Provide a comprehensive cross-database identifier and functional mapping reference for human MET. This should serve as a definitive lookup resource for researchers. ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 1: GENE IDENTIFIERS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Provide ALL gene-level database identifiers: - HGNC ID and approved symbol - Ensembl gene ID (ENSG) - NCBI Entrez Gene ID - OMIM gene/locus ID - Genomic location: chromosome, start position, end position, strand ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 2: TRANSCRIPT IDENTIFIERS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ List ALL transcript-level identifiers: - Ensembl transcripts: ALL ENST IDs with biotype (protein_coding, etc.) How many total transcripts? - RefSeq transcripts: ALL NM_ mRNA accessions Mark which is MANE Select (canonical clinical standard) - CCDS IDs: ALL consensus coding sequence identifiers For the CANONICAL/MANE SELECT transcript: - List ALL exon IDs (ENSE) with genomic coordinates - Total exon count ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 3: PROTEIN IDENTIFIERS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ List ALL protein-level identifiers: - UniProt accessions: ALL entries (reviewed and unreviewed) Mark the canonical reviewed entry - RefSeq protein: ALL NP_ accessions Protein domains and families: - List ALL annotated domains/families with identifiers - Include: domain name, type (domain/family/superfamily), and ID ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 4: STRUCTURE IDENTIFIERS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Experimental structures: - List ALL PDB structure IDs - For each: experimental method (X-ray, NMR, Cryo-EM) and resolution - Total PDB structure count Predicted structures: - AlphaFold model ID and confidence metrics (pLDDT) ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 5: CROSS-SPECIES ORTHOLOGS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ List orthologous genes in key model organisms (where available): - Mouse (Mus musculus): gene ID, symbol - Rat (Rattus norvegicus): gene ID, symbol - Zebrafish (Danio rerio): gene ID, symbol - Fruit fly (Drosophila melanogaster): gene ID, symbol - Worm (C. elegans): gene ID, symbol - Yeast (S. cerevisiae): gene ID, symbol ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 6: CLINICAL VARIANTS & AI PREDICTIONS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Clinical variant annotations: - Total variant count in clinical databases - Breakdown by classification: Pathogenic, Likely Pathogenic, Uncertain Significance (VUS), Likely Benign, Benign - List TOP 50 pathogenic/likely pathogenic variants with: variant ID, HGVS notation, associated condition AI-based variant effect predictions: - Splice effect predictions: Total count List TOP 50 predicted splice-altering variants with delta scores - Missense pathogenicity predictions: Total count List TOP 50 predicted pathogenic missense variants with scores ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 7: BIOLOGICAL PATHWAYS & GENE ONTOLOGY ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Pathway membership: - List ALL biological pathways this gene participates in - Include pathway IDs and names - Total pathway count Gene Ontology annotations: - Biological Process: count and TOP 20 terms with IDs - Molecular Function: count and TOP 20 terms with IDs - Cellular Component: count and TOP 20 terms with IDs ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 8: PROTEIN INTERACTIONS & MOLECULAR NETWORKS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Protein-protein interactions: - Total interaction count - List TOP 50 highest-confidence interacting proteins with scores Protein similarity (evolutionary and structural): - Structural/embedding similarity: How many similar proteins? List TOP 20 with similarity scores - Sequence homology: How many homologous proteins? List TOP 20 with identity/similarity scores ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 9: TRANSCRIPTION FACTOR REGULATORY DATA ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ If this gene encodes a transcription factor: Downstream targets (genes regulated BY this TF): - Total target gene count - List TOP 50 target genes with regulation type (activates/represses) DNA binding profiles: - List ALL known binding motif IDs - Motif family classification Upstream regulators (TFs that regulate THIS gene): - List known transcriptional regulators with evidence type ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 10: DRUG & PHARMACOLOGY DATA ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ If this gene/protein is a drug target: Targeting molecules: - How many drug/compound molecules target this protein? - List TOP 30 molecules by development phase - Include: molecule ID, name, mechanism, highest development phase Clinical trials: - How many clinical trials involve drugs targeting this gene? - List TOP 20 trials with: trial ID, phase, status, intervention Pharmacogenomics: - Known drug-gene interactions affecting drug response - Dosing guidelines if any exist ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 11: EXPRESSION PROFILES ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Tissue expression: - Which tissues express this gene most highly? - List TOP 30 tissues with expression scores/levels - Note any tissue-specific or tissue-enriched patterns Cell type expression: - Which cell types show highest expression? - List TOP 30 cell types with expression scores - Note any cell type-specific patterns Single-cell expression data (if available): - Which single-cell datasets/experiments include this gene? - Notable cell population patterns ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 12: DISEASE ASSOCIATIONS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Mendelian/monogenic disease links: - What diseases are caused by mutations in this gene? - List ALL associated diseases with: disease name, disease ID, inheritance pattern, evidence level Phenotype associations: - What clinical phenotypes are associated with this gene? - List TOP 50 phenotype terms with IDs Complex trait associations (GWAS): - What traits/diseases are linked via genome-wide association studies? - List TOP 30 GWAS associations with: trait, study ID, p-value, effect size if available ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ FORMATTING REQUIREMENTS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ - Present each section with clear headers - Use tables for listing multiple items - Always include COUNTS for every category - For lists with 50 items: show total count + TOP 50 - For lists with

Question

Provide a comprehensive cross-database identifier and functional mapping
reference for human MET. This should serve as a definitive
lookup resource for researchers.

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 1: GENE IDENTIFIERS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Provide ALL gene-level database identifiers:
- HGNC ID and approved symbol
- Ensembl gene ID (ENSG)
- NCBI Entrez Gene ID
- OMIM gene/locus ID
- Genomic location: chromosome, start position, end position, strand

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 2: TRANSCRIPT IDENTIFIERS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
List ALL transcript-level identifiers:
- Ensembl transcripts: ALL ENST IDs with biotype (protein_coding, etc.)
  How many total transcripts?
- RefSeq transcripts: ALL NM_ mRNA accessions
  Mark which is MANE Select (canonical clinical standard)
- CCDS IDs: ALL consensus coding sequence identifiers

For the CANONICAL/MANE SELECT transcript:
- List ALL exon IDs (ENSE) with genomic coordinates
- Total exon count

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 3: PROTEIN IDENTIFIERS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
List ALL protein-level identifiers:
- UniProt accessions: ALL entries (reviewed and unreviewed)
  Mark the canonical reviewed entry
- RefSeq protein: ALL NP_ accessions

Protein domains and families:
- List ALL annotated domains/families with identifiers
- Include: domain name, type (domain/family/superfamily), and ID

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 4: STRUCTURE IDENTIFIERS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Experimental structures:
- List ALL PDB structure IDs
- For each: experimental method (X-ray, NMR, Cryo-EM) and resolution
- Total PDB structure count

Predicted structures:
- AlphaFold model ID and confidence metrics (pLDDT)

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 5: CROSS-SPECIES ORTHOLOGS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
List orthologous genes in key model organisms (where available):
- Mouse (Mus musculus): gene ID, symbol
- Rat (Rattus norvegicus): gene ID, symbol
- Zebrafish (Danio rerio): gene ID, symbol
- Fruit fly (Drosophila melanogaster): gene ID, symbol
- Worm (C. elegans): gene ID, symbol
- Yeast (S. cerevisiae): gene ID, symbol

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 6: CLINICAL VARIANTS & AI PREDICTIONS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Clinical variant annotations:
- Total variant count in clinical databases
- Breakdown by classification: Pathogenic, Likely Pathogenic,
  Uncertain Significance (VUS), Likely Benign, Benign
- List TOP 50 pathogenic/likely pathogenic variants with:
  variant ID, HGVS notation, associated condition

AI-based variant effect predictions:
- Splice effect predictions: Total count
  List TOP 50 predicted splice-altering variants with delta scores
- Missense pathogenicity predictions: Total count
  List TOP 50 predicted pathogenic missense variants with scores

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 7: BIOLOGICAL PATHWAYS & GENE ONTOLOGY
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Pathway membership:
- List ALL biological pathways this gene participates in
- Include pathway IDs and names
- Total pathway count

Gene Ontology annotations:
- Biological Process: count and TOP 20 terms with IDs
- Molecular Function: count and TOP 20 terms with IDs
- Cellular Component: count and TOP 20 terms with IDs

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 8: PROTEIN INTERACTIONS & MOLECULAR NETWORKS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Protein-protein interactions:
- Total interaction count
- List TOP 50 highest-confidence interacting proteins with scores

Protein similarity (evolutionary and structural):
- Structural/embedding similarity: How many similar proteins?
  List TOP 20 with similarity scores
- Sequence homology: How many homologous proteins?
  List TOP 20 with identity/similarity scores

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 9: TRANSCRIPTION FACTOR REGULATORY DATA
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
If this gene encodes a transcription factor:

Downstream targets (genes regulated BY this TF):
- Total target gene count
- List TOP 50 target genes with regulation type (activates/represses)

DNA binding profiles:
- List ALL known binding motif IDs
- Motif family classification

Upstream regulators (TFs that regulate THIS gene):
- List known transcriptional regulators with evidence type

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 10: DRUG & PHARMACOLOGY DATA
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
If this gene/protein is a drug target:

Targeting molecules:
- How many drug/compound molecules target this protein?
- List TOP 30 molecules by development phase
- Include: molecule ID, name, mechanism, highest development phase

Clinical trials:
- How many clinical trials involve drugs targeting this gene?
- List TOP 20 trials with: trial ID, phase, status, intervention

Pharmacogenomics:
- Known drug-gene interactions affecting drug response
- Dosing guidelines if any exist

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 11: EXPRESSION PROFILES
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Tissue expression:
- Which tissues express this gene most highly?
- List TOP 30 tissues with expression scores/levels
- Note any tissue-specific or tissue-enriched patterns

Cell type expression:
- Which cell types show highest expression?
- List TOP 30 cell types with expression scores
- Note any cell type-specific patterns

Single-cell expression data (if available):
- Which single-cell datasets/experiments include this gene?
- Notable cell population patterns

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 12: DISEASE ASSOCIATIONS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Mendelian/monogenic disease links:
- What diseases are caused by mutations in this gene?
- List ALL associated diseases with: disease name, disease ID,
  inheritance pattern, evidence level

Phenotype associations:
- What clinical phenotypes are associated with this gene?
- List TOP 50 phenotype terms with IDs

Complex trait associations (GWAS):
- What traits/diseases are linked via genome-wide association studies?
- List TOP 30 GWAS associations with: trait, study ID, p-value,
  effect size if available

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
FORMATTING REQUIREMENTS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
- Present each section with clear headers
- Use tables for listing multiple items
- Always include COUNTS for every category
- For lists with >50 items: show total count + TOP 50
- For lists with <50 items: show ALL items
- Always include database identifiers (IDs), not just names
- Mark canonical/primary/reviewed entries where applicable
- If a section has no data available, state "No data available"
  rather than omitting the section

Accepted Answer

Section 1: Gene Identifiers
DatabaseIdentifierNotes HGNC IDHGNC:7029Approved HGNC SymbolMETApproved symbol Ensembl GeneENSG00000105976GRCh38 NCBI Entrez Gene4233 OMIM Gene164860Gene/Locus RefSeq GeneNM_000245MANE Select Genomic Location (GRCh38/hg38) AttributeValue Chromosome7 Cytogenetic Band7q31.2 Start Position116,672,051 End Position116,798,386 Strand+ (Plus/Forward) Gene Length126,335 bp Gene Aliases HGFR (Hepatocyte Growth Factor Receptor)
c-Met
RCCP2
DFNB97
AUTS9
DA11 Gene Groups …

Transcript ID	Biotype	Start	End	Notes
ENST00000318493	protein_coding	116,672,196	116,798,377	Principal isoform
ENST00000397752	protein_coding	116,672,196	116,798,377	Alternative
ENST00000422097	protein_coding	116,672,196	116,769,909	Truncated
ENST00000436117	nonsense_mediated_decay	116,672,196	116,798,377	NMD target
ENST00000454623	protein_coding	116,769,666	116,775,072	Short isoform
ENST00000456159	protein_coding	116,672,390	116,699,599	Short isoform
ENST00000495962	protein_coding_CDS_not_defined	116,724,146	116,755,414
ENST00000917365	protein_coding	116,672,285	116,798,386
ENST00000950406	protein_coding	116,672,051	116,798,375
ENST00000950407	protein_coding	116,672,156	116,798,373

RefSeq ID	Type	Status	MANE Select
NM_000245	mRNA	REVIEWED	✓ Yes
NM_001127500	mRNA	REVIEWED	No
NM_001324401	mRNA	REVIEWED	No
NM_001324402	mRNA	REVIEWED	No

RefSeq ID	Status	MANE Select
NP_000236	REVIEWED	✓ Yes
NP_001120972	REVIEWED	No
NP_001311330	REVIEWED	No
NP_001311331	REVIEWED	No

CCDS ID	Notes
CCDS43636	Consensus CDS
CCDS47689	Consensus CDS

Exon ID	Start	End	Length
ENSE00004014114	116,672,196	116,672,577	382 bp
ENSE00004014119	116,699,071	116,700,284	1,214 bp
ENSE00004014112	116,731,668	116,731,859	192 bp
ENSE00004014102	116,739,950	116,740,084	135 bp
ENSE00004014106	116,740,852	116,741,025	174 bp
ENSE00004014116	116,755,355	116,755,515	161 bp
ENSE00004014113	116,757,437	116,757,539	103 bp
ENSE00004014105	116,757,638	116,757,774	137 bp
ENSE00001619404	116,758,459	116,758,620	162 bp
ENSE00000717765	116,759,337	116,759,490	154 bp
ENSE00000717791	116,763,050	116,763,268	219 bp
ENSE00000717803	116,769,645	116,769,791	147 bp
ENSE00000717811	116,771,498	116,771,654	157 bp
ENSE00000717833	116,771,849	116,771,989	141 bp
ENSE00000717861	116,774,881	116,775,111	231 bp
ENSE00003596200	116,777,389	116,777,469	81 bp
ENSE00003663921	116,778,776	116,778,957	182 bp
ENSE00000717902	116,781,988	116,782,097	110 bp
ENSE00000717928	116,783,304	116,783,469	166 bp
ENSE00000717937	116,795,655	116,795,791	137 bp
ENSE00001898661	116,795,887	116,798,377	2,491 bp

MET Gene Complete Identifier and Functional Mapping Reference

Structured Data Sources

Database	Identifier	Notes
HGNC ID	HGNC:7029	Approved
HGNC Symbol	MET	Approved symbol
Ensembl Gene	ENSG00000105976	GRCh38
NCBI Entrez Gene	4233
OMIM Gene	164860	Gene/Locus
RefSeq Gene	NM_000245	MANE Select

Attribute	Value
Chromosome	7
Cytogenetic Band	7q31.2
Start Position	116,672,051
End Position	116,798,386
Strand	+ (Plus/Forward)
Gene Length	126,335 bp

UniProt ID	Review Status	Name	Notes
P08581	✓ Reviewed (Swiss-Prot)	Hepatocyte growth factor receptor	Canonical
C9JKM5	Unreviewed (TrEMBL)		Isoform
E6Y365	Unreviewed (TrEMBL)		Fragment
H7C130	Unreviewed (TrEMBL)		Isoform

Property	Value
Length	1,390 amino acids
Molecular Mass	155,541 Da
Alternative Names	HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, Tyrosine-protein kinase Met

InterPro ID	Name	Type
IPR000719	Prot_kinase_dom	Domain
IPR001245	Ser-Thr/Tyr_kinase_cat_dom	Domain
IPR001627	Semap_dom	Domain
IPR002165	Plexin_repeat	Repeat
IPR002909	IPT_dom	Domain
IPR008266	Tyr_kinase_AS	Active_site
IPR011009	Kinase-like_dom_sf	Homologous_superfamily
IPR013783	Ig-like_fold	Homologous_superfamily
IPR014756	Ig_E-set	Homologous_superfamily
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR016201	PSI	Domain
IPR016244	Tyr_kinase_HGF/MSP_rcpt	Family
IPR017441	Protein_kinase_ATP_BS	Binding_site
IPR020635	Tyr_kinase_cat_dom	Domain
IPR031148	Plexin	Family
IPR036352	Semap_dom_sf	Homologous_superfamily

PDB ID	Method	Resolution	Description
3DKC	X-ray	1.52 Å	MET kinase with ATP (best resolution)
4R1V	X-ray	1.2 Å	Kinase with pyridazinone inhibitor
3F66	X-ray	1.4 Å	Kinase with quinoxaline inhibitor
3ZCL	X-ray	1.4 Å	Kinase with triazolopyridazine
1R0P	X-ray	1.8 Å	Kinase with K-252a
1R1W	X-ray	1.8 Å	Apo kinase domain
1SHY	X-ray	3.22 Å	HGF-beta/Sema domain complex
1SSL	NMR	-	PSI domain solution structure
7MO7	Cryo-EM	4.8 Å	2:2 c-MET/HGF holo-complex
7MO8	Cryo-EM	4.5 Å	1:1 c-MET/HGF complex
7MO9	Cryo-EM	4.0 Å	c-MET II/HGF I/HGF II sub-complex

PDB ID	Drug/Inhibitor	Resolution
2WGJ	Crizotinib (PF-02341066)	2.0 Å
3RHK	Tivantinib (ARQ 197)	1.94 Å
5EYD	AMG 337	1.85 Å
3LQ8	Foretinib (XL880)	2.02 Å
6SD9	Foretinib	2.35 Å
6SDE	Savolitinib	2.49 Å
8AU3	Tepotinib	2.26 Å
6WVZ	Amivantamab (Fab)	3.1 Å

Property	Value
AlphaFold ID	AF-P08581-F1
Global pLDDT	79.28
Sequence Length	10,929 (includes signal peptide)
Fraction Very High Confidence (pLDDT>90)	0.43 (43%)

Species	Gene ID	Symbol	Genome
Human	ENSG00000105976	MET	homo_sapiens
Mouse (Mus musculus)	ENSMUSG00000009376	Met	mus_musculus
Rat (Rattus norvegicus)	ENSRNOG00000052745	Met	rattus_norvegicus
Zebrafish (Danio rerio)	ENSDARG00000070903	met	danio_rerio
Fruit fly (D. melanogaster)	FBGN0002723	Met	-

Gene	Name
MST1R	Macrophage stimulating 1 receptor (RON)
EGFR	Epidermal growth factor receptor
ERBB2	Erb-b2 receptor tyrosine kinase 2 (HER2)
ERBB3	Erb-b2 receptor tyrosine kinase 3 (HER3)
ERBB4	Erb-b2 receptor tyrosine kinase 4 (HER4)
FGFR1-4	Fibroblast growth factor receptors
KIT	KIT proto-oncogene
PDGFRA/B	Platelet-derived growth factor receptors
RET	RET proto-oncogene
ALK	ALK receptor tyrosine kinase
ROS1	ROS proto-oncogene 1
NTRK1-3	Neurotrophic tyrosine kinases
IGF1R	Insulin-like growth factor 1 receptor
INSR	Insulin receptor

Classification	Count
Pathogenic	6
Likely Pathogenic	2
Uncertain Significance (VUS)	~4,500+
Likely Benign	~50+
Benign	~50+
Conflicting	~30+

ClinVar ID	HGVS Notation	Type	Condition
13882	c.3562G>T (p.Val1188Leu)	Missense	Papillary RCC
13884	c.3682G>A (p.Asp1228Asn)	Missense	Papillary RCC
13889	c.3750G>A (p.Met1250Ile)	Missense	Papillary RCC
13890	c.3731A>G (p.Lys1244Arg)	Missense	Papillary RCC
183686	c.2521T>G (p.Phe841Val)	Missense	Cancer predisposition
998144	c.2855del (p.Phe952fs)	Frameshift

ClinVar ID	HGVS Notation	Type
3384110	c.3503T>G (p.Phe1168Cys)	Missense
376126	c.3749T>C (p.Met1250Thr)	Missense

Variant	Effect	Delta Score
7:116672577:GGTA>G	donor_loss	1.00
7:116672578:GTA>G	donor_loss	1.00
7:116672573:GAAAG>G	donor_gain	0.97
7:116672578:G>GG	donor_gain	0.96
7:116672504:G>GT	donor_gain	0.88
7:116674577:T>G	acceptor_gain	0.85
7:116674575:A>G	acceptor_gain	0.80
7:116674579:T>TA	acceptor_gain	0.79

Pathway ID	Name	Disease Pathway
R-HSA-6806942	MET Receptor Activation	No
R-HSA-8851805	MET activates RAS signaling	No
R-HSA-8851907	MET activates PI3K/AKT signaling	No
R-HSA-8865999	MET activates PTPN11	No
R-HSA-8874081	MET activates PTK2 signaling	No
R-HSA-8875360	InlB-mediated entry of Listeria	Yes
R-HSA-8875513	MET interacts with TNS proteins	No
R-HSA-8875555	MET activates RAP1 and RAC1	No
R-HSA-8875656	MET receptor recycling	No
R-HSA-8875791	MET activates STAT3	No
R-HSA-6807004	Negative regulation of MET activity	No
R-HSA-9734091	Drug-mediated inhibition of MET activation	No
R-HSA-1257604	PIP3 activates AKT signaling	No
R-HSA-5673001	RAF/MAP kinase cascade	No
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	Yes
R-HSA-416550	Sema4D mediated inhibition of cell attachment	No
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT	No
R-HSA-9022699	MECP2 regulates neuronal receptors	No
R-HSA-9825892	Regulation of MITF-M-dependent genes	No

GO ID	Term
GO:0005008	hepatocyte growth factor receptor activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0017154	semaphorin receptor activity
GO:0019903	protein phosphatase binding
GO:0042802	identical protein binding
GO:0140677	molecular function activator activity

GO ID	Term
GO:0048012	hepatocyte growth factor receptor signaling pathway
GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway
GO:0007166	cell surface receptor signaling pathway
GO:0001889	liver development
GO:0031016	pancreas development
GO:0030182	neuron differentiation
GO:0048754	branching morphogenesis of an epithelial tube
GO:0001886	endothelial cell morphogenesis
GO:0010507	negative regulation of autophagy
GO:0045944	positive regulation of transcription by RNA polymerase II
GO:0050918	positive chemotaxis
GO:0060079	excitatory postsynaptic potential
GO:0071526	semaphorin-plexin signaling pathway
GO:1901299	negative regulation of H2O2-mediated programmed cell death
GO:2001028	positive regulation of endothelial cell chemotaxis

GO ID	Term
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0009925	basal plasma membrane
GO:0016020	membrane
GO:0043235	receptor complex
GO:0005576	extracellular region
GO:0098794	postsynapse

UniProt	Gene	Score	Interaction Type
P14210	HGF	999	Ligand (direct)
P08581	MET	999	Homodimerization
P16070	CD44	991	Physical
P29354	SRC	980	Phosphorylation
P00533	EGFR	979	Cross-talk
P40763	STAT3	948	Signaling
P12830	CDH1	944	Complex
P24001	IL1B	921	Signaling
P05109	S100A8	920	Association
P48061	SDF1/CXCL12	902	Signaling
O43157	PLXNB1	899	Semaphorin signaling
P22681	CBL	874	Ubiquitination
P01133	EGF	852	Growth factor
P05231	IL6	852	Cytokine
Q06124	PTPN11/SHP2	810	Phosphatase
P12931	SRC	800	Kinase
P35222	CTNNB1	793	β-catenin
P35968	KDR/VEGFR2	783	RTK cross-talk
P18031	PTPN1	771	Phosphatase
P04637	TP53	769	Tumor suppressor
O60716	CTNND1	767	Catenin

Gene	Interaction Type	Confidence
HGF	Direct interaction (ligand)	0.85
EGFR	Physical association, phosphorylation	0.80
PLXNB1	Physical association	0.78
SRC	Association	0.79
PTK2/FAK	Phosphorylation, physical	0.60
GRB2	Direct interaction	0.44
DNAJA3	Physical association	0.64
InlB (Listeria)	Direct interaction	0.62

UniProt	Gene	Similarity
A0M8R7	MET (other species)	1.000
A0M8S8	MET (other species)	1.000
P16056	MST1R/RON	0.9998
P97523	Met (mouse)	0.9998
Q00PJ8	MET (primate)	0.9997
P06213	INSR	0.9997
P15208	INSR (mouse)	0.9997
Q92854	CD82	0.9995
O60486	PLXNC1	0.9991

UniProt	Gene	Identity	Bit Score
A0M8S8	MET	100%	2803
Q07E37	MET	100%	2803
A0M8R7	MET	99.3%	2784
Q2IBF2	MET	99.7%	2813
P97523	Met (mouse)	95.3%	2674
P16056	MST1R/RON	95.3%	2675
P21860	ERBB3	98.0%	2625

TF	Regulation	Confidence
CTNNB1 (β-catenin)	Activation	High
HIF1A	Activation	High
SP1	Activation	High
SP3	Activation	High
ETS1	Activation	High
SOX10	Activation	High
SMAD2	Activation	High
SMAD3	Activation	High
SMAD4	Activation	High
SMAD7	Activation	High
YBX1	Activation	High
PAX6	Activation	High
NFKB	Activation	High
TP53	Repression	High
FOXP2	Repression	High
EGR1	Repression	High
MYC	Unknown	High
MITF	Unknown	High
PAX3	Unknown	High
AR	Repression	Low
JUN	Activation	Low
RELA	Activation	Low
MACC1	Activation	-
NKX2-1	Repression	-
NME1	Repression	-
PAX5	Activation	-

Property	Value
ChEMBL Target ID	CHEMBL3717
Target Name	Hepatocyte growth factor receptor
Target Type	SINGLE PROTEIN

ChEMBL ID	Drug Name	Type	Specificity
CHEMBL3188267	CAPMATINIB	Small molecule	MET-selective
CHEMBL3402762	TEPOTINIB	Small molecule	MET-selective
CHEMBL601719	CRIZOTINIB	Small molecule	MET/ALK/ROS1
CHEMBL2105717	CABOZANTINIB	Small molecule	Multi-kinase
CHEMBL1983268	ENTRECTINIB	Small molecule	NTRK/ROS1/ALK
CHEMBL1336	SORAFENIB	Small molecule	Multi-kinase
CHEMBL535	SUNITINIB	Small molecule	Multi-kinase
CHEMBL1289926	AXITINIB	Small molecule	VEGFR
CHEMBL477772	PAZOPANIB	Small molecule	Multi-kinase
CHEMBL24828	VANDETANIB	Small molecule	Multi-kinase
CHEMBL502835	NINTEDANIB	Small molecule	Multi-kinase
CHEMBL1289494	TIVOZANIB	Small molecule	VEGFR
CHEMBL553	ERLOTINIB	Small molecule	EGFR
CHEMBL939	GEFITINIB	Small molecule	EGFR
CHEMBL1173655	AFATINIB	Small molecule	EGFR/HER2
CHEMBL180022	NERATINIB	Small molecule	HER2
CHEMBL288441	BOSUTINIB	Small molecule	BCR-ABL/SRC
CHEMBL2403108	CERITINIB	Small molecule	ALK
CHEMBL3545311	BRIGATINIB	Small molecule	ALK
CHEMBL4113131	ENSARTINIB	Small molecule	ALK
CHEMBL1287853	FEDRATINIB	Small molecule	JAK2
CHEMBL2028663	DABRAFENIB	Small molecule	BRAF
CHEMBL189963	PALBOCICLIB	Small molecule	CDK4/6
CHEMBL608533	MIDOSTAURIN	Small molecule	FLT3
CHEMBL1852688	INFIGRATINIB	Small molecule	FGFR

ChEMBL ID	Drug Name	Notes
CHEMBL3334567	SAVOLITINIB	MET-selective
CHEMBL2103882	TIVANTINIB	MET inhibitor
CHEMBL1091644	LINSITINIB	IGF1R/INSR
CHEMBL1230609	FORETINIB	MET/VEGFR2
CHEMBL3989926	SITRAVATINIB	Multi-kinase

Property	Value
Expression Breadth	Ubiquitous
Total Present Calls	270 tissues/cell types
Max Expression Score	98.73

Rank	Tissue/Cell Type	Score	Quality
1	Pigmented layer of retina	98.73	Gold
2	Germinal epithelium of ovary	98.72	Gold
3	Cartilage tissue	97.18	Gold
4	Parietal pleura	96.61	Gold
5	Calcaneal tendon	96.28	Gold
6	Middle temporal gyrus	96.11	Gold
7	Bronchial epithelial cell	95.94	Gold
8	Pleura	95.79	Gold
9	Visceral pleura	94.85	Gold
10	Epithelium of bronchus	94.76	Gold
11	Nephron tubule	94.73	Gold
12	Bronchus	94.36	Gold
13	Nasal cavity epithelium	93.93	Gold
14	Pancreatic ductal cell	93.69	Gold
15	Mucosa of paranasal sinus	93.55	Gold
16	Gluteal muscle	93.39	Gold
17	Mucosa of sigmoid colon	93.34	Gold
18	Colonic mucosa	92.53	Gold
19	Biceps brachii	92.28	Gold
20	Placenta	92.28	Gold
21	Lower lobe of lung	92.20	Gold
22	Epithelial cell of pancreas	92.16	Gold
23	Skin of hip	92.14	Gold
24	Palpebral conjunctiva	92.10	Gold
25	Mucosa of urinary bladder	92.08	Gold
26	Tendon	92.00	Gold
27	Kidney epithelium	91.39	Gold
28	Seminal vesicle	91.38	Gold
29	Amniotic fluid	91.31	Gold
30	Gingival epithelium	91.12	Gold

Disease	OMIM	Inheritance	Evidence
Hereditary papillary renal cell carcinoma	605074	AD	Definitive
Autosomal recessive nonsyndromic hearing loss 97 (DFNB97)	616705	AR	Strong
Osteofibrous dysplasia	607278	AD	Limited
Arthrogryposis, distal, type 2A11	620019	AD	Limited

Orphanet ID	Disease	Type
47044	Hereditary papillary renal cell carcinoma	Disease
319298	Papillary renal cell carcinoma	Disease
33402	Pediatric hepatocellular carcinoma	Disease
488265	Osteofibrous dysplasia	Disease
90636	Rare AR non-syndromic sensorineural deafness DFNB	Subtype

Trait	Study ID	P-value	Notes
Lung function (FEV1/FVC)	GCST007431	4×10⁻¹²	Strong
PR segment duration	GCST002456	5×10⁻¹²	Cardiac
Age at first sexual intercourse	GCST90000047	4×10⁻¹⁰	Behavioral
Alanine aminotransferase levels	GCST90011898	1×10⁻⁹	Liver
Gamma glutamyl transferase levels	GCST011349	1×10⁻⁹	Liver
Triglyceride levels	GCST004237	5×10⁻⁹	Lipids
Resting heart rate	GCST003818	7×10⁻⁹	Cardiac
Waist-to-hip ratio (BMI adj)	GCST005956	5×10⁻⁹	Metabolic
Pulse pressure	GCST007269	3×10⁻⁸	Cardiac
Triglycerides	GCST002216	2×10⁻⁸	Lipids
Heel bone mineral density	GCST012489	2×10⁻⁸	Bone
Medication use (beta blockers)	GCST007927	4×10⁻⁸	Pharmacogenomics

Category	Count
Total Ensembl Transcripts	10
Total RefSeq Transcripts (Human)	4 reviewed
Total Exons (Canonical)	21
UniProt Accessions	4
InterPro Domains	16
PDB Structures	120+
Orthologs (Key Species)	4
Human Paralogs	53
ClinVar Variants	4,647
Pathogenic/Likely Pathogenic	8
SpliceAI Predictions	3,016
AlphaMissense Predictions	9,195
Reactome Pathways	19
GO Annotations	29
STRING Interactions	5,090+
IntAct Curated	362
Approved Drugs (Phase 4)	28
Phase 3+ Drugs	42
GWAS Associations	23
Mendelian Diseases	4