{"context":{"query":">>uniprot>>signor","source_dataset":"uniprot","target_dataset":"signor"},"stats":{"queried":1,"total":100,"mapped":1},"pagination":{"has_next":true,"next_token":"-1[]P36888,1,P36888,123,3]["},"schema":"id|entity_a|entity_b|effect|mechanism|direct","mappings":[{"input":"P36888","source":"P36888|Receptor-type tyrosine-protein kinase FLT3","targets":["SIGNOR-117571|FLT3|FLT3|up-regulates|phosphorylation|false","SIGNOR-117575|FLT3|FLT3|up-regulates|phosphorylation|false","SIGNOR-117579|FLT3|FLT3|up-regulates|phosphorylation|false","SIGNOR-117583|FLT3|FLT3|up-regulates|phosphorylation|false","SIGNOR-163941|sunitinib|FLT3|down-regulates|\"chemical inhibition\"|false","SIGNOR-170614|anthra[1,9-cd]pyrazol-6(2H)-one|FLT3|down-regulates|\"chemical inhibition\"|false","SIGNOR-172911|sunitinib|FLT3|down-regulates|\"chemical inhibition\"|false","SIGNOR-176751|sunitinib|FLT3|down-regulates|\"chemical inhibition\"|false","SIGNOR-190976|CHIR-124|FLT3|down-regulates|\"chemical inhibition\"|false","SIGNOR-191406|4-amino-5-fluoro-3-[5-(4-methyl-1-piperazinyl)-1,3-dihydrobenzimidazol-2-ylidene]-2-quinolinone|FLT3|down-regulates|\"chemical inhibition\"|false","SIGNOR-191418|\"dovitinib; bis(lactic acid)\"|FLT3|down-regulates|\"chemical inhibition\"|false","SIGNOR-193615|[4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone|FLT3|down-regulates|\"chemical inhibition\"|false","SIGNOR-194378|MK-2461|FLT3|down-regulates|\"chemical inhibition\"|false","SIGNOR-202105|FLT3|Skeletal_muscle_differentiation|up-regulates||false","SIGNOR-206331|quizartinib|FLT3|down-regulates|\"chemical inhibition\"|false","SIGNOR-207209|tandutinib|FLT3|down-regulates|\"chemical inhibition\"|false","SIGNOR-207260|TG101209|FLT3|down-regulates|\"chemical inhibition\"|false","SIGNOR-245064|FLT3|AKT|\"up-regulates activity\"||false","SIGNOR-249635|FLT3|CEBPA|\"down-regulates quantity by repression\"|\"transcriptional regulation\"|false","SIGNOR-251146|FLT3|SHC1|\"up-regulates activity\"|phosphorylation|false","SIGNOR-251147|FLT3|SHC1|\"up-regulates activity\"|phosphorylation|false","SIGNOR-251148|FLT3|SHC1|\"up-regulates activity\"|phosphorylation|false","SIGNOR-252626|FLT3|AKT1|\"up-regulates activity\"||false","SIGNOR-256307|FLT3|RUNX1|\"up-regulates activity\"||false","SIGNOR-257849|sunitinib|FLT3|\"down-regulates activity\"|\"chemical inhibition\"|false","SIGNOR-259214|regorafenib|FLT3|\"down-regulates activity\"|\"chemical inhibition\"|false","SIGNOR-259927|PIM1|FLT3|\"up-regulates quantity\"|phosphorylation|false","SIGNOR-259950|FLT3|PTPN6|\"down-regulates quantity\"|\"transcriptional regulation\"|false","SIGNOR-259982|FLT3|Glycolysis|\"up-regulates activity\"||false","SIGNOR-260124|FLT3|CTNNB1|\"up-regulates activity\"|phosphorylation|false","SIGNOR-260132|FLT3|ERK1/2|\"up-regulates activity\"||false","SIGNOR-261322|FLT3|HK2|\"up-regulates activity\"||false","SIGNOR-261532|FLT3|PTPN6|\"down-regulates quantity by repression\"|\"transcriptional regulation\"|false","SIGNOR-261555|FLT3|SIRT1|\"up-regulates quantity by stabilization\"|\"post transcriptional regulation\"|false","SIGNOR-261556|FLT3|MYC|\"up-regulates quantity by expression\"||false","SIGNOR-261559|FLT3|USP22|\"up-regulates quantity by expression\"|\"transcriptional regulation\"|false","SIGNOR-262242|cabozantinib|FLT3|\"down-regulates activity\"|\"chemical inhibition\"|false","SIGNOR-267628|FLT3|ACAT1|\"up-regulates activity\"|phosphorylation|false","SIGNOR-267632|FLT3|IDH2|\"down-regulates activity\"|phosphorylation|false","SIGNOR-270268|FLT3|Hexokinase|\"up-regulates activity\"||false","SIGNOR-271919|FLT3|FLT3|\"up-regulates activity\"|phosphorylation|false","SIGNOR-277092|PTPRJ|FLT3|\"down-regulates activity\"|dephosphorylation|false","SIGNOR-278430|SYK|FLT3|\"up-regulates activity\"|phosphorylation|false","SIGNOR-278431|SYK|FLT3|\"up-regulates activity\"|phosphorylation|false","SIGNOR-279715|FYN|FLT3|\"up-regulates activity\"|phosphorylation|false","SIGNOR-65564|FLT3LG|FLT3|up-regulates|binding|false","SIGNOR-99750|FLT3LG|FLT3|up-regulates|binding|false","SIGNOR-245057|FLT3|PTPN11|\"up-regulates activity\"|binding|false","SIGNOR-245060|FLT3|GRB2|\"up-regulates activity\"|binding|false","SIGNOR-245069|FLT3|STAT5A|\"up-regulates activity\"|phosphorylation|false","SIGNOR-255698|FLT3|ID1|\"up-regulates quantity by expression\"|\"transcriptional regulation\"|false","SIGNOR-255739|CBL|FLT3|\"down-regulates activity\"|binding|false","SIGNOR-255796|FLT3|miR-155|\"up-regulates quantity by expression\"|\"transcriptional regulation\"|false","SIGNOR-255947|FLT3|GRB10|\"up-regulates activity\"|binding|false","SIGNOR-256155|SLA2|FLT3|\"down-regulates activity\"|binding|false","SIGNOR-260081|FLT3|PIK3R1|\"up-regulates activity\"||false","SIGNOR-260083|FLT3|PI3K|\"up-regulates activity\"||false","SIGNOR-260106|CBLB|FLT3|\"down-regulates activity\"|ubiquitination|false","SIGNOR-260121|FLT3|FZD4|\"up-regulates quantity by expression\"|\"transcriptional regulation\"|false","SIGNOR-261516|FLT3|STAT5A|\"up-regulates activity\"|phosphorylation|false","SIGNOR-261519|FLT3|PIM1|\"up-regulates quantity by expression\"|\"transcriptional regulation\"|false","SIGNOR-261520|FLT3|CDKN1A|\"up-regulates quantity by expression\"|\"transcriptional regulation\"|false","SIGNOR-261521|FLT3|ERK1/2|\"up-regulates activity\"||false","SIGNOR-261522|FLT3|AKT|\"up-regulates activity\"|phosphorylation|false","SIGNOR-261523|FLT3|FOXO3|\"down-regulates activity\"||false","SIGNOR-261524|FLT3|CDKN1B|\"down-regulates quantity by repression\"|\"transcriptional regulation\"|false","SIGNOR-261525|FLT3|BCL2L11|\"down-regulates quantity by repression\"|\"transcriptional regulation\"|false","SIGNOR-261529|FLT3|CEBPA|\"down-regulates quantity by repression\"|\"transcriptional regulation\"|false","SIGNOR-261530|FLT3|SPI1|\"down-regulates quantity by repression\"|\"transcriptional regulation\"|false","SIGNOR-261533|FLT3|FZD4|\"up-regulates quantity by expression\"|\"transcriptional regulation\"|false","SIGNOR-261536|FLT3|RAC1|\"up-regulates activity\"||false","SIGNOR-261537|FLT3|ZBTB16|\"down-regulates activity\"||false","SIGNOR-261538|FLT3|NCOR2|\"down-regulates activity\"|relocalization|false","SIGNOR-261540|FLT3|SHC1|\"up-regulates activity\"|phosphorylation|false","SIGNOR-261541|FLT3|PIM2|\"up-regulates quantity by expression\"|\"transcriptional regulation\"|false","SIGNOR-261542|FLT3|CISH|\"up-regulates quantity by expression\"|\"transcriptional regulation\"|false","SIGNOR-261545|FLT3|SOCS2|\"up-regulates quantity by expression\"|\"transcriptional regulation\"|false","SIGNOR-261546|FLT3|SOCS3|\"up-regulates quantity by expression\"|\"transcriptional regulation\"|false","SIGNOR-261549|FLT3|BCL2L1|\"up-regulates quantity by expression\"|\"transcriptional regulation\"|false","SIGNOR-261550|FLT3|RAD51|\"up-regulates quantity by expression\"|\"transcriptional regulation\"|false","SIGNOR-261553|FLT3|PTPRJ|\"down-regulates activity\"||false","SIGNOR-261554|FLT3|PARP1|\"up-regulates quantity by expression\"|\"transcriptional regulation\"|false","SIGNOR-261563|HES1|FLT3|\"down-regulates quantity by repression\"|\"transcriptional regulation\"|false","SIGNOR-261684|FLT3|XRCC5|\"up-regulates quantity by expression\"|\"transcriptional regulation\"|false","SIGNOR-269208|FLT3|CDKN1B|\"down-regulates activity\"|phosphorylation|false","SIGNOR-271920|FLT3|FLT3|unknown|phosphorylation|false","SIGNOR-271921|FLT3|FLT3|\"up-regulates activity\"|phosphorylation|false","SIGNOR-271922|FLT3|FLT3|unknown|phosphorylation|false","SIGNOR-271923|FLT3|FLT3|unknown|phosphorylation|false","SIGNOR-271924|FLT3|FLT3|unknown|phosphorylation|false","SIGNOR-271925|FLT3|FLT3|\"up-regulates activity\"|phosphorylation|false","SIGNOR-271926|FLT3|FLT3|\"up-regulates activity\"|phosphorylation|false","SIGNOR-249634|FLT3|SPI1|\"down-regulates quantity by repression\"|\"transcriptional regulation\"|false","SIGNOR-250563|FLT3|CEBPB|\"down-regulates quantity by repression\"|\"transcriptional regulation\"|false","SIGNOR-255666|quizartinib|FLT3|\"down-regulates activity\"|\"chemical inhibition\"|false","SIGNOR-256308|midostaurin|FLT3|\"down-regulates activity\"|\"chemical inhibition\"|false","SIGNOR-258125|\"JNJ-28312141 free base\"|FLT3|\"down-regulates activity\"|\"chemical inhibition\"|false","SIGNOR-258173|Ast-487|FLT3|\"down-regulates activity\"|\"chemical inhibition\"|false","SIGNOR-258210|4-amino-5-fluoro-3-[5-(4-methyl-1-piperazinyl)-1,3-dihydrobenzimidazol-2-ylidene]-2-quinolinone|FLT3|\"down-regulates activity\"|\"chemical inhibition\"|false","SIGNOR-258233|[4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone|FLT3|\"down-regulates activity\"|\"chemical inhibition\"|false"]}]}