Provide a comprehensive cross-database identifier and functional mapping reference for human IL1B. This should serve as a definitive lookup resource for researchers. ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 1: GENE IDENTIFIERS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Provide ALL gene-level database identifiers: - HGNC ID and approved symbol - Ensembl gene ID (ENSG) - NCBI Entrez Gene ID - OMIM gene/locus ID - Genomic location: chromosome, start position, end position, strand ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 2: TRANSCRIPT IDENTIFIERS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ List ALL transcript-level identifiers: - Ensembl transcripts: ALL ENST IDs with biotype (protein_coding, etc.) How many total transcripts? - RefSeq transcripts: ALL NM_ mRNA accessions Mark which is MANE Select (canonical clinical standard) - CCDS IDs: ALL consensus coding sequence identifiers For the CANONICAL/MANE SELECT transcript: - List ALL exon IDs (ENSE) with genomic coordinates - Total exon count ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 3: PROTEIN IDENTIFIERS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ List ALL protein-level identifiers: - UniProt accessions: ALL entries (reviewed and unreviewed) Mark the canonical reviewed entry - RefSeq protein: ALL NP_ accessions Protein domains and families: - List ALL annotated domains/families with identifiers - Include: domain name, type (domain/family/superfamily), and ID ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 4: STRUCTURE IDENTIFIERS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Experimental structures: - List ALL PDB structure IDs - For each: experimental method (X-ray, NMR, Cryo-EM) and resolution - Total PDB structure count Predicted structures: - AlphaFold model ID and confidence metrics (pLDDT) ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 5: CROSS-SPECIES ORTHOLOGS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ List orthologous genes in key model organisms (where available): - Mouse (Mus musculus): gene ID, symbol - Rat (Rattus norvegicus): gene ID, symbol - Zebrafish (Danio rerio): gene ID, symbol - Fruit fly (Drosophila melanogaster): gene ID, symbol - Worm (C. elegans): gene ID, symbol - Yeast (S. cerevisiae): gene ID, symbol ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 6: CLINICAL VARIANTS & AI PREDICTIONS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Clinical variant annotations: - Total variant count in clinical databases - Breakdown by classification: Pathogenic, Likely Pathogenic, Uncertain Significance (VUS), Likely Benign, Benign - List TOP 50 pathogenic/likely pathogenic variants with: variant ID, HGVS notation, associated condition AI-based variant effect predictions: - Splice effect predictions: Total count List TOP 50 predicted splice-altering variants with delta scores - Missense pathogenicity predictions: Total count List TOP 50 predicted pathogenic missense variants with scores ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 7: BIOLOGICAL PATHWAYS & GENE ONTOLOGY ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Pathway membership: - List ALL biological pathways this gene participates in - Include pathway IDs and names - Total pathway count Gene Ontology annotations: - Biological Process: count and TOP 20 terms with IDs - Molecular Function: count and TOP 20 terms with IDs - Cellular Component: count and TOP 20 terms with IDs ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 8: PROTEIN INTERACTIONS & MOLECULAR NETWORKS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Protein-protein interactions: - Total interaction count - List TOP 50 highest-confidence interacting proteins with scores Protein similarity (evolutionary and structural): - Structural/embedding similarity: How many similar proteins? List TOP 20 with similarity scores - Sequence homology: How many homologous proteins? List TOP 20 with identity/similarity scores ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 9: TRANSCRIPTION FACTOR REGULATORY DATA ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ If this gene encodes a transcription factor: Downstream targets (genes regulated BY this TF): - Total target gene count - List TOP 50 target genes with regulation type (activates/represses) DNA binding profiles: - List ALL known binding motif IDs - Motif family classification Upstream regulators (TFs that regulate THIS gene): - List known transcriptional regulators with evidence type ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 10: DRUG & PHARMACOLOGY DATA ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ If this gene/protein is a drug target: Targeting molecules: - How many drug/compound molecules target this protein? - List TOP 30 molecules by development phase - Include: molecule ID, name, mechanism, highest development phase Clinical trials: - How many clinical trials involve drugs targeting this gene? - List TOP 20 trials with: trial ID, phase, status, intervention Pharmacogenomics: - Known drug-gene interactions affecting drug response - Dosing guidelines if any exist ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 11: EXPRESSION PROFILES ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Tissue expression: - Which tissues express this gene most highly? - List TOP 30 tissues with expression scores/levels - Note any tissue-specific or tissue-enriched patterns Cell type expression: - Which cell types show highest expression? - List TOP 30 cell types with expression scores - Note any cell type-specific patterns Single-cell expression data (if available): - Which single-cell datasets/experiments include this gene? - Notable cell population patterns ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 12: DISEASE ASSOCIATIONS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Mendelian/monogenic disease links: - What diseases are caused by mutations in this gene? - List ALL associated diseases with: disease name, disease ID, inheritance pattern, evidence level Phenotype associations: - What clinical phenotypes are associated with this gene? - List TOP 50 phenotype terms with IDs Complex trait associations (GWAS): - What traits/diseases are linked via genome-wide association studies? - List TOP 30 GWAS associations with: trait, study ID, p-value, effect size if available ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ FORMATTING REQUIREMENTS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ - Present each section with clear headers - Use tables for listing multiple items - Always include COUNTS for every category - For lists with 50 items: show total count + TOP 50 - For lists with

Question

Provide a comprehensive cross-database identifier and functional mapping
reference for human IL1B. This should serve as a definitive
lookup resource for researchers.

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 1: GENE IDENTIFIERS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Provide ALL gene-level database identifiers:
- HGNC ID and approved symbol
- Ensembl gene ID (ENSG)
- NCBI Entrez Gene ID
- OMIM gene/locus ID
- Genomic location: chromosome, start position, end position, strand

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 2: TRANSCRIPT IDENTIFIERS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
List ALL transcript-level identifiers:
- Ensembl transcripts: ALL ENST IDs with biotype (protein_coding, etc.)
  How many total transcripts?
- RefSeq transcripts: ALL NM_ mRNA accessions
  Mark which is MANE Select (canonical clinical standard)
- CCDS IDs: ALL consensus coding sequence identifiers

For the CANONICAL/MANE SELECT transcript:
- List ALL exon IDs (ENSE) with genomic coordinates
- Total exon count

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 3: PROTEIN IDENTIFIERS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
List ALL protein-level identifiers:
- UniProt accessions: ALL entries (reviewed and unreviewed)
  Mark the canonical reviewed entry
- RefSeq protein: ALL NP_ accessions

Protein domains and families:
- List ALL annotated domains/families with identifiers
- Include: domain name, type (domain/family/superfamily), and ID

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 4: STRUCTURE IDENTIFIERS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Experimental structures:
- List ALL PDB structure IDs
- For each: experimental method (X-ray, NMR, Cryo-EM) and resolution
- Total PDB structure count

Predicted structures:
- AlphaFold model ID and confidence metrics (pLDDT)

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 5: CROSS-SPECIES ORTHOLOGS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
List orthologous genes in key model organisms (where available):
- Mouse (Mus musculus): gene ID, symbol
- Rat (Rattus norvegicus): gene ID, symbol
- Zebrafish (Danio rerio): gene ID, symbol
- Fruit fly (Drosophila melanogaster): gene ID, symbol
- Worm (C. elegans): gene ID, symbol
- Yeast (S. cerevisiae): gene ID, symbol

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 6: CLINICAL VARIANTS & AI PREDICTIONS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Clinical variant annotations:
- Total variant count in clinical databases
- Breakdown by classification: Pathogenic, Likely Pathogenic,
  Uncertain Significance (VUS), Likely Benign, Benign
- List TOP 50 pathogenic/likely pathogenic variants with:
  variant ID, HGVS notation, associated condition

AI-based variant effect predictions:
- Splice effect predictions: Total count
  List TOP 50 predicted splice-altering variants with delta scores
- Missense pathogenicity predictions: Total count
  List TOP 50 predicted pathogenic missense variants with scores

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 7: BIOLOGICAL PATHWAYS & GENE ONTOLOGY
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Pathway membership:
- List ALL biological pathways this gene participates in
- Include pathway IDs and names
- Total pathway count

Gene Ontology annotations:
- Biological Process: count and TOP 20 terms with IDs
- Molecular Function: count and TOP 20 terms with IDs
- Cellular Component: count and TOP 20 terms with IDs

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 8: PROTEIN INTERACTIONS & MOLECULAR NETWORKS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Protein-protein interactions:
- Total interaction count
- List TOP 50 highest-confidence interacting proteins with scores

Protein similarity (evolutionary and structural):
- Structural/embedding similarity: How many similar proteins?
  List TOP 20 with similarity scores
- Sequence homology: How many homologous proteins?
  List TOP 20 with identity/similarity scores

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 9: TRANSCRIPTION FACTOR REGULATORY DATA
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
If this gene encodes a transcription factor:

Downstream targets (genes regulated BY this TF):
- Total target gene count
- List TOP 50 target genes with regulation type (activates/represses)

DNA binding profiles:
- List ALL known binding motif IDs
- Motif family classification

Upstream regulators (TFs that regulate THIS gene):
- List known transcriptional regulators with evidence type

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 10: DRUG & PHARMACOLOGY DATA
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
If this gene/protein is a drug target:

Targeting molecules:
- How many drug/compound molecules target this protein?
- List TOP 30 molecules by development phase
- Include: molecule ID, name, mechanism, highest development phase

Clinical trials:
- How many clinical trials involve drugs targeting this gene?
- List TOP 20 trials with: trial ID, phase, status, intervention

Pharmacogenomics:
- Known drug-gene interactions affecting drug response
- Dosing guidelines if any exist

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 11: EXPRESSION PROFILES
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Tissue expression:
- Which tissues express this gene most highly?
- List TOP 30 tissues with expression scores/levels
- Note any tissue-specific or tissue-enriched patterns

Cell type expression:
- Which cell types show highest expression?
- List TOP 30 cell types with expression scores
- Note any cell type-specific patterns

Single-cell expression data (if available):
- Which single-cell datasets/experiments include this gene?
- Notable cell population patterns

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 12: DISEASE ASSOCIATIONS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Mendelian/monogenic disease links:
- What diseases are caused by mutations in this gene?
- List ALL associated diseases with: disease name, disease ID,
  inheritance pattern, evidence level

Phenotype associations:
- What clinical phenotypes are associated with this gene?
- List TOP 50 phenotype terms with IDs

Complex trait associations (GWAS):
- What traits/diseases are linked via genome-wide association studies?
- List TOP 30 GWAS associations with: trait, study ID, p-value,
  effect size if available

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
FORMATTING REQUIREMENTS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
- Present each section with clear headers
- Use tables for listing multiple items
- Always include COUNTS for every category
- For lists with >50 items: show total count + TOP 50
- For lists with <50 items: show ALL items
- Always include database identifiers (IDs), not just names
- Mark canonical/primary/reviewed entries where applicable
- If a section has no data available, state "No data available"
  rather than omitting the section

Accepted Answer

Section 1: Gene Identifiers
DatabaseIdentifierNotes HGNC IDHGNC:5992Approved HGNC SymbolIL1BApproved symbol Gene Nameinterleukin 1 betaOfficial name Ensembl GeneENSG00000125538Human gene NCBI Entrez Gene3553 OMIM147720Gene/locus PharmGKB GenePA29808VIP gene Genomic Location (GRCh38/hg38) AttributeValue Chromosome2 Cytogenetic Band2q14.1 Start Position112,829,751 End Position112,836,816 StrandMinus (-) Genomic AccessionNC_000002.12 Gene Aliases IL-1B
IL1-BETA
IL1F2
IL1beta
Catabolin Gene …

Transcript ID	Biotype	Start	End	Strand
ENST00000263341	protein_coding	112,829,751	112,836,779	-
ENST00000416750	protein_coding	112,832,795	112,836,702	-
ENST00000418817	protein_coding	112,832,699	112,836,816	-
ENST00000432018	protein_coding	112,832,752	112,836,434	-
ENST00000477398	retained_intron	112,835,181	112,836,779	-
ENST00000487639	retained_intron	112,831,136	112,833,575	-
ENST00000491056	protein_coding_CDS_not_defined	112,830,361	112,836,779	-
ENST00000496280	retained_intron	112,832,913	112,836,779	-

Accession	Type	Status	MANE Select
NM_000576	mRNA	REVIEWED	Yes (Canonical)
NP_000567	Protein	REVIEWED	Yes (Canonical)

Exon ID	Start	End	Strand
ENSE00001000625	112,836,708	112,836,779	-
ENSE00003647827	112,835,566	112,835,617	-
ENSE00003508205	112,836,183	112,836,244	-
ENSE00003506405	112,833,374	112,833,575	-
ENSE00003582426	112,832,662	112,832,826	-
ENSE00003615183	112,831,292	112,831,422	-
ENSE00000856835	112,829,751	112,830,573	-

Accession	Status	Name	Length	Mass
P01584	Reviewed (Swiss-Prot)	Interleukin-1 beta	269 aa	30,748 Da
C9JSC2	Unreviewed (TrEMBL)	IL1B isoform	-	-
C9JVK0	Unreviewed (TrEMBL)	IL1B isoform	-	-
C9JWV2	Unreviewed (TrEMBL)	IL1B isoform	-	-

ID	Name	Type
IPR000975	IL-1_fam	Family
IPR003502	IL-1_propep	Domain
IPR008996	IL1/FGF	Homologous_superfamily
IPR020877	IL-1_CS	Conserved_site
PF00340	IL1	Pfam domain
PF02394	IL1_propep	Pfam domain

IL1B Gene Complete Identifier and Functional Mapping Reference

Structured Data Sources

Database	Identifier	Notes
HGNC ID	HGNC:5992	Approved
HGNC Symbol	IL1B	Approved symbol
Gene Name	interleukin 1 beta	Official name
Ensembl Gene	ENSG00000125538	Human gene
NCBI Entrez Gene	3553
OMIM	147720	Gene/locus
PharmGKB Gene	PA29808	VIP gene

Attribute	Value
Chromosome	2
Cytogenetic Band	2q14.1
Start Position	112,829,751
End Position	112,836,816
Strand	Minus (-)
Genomic Accession	NC_000002.12

PDB ID	Method	Resolution	Title
8RYS	X-ray	1.16 Å	Human IL-1beta, unliganded (highest resolution)
5R8Q	X-ray	1.23 Å	Fragment Z2643472210 complex
5R7W	X-ray	1.27 Å	Ground-state model
5R8E	X-ray	1.35 Å	Fragment Z57475877 complex
5R8M	X-ray	1.39 Å	Fragment Z1818332938 complex
5R8F	X-ray	1.41 Å	Fragment Z2377835233 complex
5R8O	X-ray	1.42 Å	Fragment Z1881545321 complex
5R8G	X-ray	1.43 Å	Fragment Z1259086950 complex
5R85	X-ray	1.44 Å	Fragment Z1262246195 complex
6Y8I	X-ray	1.46 Å	Fragment KCL_I013 complex
5R8A	X-ray	1.47 Å	Fragment Z1492796719 complex
5R86	X-ray	1.50 Å	Fragment Z943693514 complex
2NVH	X-ray	1.53 Å	Solvent content determination
1L2H	X-ray	1.54 Å	F42W/W120F mutant
3POK	X-ray	1.70 Å	LBT L3 mutant
4G6M	X-ray	1.81 Å	Complex with gevokizumab Fab
8RYK	X-ray	1.80 Å	Macrocyclic peptide hit complex
8RZB	X-ray	1.84 Å	Covalent DEL hit complex
6Y8M	X-ray	1.90 Å	Fragment bikinin complex
8C3U	X-ray	1.95 Å	Low MW antagonist complex
1I1B	X-ray	2.00 Å	Recombinant human IL-1B
2I1B	X-ray	2.00 Å	Refined at 2.0 Å
4G6J	X-ray	2.03 Å	Canakinumab Fab complex
5BVP	X-ray	2.20 Å	Canakinumab mechanism
1ITB	X-ray	2.50 Å	IL-1R1 complex
6I1B	NMR	-	Solution structure
7I1B	NMR	-	Solution structure
2KH2	NMR	-	scFv-IL-1B complex

Organism	Ensembl Gene ID	Symbol	Biotype
Mouse (Mus musculus)	ENSMUSG00000027398	Il1b	protein_coding
Rat (Rattus norvegicus)	ENSRNOG00000004649	Il1b	protein_coding
Zebrafish (Danio rerio)	ENSDARG00000098700	il1b	protein_coding
Zebrafish (Danio rerio)	ENSDARG00000089383	il1fma	protein_coding

Ensembl ID	Symbol	Biotype
ENSG00000125571	IL37	protein_coding
ENSG00000136688	IL36G	protein_coding
ENSG00000136689	IL1RN	protein_coding
ENSG00000136694	IL36A	protein_coding
ENSG00000136695	IL36RN	protein_coding
ENSG00000136696	IL36B	protein_coding
ENSG00000136697	IL1F10	protein_coding

Classification	Count
Uncertain Significance (VUS)	14
Likely Benign	5
Benign	3
Benign/Likely Benign	1
Risk Factor	1
Association	3
Not Provided/Other	14

ClinVar ID	HGVS	Classification	Review Status
772847	c.100-10C>T	Benign	Multiple submitters
780097	c.138C>T (p.Gly46=)	Benign	Multiple submitters
779077	c.171C>T (p.Tyr57=)	Benign/Likely benign	Multiple submitters
2651287	c.309C>A (p.Ile103=)	Likely benign	Single submitter
916339	c.630G>A (p.Lys210=)	Likely benign	Single submitter
4274894	c.419A>G (p.Tyr140Cys)	Likely benign	Single submitter
14671	g.112836810G>A	Risk factor	No criteria
869137	c.315C>T (p.Phe105=)	Benign; Association	No criteria

ClinVar ID	HGVS Notation	Gene
1049443	c.28G>A (p.Glu10Lys)	IL1B
2210683	c.145C>A (p.Gln49Lys)	IL1B
2258916	c.114C>A (p.Asp38Glu)	IL1B
2260904	c.92A>G (p.Gln31Arg)	IL1B
2267927	c.303A>T (p.Glu101Asp)	IL1B
2392768	c.562G>A (p.Val188Met)	IL1B
2520520	c.160G>A (p.Asp54Asn)	IL1B
2533024	c.238C>T (p.Pro80Ser)	IL1B
3109228	c.364C>G (p.Leu122Val)	IL1B
3109229	c.423A>C (p.Glu141Asp)	IL1B
3109230	c.668A>G (p.Asn223Ser)	IL1B
4274892	c.214G>A (p.Asp72Asn)	IL1B
4274893	c.43T>C (p.Tyr15His)	IL1B
4678545	c.704A>G (p.Asn235Ser)	IL1B

Variant	Effect	Delta Score
2:112830570:CACT:C	acceptor_gain	1.00
2:112830572:CT:C	acceptor_gain	1.00
2:112831290:A:AC	donor_gain	1.00
2:112831291:C:CA	donor_gain	1.00
2:112831420:CCA:C	acceptor_gain	1.00
2:112831421:CA:C	acceptor_gain	1.00
2:112831397:T:C	acceptor_gain	1.00
2:112831288:TTAC:T	donor_loss	1.00
2:112831289:TACCT:T	donor_loss	1.00
2:112831418:CACCA:C	acceptor_gain	1.00
2:112831419:ACCA:A	acceptor_gain	1.00
2:112831423:C:CC	acceptor_gain	1.00
2:112831422:AC:A	acceptor_loss	1.00
2:112831423:CTGAA:C	acceptor_loss	1.00
2:112830569:ACACT:A	acceptor_gain	0.99
2:112830570:CACTC:C	acceptor_gain	0.99
2:112830573:TC:T	acceptor_loss	0.99
2:112830574:C:CC	acceptor_gain	0.99
2:112830574:CT:C	acceptor_loss	0.99
2:112830578:A:T	acceptor_gain	0.99
2:112830580:C:CT	acceptor_gain	1.00
2:112830581:G:T	acceptor_gain	0.99
2:112831421:C:T	acceptor_gain	0.99

Variant	Protein Change	AM Score	Classification
2:112830386:A:G	F262S	0.998	likely_pathogenic
2:112830385:G:C	F262L	0.996	likely_pathogenic
2:112830385:G:T	F262L	0.996	likely_pathogenic
2:112830386:A:C	F262C	0.996	likely_pathogenic
2:112830387:A:C	F262V	0.973	likely_pathogenic
2:112830387:A:T	F262I	0.966	likely_pathogenic
2:112830380:A:C	M264R	0.771	likely_pathogenic
2:112830380:A:T	M264K	0.771	likely_pathogenic
2:112830390:C:G	D261H	0.766	likely_pathogenic
2:112830386:A:T	F262Y	0.751	likely_pathogenic
2:112830395:A:T	I259K	0.748	likely_pathogenic
2:112830389:T:C	D261G	0.733	likely_pathogenic
2:112830388:G:C	D261E	0.721	likely_pathogenic
2:112830388:G:T	D261E	0.721	likely_pathogenic
2:112830389:T:A	D261V	0.694	likely_pathogenic
2:112830384:T:G	T263P	0.689	likely_pathogenic
2:112830395:A:G	I259T	0.687	likely_pathogenic
2:112830380:A:G	M264T	0.672	likely_pathogenic
2:112830395:A:C	I259R	0.670	likely_pathogenic
2:112830393:T:G	T260P	0.668	likely_pathogenic
2:112830397:A:C	D258E	0.663	likely_pathogenic
2:112830397:A:T	D258E	0.663	likely_pathogenic
2:112830373:A:C	F266L	0.658	likely_pathogenic
2:112830375:A:G	F266L	0.658	likely_pathogenic
2:112830377:T:G	Q265P	0.641	likely_pathogenic

Pathway ID	Name	Disease Pathway
R-HSA-9020702	Interleukin-1 signaling	No
R-HSA-448706	Interleukin-1 processing	No
R-HSA-5620971	Pyroptosis	No
R-HSA-5660668	CLEC7A/inflammasome pathway	No
R-HSA-6783783	Interleukin-10 signaling	No
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	No
R-HSA-9660826	Purinergic signaling in leishmaniasis infection	Yes
R-HSA-9960519	CASP4-mediated substrate cleavage	No
R-HSA-9960525	CASP5-mediated substrate cleavage	No

GO ID	Term
GO:0005125	cytokine activity
GO:0005149	interleukin-1 receptor binding
GO:0005178	integrin binding
GO:0019904	protein domain specific binding

GO ID	Term
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005764	lysosome
GO:0005829	cytosol
GO:0030141	secretory granule

GO ID	Term
GO:0001660	fever generation
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0019221	cytokine-mediated signaling pathway
GO:0070498	interleukin-1-mediated signaling pathway
GO:0050729	positive regulation of inflammatory response
GO:0031622	positive regulation of fever generation
GO:0043123	positive regulation of canonical NF-kappaB signal transduction
GO:0045944	positive regulation of transcription by RNA polymerase II
GO:0008284	positive regulation of cell population proliferation
GO:0030335	positive regulation of cell migration
GO:0045766	positive regulation of angiogenesis
GO:0032755	positive regulation of interleukin-6 production
GO:0032757	positive regulation of interleukin-8 production
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0050830	defense response to Gram-positive bacterium
GO:0030593	neutrophil chemotaxis
GO:0042102	positive regulation of T cell proliferation
GO:0002711	positive regulation of T cell mediated immunity
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0046330	positive regulation of JNK cascade
GO:1900745	positive regulation of p38MAPK cascade
GO:0051897	positive regulation of PI3K/AKT signaling
GO:0048143	astrocyte activation
GO:0150078	positive regulation of neuroinflammatory response
GO:0006915	apoptotic process
GO:0097192	extrinsic apoptotic signaling pathway
GO:0032496	response to lipopolysaccharide
GO:0071222	cellular response to lipopolysaccharide

UniProt ID	Gene	Score	Function
P01585	IL1A	999	Interleukin-1 alpha
P14778	IL1R1	999	IL-1 receptor type 1
P01579	IFNG	998	Interferon gamma
P05112	IL4	998	Interleukin-4
P05113	IL5	998	Interleukin-5
P78397	IL1RAP	998	IL-1 receptor accessory protein
P19438	TNFRSF1A	997	TNF receptor 1
Q9NPH3	IL1RAP	997	IL-1 receptor accessory protein
P04141	CSF2	996	GM-CSF
P27930	IL1R2	996	IL-1 receptor type 2 (decoy)
P01375	TNF	993	Tumor necrosis factor
P09919	CSF3	993	G-CSF
P05231	IL6	990	Interleukin-6
P29466	CASP1	988	Caspase-1
O00206	TLR4	984	Toll-like receptor 4
P01583	IL1A	983	Interleukin-1 alpha
P22301	IL10	978	Interleukin-10
P51617	IRAK1	978	IL-1R-associated kinase 1
P08700	IL3	976	Interleukin-3
P01023	A2M	975	Alpha-2-macroglobulin
Q9NR96	TLR9	975	Toll-like receptor 9
P08887	IL6R	974	IL-6 receptor
Q14116	IL18	973	Interleukin-18
P10145	IL8/CXCL8	963	Interleukin-8
P19838	NFKB1	960	NF-kappa-B p105

Interaction ID	Partner	Type	Score
EBI-15560358	IL1RAP	association	0.760
EBI-3861725	IL1RAP	physical association	0.760
EBI-1026319	IL1R1	direct interaction	0.440
EBI-15780895	CASP1	protein cleavage	0.440
EBI-9355788	PKM	phosphorylation	0.440
EBI-6858757	IKBKG	physical association	0.400
EBI-6595549	A2M	proximity	0.270

Partner	System	Notes
CASP1	Affinity Capture-Western	Processing enzyme
GSDMD	Affinity Capture-MS	Gasdermin D
NLRP3	Affinity Capture-Western	Inflammasome
HSP90AA1	Affinity Capture-MS	Chaperone
IL1R1	Reconstituted Complex	Receptor
IL18	Affinity Capture-MS	Co-secreted cytokine
APP	Reconstituted Complex	Amyloid precursor

UniProt ID	Top Similarity	Avg Similarity
P48090	1.0000	0.9916
P51493	1.0000	0.9916
P79182	1.0000	0.9916
Q2HZH0	1.0000	0.9918
Q6PUD2	1.0000	0.9918
P09428	0.9999	0.9923
P21621	0.9999	0.9920
P79162	0.9999	0.9922
P01583 (IL1A)	0.9992	0.9915

UniProt ID	Top Identity	Bitscore
Q2HZH0	100.0%	546
Q6PUD2	100.0%	546
P79182	99.3%	535
P48090	99.3%	536
P51493	98.5%	534
P09428	98.5%	527
P21621	98.5%	519

TF	Regulation	Confidence
NFKB1	Activation	High
RELA	Activation	High
REL	Activation	High
RELB	Activation	High
CEBPB	Activation	High
CREB1	Activation	High
IRF1	Activation	High
IRF4	Activation	High
IRF8	Activation	High
EGR1	Activation	High
FOXO1	Activation	High
NFE2L2	Activation	High
AP1	Unknown	High
JUN	Unknown	High
HIF1A	Unknown	High

TF	Regulation	Confidence
HSF1	Repression	High
KLF4	Repression	High
NR3C1	Repression	High
NFIL3	Repression	High
POU2F1	Repression	High
NFKBIA	Repression	High

Target Gene	Regulation	Function
IL6	Activation	Inflammatory cytokine
VCAM1	Activation	Cell adhesion
SELE	Activation	E-selectin
MMP3	Activation	Matrix metalloproteinase
CTSK	Activation	Cathepsin K
HAS2	Activation	Hyaluronan synthase
SERPINA3	Activation	Serine protease inhibitor
MC1R	Activation	Melanocortin receptor
GDF5	Repression	Growth factor
KRT1	Repression	Keratin
ENPP1	Repression	Phosphodiesterase
DIO1	Repression	Deiodinase

ChEMBL ID	Name	Type	Highest Phase
CHEMBL43452	Pomalidomide	Small molecule	Phase 4 (Approved)
CHEMBL3989927	Iberdomide	Small molecule	Phase 3
CHEMBL3989934	Avadomide	Small molecule	Phase 2
CHEMBL1911626	Preaustinoid A	Small molecule	Phase 0
CHEMBL400514	Berkeleydione	Small molecule	Phase 0

DrugBank ID	Notes
DB00843
DB01017
DB01296
DB05133
DB05260
DB05412
DB05442
DB05470
DB05507
DB05767
DB06168
DB06372
DB10772
DB11994
DB12119
DB12140
DB12899
DB18736

Drug/Class	Clinical Annotations	Variant Annotations
Platinum compounds	300	1138
Bisphosphonates	23	62
Morphine	43	263
Omeprazole	5	183
Lansoprazole	4	90
Rabeprazole	3	86
Sufentanil	12	68
Diclofenac	7	53
Ibuprofen	8	46
Pantoprazole	3	40
Ustekinumab	7	29
Sumatriptan	8	29
Indomethacin	2	13
Rizatriptan	1	12
Naproxen	3	11

Entity A	Entity B	Effect	Mechanism
Caspase 1 complex	IL1B	up-regulates activity	cleavage
NfKb-p65/p50	IL1B	up-regulates quantity	transcriptional
HIF1A	IL1B	up-regulates quantity	transcriptional
IL1B	IL1R1	up-regulates activity	binding
IL1B	IL1RAP	up-regulates	binding
IL1B	IL1R2	down-regulates	binding (decoy)
IL1B	IL6	up-regulates quantity	transcriptional
IL1B	STAT3	up-regulates activity

Rank	Tissue/Cell Type	Score	Quality
1	Periodontal ligament	99.48	Gold
2	Granulocyte	93.93	Gold
3	Monocyte	93.30	Gold
4	Leukocyte	92.97	Gold
5	Mononuclear cell	92.85	Gold
6	Blood	92.04	Gold
7	Bone marrow cell	91.60	Gold
8	Bone marrow	89.22	Gold
9	Cartilage tissue	87.85	Gold
10	Pancreatic ductal cell	86.65	Silver
11	Gall bladder	86.14	Gold
12	Vermiform appendix	86.05	Gold
13	Decidua	85.12	Gold
14	Spleen	83.86	Gold
15	Primordial germ cell	83.69	Gold
16	Urinary bladder mucosa	82.46	Gold
17	Stromal cell of endometrium	81.80	Gold
18	Parietal pleura	81.02	Gold
19	Buccal mucosa cell	81.01	Gold
20	Caecum	80.81	Gold
21	Male germ line stem cell	80.51	Gold
22	Smooth muscle tissue	79.99	Gold
23	Palpebral conjunctiva	79.38	Gold
24	Body of stomach	78.47	Gold
25	Gingival epithelium	78.35	Gold
26	Rectum	77.94	Gold
27	Temporal artery	77.92	Gold
28	Pleura	77.77	Gold
29	Gingiva	77.51	Gold
30	Nasal cavity epithelium	77.09	Gold

Dataset ID	Description	Cells
E-CURD-46	Crohn's disease lesions - anti-TNF resistance	124,518
E-HCAD-1	Ischaemic sensitivity of human tissue	425,435
E-GEOD-149689	COVID-19 vs Influenza immunophenotyping	166,852
E-HCAD-36	Aortic tissue aneurysm analysis	71,332
E-GEOD-135922	Retinal pigment epithelium/choroid	55,571
E-HCAD-6	CD34+ bone marrow hematopoiesis	34,596
E-MTAB-8559	Ovarian cancer ex vivo models	20,982
E-GEOD-130148	Lung Cell Atlas Drop-seq	14,560
E-MTAB-9067	Fetal liver/bone marrow haematopoiesis	5,865
E-GEOD-84465	Glioblastoma infiltrating cells	3,588
E-GEOD-89232	Primary dendritic cells	957
E-CURD-7	Adult breast epithelial cells	867
E-ENAD-21	Breast epithelial cells	867
E-MTAB-6075	LPS/palmitate-stimulated THP-1 macrophages	254

HPO ID	Phenotype	Notes
HP:0012126	Stomach cancer	Association
HP:0001442	Somatic mosaicism
HP:0410067	Increased L-fucose in urine

Study ID	Trait	P-value	Mapped Gene
GCST006656	Dysmenorrheic pain severity	2×10⁻¹⁶	IL1A - IL1B
GCST008751	Gestational age at birth	4×10⁻¹⁴	CKAP2L
GCST005038	Allergic disease (asthma, hay fever, eczema)	2×10⁻¹⁰	IL1B
GCST008362	Birth weight	3×10⁻⁸	IL1A - IL1B
GCST008752	Post-term birth	4×10⁻⁸	CKAP2L

Category	Count
Gene Identifiers	7 databases
Transcripts (Ensembl)	8
RefSeq mRNAs (Human)	1 canonical
CCDS	1
Exons (canonical)	7
UniProt entries	4 (1 reviewed)
Protein domains	6
PDB structures	64
AlphaFold models	1
Orthologs	4 species
Paralogs	7
ClinVar variants	41
SpliceAI predictions	573
AlphaMissense predictions	1,816
GO terms	99
Reactome pathways	9
STRING interactions	8,488
IntAct interactions	16
BioGRID interactions	60
ChEMBL molecules	100+
DrugBank entries	18
PharmGKB drug associations	24
Expression tissues	228
Single-cell datasets	14
GWAS associations	5