{"context":{"query":">>uniprot>>pdb","source_dataset":"uniprot","target_dataset":"pdb"},"stats":{"queried":5,"total":99,"mapped":5},"pagination":{"has_next":false},"schema":"id|title|method|resolution|source_organism|chain_count|header","mappings":[{"input":"P29597","source":"P29597|Non-receptor tyrosine-protein kinase TYK2","targets":["3LXN|Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE","3LXP|Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6|X-RAY DIFFRACTION|1.65|Homo sapiens|0|TRANSFERASE","3NYX|Non-phosphorylated TYK2 JH1 domain with Quinoline-Thiadiazole-Thiophene Inhibitor|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3NZ0|Non-phosphorylated TYK2 kinase with CMP6|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSFERASE","3ZON|Human TYK2 pseudokinase domain bound to a kinase inhibitor|X-RAY DIFFRACTION|2.15|HOMO SAPIENS|0|TRANSFERASE","4GFO|TYK2 kinase (JH1 domain) with 2,6-DICHLORO-N-(2-OXO-2,5-DIHYDROPYRIDIN-4-YL)BENZAMIDE|X-RAY DIFFRACTION|2.3|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4GIH|Tyk2 (JH1) in complex with 2,6-DICHLORO-N-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}BENZAMIDE|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4GII|Tyk2 (JH1) in complex with 2,6-dichloro-4-cyano-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide|X-RAY DIFFRACTION|2.31|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4GJ2|Tyk2 (JH1) in complex with 2,6-dichloro-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4GJ3|Tyk2 (JH1) in complex with 2,6-dichloro-4-cyano-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4GVJ|Tyk2 (JH1) in complex with adenosine di-phosphate|X-RAY DIFFRACTION|2.03|Homo sapiens|0|HYDROLASE","4OLI|The pseudokinase/kinase protein from JAK-family member TYK2|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE","4PO6|Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular peptide|X-RAY DIFFRACTION|1.99|Homo sapiens|0|TRANSFERASE","4PY1|Crystal structure of Tyk2 in complex with compound 15, 6-((2,5-dimethoxyphenyl)thio)-3-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazine|X-RAY DIFFRACTION|2.16|Homo sapiens|0|TRANSFERASE","4WOV|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH BMS-066 AKA 2-METHOXY-N-({6-[3-METHYL-7-(METHYLAMINO)-3,5,8,10-TETRAAZATRICYCLO[7.3.0.0, 6]DODECA-1(9),2(6),4,7,11-PENTAEN-11-YL]PYRIDIN-2-YL}METHY L)ACETAMIDE|X-RAY DIFFRACTION|1.8|Homo sapiens|0|TRANSFERASE/INHIBITOR","5C01|Crystal Structure of kinase|X-RAY DIFFRACTION|2.15|Homo sapiens|0|TRANSFERASE","5C03|Crystal Structure of kinase|X-RAY DIFFRACTION|1.9|Homo sapiens|0|TRANSFERASE","5F1Z|Structure of TYK2 with inhibitor 16: 3-azanyl-5-[(2~{S})-3-methylbutan-2-yl]-7-[1-methyl-5-(2-oxidanylpropan-2-yl)pyrazol-3-yl]-1~{H}-pyrazolo[4,3-c]pyridin-4-one|X-RAY DIFFRACTION|2.65|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5F20|Structure of TYK2 with inhibitor 4: 3-azanyl-5-(2-methylphenyl)-7-(1-methylpyrazol-3-yl)-1~{H}-pyrazolo[4,3-c]pyridin-4-one|X-RAY DIFFRACTION|2.91|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5TKD|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH 6-[(3,5-DIMETHYLPHE NYL)AMINO]-8- (METHYLAMINO)IMIDAZO[1,2-B]PYRIDAZINE-3-CARBO XAMIDE|X-RAY DIFFRACTION|1.92|Homo sapiens|0|TRANSFERASE","5WAL|Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model|X-RAY DIFFRACTION|2.45|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","6AAM|Crystal structure of TYK2 in complex with peficitinib|X-RAY DIFFRACTION|1.98|Homo sapiens|0|TRANSFERASE/INHIBITOR","6DBK|Tyk2 with compound 8|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSFERASE","6DBM|Tyk2 with compound 23|X-RAY DIFFRACTION|2.368|Homo sapiens|0|TRANSFERASE","6NSL|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound-6c AKA 6-((1-(4-CYANOPHENY L)-2-OXO-1,2-DIHYDRO-3-PYRIDINYL)AMINO)-N-CYCLOPROPYL-8-(M ETHYLAMINO)IMIDAZO[1,2-B]PYRIDAZINE-3-CARBOXAMIDE|X-RAY DIFFRACTION|2.15|Homo sapiens|0|TRANSFERASE","6NZE|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_5 AKA 4-[(2-CARBAMOYLPHEN YL)AMINO]-6-[(5-FLUOROPYRIDIN-2-YL)AMINO]-N-METHYLPYRIDINE -3-CARBOXAMIDE|X-RAY DIFFRACTION|1.96|Homo sapiens|0|TRANSFERASE","6NZF|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_5 AKA 4-[(2-CARBAMOYLPHEN YL)AMINO]-6-[(5-FLUOROPYRIDIN-2-YL)AMINO]-N-METHYLPYRIDINE -3-CARBOXAMIDE|X-RAY DIFFRACTION|2.39|Homo sapiens|0|TRANSFERASE","6NZH|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_40 AKA 6-cyclopropaneamido-4-[(2-methanesulfonylphenyl)amino]-N-methylpyridine-3-carboxamide|X-RAY DIFFRACTION|2.73|Homo sapiens|0|TRANSFERASE","6NZP|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH COMPOUND-11 AKA 6-CYCLOPROPANEAMIDO-4-{[2-METHOXY-3-(1-METHYL-1H-1,2,4-TRI AZOL-3-YL)PHENYL]AMINO}-N-(?H?)METHYLPYRIDAZINE-3-CARBOXAMIDE|X-RAY DIFFRACTION|2.35|Homo sapiens|0|TRANSFERASE","6NZQ|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_29 AKA 6-[(5-FLUORO-4-METH YLPYRIDIN-2-YL)AMINO]-4-({2-METHOXY-3-[(PYRIDIN-2-YLMETHYL )CARBAMOYL]PHENYL}AMINO)-N-METHYLPYRIDINE-3-CARBOXAMIDE|X-RAY DIFFRACTION|2.11|Homo sapiens|0|TRANSFERASE","6NZR|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_12 AKA 4-[(2-methanesulfonylphenyl)amino]-N-(H3)methyl-6-[(pyridin-2- yl)amino]pyridazine-3-carboxamide|X-RAY DIFFRACTION|2.56|Homo sapiens|0|TRANSFERASE","6OVA|Crystal Structure of TYK2 with novel pyrrolidinone inhibitor|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","6VNS|Crystal structure of TYK2 kinase with compound 13|X-RAY DIFFRACTION|2.09|Homo sapiens|0|TRANSFERASE/INHIBITOR","6VNV|Crystal structure of TYK2 kinase with compound 14|X-RAY DIFFRACTION|2.15|Homo sapiens|0|TRANSFERASE/INHIBITOR","6VNX|Crystal structure of TYK2 kinase with compound 19|X-RAY DIFFRACTION|2.18|Homo sapiens|0|TRANSFERASE/INHIBITOR","6VNY|Crystal structure of TYK2 kinase with compound 10|X-RAY DIFFRACTION|2.3|Homo sapiens|0|TRANSFERASE/INHIBITOR","6X8F|Crystal structure of TYK2 with Compound 11|X-RAY DIFFRACTION|2.15|Homo sapiens|0|TRANSFERASE","6X8G|Crystal structure of TYK2 with Compound 22|X-RAY DIFFRACTION|2.21|Homo sapiens|0|TRANSFERASE","7AX4|Human TYK2 pseudokinase domain (575-869) in complex with 5-(4-Fluoro-phenyl)-2-ureido-thiophene-3-carboxylic acid amide.|X-RAY DIFFRACTION|2.12|Homo sapiens|0|SIGNALING PROTEIN","7K7O|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH COMPOUND-12 AKA:6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(pyrimidin-2-yl)phenyl]amino}-N-methylpyridazine-3-carboxamide|X-RAY DIFFRACTION|2.82|Homo sapiens|0|TRANSFERASE","7K7Q|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH COMPOUND-12 AKA:6-[(cyclopropanecarbonyl)amino]-4-({3-[6-(dimethylcarbamoyl)pyridazin-3-yl]-2-methoxyphenyl}amino)-N-methylpyridazine-3-carboxamide|X-RAY DIFFRACTION|2.27|Homo sapiens|0|TRANSFERASE","7UYR|Crystal structure of TYK2 kinase domain in complex with compound 12|X-RAY DIFFRACTION|2.15|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","7UYS|Crystal structure of TYK2 kinase domain in complex with compound 16|X-RAY DIFFRACTION|2.15|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","7UYT|Crystal structure of TYK2 kinase domain in complex with compound 25|X-RAY DIFFRACTION|2.14|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","7UYU|Crystal structure of TYK2 kinase domain in complex with compound 30|X-RAY DIFFRACTION|2.05|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","8EXN|Crystal structure of PTP1B D181A/Q262A phosphatase domain with TYK2 activation loop phosphopeptide|X-RAY DIFFRACTION|2.151|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","8EYC|Crystal structure of PTP1B D181A/Q262A/C215A phosphatase domain with TYK2 activation loop phosphopeptide|X-RAY DIFFRACTION|2.99|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","8S98|Crystal structure of the TYK2 pseudokinase domain in complex with compound 8|X-RAY DIFFRACTION|1.87|Homo sapiens|0|TRANSFERASE","8S99|Crystal structure of the TYK2 pseudokinase domain in complex with compound 11|X-RAY DIFFRACTION|1.71|Homo sapiens|0|TRANSFERASE","8S9A|Crystal structure of the TYK2 pseudokinase domain in complex with TAK-279|X-RAY DIFFRACTION|1.83|Homo sapiens|0|TRANSFERASE","8TB5|TYK2 JH2 bound to Compound7|X-RAY DIFFRACTION|2.32|Homo sapiens|0|SIGNALING PROTEIN","8TB6|TYK2 JH2 bound to Compound14|X-RAY DIFFRACTION|1.96|Homo sapiens|0|SIGNALING PROTEIN"]},{"input":"Q5VWK5","source":"Q5VWK5|Interleukin-23 receptor","targets":["5MZV|IL-23:IL-23R:Nb22E11 complex|X-RAY DIFFRACTION|2.8|Homo sapiens; Lama glama|0|CYTOKINE","6WDQ|IL23/IL23R/IL12Rb1 signaling complex|X-RAY DIFFRACTION|3.4|Homo sapiens|0|SIGNALING PROTEIN","8OE4|Cryo-EM structure of a pre-dimerized human IL-23 complete extracellular signaling complex.|ELECTRON MICROSCOPY|3.6|Homo sapiens|0|SIGNALING PROTEIN","9MFG|Complex of IL23 receptor and VHH|X-RAY DIFFRACTION|2.85|Homo sapiens; Lama glama|0|IMMUNE SYSTEM"]},{"input":"P29460","source":"P29460|Interleukin-12 subunit beta","targets":["1F42|THE P40 DOMAIN OF HUMAN INTERLEUKIN-12|X-RAY DIFFRACTION|2.5|Homo sapiens|0|CYTOKINE","1F45|HUMAN INTERLEUKIN-12|X-RAY DIFFRACTION|2.8|Homo sapiens|0|CYTOKINE/CYTOKINE","3D85|Crystal structure of IL-23 in complex with neutralizing FAB|X-RAY DIFFRACTION|1.9|Homo sapiens|0|IMMUNE SYSTEM/CYTOKINE","3D87|Crystal structure of Interleukin-23|X-RAY DIFFRACTION|2.9|Homo sapiens|0|CYTOKINE","3DUH|Structure of Interleukin-23|X-RAY DIFFRACTION|2.3|Homo sapiens|0|IMMUNE SYSTEM/CYTOKINE","3HMX|Crystal structure of ustekinumab FAB/IL-12 complex|X-RAY DIFFRACTION|3|Homo sapiens|0|Cytokine/IMMUNE SYSTEM","3QWR|Crystal structure of IL-23 in complex with an adnectin|X-RAY DIFFRACTION|3.25|Homo sapiens|0|PROTEIN BINDING/CYTOKINE","4GRW|Structure of a complex of human IL-23 with 3 Nanobodies (Llama vHHs)|X-RAY DIFFRACTION|2.55|Homo sapiens; Lama glama|0|IMMUNE SYSTEM","5MJ3|INTERLEUKIN-23 COMPLEX WITH AN ANTAGONISTIC ALPHABODY, CRYSTAL FORM 1|X-RAY DIFFRACTION|1.74|Homo sapiens; synthetic construct|0|IMMUNE SYSTEM","5MJ4|INTERLEUKIN-23 COMPLEX WITH AN ANTAGONISTIC ALPHABODY, CRYSTAL FORM 2|X-RAY DIFFRACTION|3.4|Homo sapiens; synthetic construct|0|IMMUNE SYSTEM","5MXA|Structure of unbound Interleukin-23|X-RAY DIFFRACTION|2.501|Homo sapiens|0|CYTOKINE","5MZV|IL-23:IL-23R:Nb22E11 complex|X-RAY DIFFRACTION|2.8|Homo sapiens; Lama glama|0|CYTOKINE","5NJD|Structure of Interleukin 23 in complex with Briakinumab FAb|X-RAY DIFFRACTION|3.9|Homo sapiens|0|IMMUNE SYSTEM","6UIB|Crystal structure of IL23 bound to peptide 23-652|X-RAY DIFFRACTION|2.74|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","6WDQ|IL23/IL23R/IL12Rb1 signaling complex|X-RAY DIFFRACTION|3.4|Homo sapiens|0|SIGNALING PROTEIN","8CR8|human Interleukin-23|X-RAY DIFFRACTION|2|Homo sapiens|0|CYTOKINE","8OE4|Cryo-EM structure of a pre-dimerized human IL-23 complete extracellular signaling complex.|ELECTRON MICROSCOPY|3.6|Homo sapiens|0|SIGNALING PROTEIN","8UUI|X-ray structure of Interleukin-23 in complex with peptide 23-446|X-RAY DIFFRACTION|2.43|Homo sapiens; SYNTHETIC CONSTRUCT|0|CYTOKINE","8XRP|The Cryo-EM structure of IL-12, receptor subunit beta-1 and receptor subunit beta-2 complex|ELECTRON MICROSCOPY|3.75|Homo sapiens|0|CYTOKINE","8YI7|The Cryo-EM structure of IL-12, receptor subunit beta-1 and receptor subunit beta-2 complex, local refinement|ELECTRON MICROSCOPY|3.57|Homo sapiens|0|CYTOKINE"]},{"input":"P21580","source":"P21580|Tumor necrosis factor alpha-induced protein 3","targets":["2EQE|Solution structure of the fourth A20-type zinc finger domain from human tumor necrosis factor, alpha-induced protein3|SOLUTION NMR||Homo sapiens|0|HYDROLASE","2EQF|Solution structure of the 7th A20-type zinc finger domain from human tumor necrosis factor, alpha-induced protein3|SOLUTION NMR||Homo sapiens|0|HYDROLASE","2EQG|Solution structure of the first A20-type zinc finger domain from human tumor necrosis factor, alpha-induced protein3|SOLUTION NMR||Homo sapiens|0|HYDROLASE","2VFJ|Structure of the A20 Ovarian Tumour (OTU) domain|X-RAY DIFFRACTION|3.2|HOMO SAPIENS|0|HYDROLASE","3DKB|Crystal Structure of A20, 2.5 angstrom|X-RAY DIFFRACTION|2.5|Homo sapiens|0|HYDROLASE","3OJ3|Crystal structure of the A20 ZnF4 and ubiquitin complex|X-RAY DIFFRACTION|2.5|Homo sapiens|0|PROTEIN BINDING/HYDROLASE","3OJ4|Crystal structure of the A20 ZnF4, ubiquitin and UbcH5A complex|X-RAY DIFFRACTION|3.4|Homo sapiens|0|LIGASE/PROTEIN BINDING","3VUW|Crystal structure of A20 ZF7 in complex with linear ubiquitin, form I|X-RAY DIFFRACTION|1.95|Homo sapiens|0|PROTEIN BINDING/METAL BINDING PROTEIN","3VUX|Crystal structure of A20 ZF7 in complex with linear ubiquitin, form II|X-RAY DIFFRACTION|1.699|Homo sapiens|0|PROTEIN BINDING/METAL BINDING PROTEIN","3VUY|Crystal structure of A20 ZF7 in complex with linear tetraubiquitin|X-RAY DIFFRACTION|1.981|Homo sapiens|0|PROTEIN BINDING/METAL BINDING PROTEIN","3ZJD|A20 OTU domain in reduced, active state at 1.87 A resolution|X-RAY DIFFRACTION|1.87|HOMO SAPIENS|0|HYDROLASE","3ZJE|A20 OTU domain in reversibly oxidised (SOH) state|X-RAY DIFFRACTION|1.84|HOMO SAPIENS|0|HYDROLASE","3ZJF|A20 OTU domain with irreversibly oxidised Cys103 from 270 min H2O2 soak.|X-RAY DIFFRACTION|2.2|HOMO SAPIENS|0|HYDROLASE","3ZJG|A20 OTU domain with irreversibly oxidised Cys103 from 60 min H2O2 soak.|X-RAY DIFFRACTION|1.92|HOMO SAPIENS|0|HYDROLASE","5LRX|Structure of A20 OTU domain bound to ubiquitin|X-RAY DIFFRACTION|2.85|Homo sapiens|0|HYDROLASE","5V3B|Human A20 OTU domain (WT) with acetamidylated C103|X-RAY DIFFRACTION|3|Homo sapiens|0|HYDROLASE,LIGASE","5V3P|Human A20 OTU domain (I325N) with acetamidylated C103|X-RAY DIFFRACTION|2.5|Homo sapiens|0|HYDROLASE,LIGASE"]},{"input":"P40763","source":"P40763|Signal transducer and activator of transcription 3","targets":["5AX3|Crystal structure of ERK2 complexed with allosteric and ATP-competitive inhibitors.|X-RAY DIFFRACTION|2.984|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSFERASE/TRANSFERASE INHIBITOR","5U5S|Solution structures of Brd2 second bromodomain in complex with stat3 peptide|SOLUTION NMR||Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","6NJS|Stat3 Core in complex with compound SD36|X-RAY DIFFRACTION|2.7|Homo sapiens|0|transcription/transcription inhibitor","6NUQ|Stat3 Core in complex with compound SI109|X-RAY DIFFRACTION|3.15|Homo sapiens|0|transcription/transcription inhibitor","6QHD|Lysine acetylated and tyrosine phosphorylated STAT3 in a complex with DNA|X-RAY DIFFRACTION|2.85|Homo sapiens; SYNTHETIC CONSTRUCT|0|TRANSCRIPTION","6TLC|Unphosphorylated human STAT3 in complex with MS3-6 monobody|X-RAY DIFFRACTION|2.9|Homo sapiens|0|TRANSCRIPTION"]}]}