{"context":{"query":">>uniprot>>reactome","source_dataset":"uniprot","target_dataset":"reactome"},"stats":{"queried":1,"total":42,"mapped":1},"pagination":{"has_next":false},"schema":"id|name|tax_id|is_disease_pathway","mappings":[{"input":"P31749","source":"P31749|RAC-alpha serine/threonine-protein kinase","targets":["R-HSA-111447|Activation of BAD and translocation to mitochondria |9606|false","R-HSA-1257604|PIP3 activates AKT signaling|9606|false","R-HSA-1358803|Downregulation of ERBB2:ERBB3 signaling|9606|false","R-HSA-1445148|Translocation of SLC2A4 (GLUT4) to the plasma membrane|9606|false","R-HSA-1474151|Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation|9606|false","R-HSA-165159|MTOR signalling|9606|false","R-HSA-198323|AKT phosphorylates targets in the cytosol|9606|false","R-HSA-198693|AKT phosphorylates targets in the nucleus|9606|false","R-HSA-199418|Negative regulation of the PI3K/AKT network|9606|false","R-HSA-203615|eNOS activation|9606|false","R-HSA-211163|AKT-mediated inactivation of FOXO1A|9606|false","R-HSA-354192|Integrin signaling|9606|false","R-HSA-3769402|Deactivation of the beta-catenin transactivating complex|9606|false","R-HSA-389357|CD28 dependent PI3K/Akt signaling|9606|false","R-HSA-389513|Co-inhibition by CTLA4|9606|false","R-HSA-392451|G beta:gamma signalling through PI3Kgamma|9606|false","R-HSA-450385|Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA|9606|false","R-HSA-450604|KSRP (KHSRP) binds and destabilizes mRNA|9606|false","R-HSA-5218920|VEGFR2 mediated vascular permeability|9606|false","R-HSA-5628897|TP53 Regulates Metabolic Genes|9606|false","R-HSA-5674400|Constitutive Signaling by AKT1 E17K in Cancer|9606|true","R-HSA-6785807|Interleukin-4 and Interleukin-13 signaling|9606|false","R-HSA-6804757|Regulation of TP53 Degradation|9606|false","R-HSA-6804758|Regulation of TP53 Activity through Acetylation|9606|false","R-HSA-6804759|Regulation of TP53 Activity through Association with Co-factors|9606|false","R-HSA-6811558|PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling|9606|false","R-HSA-69202|Cyclin E associated events during G1/S transition |9606|false","R-HSA-69656|Cyclin A:Cdk2-associated events at S phase entry|9606|false","R-HSA-8849469|PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1|9606|false","R-HSA-8876198|RAB GEFs exchange GTP for GDP on RABs|9606|false","R-HSA-8941332|RUNX2 regulates genes involved in cell migration|9606|false","R-HSA-8948751|Regulation of PTEN stability and activity|9606|false","R-HSA-9009391|Extra-nuclear estrogen signaling|9606|false","R-HSA-9604323|Negative regulation of NOTCH4 signaling|9606|false","R-HSA-9607240|FLT3 Signaling|9606|false","R-HSA-9614399|Regulation of localization of FOXO transcription factors|9606|false","R-HSA-9634638|Estrogen-dependent nuclear events downstream of ESR-membrane signaling|9606|false","R-HSA-9755511|KEAP1-NFE2L2 pathway|9606|false","R-HSA-9755779|SARS-CoV-2 targets host intracellular signalling and regulatory pathways|9606|true","R-HSA-9841251|Mitochondrial unfolded protein response (UPRmt)|9606|false","R-HSA-9856530|High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells|9606|false","R-HSA-9856532|Mechanical load activates signaling by PIEZO1 and integrins in osteocytes|9606|false"]}]}