{"context":{"query":">>uniprot>>reactome","source_dataset":"uniprot","target_dataset":"reactome"},"stats":{"queried":6,"total":45,"mapped":5},"pagination":{"has_next":false},"schema":"id|name|tax_id|is_disease_pathway","mappings":[{"input":"Q13315","source":"Q13315|Serine-protein kinase ATM","targets":["R-HSA-2559586|DNA Damage/Telomere Stress Induced Senescence|9606|false","R-HSA-3371453|Regulation of HSF1-mediated heat shock response|9606|false","R-HSA-349425|Autodegradation of the E3 ubiquitin ligase COP1|9606|false","R-HSA-5685938|HDR through Single Strand Annealing (SSA)|9606|false","R-HSA-5685942|HDR through Homologous Recombination (HRR)|9606|false","R-HSA-5693548|Sensing of DNA Double Strand Breaks|9606|false","R-HSA-5693554|Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)|9606|false","R-HSA-5693565|Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks|9606|false","R-HSA-5693568|Resolution of D-loop Structures through Holliday Junction Intermediates|9606|false","R-HSA-5693571|Nonhomologous End-Joining (NHEJ)|9606|false","R-HSA-5693579|Homologous DNA Pairing and Strand Exchange|9606|false","R-HSA-5693607|Processing of DNA double-strand break ends|9606|false","R-HSA-5693616|Presynaptic phase of homologous DNA pairing and strand exchange|9606|false","R-HSA-6796648|TP53 Regulates Transcription of DNA Repair Genes|9606|false","R-HSA-6803204|TP53 Regulates Transcription of Genes Involved in Cytochrome C Release|9606|false","R-HSA-6803207|TP53 Regulates Transcription of Caspase Activators and Caspases|9606|false","R-HSA-6804756|Regulation of TP53 Activity through Phosphorylation|9606|false","R-HSA-6804757|Regulation of TP53 Degradation|9606|false","R-HSA-6804760|Regulation of TP53 Activity through Methylation|9606|false","R-HSA-69473|G2/M DNA damage checkpoint|9606|false","R-HSA-69541|Stabilization of p53|9606|false","R-HSA-912446|Meiotic recombination|9606|false","R-HSA-9664873|Pexophagy|9606|false","R-HSA-9701192|Defective homologous recombination repair (HRR) due to BRCA1 loss of function|9606|true","R-HSA-9704331|Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function|9606|true","R-HSA-9704646|Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function|9606|true","R-HSA-9709570|Impaired BRCA2 binding to RAD51|9606|true","R-HSA-9709603|Impaired BRCA2 binding to PALB2|9606|true"]},{"input":"P07288","source":"P07288|Prostate-specific antigen","targets":["R-HSA-381426|Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)|9606|false","R-HSA-5625886|Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3|9606|false"]},{"input":"O14746","source":"O14746|Telomerase reverse transcriptase","targets":["R-HSA-171319|Telomere Extension By Telomerase|9606|false","R-HSA-201722|Formation of the beta-catenin:TCF transactivating complex|9606|false","R-HSA-9825895|Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence|9606|false"]},{"input":"P40692","source":"P40692|DNA mismatch repair protein Mlh1","targets":["R-HSA-5358565|Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)|9606|false","R-HSA-5358606|Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)|9606|false","R-HSA-5545483|Defective Mismatch Repair Associated With MLH1|9606|true","R-HSA-5632987|Defective Mismatch Repair Associated With PMS2|9606|true","R-HSA-6796648|TP53 Regulates Transcription of DNA Repair Genes|9606|false","R-HSA-912446|Meiotic recombination|9606|false"]},{"input":"P43246","source":"P43246|DNA mismatch repair protein Msh2","targets":["R-HSA-5358565|Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)|9606|false","R-HSA-5358606|Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)|9606|false","R-HSA-5632927|Defective Mismatch Repair Associated With MSH3|9606|true","R-HSA-5632928|Defective Mismatch Repair Associated With MSH2|9606|true","R-HSA-5632968|Defective Mismatch Repair Associated With MSH6|9606|true","R-HSA-6796648|TP53 Regulates Transcription of DNA Repair Genes|9606|false"]}],"not_found":["Q92826"]}