{"context":{"query":">>uniprot>>pdb","source_dataset":"uniprot","target_dataset":"pdb"},"stats":{"queried":2,"total":66,"mapped":2},"pagination":{"has_next":false},"schema":"id|title|method|resolution|source_organism|chain_count|header","mappings":[{"input":"Q9Y2R2","source":"Q9Y2R2|Tyrosine-protein phosphatase non-receptor type 22","targets":["2P6X|Crystal structure of human tyrosine phosphatase PTPN22|X-RAY DIFFRACTION|1.9|Homo sapiens|0|HYDROLASE","2QCJ|Native Structure of Lyp|X-RAY DIFFRACTION|3|Homo sapiens|0|HYDROLASE","2QCT|Structure of Lyp with inhibitor I-C11|X-RAY DIFFRACTION|2.8|Homo sapiens|0|HYDROLASE","3BRH|Protein Tyrosine Phosphatase PTPN-22 (Lyp) bound to the mono-Phosphorylated Lck active site peptide|X-RAY DIFFRACTION|2.2|Homo sapiens; SYNTHETIC CONSTRUCT|0|HYDROLASE","3H2X|Crystal Structure of The Human Lymphoid Tyrosine Phosphatase Catalytic Domain|X-RAY DIFFRACTION|2.2|Homo sapiens|0|HYDROLASE","3OLR|PTPN22 in complex with consensus phospho-tyrosine peptide 1|X-RAY DIFFRACTION|2.5|Homo sapiens; SYNTHETIC CONSTRUCT|0|HYDROLASE","3OMH|Crystal structure of PTPN22 in complex with SKAP-HOM pTyr75 peptide|X-RAY DIFFRACTION|2.9|Homo sapiens; SYNTHETIC CONSTRUCT|0|HYDROLASE","4J51|Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N04|X-RAY DIFFRACTION|2.3|Homo sapiens|0|HYDROLASE/HYDROLASE INHIBITOR","7AAM|Crystal structure of the F-BAR domain of PSTIPIP1 bound to the CTH domain of the phosphatase LYP|X-RAY DIFFRACTION|2.15|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","9YDM|Targeting PTPN22 at non-orthosteric binding sites - a fragment approach|X-RAY DIFFRACTION|1.99|Homo sapiens|0|IMMUNE SYSTEM","9YG0|Targeting PTPN22 at non-orthosteric binding sites - a fragment approach|X-RAY DIFFRACTION|1.76|Homo sapiens|0|IMMUNE SYSTEM","9YG1|Targeting PTPN22 at non-orthosteric binding sites - a fragment approach|X-RAY DIFFRACTION|1.97|Homo sapiens|0|IMMUNE SYSTEM","9YG2|Targeting PTPN22 at non-orthosteric binding sites - a fragment approach|X-RAY DIFFRACTION|2.26|Homo sapiens|0|IMMUNE SYSTEM","9YG3|Targeting PTPN22 at non-orthosteric binding sites - a fragment approach|X-RAY DIFFRACTION|1.96|Homo sapiens|0|IMMUNE SYSTEM"]},{"input":"P29597","source":"P29597|Non-receptor tyrosine-protein kinase TYK2","targets":["3LXN|Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE","3LXP|Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6|X-RAY DIFFRACTION|1.65|Homo sapiens|0|TRANSFERASE","3NYX|Non-phosphorylated TYK2 JH1 domain with Quinoline-Thiadiazole-Thiophene Inhibitor|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","3NZ0|Non-phosphorylated TYK2 kinase with CMP6|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSFERASE","3ZON|Human TYK2 pseudokinase domain bound to a kinase inhibitor|X-RAY DIFFRACTION|2.15|HOMO SAPIENS|0|TRANSFERASE","4GFO|TYK2 kinase (JH1 domain) with 2,6-DICHLORO-N-(2-OXO-2,5-DIHYDROPYRIDIN-4-YL)BENZAMIDE|X-RAY DIFFRACTION|2.3|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4GIH|Tyk2 (JH1) in complex with 2,6-DICHLORO-N-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}BENZAMIDE|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4GII|Tyk2 (JH1) in complex with 2,6-dichloro-4-cyano-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide|X-RAY DIFFRACTION|2.31|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4GJ2|Tyk2 (JH1) in complex with 2,6-dichloro-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide|X-RAY DIFFRACTION|2.4|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4GJ3|Tyk2 (JH1) in complex with 2,6-dichloro-4-cyano-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","4GVJ|Tyk2 (JH1) in complex with adenosine di-phosphate|X-RAY DIFFRACTION|2.03|Homo sapiens|0|HYDROLASE","4OLI|The pseudokinase/kinase protein from JAK-family member TYK2|X-RAY DIFFRACTION|2.8|Homo sapiens|0|TRANSFERASE","4PO6|Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular peptide|X-RAY DIFFRACTION|1.99|Homo sapiens|0|TRANSFERASE","4PY1|Crystal structure of Tyk2 in complex with compound 15, 6-((2,5-dimethoxyphenyl)thio)-3-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazine|X-RAY DIFFRACTION|2.16|Homo sapiens|0|TRANSFERASE","4WOV|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH BMS-066 AKA 2-METHOXY-N-({6-[3-METHYL-7-(METHYLAMINO)-3,5,8,10-TETRAAZATRICYCLO[7.3.0.0, 6]DODECA-1(9),2(6),4,7,11-PENTAEN-11-YL]PYRIDIN-2-YL}METHY L)ACETAMIDE|X-RAY DIFFRACTION|1.8|Homo sapiens|0|TRANSFERASE/INHIBITOR","5C01|Crystal Structure of kinase|X-RAY DIFFRACTION|2.15|Homo sapiens|0|TRANSFERASE","5C03|Crystal Structure of kinase|X-RAY DIFFRACTION|1.9|Homo sapiens|0|TRANSFERASE","5F1Z|Structure of TYK2 with inhibitor 16: 3-azanyl-5-[(2~{S})-3-methylbutan-2-yl]-7-[1-methyl-5-(2-oxidanylpropan-2-yl)pyrazol-3-yl]-1~{H}-pyrazolo[4,3-c]pyridin-4-one|X-RAY DIFFRACTION|2.65|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5F20|Structure of TYK2 with inhibitor 4: 3-azanyl-5-(2-methylphenyl)-7-(1-methylpyrazol-3-yl)-1~{H}-pyrazolo[4,3-c]pyridin-4-one|X-RAY DIFFRACTION|2.91|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","5TKD|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH 6-[(3,5-DIMETHYLPHE NYL)AMINO]-8- (METHYLAMINO)IMIDAZO[1,2-B]PYRIDAZINE-3-CARBO XAMIDE|X-RAY DIFFRACTION|1.92|Homo sapiens|0|TRANSFERASE","5WAL|Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model|X-RAY DIFFRACTION|2.45|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","6AAM|Crystal structure of TYK2 in complex with peficitinib|X-RAY DIFFRACTION|1.98|Homo sapiens|0|TRANSFERASE/INHIBITOR","6DBK|Tyk2 with compound 8|X-RAY DIFFRACTION|2|Homo sapiens|0|TRANSFERASE","6DBM|Tyk2 with compound 23|X-RAY DIFFRACTION|2.368|Homo sapiens|0|TRANSFERASE","6NSL|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound-6c AKA 6-((1-(4-CYANOPHENY L)-2-OXO-1,2-DIHYDRO-3-PYRIDINYL)AMINO)-N-CYCLOPROPYL-8-(M ETHYLAMINO)IMIDAZO[1,2-B]PYRIDAZINE-3-CARBOXAMIDE|X-RAY DIFFRACTION|2.15|Homo sapiens|0|TRANSFERASE","6NZE|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_5 AKA 4-[(2-CARBAMOYLPHEN YL)AMINO]-6-[(5-FLUOROPYRIDIN-2-YL)AMINO]-N-METHYLPYRIDINE -3-CARBOXAMIDE|X-RAY DIFFRACTION|1.96|Homo sapiens|0|TRANSFERASE","6NZF|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_5 AKA 4-[(2-CARBAMOYLPHEN YL)AMINO]-6-[(5-FLUOROPYRIDIN-2-YL)AMINO]-N-METHYLPYRIDINE -3-CARBOXAMIDE|X-RAY DIFFRACTION|2.39|Homo sapiens|0|TRANSFERASE","6NZH|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_40 AKA 6-cyclopropaneamido-4-[(2-methanesulfonylphenyl)amino]-N-methylpyridine-3-carboxamide|X-RAY DIFFRACTION|2.73|Homo sapiens|0|TRANSFERASE","6NZP|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH COMPOUND-11 AKA 6-CYCLOPROPANEAMIDO-4-{[2-METHOXY-3-(1-METHYL-1H-1,2,4-TRI AZOL-3-YL)PHENYL]AMINO}-N-(?H?)METHYLPYRIDAZINE-3-CARBOXAMIDE|X-RAY DIFFRACTION|2.35|Homo sapiens|0|TRANSFERASE","6NZQ|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_29 AKA 6-[(5-FLUORO-4-METH YLPYRIDIN-2-YL)AMINO]-4-({2-METHOXY-3-[(PYRIDIN-2-YLMETHYL )CARBAMOYL]PHENYL}AMINO)-N-METHYLPYRIDINE-3-CARBOXAMIDE|X-RAY DIFFRACTION|2.11|Homo sapiens|0|TRANSFERASE","6NZR|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_12 AKA 4-[(2-methanesulfonylphenyl)amino]-N-(H3)methyl-6-[(pyridin-2- yl)amino]pyridazine-3-carboxamide|X-RAY DIFFRACTION|2.56|Homo sapiens|0|TRANSFERASE","6OVA|Crystal Structure of TYK2 with novel pyrrolidinone inhibitor|X-RAY DIFFRACTION|2.5|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","6VNS|Crystal structure of TYK2 kinase with compound 13|X-RAY DIFFRACTION|2.09|Homo sapiens|0|TRANSFERASE/INHIBITOR","6VNV|Crystal structure of TYK2 kinase with compound 14|X-RAY DIFFRACTION|2.15|Homo sapiens|0|TRANSFERASE/INHIBITOR","6VNX|Crystal structure of TYK2 kinase with compound 19|X-RAY DIFFRACTION|2.18|Homo sapiens|0|TRANSFERASE/INHIBITOR","6VNY|Crystal structure of TYK2 kinase with compound 10|X-RAY DIFFRACTION|2.3|Homo sapiens|0|TRANSFERASE/INHIBITOR","6X8F|Crystal structure of TYK2 with Compound 11|X-RAY DIFFRACTION|2.15|Homo sapiens|0|TRANSFERASE","6X8G|Crystal structure of TYK2 with Compound 22|X-RAY DIFFRACTION|2.21|Homo sapiens|0|TRANSFERASE","7AX4|Human TYK2 pseudokinase domain (575-869) in complex with 5-(4-Fluoro-phenyl)-2-ureido-thiophene-3-carboxylic acid amide.|X-RAY DIFFRACTION|2.12|Homo sapiens|0|SIGNALING PROTEIN","7K7O|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH COMPOUND-12 AKA:6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(pyrimidin-2-yl)phenyl]amino}-N-methylpyridazine-3-carboxamide|X-RAY DIFFRACTION|2.82|Homo sapiens|0|TRANSFERASE","7K7Q|CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH COMPOUND-12 AKA:6-[(cyclopropanecarbonyl)amino]-4-({3-[6-(dimethylcarbamoyl)pyridazin-3-yl]-2-methoxyphenyl}amino)-N-methylpyridazine-3-carboxamide|X-RAY DIFFRACTION|2.27|Homo sapiens|0|TRANSFERASE","7UYR|Crystal structure of TYK2 kinase domain in complex with compound 12|X-RAY DIFFRACTION|2.15|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","7UYS|Crystal structure of TYK2 kinase domain in complex with compound 16|X-RAY DIFFRACTION|2.15|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","7UYT|Crystal structure of TYK2 kinase domain in complex with compound 25|X-RAY DIFFRACTION|2.14|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","7UYU|Crystal structure of TYK2 kinase domain in complex with compound 30|X-RAY DIFFRACTION|2.05|Homo sapiens|0|TRANSFERASE/TRANSFERASE INHIBITOR","8EXN|Crystal structure of PTP1B D181A/Q262A phosphatase domain with TYK2 activation loop phosphopeptide|X-RAY DIFFRACTION|2.151|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","8EYC|Crystal structure of PTP1B D181A/Q262A/C215A phosphatase domain with TYK2 activation loop phosphopeptide|X-RAY DIFFRACTION|2.99|Homo sapiens; SYNTHETIC CONSTRUCT|0|SIGNALING PROTEIN","8S98|Crystal structure of the TYK2 pseudokinase domain in complex with compound 8|X-RAY DIFFRACTION|1.87|Homo sapiens|0|TRANSFERASE","8S99|Crystal structure of the TYK2 pseudokinase domain in complex with compound 11|X-RAY DIFFRACTION|1.71|Homo sapiens|0|TRANSFERASE","8S9A|Crystal structure of the TYK2 pseudokinase domain in complex with TAK-279|X-RAY DIFFRACTION|1.83|Homo sapiens|0|TRANSFERASE","8TB5|TYK2 JH2 bound to Compound7|X-RAY DIFFRACTION|2.32|Homo sapiens|0|SIGNALING PROTEIN","8TB6|TYK2 JH2 bound to Compound14|X-RAY DIFFRACTION|1.96|Homo sapiens|0|SIGNALING PROTEIN"]}]}