{"context":{"query":">>uniprot>>signor","source_dataset":"uniprot","target_dataset":"signor"},"stats":{"queried":1,"total":76,"mapped":1},"pagination":{"has_next":false},"schema":"id|entity_a|entity_b|effect|mechanism|direct|score","mappings":[{"input":"P42574","source":"P42574|Caspase-3","targets":["SIGNOR-104585|CASP3|PTCH1|down-regulates activity|cleavage|true|0.32","SIGNOR-106546|CASP3|ROCK1|up-regulates|cleavage|true|0.73","SIGNOR-109243|XIAP|CASP3|down-regulates quantity by destabilization|ubiquitination|true|0.94","SIGNOR-109874|CASP3|STK4|up-regulates activity|cleavage|true|0.62","SIGNOR-109878|CASP3|STK4|up-regulates activity|cleavage|true|0.62","SIGNOR-110837|XIAP|CASP3|down-regulates activity|binding|true|0.94","SIGNOR-112788|CASP3|IKBKB|down-regulates|cleavage|true|0.36","SIGNOR-112792|CASP3|IKBKB|down-regulates|cleavage|true|0.36","SIGNOR-112796|CASP3|IKBKB|down-regulates|cleavage|true|0.36","SIGNOR-112800|CASP3|IKBKB|down-regulates|cleavage|true|0.36","SIGNOR-116178|CASP3|PARP1|down-regulates activity|cleavage|true|0.78","SIGNOR-122099|MAPK14|CASP3|down-regulates|phosphorylation|true|0.78","SIGNOR-125956|BIRC6|CASP3|down-regulates|binding|true|0.46","SIGNOR-126727|CASP3|BAD|up-regulates activity|cleavage|true|0.54","SIGNOR-131435|PPP2R5B|CASP3|up-regulates|dephosphorylation|true|0.20","SIGNOR-133264|CASP3|CASP9|up-regulates activity|cleavage|true|0.64","SIGNOR-133267|CASP9|CASP3|up-regulates activity|cleavage|true|0.64","SIGNOR-149420|CASP8|CASP3|up-regulates activity|cleavage|true|0.73","SIGNOR-171767|CASP8|CASP3|up-regulates activity|cleavage|true|0.73","SIGNOR-180144|CASP3|PSIP1|down-regulates|cleavage|true|0.35","SIGNOR-198535|PAC-1|CASP3|up-regulates|chemical activation|true|0.80","SIGNOR-199111|CASP3|PTCH1|down-regulates|cleavage|true|0.32","SIGNOR-252624|CASP3|AKT1|down-regulates activity|cleavage|true|0.60","SIGNOR-254489|ING1|CASP3|up-regulates quantity by expression|transcriptional regulation|false|0.26","SIGNOR-255335|STAT3|CASP3|up-regulates quantity by expression|transcriptional regulation|false|0.46","SIGNOR-255336|CASP3|Muscle_atrophy|up-regulates||false|0.70","SIGNOR-255337|CASP3|Protein_degradation|up-regulates||false|0.70","SIGNOR-256326|CASP3|BRCA1|down-regulates quantity by destabilization|cleavage|true|0.47","SIGNOR-256357|CASP3|GSN|down-regulates activity|cleavage|true|0.64","SIGNOR-256387|CASP3|Caspase 3 complex|form complex|binding|true|0.20","SIGNOR-256448|Caspase 9 complex|CASP3|up-regulates activity|cleavage|true|0.64","SIGNOR-256451|Caspase 8 complex|CASP3|up-regulates activity|cleavage|true|0.73","SIGNOR-256452|Caspase 8 complex|CASP3|up-regulates activity|cleavage|true|0.73","SIGNOR-256458|Caspase 8 complex|CASP3|up-regulates activity|cleavage|true|0.73","SIGNOR-256462|Caspase 9 complex|CASP3|up-regulates activity|cleavage|true|0.64","SIGNOR-256471|Apoptosome|CASP3|up-regulates activity|cleavage|true|0.74","SIGNOR-256472|Apoptosome|CASP3|up-regulates activity|cleavage|true|0.74","SIGNOR-256638|CASP3|Cell_death|up-regulates||false|0.70","SIGNOR-259152|RBM10|CASP3|down-regulates quantity by repression|transcriptional regulation|false|0.20","SIGNOR-260602|CASP3|GORASP1|down-regulates quantity by destabilization|cleavage|true|0.40","SIGNOR-260603|CASP3|GORASP1|down-regulates quantity by destabilization|cleavage|true|0.40","SIGNOR-260604|CASP3|GORASP1|down-regulates quantity by destabilization|cleavage|true|0.40","SIGNOR-260613|CASP3|GORASP1|up-regulates activity|cleavage|true|0.40","SIGNOR-260641|CASP3|GRIPAP1|up-regulates activity|cleavage|true|0.41","SIGNOR-261743|CASP3|PSEN2|up-regulates activity|cleavage|true|0.41","SIGNOR-261749|CASP3|PSEN2|up-regulates activity|cleavage|true|0.41","SIGNOR-261756|CASP3|PSEN1|up-regulates activity|cleavage|true|0.45","SIGNOR-261942|MYCT1|CASP3|up-regulates activity||false|0.20","SIGNOR-262016|Pac-1|CASP3|up-regulates activity|chemical activation|true|0.80","SIGNOR-262209|ANXA3|CASP3|down-regulates quantity by repression|transcriptional regulation|false|0.26","SIGNOR-263870|CASP3|KDM4C|down-regulates activity|cleavage|true|0.20","SIGNOR-270593|CASP3|MYL3|down-regulates quantity by destabilization|cleavage|true|0.38","SIGNOR-271448|RNF7|CASP3|down-regulates activity|ubiquitination|true|0.20","SIGNOR-271704|BCR-ABL|CASP3|down-regulates activity||false|0.20","SIGNOR-271709|CASP3|RAD51|down-regulates quantity by destabilization|cleavage|true|0.47","SIGNOR-278960|MAPKAPK2|CASP3|up-regulates activity|phosphorylation|true|0.31","SIGNOR-47416|CASP3|DFFA|up-regulates activity|cleavage|true|0.76","SIGNOR-47419|CASP3|DFFB|up-regulates|cleavage|true|0.68","SIGNOR-51652|CASP3|GSN|down-regulates|cleavage|true|0.64","SIGNOR-51936|CASP3|NFKBIA|up-regulates quantity by stabilization|cleavage|true|0.42","SIGNOR-53582|CASP9|CASP3|up-regulates activity|cleavage|true|0.64","SIGNOR-57891|CASP3|SPTAN1|down-regulates|cleavage|true|0.68","SIGNOR-62484|BIRC5|CASP3|down-regulates|binding|true|0.49","SIGNOR-64179|CASP3|CASP6|up-regulates|cleavage|true|0.62","SIGNOR-66860|CASP3|Chromatine_condensation|up-regulates||false|0.70","SIGNOR-66863|CASP3|DNA_fragmentation|up-regulates||false|0.70","SIGNOR-66866|CASP3|Membrane_blebbing|up-regulates||false|0.70","SIGNOR-70800|CASP3|ACIN1|up-regulates|cleavage|true|0.63","SIGNOR-71869|HSPB1|CASP3|down-regulates||false|0.56","SIGNOR-71954|XIAP|CASP3|down-regulates activity|binding|true|0.94","SIGNOR-72347|CASP3|GAS2|up-regulates|cleavage|true|0.45","SIGNOR-72677|CASP3|AKT|down-regulates activity|cleavage|true|0.64","SIGNOR-72882|BIRC5|CASP3|down-regulates|binding|true|0.49","SIGNOR-81808|CASP8|CASP3|up-regulates activity|cleavage|true|0.73","SIGNOR-89244|CASP3|Apoptosis|up-regulates||false|0.70","SIGNOR-90397|CASP3|CASP9|up-regulates activity|cleavage|true|0.64"]}]}