{"context":{"query":">>uniprot>>reactome","source_dataset":"uniprot","target_dataset":"reactome"},"stats":{"queried":6,"total":79,"mapped":6},"pagination":{"has_next":false},"schema":"id|name|tax_id|is_disease_pathway","mappings":[{"input":"P43026","source":"P43026|Growth/differentiation factor 5","targets":["R-HSA-2129379|Molecules associated with elastic fibres|9606|false"]},{"input":"P01137","source":"P01137|Transforming growth factor beta-1 proprotein","targets":["R-HSA-114608|Platelet degranulation |9606|false","R-HSA-168277|Influenza Virus Induced Apoptosis|9606|true","R-HSA-202733|Cell surface interactions at the vascular wall|9606|false","R-HSA-2129379|Molecules associated with elastic fibres|9606|false","R-HSA-2173788|Downregulation of TGF-beta receptor signaling|9606|false","R-HSA-2173789|TGF-beta receptor signaling activates SMADs|9606|false","R-HSA-2173791|TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)|9606|false","R-HSA-3000170|Syndecan interactions|9606|false","R-HSA-3000178|ECM proteoglycans|9606|false","R-HSA-3304356|SMAD2/3 Phosphorylation Motif Mutants in Cancer|9606|true","R-HSA-3642279|TGFBR2 MSI Frameshift Mutants in Cancer|9606|true","R-HSA-3645790|TGFBR2 Kinase Domain Mutants in Cancer|9606|true","R-HSA-3656532|TGFBR1 KD Mutants in Cancer|9606|true","R-HSA-3656535|TGFBR1 LBD Mutants in Cancer|9606|true","R-HSA-381340|Transcriptional regulation of white adipocyte differentiation|9606|false","R-HSA-5689603|UCH proteinases|9606|false","R-HSA-6785807|Interleukin-4 and Interleukin-13 signaling|9606|false","R-HSA-8941855|RUNX3 regulates CDKN1A transcription|9606|false","R-HSA-8941858|Regulation of RUNX3 expression and activity|9606|false","R-HSA-8951936|RUNX3 regulates p14-ARF|9606|false","R-HSA-9839389|TGFBR3 regulates TGF-beta signaling|9606|false"]},{"input":"P84022","source":"P84022|SMAD family member 3","targets":["R-HSA-1181150|Signaling by NODAL|9606|false","R-HSA-1502540|Signaling by Activin|9606|false","R-HSA-2173788|Downregulation of TGF-beta receptor signaling|9606|false","R-HSA-2173789|TGF-beta receptor signaling activates SMADs|9606|false","R-HSA-2173795|Downregulation of SMAD2/3:SMAD4 transcriptional activity|9606|false","R-HSA-2173796|SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription|9606|false","R-HSA-3304356|SMAD2/3 Phosphorylation Motif Mutants in Cancer|9606|true","R-HSA-3311021|SMAD4 MH2 Domain Mutants in Cancer|9606|true","R-HSA-3315487|SMAD2/3 MH2 Domain Mutants in Cancer|9606|true","R-HSA-3656532|TGFBR1 KD Mutants in Cancer|9606|true","R-HSA-5689880|Ub-specific processing proteases|9606|false","R-HSA-8941855|RUNX3 regulates CDKN1A transcription|9606|false","R-HSA-8952158|RUNX3 regulates BCL2L11 (BIM) transcription|9606|false","R-HSA-9008059|Interleukin-37 signaling|9606|false","R-HSA-9013695|NOTCH4 Intracellular Domain Regulates Transcription|9606|false","R-HSA-9615017|FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes|9606|false","R-HSA-9617828|FOXO-mediated transcription of cell cycle genes|9606|false","R-HSA-9735871|SARS-CoV-1 targets host intracellular signalling and regulatory pathways|9606|true","R-HSA-9754189|Germ layer formation at gastrulation|9606|false","R-HSA-9796292|Formation of axial mesoderm|9606|false","R-HSA-9823730|Formation of definitive endoderm|9606|false","R-HSA-9839394|TGFBR3 expression|9606|false"]},{"input":"Q99835","source":"Q99835|Protein smoothened","targets":["R-HSA-373080|Class B/2 (Secretin family receptors)|9606|false","R-HSA-5610787|Hedgehog 'off' state|9606|false","R-HSA-5620922|BBSome-mediated cargo-targeting to cilium|9606|false","R-HSA-5632684|Hedgehog 'on' state|9606|false","R-HSA-5635838|Activation of SMO|9606|false"]},{"input":"O76093","source":"O76093|Fibroblast growth factor 18","targets":["R-HSA-109704|PI3K Cascade|9606|false","R-HSA-1257604|PIP3 activates AKT signaling|9606|false","R-HSA-1839130|Signaling by activated point mutants of FGFR3|9606|true","R-HSA-190322|FGFR4 ligand binding and activation|9606|false","R-HSA-190371|FGFR3b ligand binding and activation|9606|false","R-HSA-190372|FGFR3c ligand binding and activation|9606|false","R-HSA-190375|FGFR2c ligand binding and activation|9606|false","R-HSA-2033519|Activated point mutants of FGFR2|9606|true","R-HSA-2219530|Constitutive Signaling by Aberrant PI3K in Cancer|9606|true","R-HSA-5654221|Phospholipase C-mediated cascade; FGFR2|9606|false","R-HSA-5654227|Phospholipase C-mediated cascade; FGFR3|9606|false","R-HSA-5654228|Phospholipase C-mediated cascade; FGFR4|9606|false","R-HSA-5654695|PI-3K cascade:FGFR2|9606|false","R-HSA-5654699|SHC-mediated cascade:FGFR2|9606|false","R-HSA-5654700|FRS-mediated FGFR2 signaling|9606|false","R-HSA-5654704|SHC-mediated cascade:FGFR3|9606|false","R-HSA-5654706|FRS-mediated FGFR3 signaling|9606|false","R-HSA-5654710|PI-3K cascade:FGFR3|9606|false","R-HSA-5654712|FRS-mediated FGFR4 signaling|9606|false","R-HSA-5654719|SHC-mediated cascade:FGFR4|9606|false","R-HSA-5654720|PI-3K cascade:FGFR4|9606|false","R-HSA-5654727|Negative regulation of FGFR2 signaling|9606|false","R-HSA-5654732|Negative regulation of FGFR3 signaling|9606|false","R-HSA-5654733|Negative regulation of FGFR4 signaling|9606|false","R-HSA-5655253|Signaling by FGFR2 in disease|9606|true","R-HSA-5655332|Signaling by FGFR3 in disease|9606|true","R-HSA-5658623|FGFRL1 modulation of FGFR1 signaling|9606|false","R-HSA-5673001|RAF/MAP kinase cascade|9606|false","R-HSA-6811558|PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling|9606|false"]},{"input":"P20809","source":"P20809|Interleukin-11","targets":["R-HSA-6788467|IL-6-type cytokine receptor ligand interactions|9606|false"]}]}