{"context":{"query":">>uniprot>>ufeature","source_dataset":"uniprot","target_dataset":"ufeature"},"stats":{"queried":1,"total":100,"mapped":1},"pagination":{"has_next":true,"next_token":"-1[]P36888,1,P36888,179,1]["},"schema":"id|type|description|location_begin|location_end","mappings":[{"input":"P36888","source":"P36888|Receptor-type tyrosine-protein kinase FLT3","targets":["Q00342_F13|modified residue|phosphotyrosine|573|573","Q00342_F14|modified residue|phosphoserine|575|575","Q00342_F15|modified residue|phosphotyrosine; by autocatalysis|590|590","Q00342_F16|modified residue|phosphotyrosine; by autocatalysis|592|592","Q00342_F17|modified residue|phosphotyrosine|600|600","Q00342_F18|modified residue|phosphotyrosine; by autocatalysis|727|727","Q00342_F19|modified residue|phosphoserine|760|760","Q00342_F20|modified residue|phosphotyrosine|769|769","Q00342_F21|modified residue|phosphotyrosine|796|796","Q00342_F22|modified residue|phosphotyrosine; by autocatalysis|845|845","Q00342_F23|modified residue|phosphotyrosine|958|958","Q00342_F24|modified residue|phosphotyrosine|972|972","Q00342_F25|modified residue|phosphoserine|1000|1000","P36888_F0|signal peptide||1|26","P36888_F1|chain|receptor-type tyrosine-protein kinase flt3|27|993","P36888_F10|binding site||644|644","P36888_F11|modified residue|phosphotyrosine|572|572","P36888_F12|modified residue|phosphoserine|574|574","P36888_F13|modified residue|phosphotyrosine; by autocatalysis|589|589","P36888_F14|modified residue|phosphotyrosine; by autocatalysis|591|591","P36888_F15|modified residue|phosphotyrosine; by autocatalysis|599|599","P36888_F16|modified residue|phosphotyrosine; by autocatalysis|726|726","P36888_F17|modified residue|phosphoserine|759|759","P36888_F18|modified residue|phosphotyrosine|768|768","P36888_F19|modified residue|phosphotyrosine|793|793","P36888_F2|topological domain|extracellular|27|543","P36888_F20|modified residue|phosphotyrosine; by autocatalysis|842|842","P36888_F21|modified residue|phosphotyrosine; by autocatalysis|955|955","P36888_F22|modified residue|phosphotyrosine; by autocatalysis|969|969","P36888_F23|modified residue|phosphoserine|993|993","P36888_F24|glycosylation site|n-linked (glcnac...) asparagine|43|43","P36888_F25|glycosylation site|n-linked (glcnac...) asparagine|100|100","P36888_F26|glycosylation site|n-linked (glcnac...) asparagine|151|151","P36888_F27|glycosylation site|n-linked (glcnac...) asparagine|306|306","P36888_F28|glycosylation site|n-linked (glcnac...) asparagine|323|323","P36888_F29|glycosylation site|n-linked (glcnac...) asparagine|351|351","P36888_F3|transmembrane region|helical|544|563","P36888_F30|glycosylation site|n-linked (glcnac...) asparagine|354|354","P36888_F31|glycosylation site|n-linked (glcnac...) asparagine|473|473","P36888_F32|glycosylation site|n-linked (glcnac...) asparagine|502|502","P36888_F33|glycosylation site|n-linked (glcnac...) asparagine|541|541","P36888_F34|disulfide bond||35|65","P36888_F35|disulfide bond||103|114","P36888_F36|disulfide bond||199|206","P36888_F37|disulfide bond||232|241","P36888_F38|disulfide bond||272|330","P36888_F39|disulfide bond||368|407","P36888_F4|topological domain|cytoplasmic|564|993","P36888_F40|disulfide bond||381|392","P36888_F41|splice variant|in isoform 2.|807|847","P36888_F42|sequence variant|in dbsnp:rs12872889.|7|7","P36888_F43|sequence variant|in dbsnp:rs56321896.|158|158","P36888_F44|sequence variant|in dbsnp:rs146030737.|194|194","P36888_F45|sequence variant|in dbsnp:rs1933437.|227|227","P36888_F46|sequence variant|in dbsnp:rs35602083.|324|324","P36888_F47|sequence variant|in dbsnp:rs34172843.|358|358","P36888_F48|sequence variant|in dbsnp:rs56090538.|417|417","P36888_F49|sequence variant|in dbsnp:rs35958982.|557|557","P36888_F5|domain|ig-like c2-type|253|343","P36888_F50|sequence variant|in acute lymphoblastic leukemia patients and acute myelogenous leukemia patients; somatic mutation; constitutively activated; dbsnp:rs121913487.|835|835","P36888_F51|sequence variant|in acute lymphoblastic leukemia patients and in acute myelogenous leukemia patients; somatic mutation; constitutively activated; dbsnp:rs121913488.|835|835","P36888_F52|sequence variant|in acute lymphoblastic leukemia patients and in acute myelogenous leukemia patients; somatic mutation; constitutively activated; dbsnp:rs121913488.|835|835","P36888_F53|sequence variant|in acute lymphoblastic leukemia patients and in acute myelogenous leukemia patients; somatic mutation; constitutively activated; dbsnp:rs121909646.|835|835","P36888_F54|sequence variant|in acute lymphoblastic leukemia patients and in acute myelogenous leukemia patients; somatic mutation; constitutively activated; dbsnp:rs121913488.|835|835","P36888_F55|sequence variant|in acute lymphoblastic leukemia patients; somatic mutation; dbsnp:rs121913232.|836|836","P36888_F56|mutagenesis site|reduced phosphorylation of the wild-type kinase in response to ligand binding. no effect on the phosphorylation of the constitutively activated mutant kinase variants. abolishes activation of stat5a.|589|589","P36888_F57|mutagenesis site|no significant effect on tyrosine phosphorylation. abolishes activation of stat5a.|591|591","P36888_F58|mutagenesis site|abolishes interaction with ptpn11/shp2 and phosphorylation of ptpn11/shp2.|599|599","P36888_F59|mutagenesis site|abolishes kinase activity.|644|644","P36888_F6|domain|protein kinase|610|943","P36888_F60|sequence conflict|in ref. 1; aaa18947.|8|8","P36888_F61|sequence conflict|in ref. 1; aaa18947.|10|11","P36888_F62|sequence conflict|in ref. 5; aai44040.|71|71","P36888_F63|sequence conflict|in ref. 2; caa81393.|78|78","P36888_F64|sequence conflict|in ref. 1; aaa18947.|346|346","P36888_F65|sequence conflict|in ref. 6; aaa35487.|940|940","P36888_F66|strand||575|581","P36888_F67|strand||583|585","P36888_F68|strand||589|591","P36888_F69|helix||594|596","P36888_F7|region of interest|important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of bound ligand|591|597","P36888_F70|helix||601|603","P36888_F71|helix||607|609","P36888_F72|strand||610|618","P36888_F73|strand||620|631","P36888_F74|strand||633|636","P36888_F75|strand||638|646","P36888_F76|helix||656|668","P36888_F77|strand||677|681","P36888_F78|strand||683|686","P36888_F79|strand||688|692","P36888_F8|active site|proton acceptor|811|811","P36888_F80|helix||699|704","P36888_F81|turn||705|708","P36888_F82|helix||785|804","P36888_F83|strand||807|809","P36888_F84|helix||814|816","P36888_F85|strand||817|820","P36888_F86|turn||821|823","P36888_F87|strand||824|827"]}]}