Provide a comprehensive cross-database identifier and functional mapping reference for human IL6. This should serve as a definitive lookup resource for researchers. ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 1: GENE IDENTIFIERS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Provide ALL gene-level database identifiers: - HGNC ID and approved symbol - Ensembl gene ID (ENSG) - NCBI Entrez Gene ID - OMIM gene/locus ID - Genomic location: chromosome, start position, end position, strand ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 2: TRANSCRIPT IDENTIFIERS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ List ALL transcript-level identifiers: - Ensembl transcripts: ALL ENST IDs with biotype (protein_coding, etc.) How many total transcripts? - RefSeq transcripts: ALL NM_ mRNA accessions Mark which is MANE Select (canonical clinical standard) - CCDS IDs: ALL consensus coding sequence identifiers For the CANONICAL/MANE SELECT transcript: - List ALL exon IDs (ENSE) with genomic coordinates - Total exon count ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 3: PROTEIN IDENTIFIERS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ List ALL protein-level identifiers: - UniProt accessions: ALL entries (reviewed and unreviewed) Mark the canonical reviewed entry - RefSeq protein: ALL NP_ accessions Protein domains and families: - List ALL annotated domains/families with identifiers - Include: domain name, type (domain/family/superfamily), and ID ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 4: STRUCTURE IDENTIFIERS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Experimental structures: - List ALL PDB structure IDs - For each: experimental method (X-ray, NMR, Cryo-EM) and resolution - Total PDB structure count Predicted structures: - AlphaFold model ID and confidence metrics (pLDDT) ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 5: CROSS-SPECIES ORTHOLOGS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ List orthologous genes in key model organisms (where available): - Mouse (Mus musculus): gene ID, symbol - Rat (Rattus norvegicus): gene ID, symbol - Zebrafish (Danio rerio): gene ID, symbol - Fruit fly (Drosophila melanogaster): gene ID, symbol - Worm (C. elegans): gene ID, symbol - Yeast (S. cerevisiae): gene ID, symbol ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 6: CLINICAL VARIANTS & AI PREDICTIONS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Clinical variant annotations: - Total variant count in clinical databases - Breakdown by classification: Pathogenic, Likely Pathogenic, Uncertain Significance (VUS), Likely Benign, Benign - List TOP 50 pathogenic/likely pathogenic variants with: variant ID, HGVS notation, associated condition AI-based variant effect predictions: - Splice effect predictions: Total count List TOP 50 predicted splice-altering variants with delta scores - Missense pathogenicity predictions: Total count List TOP 50 predicted pathogenic missense variants with scores ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 7: BIOLOGICAL PATHWAYS & GENE ONTOLOGY ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Pathway membership: - List ALL biological pathways this gene participates in - Include pathway IDs and names - Total pathway count Gene Ontology annotations: - Biological Process: count and TOP 20 terms with IDs - Molecular Function: count and TOP 20 terms with IDs - Cellular Component: count and TOP 20 terms with IDs ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 8: PROTEIN INTERACTIONS & MOLECULAR NETWORKS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Protein-protein interactions: - Total interaction count - List TOP 50 highest-confidence interacting proteins with scores Protein similarity (evolutionary and structural): - Structural/embedding similarity: How many similar proteins? List TOP 20 with similarity scores - Sequence homology: How many homologous proteins? List TOP 20 with identity/similarity scores ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 9: TRANSCRIPTION FACTOR REGULATORY DATA ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ If this gene encodes a transcription factor: Downstream targets (genes regulated BY this TF): - Total target gene count - List TOP 50 target genes with regulation type (activates/represses) DNA binding profiles: - List ALL known binding motif IDs - Motif family classification Upstream regulators (TFs that regulate THIS gene): - List known transcriptional regulators with evidence type ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 10: DRUG & PHARMACOLOGY DATA ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ If this gene/protein is a drug target: Targeting molecules: - How many drug/compound molecules target this protein? - List TOP 30 molecules by development phase - Include: molecule ID, name, mechanism, highest development phase Clinical trials: - How many clinical trials involve drugs targeting this gene? - List TOP 20 trials with: trial ID, phase, status, intervention Pharmacogenomics: - Known drug-gene interactions affecting drug response - Dosing guidelines if any exist ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 11: EXPRESSION PROFILES ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Tissue expression: - Which tissues express this gene most highly? - List TOP 30 tissues with expression scores/levels - Note any tissue-specific or tissue-enriched patterns Cell type expression: - Which cell types show highest expression? - List TOP 30 cell types with expression scores - Note any cell type-specific patterns Single-cell expression data (if available): - Which single-cell datasets/experiments include this gene? - Notable cell population patterns ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 12: DISEASE ASSOCIATIONS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Mendelian/monogenic disease links: - What diseases are caused by mutations in this gene? - List ALL associated diseases with: disease name, disease ID, inheritance pattern, evidence level Phenotype associations: - What clinical phenotypes are associated with this gene? - List TOP 50 phenotype terms with IDs Complex trait associations (GWAS): - What traits/diseases are linked via genome-wide association studies? - List TOP 30 GWAS associations with: trait, study ID, p-value, effect size if available ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ FORMATTING REQUIREMENTS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ - Present each section with clear headers - Use tables for listing multiple items - Always include COUNTS for every category - For lists with 50 items: show total count + TOP 50 - For lists with

Question

Provide a comprehensive cross-database identifier and functional mapping
reference for human IL6. This should serve as a definitive
lookup resource for researchers.

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 1: GENE IDENTIFIERS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Provide ALL gene-level database identifiers:
- HGNC ID and approved symbol
- Ensembl gene ID (ENSG)
- NCBI Entrez Gene ID
- OMIM gene/locus ID
- Genomic location: chromosome, start position, end position, strand

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 2: TRANSCRIPT IDENTIFIERS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
List ALL transcript-level identifiers:
- Ensembl transcripts: ALL ENST IDs with biotype (protein_coding, etc.)
  How many total transcripts?
- RefSeq transcripts: ALL NM_ mRNA accessions
  Mark which is MANE Select (canonical clinical standard)
- CCDS IDs: ALL consensus coding sequence identifiers

For the CANONICAL/MANE SELECT transcript:
- List ALL exon IDs (ENSE) with genomic coordinates
- Total exon count

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 3: PROTEIN IDENTIFIERS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
List ALL protein-level identifiers:
- UniProt accessions: ALL entries (reviewed and unreviewed)
  Mark the canonical reviewed entry
- RefSeq protein: ALL NP_ accessions

Protein domains and families:
- List ALL annotated domains/families with identifiers
- Include: domain name, type (domain/family/superfamily), and ID

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 4: STRUCTURE IDENTIFIERS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Experimental structures:
- List ALL PDB structure IDs
- For each: experimental method (X-ray, NMR, Cryo-EM) and resolution
- Total PDB structure count

Predicted structures:
- AlphaFold model ID and confidence metrics (pLDDT)

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 5: CROSS-SPECIES ORTHOLOGS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
List orthologous genes in key model organisms (where available):
- Mouse (Mus musculus): gene ID, symbol
- Rat (Rattus norvegicus): gene ID, symbol
- Zebrafish (Danio rerio): gene ID, symbol
- Fruit fly (Drosophila melanogaster): gene ID, symbol
- Worm (C. elegans): gene ID, symbol
- Yeast (S. cerevisiae): gene ID, symbol

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 6: CLINICAL VARIANTS & AI PREDICTIONS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Clinical variant annotations:
- Total variant count in clinical databases
- Breakdown by classification: Pathogenic, Likely Pathogenic,
  Uncertain Significance (VUS), Likely Benign, Benign
- List TOP 50 pathogenic/likely pathogenic variants with:
  variant ID, HGVS notation, associated condition

AI-based variant effect predictions:
- Splice effect predictions: Total count
  List TOP 50 predicted splice-altering variants with delta scores
- Missense pathogenicity predictions: Total count
  List TOP 50 predicted pathogenic missense variants with scores

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 7: BIOLOGICAL PATHWAYS & GENE ONTOLOGY
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Pathway membership:
- List ALL biological pathways this gene participates in
- Include pathway IDs and names
- Total pathway count

Gene Ontology annotations:
- Biological Process: count and TOP 20 terms with IDs
- Molecular Function: count and TOP 20 terms with IDs
- Cellular Component: count and TOP 20 terms with IDs

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 8: PROTEIN INTERACTIONS & MOLECULAR NETWORKS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Protein-protein interactions:
- Total interaction count
- List TOP 50 highest-confidence interacting proteins with scores

Protein similarity (evolutionary and structural):
- Structural/embedding similarity: How many similar proteins?
  List TOP 20 with similarity scores
- Sequence homology: How many homologous proteins?
  List TOP 20 with identity/similarity scores

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 9: TRANSCRIPTION FACTOR REGULATORY DATA
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
If this gene encodes a transcription factor:

Downstream targets (genes regulated BY this TF):
- Total target gene count
- List TOP 50 target genes with regulation type (activates/represses)

DNA binding profiles:
- List ALL known binding motif IDs
- Motif family classification

Upstream regulators (TFs that regulate THIS gene):
- List known transcriptional regulators with evidence type

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 10: DRUG & PHARMACOLOGY DATA
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
If this gene/protein is a drug target:

Targeting molecules:
- How many drug/compound molecules target this protein?
- List TOP 30 molecules by development phase
- Include: molecule ID, name, mechanism, highest development phase

Clinical trials:
- How many clinical trials involve drugs targeting this gene?
- List TOP 20 trials with: trial ID, phase, status, intervention

Pharmacogenomics:
- Known drug-gene interactions affecting drug response
- Dosing guidelines if any exist

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 11: EXPRESSION PROFILES
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Tissue expression:
- Which tissues express this gene most highly?
- List TOP 30 tissues with expression scores/levels
- Note any tissue-specific or tissue-enriched patterns

Cell type expression:
- Which cell types show highest expression?
- List TOP 30 cell types with expression scores
- Note any cell type-specific patterns

Single-cell expression data (if available):
- Which single-cell datasets/experiments include this gene?
- Notable cell population patterns

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 12: DISEASE ASSOCIATIONS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Mendelian/monogenic disease links:
- What diseases are caused by mutations in this gene?
- List ALL associated diseases with: disease name, disease ID,
  inheritance pattern, evidence level

Phenotype associations:
- What clinical phenotypes are associated with this gene?
- List TOP 50 phenotype terms with IDs

Complex trait associations (GWAS):
- What traits/diseases are linked via genome-wide association studies?
- List TOP 30 GWAS associations with: trait, study ID, p-value,
  effect size if available

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
FORMATTING REQUIREMENTS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
- Present each section with clear headers
- Use tables for listing multiple items
- Always include COUNTS for every category
- For lists with >50 items: show total count + TOP 50
- For lists with <50 items: show ALL items
- Always include database identifiers (IDs), not just names
- Mark canonical/primary/reviewed entries where applicable
- If a section has no data available, state "No data available"
  rather than omitting the section

Accepted Answer

IL6 (Interleukin-6) - Comprehensive Cross-Database Identifier and Functional Mapping Reference
Section 1: Gene Identifiers
DatabaseIdentifierDetails HGNCHGNC:6018Approved symbol: IL6 Approved Nameinterleukin 6 Previous SymbolsIFNB2 Previous Namesinterleukin 6 (interferon, beta 2) AliasesIL-6, BSF2, HGF, HSF Ensembl GeneENSG00000136244 NCBI Entrez Gene3569 OMIM147620 Locus Typeprotein-coding gene Gene GroupsInterleukins, Interleukin 6 type cytokine family StatusApproved Genomic Location …

Attribute	Value
Chromosome	7
Cytogenetic Band	7p15.3
Start Position	22,725,884
End Position	22,732,002
Strand	+ (positive)
Genome Assembly	GRCh38/hg38
Genomic Accession	NC_000007.14

Transcript ID	Biotype	Start	End	Strand	UTR5	UTR3
ENST00000258743	protein_coding	22,727,200	22,731,998	+	22727200-22727262	22731574-22731998
ENST00000401630	protein_coding	22,727,224	22,731,729	+	22727224-22727262	22731574-22731729
ENST00000401651	protein_coding	22,727,147	22,729,803	+	22728693-22728710	22729787-22729803
ENST00000404625	protein_coding	22,725,884	22,732,002	+	22727179-22727262	22731574-22732002
ENST00000406575	protein_coding	22,727,240	22,729,815	+	22727240-22727262	22729787-22729815
ENST00000407492	protein_coding	22,727,214	22,732,002	+	22728693-22728710	22731574-22732002
ENST00000426291	protein_coding	22,727,147	22,729,647	+	22727147-22727262	N/A
ENST00000464710	retained_intron	22,727,177	22,731,202	+	N/A	N/A
ENST00000485300	protein_coding	22,727,200	22,731,694	+	22727200-22727262	22731574-22731694
ENST00000964192	protein_coding	22,727,198	22,731,988	+	22727198-22727262	22731574-22731988

Exon ID	Start	End	Strand	Chromosome
ENSE00003846286	22,727,200	22,727,281	+	7
ENSE00003892968	22,727,444	22,727,634	+	7
ENSE00003681793	22,728,693	22,728,806	+	7
ENSE00003614837	22,729,514	22,729,660	+	7
ENSE00001128385	22,731,406	22,731,998	+	7

UniProt ID	Status	Name
P05231	Reviewed (Swiss-Prot)	Interleukin-6 (Canonical)
A0A8Q3SJL1	Unreviewed
B4DNV3	Unreviewed
B5MC14	Unreviewed
B5MC21	Unreviewed
B5MCZ3	Unreviewed
C9J5B0	Unreviewed
Q75MH2	Unreviewed

Attribute	Value
Primary Name	Interleukin-6
Alternative Names	B-cell stimulatory factor 2, CTL differentiation factor, Hybridoma growth factor, Interferon beta-2
Sequence Length	212 amino acids
Molecular Mass	23,718 Da

IL6 Gene Complete Identifier and Functional Mapping Reference

Structured Data Sources

Database	Identifier	Details
HGNC	HGNC:6018	Approved symbol: IL6
Approved Name	interleukin 6
Previous Symbols	IFNB2
Previous Names	interleukin 6 (interferon, beta 2)
Aliases	IL-6, BSF2, HGF, HSF
Ensembl Gene	ENSG00000136244
NCBI Entrez Gene	3569
OMIM	147620
Locus Type	protein-coding gene
Gene Groups	Interleukins, Interleukin 6 type cytokine family
Status	Approved

RefSeq ID	Type	Status	MANE Select
NM_000600	mRNA	REVIEWED	✓ Yes
NM_001318095	mRNA	REVIEWED	No
NM_001371096	mRNA	REVIEWED	No
XM_005249745	mRNA	PREDICTED	No
XM_054358145	mRNA	PREDICTED	No
XM_054358146	mRNA	PREDICTED	No

RefSeq ID	Type	MANE Select
NP_000591	protein	✓ Yes
NP_001305024	protein	No
NP_001358025	protein	No
XP_005249802	predicted_protein	No
XP_054214120	predicted_protein	No
XP_054214121	predicted_protein	No

InterPro ID	Name	Type
IPR003574	IL-6-like	Family
IPR009079	4_helix_cytokine-like_core	Homologous_superfamily
IPR030473	IL6/GCSF/MGF_CS	Conserved_site
IPR030474	IL-6/GCSF/MGF	Family

PDB ID	Title	Method	Resolution (Å)
1ALU	Human Interleukin-6	X-RAY DIFFRACTION	1.9
1IL6	Human Interleukin-6, NMR, minimized average structure	SOLUTION NMR	-
1P9M	Crystal structure of hexameric human IL-6/IL-6R/gp130 complex	X-RAY DIFFRACTION	3.65
2IL6	Human Interleukin-6, NMR, 32 structures	SOLUTION NMR	-
4CNI	Crystal structure of Fab of Olokizumab in complex with IL-6	X-RAY DIFFRACTION	2.2
4J4L	Modular evolution and design of protein binding interface	X-RAY DIFFRACTION	2.3
4NI7	Human IL-6 in complex with modified nucleotide aptamer	X-RAY DIFFRACTION	2.4
4NI9	Human IL-6 in complex with aptamer FORM 2	X-RAY DIFFRACTION	2.55
4O9H	IL-6 in complex with Camelid Fab fragment	X-RAY DIFFRACTION	2.42
4ZS7	Structural mimicry of receptor interaction by antagonistic antibodies	X-RAY DIFFRACTION	2.93
5FUC	Junctional epitope antibody locking IL-6 and gp80	X-RAY DIFFRACTION	2.7
7NXZ	Synthetic glycoform of Human Interleukin 6	X-RAY DIFFRACTION	1.998
8D82	Cryo-EM structure of human IL-6 signaling complex	ELECTRON MICROSCOPY	3.22
8QY5	Structure of interleukin 6	ELECTRON MICROSCOPY	3.1
8QY6	Structure of interleukin 6 (gp130 P496L mutant)	ELECTRON MICROSCOPY	3.16
8YWQ	Fab fragment of anti-IL-6 antibody I9H with IL-6 dimer	X-RAY DIFFRACTION	2.51
8YWR	Fab fragment of anti-IL-6 antibody 68F2 with IL-6 dimer	X-RAY DIFFRACTION	2.93

Organism	Gene Symbol	Ensembl Gene ID	Chromosome	Position
Mouse (Mus musculus)	Il6	ENSMUSG00000025746	5	30,218,112-30,224,979 (+)
Rat (Rattus norvegicus)	Il6	ENSRNOG00000010278	4	5,889,999-5,894,610 (-)
Zebrafish (Danio rerio)	il6	ENSDARG00000102318	-	-
Fruit fly (D. melanogaster)	-	No ortholog identified	-	-
Worm (C. elegans)	-	No ortholog identified	-	-
Yeast (S. cerevisiae)	-	No ortholog identified	-	-

Classification	Count
Pathogenic	0
Likely Pathogenic	0
Uncertain Significance (VUS)	14
Likely Benign	4
Benign	5
Other/Not Provided	2

Variant ID	HGVS Notation	Classification	Review Status
2245276	NM_000600.5(IL6):c.119C>A (p.Ala40Asp)	Uncertain significance	criteria provided, single submitter
2303034	NM_000600.5(IL6):c.620G>C (p.Arg207Thr)	Uncertain significance	criteria provided, single submitter
2406494	NM_000600.5(IL6):c.285G>C (p.Met95Ile)	Uncertain significance	criteria provided, single submitter
2495660	NM_000600.5(IL6):c.168A>C (p.Gln56His)	Likely benign	criteria provided, single submitter
2534860	NM_000600.5(IL6):c.549C>A (p.Asn183Lys)	Uncertain significance	criteria provided, single submitter
3056054	NM_000600.5(IL6):c.603C>T (p.Phe201=)	Benign	no assertion criteria provided
3285905	NM_000600.5(IL6):c.326A>G (p.Glu109Gly)	Uncertain significance	criteria provided, single submitter
3860355	NM_000600.5(IL6):c.533A>C (p.Lys178Thr)	Uncertain significance	criteria provided, single submitter
3860356	NM_000600.5(IL6):c.218A>G (p.Asn73Ser)	Uncertain significance	criteria provided, single submitter
3860357	NM_000600.5(IL6):c.586C>A (p.Arg196Ser)	Uncertain significance	criteria provided, single submitter
4038473	NM_000600.5(IL6):c.422G>T (p.Arg141Ile)	Uncertain significance	criteria provided, single submitter
4038474	NM_000600.5(IL6):c.163A>G (p.Lys55Glu)	Likely benign	criteria provided, single submitter
4275185	NM_000600.5(IL6):c.261A>C (p.Glu87Asp)	Uncertain significance	criteria provided, single submitter
4678713	NM_000600.5(IL6):c.175T>C (p.Tyr59His)	Uncertain significance	criteria provided, single submitter
4678714	NM_000600.5(IL6):c.470A>C (p.Lys157Thr)	Uncertain significance	criteria provided, single submitter
709119	NM_000600.5(IL6):c.91C>A (p.Pro31Thr)	Benign	criteria provided, single submitter
717506	NM_000600.5(IL6):c.183C>T (p.Leu61=)	Likely benign	criteria provided, multiple submitters
768143	NM_000600.5(IL6):c.94C>T (p.Pro32Ser)	Benign	criteria provided, single submitter
777811	NM_000600.5(IL6):c.485A>T (p.Asp162Val)	Benign	criteria provided, multiple submitters
14718	NC_000007.14:g.22727026C>G	Other; risk factor	no assertion criteria provided
14719	NC_000007.14:g.22726602A>G	Benign	no assertion criteria provided

Variant	Gene	Effect	Delta Score
7:22727282:G:GG	IL6	donor_gain	0.99
7:22727279:CAAGT:C	IL6	donor_loss	0.96
7:22727280:AAGT:A	IL6	donor_loss	0.96
7:22727281:AGT:A	IL6	donor_loss	0.96
7:22727283:T:A	IL6	donor_loss	0.96
7:22727279:CAA:C	IL6	donor_gain	0.96
7:22727174:TATA:T	IL6	acceptor_loss	0.95
7:22727176:TA:T	IL6	acceptor_loss	0.95
7:22727177:A:AC	IL6	acceptor_loss	0.95
7:22726053:G:T	IL6	donor_gain	0.93
7:22726256:GAG:G	IL6	donor_gain	0.93
7:22726260:T:A	IL6	donor_loss	0.93
7:22727280:AA:A	IL6	donor_gain	0.93
7:22727277:CACAA:C	IL6	donor_gain	0.90
7:22727278:ACAA:A	IL6	donor_gain	0.90
7:22726261:GAGTA:G	IL6	donor_loss	0.90
7:22726259:G:GG	IL6	donor_gain	0.90
7:22727210:C:CA	IL6	acceptor_gain	0.88
7:22727211:G:GC	IL6	acceptor_gain	0.88
7:22726635:G:GT	IL6	donor_gain	0.86
7:22727172:A:G	IL6	acceptor_gain	0.84
7:22726254:AAGAG:A	IL6	donor_gain	0.81
7:22727177:A:AG	IL6	acceptor_gain	0.81
7:22727178:G:GG	IL6	acceptor_gain	0.81
7:22726262:AGTAG:A	IL6	donor_loss	0.77
7:22727178:GGACT:G	IL6	acceptor_gain	0.76
7:22726145:T:TA	IL6	donor_gain	0.75
7:22726146:A:AA	IL6	donor_gain	0.75
7:22726255:AGAG:A	IL6	donor_gain	0.74
7:22726662:A:G	IL6	donor_gain	0.74
7:22727170:T:G	IL6	acceptor_loss	0.72
7:22726257:AG:A	IL6	donor_gain	0.72
7:22726258:GG:G	IL6	donor_gain	0.72
7:22727173:A:AG	IL6	acceptor_loss	0.71
7:22727168:A:AG	IL6	acceptor_gain	0.70
7:22726723:GAAAC:G	IL6	donor_gain	0.70
7:22727178:GGA:G	IL6	acceptor_gain	0.65
7:22727171:A:AG	IL6	acceptor_gain	0.63
7:22726053:G:GT	IL6	donor_gain	0.63
7:22726724:A:T	IL6	donor_gain	0.62
7:22727219:C:A	IL6	acceptor_gain	0.62
7:22727226:G:T	IL6	acceptor_gain	0.59
7:22726263:G:C	IL6	donor_loss	0.58
7:22727175:ATAG:A	IL6	acceptor_gain	0.55
7:22727139:TGAG:T	IL6	acceptor_gain	0.55
7:22726670:T:TA	IL6	donor_gain	0.56
7:22726671:A:AA	IL6	donor_gain	0.56
7:22726669:G:T	IL6	donor_gain	0.55
7:22726675:T:TG	IL6	donor_gain	0.55
7:22727141:A:T	IL6	acceptor_gain	0.51

Variant	Protein Change	AM Pathogenicity	Classification
7:22727473:G:A	G17R	0.933	likely_pathogenic
7:22727474:G:A	G17E	0.891	likely_pathogenic
7:22727498:C:A	A25D	0.726	likely_pathogenic
7:22727477:T:G	L18R	0.695	likely_pathogenic
7:22727486:T:A	V21E	0.681	likely_pathogenic
7:22727483:T:G	L20R	0.659	likely_pathogenic
7:22727500:T:C	F26L	0.657	likely_pathogenic
7:22727502:C:A	F26L	0.657	likely_pathogenic
7:22727502:C:G	F26L	0.657	likely_pathogenic
7:22727477:T:A	L18Q	0.654	likely_pathogenic
7:22727471:T:A	L16Q	0.631	likely_pathogenic
7:22727471:T:G	L16R	0.631	likely_pathogenic
7:22727477:T:C	L18P	0.628	likely_pathogenic
7:22727480:T:G	L19R	0.609	likely_pathogenic
7:22727464:T:C	F14L	0.600	likely_pathogenic
7:22727466:C:A	F14L	0.600	likely_pathogenic
7:22727466:C:G	F14L	0.600	likely_pathogenic
7:22727473:G:T	G17W	0.595	likely_pathogenic
7:22727480:T:A	L19H	0.585	likely_pathogenic
7:22727449:T:C	F9L	0.550	ambiguous
7:22727451:C:A	F9L	0.550	ambiguous
7:22727451:C:G	F9L	0.550	ambiguous
7:22727459:T:A	V12D	0.519	ambiguous
7:22727471:T:C	L16P	0.454	ambiguous
7:22727480:T:C	L19P	0.452	ambiguous
7:22727495:C:A	A24D	0.450	ambiguous
7:22727483:T:C	L20P	0.432	ambiguous
7:22727461:G:C	A13P	0.406	ambiguous
7:22727498:C:T	A25V	0.405	ambiguous
7:22727497:G:C	A25P	0.398	ambiguous
7:22727465:T:C	F14S	0.380	ambiguous
7:22727492:C:G	P23R	0.379	ambiguous
7:22727501:T:G	F26C	0.343	ambiguous
7:22727492:C:A	P23H	0.341	ambiguous
7:22727465:T:A	F14Y	0.344	ambiguous
7:22727468:C:A	S15Y	0.324	likely_benign
7:22727497:G:A	A25T	0.320	likely_benign
7:22727453:G:A	G10D	0.299	likely_benign
7:22727501:T:C	F26S	0.287	likely_benign
7:22727462:C:T	A13V	0.287	likely_benign
7:22727462:C:A	A13D	0.780	likely_pathogenic
7:22727274:G:A	A13T	0.274	likely_benign

CCDS ID
CCDS5375
CCDS83166
CCDS94066

Pathway ID	Pathway Name	Disease Pathway
R-HSA-1059683	Interleukin-6 signaling	No
R-HSA-110056	MAPK3 (ERK1) activation	No
R-HSA-112411	MAPK1 (ERK2) activation	No
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	No
R-HSA-381426	Regulation of IGF transport and uptake by IGFBPs	No
R-HSA-6783783	Interleukin-10 signaling	No
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	No
R-HSA-8853884	Transcriptional Regulation by VENTX	No
R-HSA-8957275	Post-translational protein phosphorylation	No
R-HSA-9660821	ADORA2B mediated anti-inflammatory cytokines production	Yes
R-HSA-9662834	CD163 mediating an anti-inflammatory response	Yes

GO ID	Term
GO:0006953	acute-phase response
GO:0006954	inflammatory response
GO:0006959	humoral immune response
GO:0007259	cell surface receptor signaling pathway via JAK-STAT
GO:0019221	cytokine-mediated signaling pathway
GO:0070102	interleukin-6-mediated signaling pathway
GO:0002675	positive regulation of acute inflammatory response
GO:0008284	positive regulation of cell population proliferation
GO:0008285	negative regulation of cell population proliferation
GO:0032755	positive regulation of interleukin-6 production
GO:0042102	positive regulation of T cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0050871	positive regulation of B cell activation
GO:0045944	positive regulation of transcription by RNA polymerase II
GO:0043410	positive regulation of MAPK cascade
GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT
GO:0032760	positive regulation of tumor necrosis factor production
GO:0051607	defense response to virus
GO:0097421	liver regeneration
GO:0030168	platelet activation

GO ID	Term
GO:0005125	cytokine activity
GO:0005138	interleukin-6 receptor binding
GO:0008083	growth factor activity
GO:0042802	identical protein binding

GO ID	Term
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005788	endoplasmic reticulum lumen
GO:0005896	interleukin-6 receptor complex

Partner UniProt	Partner Gene	Confidence Score
P05231	IL6 (self)	999
P08887	IL6R	999
P01585	IFNB1	999
P08700	IL3	998
P14778	IL1R1	997
P19438	TNFRSF1A	997
P40189	IL6ST	997
P01584	IL1B	990
P15248	IL9	990
P01375	TNF	989
P22301	IL10	988
P13232	CXCL1	984
P01579	IFNG	982
P05112	IL4	979
P05113	IL5	977
P10145	CXCL8	977
P01583	IL1A	975
P09919	CSF3	972
P29597	TYK2	972
O00206	TLR4	971
P02741	CRP	969
Q16552	IL17A	969
P01730	CD4	967
P40763	STAT3	965
P23458	JAK1	960
P20809	IL11	957
P13500	CCL2	954
O60674	JAK2	953
Q14116	IL18	953
P01023	A2M	950
P04141	CSF2	945
P78397	STAT4	945
P00533	EGFR	943
P19838	NFKB1	943
P42224	STAT1	941
O60603	TLR2	939
P45983	MAPK8	938
P09341	CXCL1	936
P01308	INS	933
P01137	TGFB1	932
P01732	CD8A	931
P05362	ICAM1	931
P14780	MMP9	931
P35225	IL13	930
P35354	PTGS2	927
P81172	TSLP	927
P02768	ALB	926
P02778	CXCL10	924
P01562	IFNA1	923
P21583	SCF	921

Interaction ID	Partner A	Partner B	Type	Confidence
EBI-1036752	IL6	IL6R	physical association	0.910
EBI-25299566	IL6R	IL6	direct interaction	0.910
EBI-52314950	IL6ST	IL6	association	0.840
EBI-64053718	IL6	IL6ST	physical association	0.840
EBI-25299674	IL6	SORL1	direct interaction	0.570
EBI-25396627	SORT1	IL6	direct interaction	0.570
EBI-52312386	IL6	IL6	direct interaction	0.560
EBI-6592703	IL6	ZBTB16	proximity	0.520
EBI-13915421	FAM20C	IL6	phosphorylation reaction	0.440
EBI-64053738	IL6	MUSK	physical association	0.400
EBI-64053678	FCGR3B	IL6	physical association	0.400

UniProt ID	Similarity Count	Top Similarity	Avg Similarity
P26892	50	1.0000	0.9926
P79341	50	1.0000	0.9943
Q2MH06	50	1.0000	0.9924
Q5I6E3	50	1.0000	0.9943
Q6V919	50	1.0000	0.9924
P05231	50	0.9999	0.9944
P29455	50	0.9999	0.9933
P46650	50	0.9999	0.9944
P51494	50	0.9999	0.9945
P54349	50	0.9999	0.9929
Q28319	50	0.9999	0.9930
Q865W7	50	0.9999	0.9942
Q865X6	50	0.9999	0.9941
O02814	50	0.9998	0.9930
Q9TU27	50	0.9998	0.9933
Q28747	50	0.9997	0.9929
P48091	50	0.9997	0.9924
Q865Y2	50	0.9997	0.9926
Q9XT80	50	0.9997	0.9932
P15018	50	0.9996	0.9896

UniProt ID	Identity (%)	Bitscore
Q2MH06	100.0	403
Q6V919	100.0	403
P79341	99.5	401
P26892	99.0	400
Q5I6E3	99.5	400
Q865W7	98.6	405
Q865X6	98.6	403
P51494	98.6	398
P46650	98.1	396
P05231	96.7	388
Q25BC2	95.7	383
P41323	95.7	380
Q9XT80	96.6	382
Q28747	96.6	380
P20607	85.3	362
P08505	85.3	360
Q8MKH0	87.7	350
Q28819	82.1	333
A3FBE9	96.0	330
P26893	82.0	330

Target Gene	Regulation Type
CXCL8	Activation
GCH1	Repression
HAMP	Activation
IL10	Activation
IL1B	Activation
NOS2	Activation
TNF	Activation
VTCN1	Activation

TF Gene	Regulation	Confidence
NFKB1	Activation	High
NFKB	Activation	High
RELA	Activation	High
STAT3	Activation	High
SP1	Activation	High
JUN	Activation	High
JUNB	Activation	High
JUND	Activation	High
FOS	Activation	Low
FOSL1	Activation	High
AP1	Activation	High
CEBPB	Activation	High
CEBPD	Activation	High
CREB1	Activation	High
ATF1	Activation	High
ATF2	Activation	High
ATF3	Activation	High
HIF1A	Activation	Low
HSF1	Activation	High
IRF1	Activation	High
SPI1	Activation	High
KLF4	Activation	High
MEF2A	Activation	High
TP53	Activation	High
TP63	Activation	High
RORC	Activation	High
RBPJ	Activation	High
ESR1	Activation	High
FOXO1	Activation	High
NR3C1	Repression	High
BCL6	Repression	High
BACH1	Repression	High
NFE2L2	Repression	High
STAT1	Repression	High
PRDM1	Repression	High
PPARG	Repression	High
SMAD3	Repression	High
SMAD7	Repression	High
NR1D1	Repression	High
NFAT5	Repression	High
EGR1	Repression	High
CEBPG	Repression	High
REL	Repression	High
DDIT3	Activation	High
GBX2	Activation	High
NKX2-1	Activation	-
NKX6-1	Activation	-
TNF	Activation	-
IL1B	Activation	-
TLR4	Activation	-

Attribute	Value
ChEMBL Target ID	CHEMBL1795129
Target Name	Interleukin-6
Target Type	SINGLE PROTEIN

ChEMBL ID	Name	Type	Highest Development Phase
CHEMBL131	PREDNISOLONE	Small molecule	Phase 4 (Approved)
CHEMBL3137316	FOSDAGROCORAT	Small molecule	Phase 2
CHEMBL3358954	BI 653048	Small molecule	Phase 1
CHEMBL273019	BERGENIN	Small molecule	Natural product (-1)
CHEMBL4648362	GSK789	Unknown	Phase 0
CHEMBL478482	-	Small molecule	Phase 0
CHEMBL2391027	-	Small molecule	Phase 0
CHEMBL3647440-48	Various compounds	Small molecule	Preclinical

PharmGKB ID	Drug Name	Type	Clinical Annotations	Variant Annotations
PA165292659	Tocilizumab	Drug	6	23
PA449515	Etanercept	Drug	15	99
PA452639	Infliximab	Drug	21	128
PA10004	Adalimumab	Drug	18	118
PA164713366	TNF-alpha Inhibitors	Drug Class	122	508
PA451578	Tacrolimus	Drug	82	1120
PA449167	Cyclosporine	Drug	26	157
PA128406956	Fluorouracil	Drug	197	1031
PA449014	Cisplatin	Drug	123	541
PA449383	Docetaxel	Drug	81	247
PA448497	Aspirin	Drug	79	317
PA450085	Irinotecan	Prodrug	54	434
PA450550	Morphine	Drug	43	263
PA451241	Ribavirin	Drug	46	346
PA164749390	Peginterferon alfa-2a	Drug	31	211
PA452618	Opioids	Drug Class	288	1395
PA449599	Fentanyl	Drug	48	252
PA10066	Duloxetine	Drug	73	101
PA449594	Fenofibrate	Drug	17	51
PA451250	Rifampin	Drug	24	182

Attribute	Value
Gene	IL6 (ENSG00000136244)
Species	Homo sapiens
Expression Breadth	Ubiquitous
Total Present Calls	200
Maximum Expression Score	97.93

Anatomical Entity	Expression	Score	Rank
Cartilage tissue	present	97.93	967
Vena cava	present	97.56	1,140
Gall bladder	present	95.33	2,180
Left uterine tube	present	90.82	4,280
Omental fat pad	present	90.73	4,320
Peritoneum	present	90.67	4,350
Primordial germ cell in gonad	present	89.10	5,080
Smooth muscle tissue	present	88.29	5,460
Mucosa of urinary bladder	present	88.17	5,520
Adipose tissue of abdominal region	present	88.10	5,550
Upper lobe of left lung	present	87.97	5,610
Upper lobe of lung	present	86.39	6,350
Islet of Langerhans	present	85.77	6,640
Male germ line stem cell	present	85.43	6,790
Olfactory segment of nasal mucosa	present	85.18	6,910
Vermiform appendix	present	84.69	7,140
Lung	present	82.98	7,940
Trachea	present	81.48	8,640
Ascending aorta	present	81.29	8,720
Thoracic aorta	present	80.79	8,960
Right atrium auricular region	present	80.78	8,960
Pericardium	present	80.09	9,280
Cardiac atrium	present	79.75	9,440
Lower lobe of lung	present	78.93	9,820
Muscle layer of sigmoid colon	present	78.51	10,000
Lymph node	present	78.34	10,100
Caecum	present	78.25	10,100
Seminal vesicle	present	78.19	10,200
Mucosa of stomach	present	77.88	10,300
Rectum	present	76.94	10,800

Dataset ID	Description	Species	Cell Count
E-CURD-10	Single-cell transcriptome profiling for metastatic renal cell carcinoma patient-derived cells and xenografts	Homo sapiens	118
E-MTAB-8142	Single cell RNA-seq of human breast skin cells	Homo sapiens	809,675

HPO ID	Phenotype
HP:0000006	Autosomal dominant inheritance
HP:0001945	Fever
HP:0001369	Arthritis
HP:0002829	Arthralgia
HP:0001386	Joint swelling
HP:0005681	Juvenile rheumatoid arthritis
HP:0001744	Splenomegaly
HP:0002240	Hepatomegaly
HP:0002716	Lymphadenopathy
HP:0002664	Neoplasm
HP:0100726	Kaposi's sarcoma
HP:0001824	Weight loss
HP:0000969	Edema
HP:0000988	Skin rash
HP:0002960	Autoimmunity
HP:0011227	Elevated circulating C-reactive protein concentration
HP:0003565	Elevated erythrocyte sedimentation rate
HP:0003281	Increased circulating ferritin concentration
HP:0000819	Diabetes mellitus
HP:0005978	Type II diabetes mellitus
HP:0000855	Insulin resistance
HP:0003074	Hyperglycemia
HP:0001993	Ketoacidosis
HP:0002591	Polyphagia
HP:0001959	Polydipsia
HP:0000103	Polyuria
HP:0000938	Osteopenia
HP:0001701	Pericarditis
HP:0002202	Pleural effusion
HP:0004890	Elevated pulmonary artery pressure
HP:0002014	Diarrhea
HP:0002027	Abdominal pain
HP:0002037	Inflammation of the large intestine
HP:0100279	Ulcerative colitis
HP:0100280	Crohn's disease
HP:0005214	Intestinal obstruction
HP:0100819	Intestinal fistula
HP:0011107	Recurrent aphthous stomatitis
HP:0032154	Aphthous ulcer
HP:0012122	Anterior uveitis
HP:0000099	Glomerulonephritis
HP:0002408	Cerebral arteriovenous malformation
HP:0033430	Non-infectious meningitis
HP:0001510	Growth delay
HP:0001034	Hypermelanotic macule
HP:0001442	Typified by somatic mosaicism
HP:0010982	Polygenic inheritance
HP:0003584	Late onset
HP:0031819	Increased waist to hip ratio
HP:0410050	Decreased level of 1,5 anhydroglucitol in serum

Study ID	Disease/Trait	Mapped Gene	p-value
GCST006629_9	Pulse pressure	IL6-AS1, STEAP1B, IL6	2×10⁻²⁵
GCST007269_116	Pulse pressure	IL6	2×10⁻¹⁹
GCST010043_154	Asthma	IL6-AS1, IL6, STEAP1B	4×10⁻¹⁴
GCST007614_15	C-reactive protein levels	STEAP1B	8×10⁻¹⁴
GCST000933_2	C-reactive protein	STEAP1B	4×10⁻¹¹
GCST008474_7	Peripheral artery disease	IL6 - MTCYBP42	4×10⁻¹¹
GCST009798_72	Asthma	IL6-AS1, IL6, STEAP1B	3×10⁻¹⁰
GCST007995_51	Asthma (childhood onset)	IL6 - MTCYBP42	5×10⁻¹⁰
GCST008916_85	Asthma	MTCYBP42 - TOMM7	1×10⁻⁹
GCST003425_1	Longevity	IL6	2×10⁻⁹
GCST008362_83	Birth weight	STEAP1B	2×10⁻⁹
GCST008363_65	Offspring birth weight	MTCYBP42 - TOMM7	2×10⁻⁹
GCST002147_24	Fibrinogen	TOMM7	7×10⁻⁹
GCST006575_49	Takayasu arteritis	IL6	7×10⁻⁹
GCST009870_24	Calcific aortic valve stenosis	IL6	1×10⁻⁸
GCST001066_8	Dialysis-related mortality	STEAP1B	4×10⁻⁶
GCST008601_3	Longevity (age >99th percentile)	IL6	1×10⁻⁸
GCST008600_5	Longevity (age >90th percentile)	IL6	5×10⁻⁸
GCST003137_1	Cerebrospinal fluid clusterin levels in APOEe4- carriers	IL6-AS1, STEAP1B, IL6	7×10⁻⁸
GCST007800_15	Asthma (childhood onset)	IL6 - MTCYBP42	3×10⁻⁸
GCST005528_19	Juvenile idiopathic arthritis	MTCYBP42 - TOMM7	3×10⁻⁸
GCST006575_18	Takayasu arteritis	IL6	2×10⁻⁷
GCST009597_173	Multiple sclerosis	IL6 - MTCYBP42	8×10⁻⁷
GCST007798_107	Asthma	IL6 - MTCYBP42	3×10⁻⁶
GCST008363_64	Offspring birth weight	STEAP1B	6×10⁻⁷
GCST007994_10	Asthma (age of onset)	IL6 - MTCYBP42	8×10⁻⁶

Category	Count
Gene Identifiers	7 databases
Ensembl Transcripts	10
RefSeq Transcripts (Human)	6
CCDS IDs	3
Exons (canonical)	5
UniProt Entries	8
Protein Domains	4
PDB Structures	17
Cross-species Orthologs	3
ClinVar Variants	25
SpliceAI Predictions	526
AlphaMissense Predictions	1,395
Reactome Pathways	11
GO Annotations	97
STRING Interactions	9,188
IntAct Interactions	35
ESM2 Similar Proteins	60
DIAMOND Homologs	28
TFs Regulating IL6	169
ChEMBL Targeting Molecules	100+
PharmGKB Drug Associations	45
Tissue Expression Calls	200
HPO Phenotypes	50
GWAS Associations	27