{"context":{"query":">>uniprot>>pdb","source_dataset":"uniprot","target_dataset":"pdb"},"stats":{"queried":1,"total":100,"mapped":1},"pagination":{"has_next":true,"next_token":"-1[]P42336,1,P42336,76,1]["},"schema":"id|title|method|resolution|source_organism|chain_count|header","mappings":[{"input":"P42336","source":"P42336|Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform","targets":["2ENQ|Solution structure of the C2 domain from human PI3-kinase p110 subunit alpha|SOLUTION NMR||Homo sapiens|0|TRANSFERASE","2RD0|Structure of a human p110alpha/p85alpha complex|X-RAY DIFFRACTION|3.05|Homo sapiens|0|Transferase/Oncoprotein","3HHM|Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE/ONCOPROTEIN","3HIZ|Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha|X-RAY DIFFRACTION|3.3|Homo sapiens|0|TRANSFERASE/ONCOPROTEIN","3ZIM|Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Kalpha|X-RAY DIFFRACTION|2.85|HOMO SAPIENS|0|TRANSFERASE","4JPS|Co-crystal Structures of the Lipid Kinase PI3K alpha with Pan and Isoform Selective Inhibitors|X-RAY DIFFRACTION|2.2|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4L1B|Crystal Structure of p110alpha complexed with niSH2 of p85alpha|X-RAY DIFFRACTION|2.586|Homo sapiens|0|signaling Protein/transferase/Inhibitor","4L23|Crystal Structure of p110alpha complexed with niSH2 of p85alpha and PI-103|X-RAY DIFFRACTION|2.501|Homo sapiens|0|signaling Protein/transferase/Inhibitor","4L2Y|Crystal Structure of p110alpha complexed with niSH2 of p85alpha and compound 9d|X-RAY DIFFRACTION|2.8|Homo sapiens|0|signaling Protein/transferase/Inhibitor","4OVU|Crystal Structure of p110alpha in complex with niSH2 of p85alpha|X-RAY DIFFRACTION|2.96|Homo sapiens|0|TRANSFERASE/TRANSFERASE REGULATOR","4OVV|Crystal Structure of PI3Kalpha in complex with diC4-PIP2|X-RAY DIFFRACTION|3.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE REGULATOR","4TUU|Isolated p110a subunit of PI3Ka provides a platform for structure-based drug design|X-RAY DIFFRACTION|2.64|Homo sapiens|0|TRANSFERASE","4TV3|Isolated p110a subunit of PI3Ka provides a platform for structure-based drug design|X-RAY DIFFRACTION|2.85|Homo sapiens|0|TRANSFERASE/TRANSFERASE Inhibitor","4WAF|Crystal Structure of a novel tetrahydropyrazolo[1,5-a]pyrazine in an engineered PI3K alpha|X-RAY DIFFRACTION|2.39|Homo sapiens|0|transferase/transferase inhibitor","4YKN|Pi3K alpha lipid kinase with Active Site Inhibitor|X-RAY DIFFRACTION|2.9|Homo sapiens|0|Transferase/Transferase Inhibitor","4ZOP|Co-crystal Structure of Lipid Kinase PI3K alpha with a selective phosphatidylinositol-3 kinase alpha inhibitor|X-RAY DIFFRACTION|2.62|Homo sapiens|0|transferase/transferase inhibitor","5DXH|p110alpha/p85alpha with compound 5|X-RAY DIFFRACTION|3|Bos taurus; Homo sapiens|0|Transferase/Transferase Inhibitor","5DXT|p110alpha with GDC-0326|X-RAY DIFFRACTION|2.25|Homo sapiens|0|Transferase/Inhibitor","5FI4|Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5ITD|Crystal structure of PI3K alpha with PI3K delta inhibitor|X-RAY DIFFRACTION|3.02|Homo sapiens|0|Transferase/Protein Transport/Inhibitor","5SW8|Crystal structure of PI3Kalpha in complex with fragments 7 and 11|X-RAY DIFFRACTION|3.3|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SWG|Crystal Structure of PI3Kalpha in complex with fragments 5 and 21|X-RAY DIFFRACTION|3.11|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SWO|Crystal Structure of PI3Kalpha in complex with fragments 4 and 19|X-RAY DIFFRACTION|3.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SWP|Crystal Structure of PI3Kalpha in complex with fragments 6 and 24|X-RAY DIFFRACTION|3.41|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SWR|Crystal Structure of PI3Kalpha in complex with fragments 20 and 26|X-RAY DIFFRACTION|3.31|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SWT|Crystal Structure of PI3Kalpha in complex with fragments 17 and 27|X-RAY DIFFRACTION|3.49|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SX8|Crystal Structure of PI3Kalpha in complex with fragments 12 and 15|X-RAY DIFFRACTION|3.47|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SX9|Crystal Structure of PI3Kalpha in complex with fragment 14|X-RAY DIFFRACTION|3.52|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXA|Crystal Structure of PI3Kalpha in complex with fragment 10|X-RAY DIFFRACTION|3.35|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXB|Crystal Structure of PI3Kalpha in complex with fragment 23|X-RAY DIFFRACTION|3.3|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXC|Crystal Structure of PI3Kalpha in complex with fragment 8|X-RAY DIFFRACTION|3.55|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXD|Crystal Structure of PI3Kalpha in complex with fragment 22|X-RAY DIFFRACTION|3.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXE|Crystal Structure of PI3Kalpha in complex with fragments 19 and 28|X-RAY DIFFRACTION|3.51|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXF|Crystal Structure of PI3Kalpha in complex with fragment 9|X-RAY DIFFRACTION|3.46|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXI|Crystal Structure of PI3Kalpha in complex with fragment 13|X-RAY DIFFRACTION|3.4|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXJ|Crystal Structure of PI3Kalpha in complex with fragment 29|X-RAY DIFFRACTION|3.42|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5SXK|Crystal Structure of PI3Kalpha in complex with fragment 18|X-RAY DIFFRACTION|3.55|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5UBR|CRYSTAL STRUCTURE OF PI3K ALPHA IN COMPLEX WITH A 7-(3-(PIPERAZIN-1-YL)PHENYL)PYRROLO[2,1-F][1,2,4] TRIAZIN-4-AMINE DERIVIATINE|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE/TRANSFERASE REGULATOR","5UK8|The co-structure of (R)-4-(6-(1-(cyclopropylsulfonyl)cyclopropyl)-2-(1H-indol-4-yl)pyrimidin-4-yl)-3-methylmorpholine and a rationally designed PI3K-alpha mutant that mimics ATR|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE/SIGNALING PROTEIN/INHIBITOR","5UKJ|The co-structure of N,N-dimethyl-4-[(6R)-6-methyl-5-(1H-pyrrolo[2,3- b]pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5- a]pyrazin-3-yl]benzenesulfonamide and a rationally designed PI3K-alpha mutant that mimics ATR|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE/SIGNALING PROTEIN/INHIBITOR","5UL1|The co-structure of 3-amino-6-(4-((1-(dimethylamino)propan-2-yl)sulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide and a rationally designed PI3K-alpha mutant that mimics ATR|X-RAY DIFFRACTION|3|Homo sapiens|0|TRANSFERASE/SIGNALING PROTEIN/INHIBITOR","5XGH|Crystal structure of PI3K complex with an inhibitor|X-RAY DIFFRACTION|2.97|Homo sapiens|0|TRANSFERASE/INHIBITOR","5XGI|Crystal structure of PI3K complex with an inhibitor|X-RAY DIFFRACTION|2.56|Homo sapiens|0|TRANSFERASE/INHIBITOR","5XGJ|Crystal structure of PI3K complex with an inhibitor|X-RAY DIFFRACTION|2.97|Homo sapiens|0|TRANSFERASE/INHIBITOR","6GVF|Crystal structure of PI3K alpha in complex with 3-(2-Amino-benzooxazol-5-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE","6GVG|Crystal structure of PI3K alpha in complex with 3-(2-Amino-benzooxazol-5-yl)-1-isopropyl-4-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine|X-RAY DIFFRACTION|3|Homo sapiens|0|TRANSFERASE","6GVH|Crystal structure of PI3K alpha in complex with 3-(2-Amino-benzooxazol-5-yl)-4-chloro-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine|X-RAY DIFFRACTION|2.74|Homo sapiens|0|TRANSFERASE","6GVI|Crystal structure of PI3K alpha in complex with 3-(2-Amino-benzooxazol-5-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine|X-RAY DIFFRACTION|2.9|Homo sapiens|0|TRANSFERASE","6NCT|Structure of p110alpha/niSH2 - vector data collection|X-RAY DIFFRACTION|3.35|Homo sapiens|0|TRANSFERASE","6OAC|PQR530 [(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine] bound to the PI3Ka catalytic subunit p110alpha|X-RAY DIFFRACTION|3.15|Homo sapiens|0|TRANSFERASE","6PYS|Human PI3Kalpha in complex with Compound 2-10 ((3S)-3-benzyl-3-methyl-5-[5-(2-methylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1,3-dihydro-2H-indol-2-one)|X-RAY DIFFRACTION|2.19|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","6VO7|Crystal structure of PI3K-alpha Ras Binding Domain (RBD)|X-RAY DIFFRACTION|2.31|Homo sapiens|0|ONCOPROTEIN","7JIU|HUMAN PI3KDELTA IN COMPLEX WITH COMPOUND 2F|X-RAY DIFFRACTION|2.12||0|TRANSFERASE/TRANSFERASE INHIBITOR","7K6M|Crystal structure of PI3Kalpha selective Inhibitor PF-06843195|X-RAY DIFFRACTION|2.413|Homo sapiens|0|SIGNALING PROTEIN, Transferase","7K6N|Crystal structure of PI3Kalpha selective Inhibitor 11-1575|X-RAY DIFFRACTION|2.77|Homo sapiens|0|SIGNALING PROTEIN, Transferase","7K6O|Crystal structure of PI3Kalpha inhibitor 10-5429|X-RAY DIFFRACTION|2.738|Homo sapiens|0|SIGNALING PROTEIN, Transferase","7K71|Crystal structure of PI3Kalpha inhibitor 4-0686|X-RAY DIFFRACTION|2.9|Homo sapiens|0|SIGNALING PROTEIN, Transferase","7L1B|Crystal structure of HLA-A*03:01 in complex with a wild-type PIK3CA peptide|X-RAY DIFFRACTION|2.04|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","7L1C|Crystal structure of HLA-A*03:01 in complex with a mutant PIK3CA peptide|X-RAY DIFFRACTION|1.96|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","7L1D|Crystal structure of human 21LT2-2 TCR bound to HLA-A*03:01 in complex with a mutant PIK3CA peptide|X-RAY DIFFRACTION|3.11|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","7MLK|Crystal structure of human PI3Ka (p110a subunit) with MMV085400 bound to the active site determined at 2.9 angstroms resolution|X-RAY DIFFRACTION|2.91|Homo sapiens|0|TRANSFERASE/INHIBITOR","7MYN|Cryo-EM Structure of p110alpha in complex with p85alpha|ELECTRON MICROSCOPY|2.79|Homo sapiens|0|TRANSFERASE","7MYO|Cryo-EM structure of p110alpha in complex with p85alpha inhibited by BYL-719|ELECTRON MICROSCOPY|2.92|Homo sapiens|0|TRANSFERASE","7PG5|Crystal Structure of PI3Kalpha|X-RAY DIFFRACTION|2.20029|Homo sapiens|0|TRANSFERASE","7PG6|Crystal Structure of PI3Kalpha in complex with the inhibitor NVP-BYL719|X-RAY DIFFRACTION|2.49944|Homo sapiens|0|TRANSFERASE","7R9V|Structure of PIK3CA with covalent inhibitor 19|X-RAY DIFFRACTION|2.69|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","7R9Y|Structure of PIK3CA with covalent inhibitor 22|X-RAY DIFFRACTION|2.85|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","7RRG|Crystal structure of human 0606T1-2 TCR bound to HLA-A*03:01 in complex with a mutant PIK3CA peptide|X-RAY DIFFRACTION|2.12|Homo sapiens; SYNTHETIC CONSTRUCT|0|IMMUNE SYSTEM","7TZ7|PI3K alpha in complex with an inhibitor|X-RAY DIFFRACTION|2.41|Homo sapiens|0|transferase/inhibitor","8AM0|Crystal structure of human T1061E PI3Kalpha in complex with its regulatory subunit and the inhibitor GDC-0077 (Inavolisib)|X-RAY DIFFRACTION|2.818|Homo sapiens|0|TRANSFERASE","8BFU|Crystal structure of the apo p110alpha catalytic subunit from homo sapiens|X-RAY DIFFRACTION|2.41|Homo sapiens|0|TRANSFERASE","8DCP|PI 3-kinase alpha with nanobody 3-126|ELECTRON MICROSCOPY|2.41|Homo sapiens|0|TRANSFERASE","8DCX|PI 3-kinase alpha with nanobody 3-159|ELECTRON MICROSCOPY|2.8|Homo sapiens|0|TRANSFERASE","8DD4|PI 3-kinase alpha with nanobody 3-142|ELECTRON MICROSCOPY|3.1|Homo sapiens|0|TRANSFERASE","8DD8|PI 3-kinase alpha with nanobody 3-142, crosslinked with DSG|ELECTRON MICROSCOPY|3.4|Homo sapiens|0|TRANSFERASE","8EXL|Crystal structure of PI3K-alpha in complex with taselisib|X-RAY DIFFRACTION|1.989|Homo sapiens|0|CELL CYCLE","8EXO|Crystal structure of PI3K-alpha in complex with compound 19|X-RAY DIFFRACTION|2.46|Homo sapiens|0|CELL CYCLE","8EXU|Crystal structure of PI3K-alpha in complex with compound 30|X-RAY DIFFRACTION|2.68|Homo sapiens|0|CELL CYCLE","8EXV|Crystal structure of PI3K-alpha in complex with compound 32|X-RAY DIFFRACTION|2.48|Homo sapiens|0|CELL CYCLE","8GUA|Cryo-EM structure of cancer-specific PI3Kalpha mutant E542K in complex with BYL-719|ELECTRON MICROSCOPY|2.77|Homo sapiens|0|STRUCTURAL PROTEIN","8GUB|Cryo-EM structure of cancer-specific PI3Kalpha mutant H1047R in complex with BYL-719|ELECTRON MICROSCOPY|2.73|Homo sapiens|0|STRUCTURAL PROTEIN","8GUD|Cryo-EM structure of cancer-specific PI3Kalpha mutant E545K in complex with BYL-719|ELECTRON MICROSCOPY|2.62|Homo sapiens|0|STRUCTURAL PROTEIN","8ILR|Cryo-EM structure of PI3Kalpha in complex with compound 16|ELECTRON MICROSCOPY|3.05|Homo sapiens|0|STRUCTURAL PROTEIN","8ILS|Cryo-EM structure of PI3Kalpha in complex with compound 17|ELECTRON MICROSCOPY|3.1|Homo sapiens|0|STRUCTURAL PROTEIN","8ILV|Cryo-EM structure of PI3Kalpha in complex with compound 18|ELECTRON MICROSCOPY|3.19|Homo sapiens|0|STRUCTURAL PROTEIN","8OW2|Crystal structure of the p110alpha catalytic subunit from homo sapiens in complex with activator 1938|X-RAY DIFFRACTION|2.57|Homo sapiens|0|TRANSFERASE","8SBC|Co-structure of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform and brain penetrant inhibitors|X-RAY DIFFRACTION|2.3|Homo sapiens|0|TRANSFERASE","8SBJ|Co-structure Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform complexed with brain penetrant inhibitors|X-RAY DIFFRACTION|3.1|Homo sapiens|0|TRANSFERASE","8TDU|STX-478, a Mutant-Selective, Allosteric Inhibitor bound to PI3Kalpha|X-RAY DIFFRACTION|3.11|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","8TGD|STX-478, a Mutant-Selective, Allosteric Inhibitor bound to H1047R PI3Kalpha|X-RAY DIFFRACTION|2.928|Homo sapiens|0|TRANSFERASE/TRANSFERSE INHIBITOR","8TS7|Human PI3K p85alpha/p110alpha|X-RAY DIFFRACTION|2.71|Homo sapiens|0|SIGNALING PROTEIN","8TS8|p85alpha/p110alpha heterodimer H1047R mutant|X-RAY DIFFRACTION|2.72|Homo sapiens|0|SIGNALING PROTEIN","8TS9|Human PI3K p85alpha/p110alpha H1047R bound to compound 1|X-RAY DIFFRACTION|2.83|Homo sapiens|0|SIGNALING PROTEIN/INHIBITOR","8TSA|Human PI3K p85alpha/p110alpha H1047R bound to compound 2|X-RAY DIFFRACTION|2.51|Homo sapiens|0|SIGNALING PROTEIN/INHIBITOR","8TSB|Human PI3K p85alpha/p110alpha bound to compound 2|X-RAY DIFFRACTION|3.53|Homo sapiens|0|SIGNALING PROTEIN/INHIBITOR","8TSC|Human PI3K p85alpha/p110alpha H1047R bound to compound 3|X-RAY DIFFRACTION|3.62|Homo sapiens|0|SIGNALING PROTEIN/INHIBITOR","8TSD|Human PI3K p85alpha/p110alpha bound to RLY-2608|X-RAY DIFFRACTION|2.7|Homo sapiens|0|SIGNALING PROTEIN,TRANSFERASE/INHIBITOR","8TU6|CryoEM structure of PI3Kalpha|ELECTRON MICROSCOPY|3.12|Homo sapiens|0|CYTOSOLIC PROTEIN","8TWY|Structure of p110 alpha bound to (S)-1-(4-((2-(4-(4-(2-amino-4-(difluoromethyl)pyrimidin-5-yl)-6-(3-methylmorpholino)-1,3,5- triazin-2-yl)piperazin-1-yl)-2-oxoethoxy)methyl)piperidin-1-yl)prop-2-en-1-one (compound 9)|X-RAY DIFFRACTION|2.67|Homo sapiens|0|TRANSFERASE/Inhibitor","8V8H|PI3Ka H1047R co-crystal structure with inhibitor in cryptic pocket near H1047R (compound 4).|X-RAY DIFFRACTION|3.58|Homo sapiens|0|SIGNALING PROTEIN"]}]}