CMP6|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSFERASE","3ZON|Human TYK2 pseudokinase domain bound to a kinase inhibitor|X-RAY DIFFRACTION|2.15|HOMO SAPIENS|0|TRANSFERASE","4GFO|TYK2 kinase (JH1 domain) with 2,6-DICHLORO-N-(2-OXO-2,5-DIHYDROPYRIDIN-4-YL)BENZAMIDE|X-RAY DIFFRACTION|2.3|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4GIH|Tyk2 (JH1) in complex with 2,6-DICHLORO-N-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}BENZAMIDE|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4GII|Tyk2 (JH1) in complex with 2,6-dichloro-4-cyano-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide|X-RAY DIFFRACTION|2.31|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4GJ2|Tyk2 (JH1) in complex with 2,6-dichloro-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4GJ3|Tyk2 (JH1) in complex with 2,6-dichloro-4-cyano-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4GVJ|Tyk2 (JH1) in complex with adenosine di-phosphate|X-RAY DIFFRACTION|2.03|Homo sapiens|0|HYDROLASE","4OLI|The pseudokinase/kinase protein from JAK-family member TYK2|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE","4PO6|Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular peptide|X-RAY DIFFRACTION|1.99|Homo sapiens|0|TRANSFERASE","4PY1|Crystal structure of Tyk2 in complex with compound 15, 6-((2,5-dimethoxyphenyl)thio)-3-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazine|X-RAY DIFFRACTION|2.16|Homo sapiens|0|TRANSFERASE","4WOV|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH BMS-066 AKA 2-METHOXY-N-({6-[3-METHYL-7-(METHYLAMINO)-3,5,8,10-TETRAAZATRICYCLO[7.3.0.0, 6]DODECA-1(9),2(6),4,7,11-PENTAEN-11-YL]PYRIDIN-2-YL}METHY L)ACETAMIDE|X-RAY DIFFRACTION|1.8|Homo sapiens|0|TRANSFERASE/INHIBITOR","5C01|Crystal Structure of kinase|X-RAY DIFFRACTION|2.15|Homo sapiens|0|TRANSFERASE","5C03|Crystal Structure of kinase|X-RAY DIFFRACTION|1.9|Homo sapiens|0|TRANSFERASE","5F1Z|Structure of TYK2 with inhibitor 16: 3-azanyl-5-[(2~{S})-3-methylbutan-2-yl]-7-[1-methyl-5-(2-oxidanylpropan-2-yl)pyrazol-3-yl]-1~{H}-pyrazolo[4,3-c]pyridin-4-one|X-RAY DIFFRACTION|2.65|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5F20|Structure of TYK2 with inhibitor 4: 3-azanyl-5-(2-methylphenyl)-7-(1-methylpyrazol-3-yl)-1~{H}-pyrazolo[4,3-c]pyridin-4-one|X-RAY DIFFRACTION|2.91|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5TKD|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH 6-[(3,5-DIMETHYLPHE NYL)AMINO]-8- (METHYLAMINO)IMIDAZO[1,2-B]PYRIDAZINE-3-CARBO XAMIDE|X-RAY DIFFRACTION|1.92|Homo sapiens|0|TRANSFERASE","5WAL|Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model|X-RAY DIFFRACTION|2.45|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","6AAM|Crystal structure of TYK2 in complex with peficitinib|X-RAY DIFFRACTION|1.98|Homo sapiens|0|TRANSFERASE/INHIBITOR","6DBK|Tyk2 with compound 8|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSFERASE","6DBM|Tyk2 with compound 23|X-RAY DIFFRACTION|2.368|Homo sapiens|0|TRANSFERASE","6NSL|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound-6c AKA 6-((1-(4-CYANOPHENY L)-2-OXO-1,2-DIHYDRO-3-PYRIDINYL)AMINO)-N-CYCLOPROPYL-8-(M ETHYLAMINO)IMIDAZO[1,2-B]PYRIDAZINE-3-CARBOXAMIDE|X-RAY DIFFRACTION|2.15|Homo sapiens|0|TRANSFERASE","6NZE|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_5 AKA 4-[(2-CARBAMOYLPHEN YL)AMINO]-6-[(5-FLUOROPYRIDIN-2-YL)AMINO]-N-METHYLPYRIDINE -3-CARBOXAMIDE|X-RAY DIFFRACTION|1.96|Homo sapiens|0|TRANSFERASE","6NZF|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_5 AKA 4-[(2-CARBAMOYLPHEN YL)AMINO]-6-[(5-FLUOROPYRIDIN-2-YL)AMINO]-N-METHYLPYRIDINE -3-CARBOXAMIDE|X-RAY DIFFRACTION|2.39|Homo sapiens|0|TRANSFERASE","6NZH|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_40 AKA 6-cyclopropaneamido-4-[(2-methanesulfonylphenyl)amino]-N-methylpyridine-3-carboxamide|X-RAY DIFFRACTION|2.73|Homo sapiens|0|TRANSFERASE","6NZP|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH COMPOUND-11 AKA 6-CYCLOPROPANEAMIDO-4-{[2-METHOXY-3-(1-METHYL-1H-1,2,4-TRI AZOL-3-YL)PHENYL]AMINO}-N-(?H?)METHYLPYRIDAZINE-3-CARBOXAMIDE|X-RAY DIFFRACTION|2.35|Homo sapiens|0|TRANSFERASE","6NZQ|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_29 AKA 6-[(5-FLUORO-4-METH YLPYRIDIN-2-YL)AMINO]-4-({2-METHOXY-3-[(PYRIDIN-2-YLMETHYL )CARBAMOYL]PHENYL}AMINO)-N-METHYLPYRIDINE-3-CARBOXAMIDE|X-RAY DIFFRACTION|2.11|Homo sapiens|0|TRANSFERASE","6NZR|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_12 AKA 4-[(2-methanesulfonylphenyl)amino]-N-(H3)methyl-6-[(pyridin-2- yl)amino]pyridazine-3-carboxamide|X-RAY DIFFRACTION|2.56|Homo sapiens|0|TRANSFERASE","6OVA|Crystal Structure of TYK2 with novel pyrrolidinone inhibitor|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","6VNS|Crystal structure of TYK2 kinase with compound 13|X-RAY DIFFRACTION|2.09|Homo sapiens|0|TRANSFERASE/INHIBITOR","6VNV|Crystal structure of TYK2 kinase with compound 14|X-RAY DIFFRACTION|2.15|Homo sapiens|0|TRANSFERASE/INHIBITOR","6VNX|Crystal structure of TYK2 kinase with compound 19|X-RAY DIFFRACTION|2.18|Homo sapiens|0|TRANSFERASE/INHIBITOR","6VNY|Crystal structure of TYK2 kinase with compound 10|X-RAY DIFFRACTION|2.3|Homo sapiens|0|TRANSFERASE/INHIBITOR","6X8F|Crystal structure of TYK2 with Compound 11|X-RAY DIFFRACTION|2.15|Homo sapiens|0|TRANSFERASE","6X8G|Crystal structure of TYK2 with Compound 22|X-RAY DIFFRACTION|2.21|Homo sapiens|0|TRANSFERASE","7AX4|Human TYK2 pseudokinase domain (575-869) in complex with 5-(4-Fluoro-phenyl)-2-ureido-thiophene-3-carboxylic acid amide.|X-RAY DIFFRACTION|2.12|Homo sapiens|0|SIGNALING PROTEIN","7K7O|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH COMPOUND-12 AKA:6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(pyrimidin-2-yl)phenyl]amino}-N-methylpyridazine-3-carboxamide|X-RAY DIFFRACTION|2.82|Homo sapiens|0|TRANSFERASE","7K7Q|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH COMPOUND-12 AKA:6-[(cyclopropanecarbonyl)amino]-4-({3-[6-(dimethylcarbamoyl)pyridazin-3-yl]-2-methoxyphenyl}amino)-N-methylpyridazine-3-carboxamide|X-RAY DIFFRACTION|2.27|Homo sapiens|0|TRANSFERASE","7UYR|Crystal structure of TYK2 kinase domain in complex with compound 12|X-RAY DIFFRACTION|2.15|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","7UYS|Crystal structure of TYK2 kinase domain in complex with compound 16|X-RAY DIFFRACTION|2.15|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","7UYT|Crystal structure of TYK2 kinase domain in complex with compound 25|X-RAY DIFFRACTION|2.14|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","7UYU|Crystal structure of TYK2 kinase domain in complex with compound 30|X-RAY DIFFRACTION|2.05|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","8EXN|Crystal structure of PTP1B D181A/Q262A phosphatase domain with TYK2 activation loop phosphopeptide|X-RAY DIFFRACTION|2.151|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","8EYC|Crystal structure of PTP1B D181A/Q262A/C215A phosphatase domain with TYK2 activation loop phosphopeptide|X-RAY DIFFRACTION|2.99|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","8S98|Crystal structure of the TYK2 pseudokinase domain in complex with compound 8|X-RAY DIFFRACTION|1.87|Homo sapiens|0|TRANSFERASE","8S99|Crystal structure of the TYK2 pseudokinase domain in complex with compound 11|X-RAY DIFFRACTION|1.71|Homo sapiens|0|TRANSFERASE","8S9A|Crystal structure of the TYK2 pseudokinase domain in complex with TAK-279|X-RAY DIFFRACTION|1.83|Homo sapiens|0|TRANSFERASE","8TB5|TYK2 JH2 bound to Compound7|X-RAY DIFFRACTION|2.32|Homo sapiens|0|SIGNALING PROTEIN","8TB6|TYK2 JH2 bound to Compound14|X-RAY DIFFRACTION|1.96|Homo sapiens|0|SIGNALING PROTEIN"]},{"input":"P23458","source":"P23458|Tyrosine-protein kinase JAK1","targets":["3EYG|Crystal structures of JAK1 and JAK2 inhibitor complexes|X-RAY DIFFRACTION|1.9|Homo sapiens|0|TRANSFERASE","3EYH|Crystal structures of JAK1 and JAK2 inhibitor complexes|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSFERASE","4E4L|JAK1 kinase (JH1 domain) in complex with compound 30|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4E4N|JAK1 kinase (JH1 domain) in complex with compound 49|X-RAY DIFFRACTION|1.9|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4E5W|JAK1 kinase (JH1 domain) in complex with compound 26|X-RAY DIFFRACTION|1.86|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4EHZ|The Jak1 kinase domain in complex with inhibitor|X-RAY DIFFRACTION|2.174|Homo sapiens|0|Transferase/Transferase Inhibitor","4EI4|JAK1 kinase (JH1 domain) in complex with compound 20|X-RAY DIFFRACTION|2.22|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4FK6|JAK1 kinase (JH1 domain) in complex with compound 72|X-RAY DIFFRACTION|2.2|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4I5C|The Jak1 kinase domain in complex with inhibitor|X-RAY DIFFRACTION|2.1|Homo sapiens|0|TRANSFERASE","4IVB|JAK1 kinase (JH1 domain) in complex with the inhibitor TRANS-4-{2-[(1R)-1-HYDROXYETHYL]IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(6H)-YL}CYCLOHEXANECARBONITRILE|X-RAY DIFFRACTION|1.9|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4IVC|JAK1 kinase (JH1 domain) in complex with the inhibitor (TRANS-4-{2-[(1R)-1-HYDROXYETHYL]IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(6H)-YL}CYCLOHEXYL)ACETONITRILE|X-RAY DIFFRACTION|2.35|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4IVD|JAK1 kinase (JH1 domain) in complex with compound 34|X-RAY DIFFRACTION|1.93|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4K6Z|The Jak1 kinase domain in complex with compound 37|X-RAY DIFFRACTION|2.73|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4K77|JAK1 kinase (JH1 domain) in complex with compound 6|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4L00|Crystal structure of the apo Jak1 pseudokinase domain|X-RAY DIFFRACTION|1.8|Homo sapiens|0|TRANSFERASE","4L01|Crystal structure of the V658F apo Jak1 pseudokinase domain|X-RAY DIFFRACTION|1.9|Homo sapiens|0|TRANSFERASE","5E1E|Human JAK1 kinase in complex with compound 30 at 2.30 Angstroms resolution|X-RAY DIFFRACTION|2.3|Homo sapiens|0|TRANSFERASE","5HX8|Jak1 complex with 4-[(4-aminocyclohexyl)amino]-3-(1H-benzimidazol-2-yl)-1H-pyridin-2-one|X-RAY DIFFRACTION|2.2|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5IXD|Structure of human JAK1 FERM/SH2 in complex with IFN lambda receptor|X-RAY DIFFRACTION|2.85|Homo sapiens|0|CYTOKINE","5IXI|Structure of human JAK1 FERM/SH2 in complex with IFNLR1/IL10RA chimera|X-RAY DIFFRACTION|2.57|Homo sapiens|0|CYTOKINE","5KHW|Crystal structure of JAK1 in complex with ADP|X-RAY DIFFRACTION|2.47|Homo sapiens|0|TRANSFERASE","5KHX|Crystal structure of JAK1 in complex with PF-4950736|X-RAY DIFFRACTION|2.4|Homo sapiens|0|transferase/transferase INHIBITOR","5L04|STRUCTURE OF INTERFERON LAMBDA 1 RECEPTOR WITH HUMAN KINASE JAK1|X-RAY DIFFRACTION|2.1|Homo sapiens|0|transferase/transferase inhibitor","5WO4|JAK1 complexed with compound 28|X-RAY DIFFRACTION|1.84|Homo sapiens|0|TRANSFERASE","6AAH|Crystal structure of JAK1 in complex with peficitinib|X-RAY DIFFRACTION|1.83|Homo sapiens|0|TRANSFERASE/INHIBITOR","6BBU|Crystal Structure of JAK1 in complex with compound 25|X-RAY DIFFRACTION|2.08|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","6C7Y|Crystal structure of inhibitory protein SOCS1 in complex with JAK1 kinase domain|X-RAY DIFFRACTION|2.499|Gallus gallus; Homo sapiens|0|SIGNALING PROTEIN, TRANSFERASE/INHIBITOR","6DBN|Jak1 with compound 23|X-RAY DIFFRACTION|2.48|Homo sapiens|0|TRANSFERASE","6ELR|Human jak1 kinase domain in complex with compound 7|X-RAY DIFFRACTION|1.8|Homo sapiens|0|TRANSFERASE","6GGH|Human jak1 kinase domain in complex with inhibitor|X-RAY DIFFRACTION|1.7||0|TRANSFERASE","6HZU|HUMAN JAK1 IN COMPLEX WITH LASW1393|X-RAY DIFFRACTION|2.2||0|PROTEIN BINDING","6N77|Structure of the human JAK1 kinase domain with compound 15|X-RAY DIFFRACTION|1.64|Homo sapiens|0|IMMUNE SYSTEM","6N78|Structure of the human JAK1 kinase domain with compound 21|X-RAY DIFFRACTION|1.83|Homo sapiens|0|IMMUNE SYSTEM","6N79|Structure of the human JAK1 kinase domain with compound 20|X-RAY DIFFRACTION|2.27|Homo sapiens|0|IMMUNE SYSTEM","6N7A|Structure of the human JAK1 kinase domain with compound 39|X-RAY DIFFRACTION|1.33|Homo sapiens|0|IMMUNE SYSTEM","6N7B|Structure of the human JAK1 kinase domain with compound 38|X-RAY DIFFRACTION|1.81|Homo sapiens|0|IMMUNE SYSTEM","6N7C|Structure of the human JAK1 kinase domain with compound 56|X-RAY DIFFRACTION|1.69|Homo sapiens|0|IMMUNE SYSTEM","6N7D|Structure of the human JAK1 kinase domain with compound 54|X-RAY DIFFRACTION|1.78|Homo sapiens|0|IMMUNE SYSTEM","6RSB|Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class|X-RAY DIFFRACTION|1.8|Homo sapiens|0|TRANSFERASE","6RSC|Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class|X-RAY DIFFRACTION|1.85|Homo sapiens|0|TRANSFERASE","6RSD|Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class|X-RAY DIFFRACTION|1.76|Homo sapiens|0|TRANSFERASE","6RSE|Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class|X-RAY DIFFRACTION|1.8|Homo sapiens|0|TRANSFERASE","6RSH|Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class|X-RAY DIFFRACTION|1.71|Homo sapiens|0|TRANSFERASE","6SM8|Human jak1 kinase domain in complex with inhibitor|X-RAY DIFFRACTION|1.85|Homo sapiens|0|TRANSFERASE","6SMB|Human jak1 kinase domain in complex with inhibitor|X-RAY DIFFRACTION|2.04|Homo sapiens|0|TRANSFERASE","6TPE|Fragment-based discovery of pyrazolopyridones as JAK1 inhibitors with excellent subtype selectivity|X-RAY DIFFRACTION|2.87|Homo sapiens|0|TRANSFERASE","6TPF|Fragment-based discovery of pyrazolopyridones as JAK1 inhibitors with excellent subtype selectivity|X-RAY DIFFRACTION|2.31||0|TRANSFERASE","6W8L|Crystal structure of JAK1 kinase with compound 10|X-RAY DIFFRACTION|2.11|Homo sapiens|0|TRANSFERASE/INHIBITOR","8EXJ|Crystal structure of PTP1B D181A/Q262A phosphatase domain in complex with a JAK1 activation loop phosphopeptide|X-RAY DIFFRACTION|2.301|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","8S85|Crystal structure of JAK1 JH1 domain in complex with an inhibitor|X-RAY DIFFRACTION|1.75|Homo sapiens|0|SIGNALING PROTEIN","4GS0|Crystal structure of SHP1 catalytic domain with JAK1 activation loop peptide|X-RAY DIFFRACTION|1.7961|Homo sapiens; SYNTHETIC CONSTRUCT|0|HYDROLASE/TRANSFERASE"]},{"input":"Q12866","source":"Q12866|Tyrosine-protein kinase Mer","targets":["2DBJ|Solution structures of the fn3 domain of human Proto-oncogene tyrosine-protein kinase MER precursor|SOLUTION NMR||Homo sapiens|0|Transferase, SIGNALING PROTEIN","2P0C|Catalytic Domain of the Proto-oncogene Tyrosine-protein Kinase MER|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE","3BPR|Crystal structure of catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor C52|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE","3BRB|Crystal structure of catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with ADP|X-RAY DIFFRACTION|1.9|Homo sapiens|0|TRANSFERASE","3TCP|Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC569|X-RAY DIFFRACTION|2.69|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4M3Q|Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1917|X-RAY DIFFRACTION|2.718|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4MH7|Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1896|X-RAY DIFFRACTION|2.51|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4MHA|Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1817|X-RAY DIFFRACTION|2.59|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5K0K|Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC2434|X-RAY DIFFRACTION|2.545|Homo sapiens|0|Transferase/Transferase Inhibitor","5K0X|Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC2541|X-RAY DIFFRACTION|2.231|Homo sapiens|0|Transferase/Transferase Inhibitor","5TC0|Structure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate|X-RAY DIFFRACTION|2.24|Homo sapiens|0|Transferase/Transferase Inhibitor","5TD2|Structure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate|X-RAY DIFFRACTION|2.68|Homo sapiens|0|Transferase/Transferase Inhibitor","5U6C|Crystal structure of the Mer kinase domain in complex with a macrocyclic inhibitor|X-RAY DIFFRACTION|2.1|Homo sapiens|0|Transferase/Transferase Inhibitor","6MEP|Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC3437|X-RAY DIFFRACTION|2.893|Homo sapiens|0|Transferase/Transferase Inhibitor","7AAX|Crystal structure of MerTK kinase domain in complex with LDC1267|X-RAY DIFFRACTION|1.762|Homo sapiens|0|TRANSFERASE","7AAY|Crystal structure of MerTK kinase domain in complex with Merestinib|X-RAY DIFFRACTION|1.87|Homo sapiens|0|TRANSFERASE","7AAZ|Crystal structure of MerTK in complex with a type 1.5 aminopyridine inhibitor|X-RAY DIFFRACTION|1.855|Homo sapiens|0|TRANSFERASE","7AB0|Apo crystal structure of the MerTK kinase domain|X-RAY DIFFRACTION|1.74|Homo sapiens|0|TRANSFERASE","7AB1|Crystal structure of MerTK kinase domain in complex with Gilteritinib|X-RAY DIFFRACTION|1.93|Homo sapiens|0|TRANSFERASE","7AB2|Crystal structure of MerTK kinase domain in complex with UNC2025|X-RAY DIFFRACTION|1.78|Homo sapiens|0|TRANSFERASE","7AVX|MerTK kinase domain in complex with NPS-1034|X-RAY DIFFRACTION|2.44|Homo sapiens|0|SIGNALING PROTEIN","7AVY|MerTK kinase domain in complex with quinazoline-based inhbitor|X-RAY DIFFRACTION|2.31|Homo sapiens|0|SIGNALING PROTEIN","7AVZ|MerTK kinase domain in complex with a bisaminopyrimidine inhibitor|X-RAY DIFFRACTION|2.04|Homo sapiens|0|SIGNALING PROTEIN","7AW0|MerTK kinase domain in complex with purine inhibitor|X-RAY DIFFRACTION|1.893|Homo sapiens|0|SIGNALING PROTEIN","7AW1|MerTK kinase domain in complex with a type 2 inhibitor|X-RAY DIFFRACTION|1.98|Homo sapiens|0|SIGNALING PROTEIN","7AW2|MerTK kinase domain with type 1.5 inhibitor from a DNA-encoded library|X-RAY DIFFRACTION|2.1|Homo sapiens|0|SIGNALING PROTEIN","7AW3|MerTK kinase domain with type 1 inhibitor from a DNA-encoded library|X-RAY DIFFRACTION|1.99|Homo sapiens|0|SIGNALING PROTEIN","7AW4|MerTK kinase domain with type 3 inhibitor from a DNA-encoded library|X-RAY DIFFRACTION|1.98|Homo sapiens|0|SIGNALING PROTEIN","7CQE|Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with AZD-7762|X-RAY DIFFRACTION|2.69|Homo sapiens|0|TRANSFERASE","7DXL|Fragment-based Lead Discovery of Indazole-based Compounds as AXL Kinase Inhibitors|X-RAY DIFFRACTION|3.146|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","7M5Z|Crystal Structure of the MerTK Kinase Domain in Complex with Inhibitor MIPS15692|X-RAY DIFFRACTION|3.06|Homo sapiens|0|SIGNALING PROTEIN/INHIBITOR","7OAM|Kinase domain of MERTK in complex with compound 8|X-RAY DIFFRACTION|2.65|Homo sapiens|0|TRANSFERASE","7OLS|MerTK kinase domain with type 1.5 inhibitor containing a di-methyl pyrazole group|X-RAY DIFFRACTION|1.89|Homo sapiens|0|TRANSFERASE","7OLV|MerTK kinase domain with type 1.5 inhibitor containing a di-methyl, cyano pyrazole group|X-RAY DIFFRACTION|2.13|Homo sapiens|0|TRANSFERASE","7OLX|MerTK kinase domain with type 1.5 inhibitor containing a tri-methyl pyrazole group|X-RAY DIFFRACTION|1.98|Homo sapiens|0|TRANSFERASE","7XHY|Crystal structure of MerTK Kinase domain with BMS794833|X-RAY DIFFRACTION|2.16|Homo sapiens|0|TRANSFERASE","9BHI|Crystal structure of the MerTK kinase domain with SA4488|X-RAY DIFFRACTION|2.07|Homo sapiens|0|TRANSFERASE","9BHJ|MerTK in complex with small molecule 6-{1-[([1,1'-biphenyl]-4-yl)carbamoyl]azetidin-3-yl}-3-[(1-methyl-1H-pyrazol-4-yl)amino]pyrazine-2-carboxamide|X-RAY DIFFRACTION|2.294|Homo sapiens|0|TRANSFERASE/INHIBITOR","9BHK|MerTK in complex with small molecule inhibitor 6-{1-[6-(3-hydroxy-3-methylbutoxy)-1,3-benzoxazol-2-yl]azetidin-3-yl}-3-[(1-methyl-1H-pyrazol-4-yl)amino]pyrazine-2-carboxamide|X-RAY DIFFRACTION|2.106|Homo sapiens|0|TRANSFERASE/INHIBITOR","9KRY|Crystal structure Of MerTK kinase domain in complex With compound 1|X-RAY DIFFRACTION|2.25|Homo sapiens|0|TRANSFERASE","9KRZ|Crystal structure Of MerTK kinase domain in complex with compound 11|X-RAY DIFFRACTION|2.6|Homo sapiens|0|TRANSFERASE","9KS9|Crystal structure of MerTK kinase domain in complex with compound 6|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE"]},{"input":"P40763","source":"P40763|Signal transducer and activator of transcription 3","targets":["5AX3|Crystal structure of ERK2 complexed with allosteric and ATP-competitive inhibitors.|X-RAY DIFFRACTION|2.984|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE/TRANSFERASE INHIBITOR","5U5S|Solution structures of Brd2 second bromodomain in complex with stat3 peptide|SOLUTION NMR||Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","6NJS|Stat3 Core in complex with compound SD36|X-RAY DIFFRACTION|2.7|Homo sapiens|0|transcription/transcription inhibitor","6NUQ|Stat3 Core in complex with compound SI109|X-RAY DIFFRACTION|3.15|Homo sapiens|0|transcription/transcription inhibitor","6QHD|Lysine acetylated and tyrosine phosphorylated STAT3 in a complex with DNA|X-RAY DIFFRACTION|2.85|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","6TLC|Unphosphorylated human STAT3 in complex with MS3-6 monobody|X-RAY DIFFRACTION|2.9|Homo sapiens|0|TRANSCRIPTION"]}]}