Provide a comprehensive cross-database identifier and functional mapping reference for human SRC. This should serve as a definitive lookup resource for researchers. ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 1: GENE IDENTIFIERS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Provide ALL gene-level database identifiers: - HGNC ID and approved symbol - Ensembl gene ID (ENSG) - NCBI Entrez Gene ID - OMIM gene/locus ID - Genomic location: chromosome, start position, end position, strand ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 2: TRANSCRIPT IDENTIFIERS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ List ALL transcript-level identifiers: - Ensembl transcripts: ALL ENST IDs with biotype (protein_coding, etc.) How many total transcripts? - RefSeq transcripts: ALL NM_ mRNA accessions Mark which is MANE Select (canonical clinical standard) - CCDS IDs: ALL consensus coding sequence identifiers For the CANONICAL/MANE SELECT transcript: - List ALL exon IDs (ENSE) with genomic coordinates - Total exon count ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 3: PROTEIN IDENTIFIERS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ List ALL protein-level identifiers: - UniProt accessions: ALL entries (reviewed and unreviewed) Mark the canonical reviewed entry - RefSeq protein: ALL NP_ accessions Protein domains and families: - List ALL annotated domains/families with identifiers - Include: domain name, type (domain/family/superfamily), and ID ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 4: STRUCTURE IDENTIFIERS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Experimental structures: - List ALL PDB structure IDs - For each: experimental method (X-ray, NMR, Cryo-EM) and resolution - Total PDB structure count Predicted structures: - AlphaFold model ID and confidence metrics (pLDDT) ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 5: CROSS-SPECIES ORTHOLOGS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ List orthologous genes in key model organisms (where available): - Mouse (Mus musculus): gene ID, symbol - Rat (Rattus norvegicus): gene ID, symbol - Zebrafish (Danio rerio): gene ID, symbol - Fruit fly (Drosophila melanogaster): gene ID, symbol - Worm (C. elegans): gene ID, symbol - Yeast (S. cerevisiae): gene ID, symbol ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 6: CLINICAL VARIANTS & AI PREDICTIONS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Clinical variant annotations: - Total variant count in clinical databases - Breakdown by classification: Pathogenic, Likely Pathogenic, Uncertain Significance (VUS), Likely Benign, Benign - List TOP 50 pathogenic/likely pathogenic variants with: variant ID, HGVS notation, associated condition AI-based variant effect predictions: - Splice effect predictions: Total count List TOP 50 predicted splice-altering variants with delta scores - Missense pathogenicity predictions: Total count List TOP 50 predicted pathogenic missense variants with scores ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 7: BIOLOGICAL PATHWAYS & GENE ONTOLOGY ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Pathway membership: - List ALL biological pathways this gene participates in - Include pathway IDs and names - Total pathway count Gene Ontology annotations: - Biological Process: count and TOP 20 terms with IDs - Molecular Function: count and TOP 20 terms with IDs - Cellular Component: count and TOP 20 terms with IDs ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 8: PROTEIN INTERACTIONS & MOLECULAR NETWORKS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Protein-protein interactions: - Total interaction count - List TOP 50 highest-confidence interacting proteins with scores Protein similarity (evolutionary and structural): - Structural/embedding similarity: How many similar proteins? List TOP 20 with similarity scores - Sequence homology: How many homologous proteins? List TOP 20 with identity/similarity scores ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 9: TRANSCRIPTION FACTOR REGULATORY DATA ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ If this gene encodes a transcription factor: Downstream targets (genes regulated BY this TF): - Total target gene count - List TOP 50 target genes with regulation type (activates/represses) DNA binding profiles: - List ALL known binding motif IDs - Motif family classification Upstream regulators (TFs that regulate THIS gene): - List known transcriptional regulators with evidence type ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 10: DRUG & PHARMACOLOGY DATA ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ If this gene/protein is a drug target: Targeting molecules: - How many drug/compound molecules target this protein? - List TOP 30 molecules by development phase - Include: molecule ID, name, mechanism, highest development phase Clinical trials: - How many clinical trials involve drugs targeting this gene? - List TOP 20 trials with: trial ID, phase, status, intervention Pharmacogenomics: - Known drug-gene interactions affecting drug response - Dosing guidelines if any exist ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 11: EXPRESSION PROFILES ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Tissue expression: - Which tissues express this gene most highly? - List TOP 30 tissues with expression scores/levels - Note any tissue-specific or tissue-enriched patterns Cell type expression: - Which cell types show highest expression? - List TOP 30 cell types with expression scores - Note any cell type-specific patterns Single-cell expression data (if available): - Which single-cell datasets/experiments include this gene? - Notable cell population patterns ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 12: DISEASE ASSOCIATIONS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Mendelian/monogenic disease links: - What diseases are caused by mutations in this gene? - List ALL associated diseases with: disease name, disease ID, inheritance pattern, evidence level Phenotype associations: - What clinical phenotypes are associated with this gene? - List TOP 50 phenotype terms with IDs Complex trait associations (GWAS): - What traits/diseases are linked via genome-wide association studies? - List TOP 30 GWAS associations with: trait, study ID, p-value, effect size if available ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ FORMATTING REQUIREMENTS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ - Present each section with clear headers - Use tables for listing multiple items - Always include COUNTS for every category - For lists with 50 items: show total count + TOP 50 - For lists with

Question

Provide a comprehensive cross-database identifier and functional mapping
reference for human SRC. This should serve as a definitive
lookup resource for researchers.

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 1: GENE IDENTIFIERS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Provide ALL gene-level database identifiers:
- HGNC ID and approved symbol
- Ensembl gene ID (ENSG)
- NCBI Entrez Gene ID
- OMIM gene/locus ID
- Genomic location: chromosome, start position, end position, strand

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 2: TRANSCRIPT IDENTIFIERS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
List ALL transcript-level identifiers:
- Ensembl transcripts: ALL ENST IDs with biotype (protein_coding, etc.)
  How many total transcripts?
- RefSeq transcripts: ALL NM_ mRNA accessions
  Mark which is MANE Select (canonical clinical standard)
- CCDS IDs: ALL consensus coding sequence identifiers

For the CANONICAL/MANE SELECT transcript:
- List ALL exon IDs (ENSE) with genomic coordinates
- Total exon count

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 3: PROTEIN IDENTIFIERS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
List ALL protein-level identifiers:
- UniProt accessions: ALL entries (reviewed and unreviewed)
  Mark the canonical reviewed entry
- RefSeq protein: ALL NP_ accessions

Protein domains and families:
- List ALL annotated domains/families with identifiers
- Include: domain name, type (domain/family/superfamily), and ID

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 4: STRUCTURE IDENTIFIERS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Experimental structures:
- List ALL PDB structure IDs
- For each: experimental method (X-ray, NMR, Cryo-EM) and resolution
- Total PDB structure count

Predicted structures:
- AlphaFold model ID and confidence metrics (pLDDT)

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 5: CROSS-SPECIES ORTHOLOGS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
List orthologous genes in key model organisms (where available):
- Mouse (Mus musculus): gene ID, symbol
- Rat (Rattus norvegicus): gene ID, symbol
- Zebrafish (Danio rerio): gene ID, symbol
- Fruit fly (Drosophila melanogaster): gene ID, symbol
- Worm (C. elegans): gene ID, symbol
- Yeast (S. cerevisiae): gene ID, symbol

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 6: CLINICAL VARIANTS & AI PREDICTIONS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Clinical variant annotations:
- Total variant count in clinical databases
- Breakdown by classification: Pathogenic, Likely Pathogenic,
  Uncertain Significance (VUS), Likely Benign, Benign
- List TOP 50 pathogenic/likely pathogenic variants with:
  variant ID, HGVS notation, associated condition

AI-based variant effect predictions:
- Splice effect predictions: Total count
  List TOP 50 predicted splice-altering variants with delta scores
- Missense pathogenicity predictions: Total count
  List TOP 50 predicted pathogenic missense variants with scores

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 7: BIOLOGICAL PATHWAYS & GENE ONTOLOGY
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Pathway membership:
- List ALL biological pathways this gene participates in
- Include pathway IDs and names
- Total pathway count

Gene Ontology annotations:
- Biological Process: count and TOP 20 terms with IDs
- Molecular Function: count and TOP 20 terms with IDs
- Cellular Component: count and TOP 20 terms with IDs

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 8: PROTEIN INTERACTIONS & MOLECULAR NETWORKS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Protein-protein interactions:
- Total interaction count
- List TOP 50 highest-confidence interacting proteins with scores

Protein similarity (evolutionary and structural):
- Structural/embedding similarity: How many similar proteins?
  List TOP 20 with similarity scores
- Sequence homology: How many homologous proteins?
  List TOP 20 with identity/similarity scores

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 9: TRANSCRIPTION FACTOR REGULATORY DATA
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
If this gene encodes a transcription factor:

Downstream targets (genes regulated BY this TF):
- Total target gene count
- List TOP 50 target genes with regulation type (activates/represses)

DNA binding profiles:
- List ALL known binding motif IDs
- Motif family classification

Upstream regulators (TFs that regulate THIS gene):
- List known transcriptional regulators with evidence type

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 10: DRUG & PHARMACOLOGY DATA
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
If this gene/protein is a drug target:

Targeting molecules:
- How many drug/compound molecules target this protein?
- List TOP 30 molecules by development phase
- Include: molecule ID, name, mechanism, highest development phase

Clinical trials:
- How many clinical trials involve drugs targeting this gene?
- List TOP 20 trials with: trial ID, phase, status, intervention

Pharmacogenomics:
- Known drug-gene interactions affecting drug response
- Dosing guidelines if any exist

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 11: EXPRESSION PROFILES
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Tissue expression:
- Which tissues express this gene most highly?
- List TOP 30 tissues with expression scores/levels
- Note any tissue-specific or tissue-enriched patterns

Cell type expression:
- Which cell types show highest expression?
- List TOP 30 cell types with expression scores
- Note any cell type-specific patterns

Single-cell expression data (if available):
- Which single-cell datasets/experiments include this gene?
- Notable cell population patterns

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 12: DISEASE ASSOCIATIONS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Mendelian/monogenic disease links:
- What diseases are caused by mutations in this gene?
- List ALL associated diseases with: disease name, disease ID,
  inheritance pattern, evidence level

Phenotype associations:
- What clinical phenotypes are associated with this gene?
- List TOP 50 phenotype terms with IDs

Complex trait associations (GWAS):
- What traits/diseases are linked via genome-wide association studies?
- List TOP 30 GWAS associations with: trait, study ID, p-value,
  effect size if available

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
FORMATTING REQUIREMENTS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
- Present each section with clear headers
- Use tables for listing multiple items
- Always include COUNTS for every category
- For lists with >50 items: show total count + TOP 50
- For lists with <50 items: show ALL items
- Always include database identifiers (IDs), not just names
- Mark canonical/primary/reviewed entries where applicable
- If a section has no data available, state "No data available"
  rather than omitting the section

Accepted Answer

SRC Gene: Complete Identifier and Functional Mapping Reference ╔═══════════════════════════════════════════════════════════════════════════════╗ ║ ║ ║ ███████╗██████╗ ██████╗ ║ ║ ██╔════╝██╔══██╗██╔════╝ ║ ║ ███████╗██████╔╝██║ ║ ║ ╚════██║██╔══██╗██║ ║ ║ ███████║██║ ██║╚██████╗ ║ ║ ╚══════╝╚═╝ ╚═╝ ╚═════╝ ║ ║ ║ ║ Proto-oncogene tyrosine-protein kinase Src ║ ║ Cross-Database Identifier & Functional Mapping Reference ║ ║ ║ …

Database	Identifier	Description
HGNC	HGNC:11283	Approved symbol: SRC
HGNC Name	SRC proto-oncogene, non-receptor tyrosine kinase	Official full name
Ensembl Gene	ENSG00000197122	Human gene (GRCh38)
NCBI Entrez	6714	Gene ID
OMIM	190090	Gene/locus entry

Attribute	Value
Chromosome	20
Start Position	37,344,673
End Position	37,406,050
Strand	+ (positive)
Cytoband	20q11.23
Gene Length	61,378 bp
Biotype	protein_coding

Attribute	Value
Locus Type	gene with protein product
Gene Groups	SH2 domain containing; Src family tyrosine kinases
Previous Symbols	SRC1
Aliases	ASV, c-src
Status	Approved

Transcript ID	Biotype	Start	End	Notes
ENST00000373578	protein_coding	37,346,140	37,406,050	Major transcript
ENST00000358208	protein_coding	37,384,150	37,406,050
ENST00000373558	protein_coding	37,384,150	37,406,050
ENST00000373567	protein_coding	37,383,668	37,406,050
ENST00000692112	protein_coding	37,346,109	37,406,050
ENST00000692423	protein_coding	37,346,140	37,406,050
ENST00000693012	protein_coding	37,346,140	37,387,801
ENST00000876226	protein_coding	37,344,673	37,405,431
ENST00000876227	protein_coding	37,344,681	37,405,429
ENST00000876228	protein_coding	37,344,714	37,405,418
ENST00000876229	protein_coding	37,344,718	37,405,415
ENST00000876230	protein_coding	37,345,108	37,405,414
ENST00000876231	protein_coding	37,345,138	37,405,432
ENST00000876232	protein_coding	37,345,213	37,405,418
ENST00000876233	protein_coding	37,345,936	37,405,418
ENST00000876234	protein_coding	37,346,125	37,405,415
ENST00000876235	protein_coding	37,346,140	37,405,415
ENST00000876236	protein_coding	37,346,140	37,404,632
ENST00000876237	protein_coding	37,383,899	37,405,420
ENST00000921683	protein_coding	37,345,711	37,405,415
ENST00000921684	protein_coding	37,346,324	37,405,415
ENST00000950593	protein_coding	37,383,596	37,405,416
ENST00000467556	retained_intron	37,400,149	37,401,957
ENST00000472968	retained_intron	37,384,323	37,394,174
ENST00000489153	retained_intron	37,393,745	37,397,746
ENST00000493775	retained_intron	37,402,313	37,403,031
ENST00000477066	CDS_not_defined	37,396,426	37,405,422
ENST00000477475	CDS_not_defined	37,400,251	37,402,292
ENST00000497734	CDS_not_defined	37,344,685	37,382,787

Accession	Type	Status	MANE Select
NM_198291	mRNA	REVIEWED	✓ MANE Select
NM_005417	mRNA	REVIEWED

SRC Gene Complete Identifier and Functional Mapping Reference

Structured Data Sources

Exon ID	Start	End	Strand
ENSE00001460945	37,346,140	37,346,255	+
ENSE00001460974	37,365,204	37,365,277	+
ENSE00001798147	37,382,619	37,382,786	+
ENSE00000661877	37,384,150	37,384,403	+
ENSE00003544319	37,386,075	37,386,174	+
ENSE00000661879	37,393,895	37,393,993	+
ENSE00003523341	37,394,174	37,394,277	+
ENSE00003678936	37,396,162	37,396,311	+
ENSE00003516229	37,397,699	37,397,854	+
ENSE00003564760	37,400,115	37,400,294	+
ENSE00003669255	37,401,602	37,401,678	+
ENSE00003543788	37,402,435	37,402,588	+
ENSE00003638193	37,402,749	37,402,880	+
ENSE00001460955	37,403,171	37,406,050	+

Accession	Status	Name	Mass	Length
P12931	✓ Reviewed (Swiss-Prot)	Proto-oncogene tyrosine-protein kinase Src	59,835 Da	536 aa
A0A8I5KYU4	Unreviewed (TrEMBL)	-	-	-

InterPro ID	Name	Type
IPR050198	Non-receptor_tyrosine_kinases	Family
IPR000719	Prot_kinase_dom	Domain
IPR000980	SH2	Domain
IPR001245	Ser-Thr/Tyr_kinase_cat_dom	Domain
IPR001452	SH3_domain	Domain
IPR020635	Tyr_kinase_cat_dom	Domain
IPR008266	Tyr_kinase_AS	Active_site
IPR017441	Protein_kinase_ATP_BS	Binding_site
IPR011009	Kinase-like_dom_sf	Homologous_superfamily
IPR036028	SH3-like_dom_sf	Homologous_superfamily
IPR036860	SH2_dom_sf	Homologous_superfamily

PDB ID	Method	Resolution (Å)	Title
1FMK	X-ray	1.50	Crystal structure of human tyrosine-protein kinase C-SRC
2SRC	X-ray	1.50	Human tyrosine-protein kinase C-SRC with AMP-PNP
7NG7	X-ray	1.50	Src kinase bound to eCF506 trapped in inactive conformation
9OFX	X-ray	1.45	c-Src SH3 domain in H32 space group
1O43	X-ray	1.50	SH2 in complex with RU82129
1O4A	X-ray	1.50	SH2 in complex with RU82197
1O4R	X-ray	1.50	SH2 in complex with RU78783
6C4S	X-ray	1.50	cSrc SH3 Domain in complex with Choline Kinase
8VCF	X-ray	1.50	Superbinder Src SH2 domain
1O42	X-ray	1.70	SH2 in complex with RU81843
4F5B	X-ray	1.57	Triple mutant Src SH2 domain with phosphotyrosine
8VCG	X-ray	1.61	Mutant Src SH2 domain with phosphotyrosine
1A09	X-ray	2.00	C-src (SH2 domain) complexed
1Y57	X-ray	1.91	Unphosphorylated c-Src in complex with inhibitor
1YOJ	X-ray	1.95	Src kinase domain
2BDF	X-ray	2.10	Src kinase with inhibitor AP23451
4MXO	X-ray	2.11	Src kinase bound to bosutinib
6E6E	X-ray	2.15	DGY-06-116 covalent inhibitor of SRC kinase
9NS0	NMR	-	Ground state of Src kinase domain
9NS1	NMR	-	Intermediate state of Src kinase domain
1HCS	NMR	-	Human SRC SH2 domain complex
1HCT	NMR	-	Human SRC SH2 domain complex

Organism	Gene ID	Symbol	Biotype
Mouse (Mus musculus)	ENSMUSG00000027646	Src	protein_coding
Rat (Rattus norvegicus)	ENSRNOG00000009495	Src	protein_coding
Zebrafish (Danio rerio)	ENSDARG00000008107	src	protein_coding

Gene ID	Symbol	Family
ENSG00000010810	FYN	Src family
ENSG00000176105	YES1	Src family
ENSG00000182866	LCK	Src family
ENSG00000254087	LYN	Src family
ENSG00000101336	HCK	Src family
ENSG00000136573	BLK	Src family
ENSG00000000938	FGR	Src family
ENSG00000111816	FRK	Src-related
ENSG00000101213	PTK6	Src-related
ENSG00000125508	SRMS	Src-related
ENSG00000097007	ABL1	Non-receptor TK
ENSG00000143322	ABL2	Non-receptor TK
ENSG00000096968	JAK2	JAK family
ENSG00000162434	JAK1	JAK family
ENSG00000105639	JAK3	JAK family
ENSG00000105397	TYK2	JAK family
ENSG00000169398	PTK2	Focal adhesion kinase
ENSG00000120899	PTK2B	Focal adhesion kinase
ENSG00000165025	SYK	Spleen TK
ENSG00000115085	ZAP70	Immune signaling

Classification	Count
Pathogenic	1
Likely Pathogenic	1
Uncertain Significance (VUS)	35+
Likely Benign	20+
Benign	30+
Benign/Likely Benign	5
Not Provided	15+

ClinVar ID	HGVS Notation	Classification	Condition
12573	NM_198291.3(SRC):c.1591C>T (p.Gln531Ter)	Pathogenic	Thrombocytopenia
225689	NM_198291.3(SRC):c.1579G>A (p.Glu527Lys)	Likely Pathogenic	Thrombocytopenia

ClinVar ID	HGVS Notation	Classification
100851	c.1200C>G (p.Asn400Lys)	Uncertain significance
2234627	c.1018G>A (p.Val340Ile)	Uncertain significance
2310404	c.811C>T (p.Arg271Trp)	Uncertain significance
2388133	c.475C>T (p.Arg159Trp)	Uncertain significance
2475250	c.296C>T (p.Thr99Met)	Uncertain significance
2477836	c.327G>T (p.Glu109Asp)	Uncertain significance
2548214	c.1439G>A (p.Arg480Gln)	Uncertain significance
2572134	c.1585C>G (p.Gln529Glu)	Uncertain significance
2584809	c.919C>T (p.Pro307Ser)	Uncertain significance
2614414	c.869A>G (p.Asn290Ser)	Uncertain significance
2619551	c.890T>C (p.Ile297Thr)	Uncertain significance
3169832	c.529G>T (p.Val177Leu)	Uncertain significance
3169833	c.871G>T (p.Gly291Cys)	Uncertain significance
3252560	c.1250_1253del (p.Asn417fs)	Uncertain significance
3252895	c.1039+5G>C	Uncertain significance
3322569	c.1460C>T (p.Pro487Leu)	Uncertain significance
3322570	c.1513G>C (p.Glu505Gln)	Uncertain significance
3449216	c.242C>A (p.Pro81Gln)	Uncertain significance
3449217	c.100G>C (p.Ala34Pro)	Uncertain significance
3764601	c.1070C>T (p.Thr357Ile)	Uncertain significance

Variant	Gene	Effect	Delta Score
20:37346252:CCAG:C	SRC	donor_loss	0.99
20:37346254:AG:A	SRC	donor_loss	0.99
20:37346257:T:A	SRC	donor_loss	0.99
20:37346256:G:GG	SRC	donor_gain	0.95
20:37346258:GAGC:G	SRC	donor_loss	0.75
20:37346254:AGGTG:A	SRC	donor_gain	0.74
20:37346251:CCCAG:C	SRC	donor_gain	0.73
20:37346252:CCAGG:C	SRC	donor_gain	0.73
20:37346253:CAGG:C	SRC	donor_gain	0.73
20:37346255:GGTGA:G	SRC	donor_gain	0.73
20:37346256:GTGAG:G	SRC	donor_gain	0.73
20:37346257:T:TT	SRC	donor_gain	0.73
20:37346258:GAGCG:G	SRC	donor_gain	0.73
20:37346234:G:GT	SRC	donor_gain	0.71
20:37346259:AGCGC:A	SRC	donor_gain	0.71
20:37346228:C:CA	SRC	donor_gain	0.70
20:37346250:GCCCA:G	SRC	donor_gain	0.70
20:37346232:G:A	SRC	donor_gain	0.68
20:37346235:C:T	SRC	donor_gain	0.68
20:37346260:G:C	SRC	donor_gain	0.67

Variant	Protein Change	AM Score	Classification
20:37384169:A:C	S6R	0.864	likely_pathogenic
20:37384171:C:A	S6R	0.864	likely_pathogenic
20:37384171:C:G	S6R	0.864	likely_pathogenic
20:37384174:G:C	K7N	0.860	likely_pathogenic
20:37384174:G:T	K7N	0.860	likely_pathogenic
20:37384157:G:C	G2R	0.813	likely_pathogenic
20:37384168:G:C	K5N	0.775	likely_pathogenic
20:37384168:G:T	K5N	0.775	likely_pathogenic
20:37384172:A:G	K7E	0.763	likely_pathogenic
20:37384180:G:C	K9N	0.744	likely_pathogenic
20:37384180:G:T	K9N	0.744	likely_pathogenic
20:37384173:A:G	K7M	0.719	likely_pathogenic
20:37384166:A:G	K5E	0.728	likely_pathogenic
20:37384173:A:C	K7T	0.654	likely_pathogenic
20:37384179:A:T	K9M	0.649	likely_pathogenic
20:37384158:G:A	G2D	0.640	likely_pathogenic
20:37384187:A:C	S12R	0.572	likely_pathogenic
20:37384189:C:A	S12R	0.572	likely_pathogenic
20:37384189:C:G	S12R	0.572	likely_pathogenic
20:37384160:A:C	S3R	0.707	likely_pathogenic

Pathway ID	Pathway Name	Disease Pathway
R-HSA-177929	Signaling by EGFR	No
R-HSA-1227986	Signaling by ERBB2	No
R-HSA-354192	Integrin signaling	No
R-HSA-354194	GRB2:SOS provides linkage to MAPK signaling for Integrins	No
R-HSA-372708	p130Cas linkage to MAPK signaling for integrins	No
R-HSA-4420097	VEGFA-VEGFR2 Pathway	No
R-HSA-5218921	VEGFR2 mediated cell proliferation	No
R-HSA-2682334	EPH-Ephrin signaling	No
R-HSA-3928662	EPHB-mediated forward signaling	No
R-HSA-3928663	EPHA-mediated growth cone collapse	No
R-HSA-8853659	RET signaling	No
R-HSA-1433557	Signaling by SCF-KIT	No
R-HSA-201556	Signaling by ALK	No
R-HSA-1257604	PIP3 activates AKT signaling	No
R-HSA-5673000	RAF activation	No
R-HSA-5674135	MAP2K and MAPK activation	No
R-HSA-171007	p38MAPK events	No
R-HSA-69231	Cyclin D associated events in G1	No
R-HSA-389356	Co-stimulation by CD28	No
R-HSA-389513	Co-inhibition by CTLA4	No
R-HSA-2029481	FCGR activation	No
R-HSA-5607764	CLEC7A (Dectin-1) signaling	No
R-HSA-30168	Platelet activation	No
R-HSA-9009391	Extra-nuclear estrogen signaling	No
R-HSA-9620244	Long-term potentiation	No
R-HSA-8934903	Receptor Mediated Mitophagy	No
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	Yes
R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants	Yes
R-HSA-6802948	Signaling by high-kinase activity BRAF mutants	Yes
R-HSA-6802952	Signaling by BRAF and RAF1 fusions	Yes
R-HSA-9649948	Signaling downstream of RAS mutants	Yes
R-HSA-9656223	Signaling by RAF1 mutants	Yes
R-HSA-8876493	InlA-mediated entry of Listeria monocytogenes	Yes

GO ID	Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0005102	signaling receptor binding
GO:0005178	integrin binding
GO:0019899	enzyme binding
GO:0020037	heme binding
GO:0016004	phospholipase activator activity
GO:0030296	protein tyrosine kinase activator activity
GO:0030546	signaling receptor activator activity
GO:0035255	ionotropic glutamate receptor binding
GO:0042169	SH2 domain binding
GO:0043274	phospholipase binding
GO:0044325	transmembrane transporter binding
GO:0045296	cadherin binding
GO:0046875	ephrin receptor binding
GO:0051117	ATPase binding
GO:0051219	phosphoprotein binding
GO:0070700	BMP receptor binding

GO ID	Term
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007229	integrin-mediated signaling pathway
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030154	cell differentiation
GO:0030168	platelet activation
GO:0035556	intracellular signal transduction
GO:0043066	negative regulation of apoptotic process
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048013	ephrin receptor signaling pathway
GO:0050900	leukocyte migration
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0051897	positive regulation of PI3K/AKT signal transduction
GO:0010634	positive regulation of epithelial cell migration
GO:0034446	substrate adhesion-dependent cell spreading
GO:0048041	focal adhesion assembly
GO:0045747	positive regulation of Notch signaling pathway
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:2000811	negative regulation of anoikis

GO ID	Term
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005764	lysosome
GO:0005770	late endosome
GO:0005829	cytosol
GO:0005884	actin filament
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0005911	cell-cell junction
GO:0005925	focal adhesion
GO:0002102	podosome
GO:0030054	cell junction
GO:0032587	ruffle membrane
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular exosome

UniProt ID	Score	Protein Name
P49023	998	Paxillin
P56945	998	BCAR1 (p130Cas)
Q14247	997	Cortactin (CTTN)
P03372	996	Estrogen receptor alpha (ESR1)
P40763	996	STAT3
Q9Y490	996	Talin-1 (TLN1)
P18206	995	Vinculin
P46108	995	CRK
P49407	995	β-Arrestin-1
P07900	994	HSP90AA1
P14317	994	FLII
Q03135	994	Caveolin-1
Q9Y4G6	994	TLN2
P08238	993	HSP90AB1
P22681	993	CBL
Q9Y4K3	991	TNK2
P29353	990	SHC1
P32121	989	β-Arrestin-2
P00533	988	EGFR
Q05397	988	PTK2 (FAK)
Q14289	987	PTK2B (PYK2)
P29354	986	SHC2
P35222	986	β-Catenin
P13931	983	Glycogen synthase kinase-3β
P25388	983	RRAS2
P04626	980	ERBB2
Q06124	980	PTPN11 (SHP2)
P31749	977	AKT1
P43405	976	SYK
P17302	975	GJA1
Q9UKG1	974	ASAP1
P42768	973	WAS
P05106	972	Integrin β3
P09619	972	PDGFRB
P78352	964	DLG4
Q8N556	963	AFDN
P35568	961	IRS1
P08069	959	IGF1R
P12830	955	CDH1 (E-cadherin)
Q14185	955	DOCK1
Q13094	953	LCP2
Q07666	949	KHDRBS1
Q9ULH1	947	ASAP2
P10275	944	Androgen receptor
Q09472	943	EP300
P35968	938	KDR (VEGFR2)
Q14511	929	NEDD9
P16070	926	CD44
Q9NP31	925	SH3PXD2B
P27482	923	CALM3

Partner	Interaction Type	Confidence
PTK2 (FAK)	physical association	0.92
ESR1	association	0.85
KDR (VEGFR2)	physical association	0.77
LYN	association	0.67
HSP90AA1	physical association	0.67
MED28	physical association	0.66
PIK3R3	physical association	0.62
ARRB1	physical association	0.62
ASAP1	physical association	0.61
PECAM1	direct interaction	0.59
ABL1	physical association	0.59
ARRB2	physical association	0.56
CTNNB1	phosphorylation	0.54
HK1	physical association	0.52
STAT3	enzymatic reaction	0.44
BCAR1	enzymatic reaction	0.44
CDKN1B	phosphorylation reaction	0.44
TXNIP	direct interaction	0.44
CTTN	phosphorylation reaction	0.44
SHC1	phosphorylation reaction	0.44

UniProt ID	Top Similarity	Avg Similarity	Protein
P06241	1.0000	0.9955	Fyn proto-oncogene
Q62844	1.0000	0.9956	Src (mouse)
A1Y2K1	1.0000	0.9956	Src homolog
P39688	1.0000	0.9955	Src family kinase
P05480	0.9999	0.9949	Src (chicken)
P06240	0.9999	0.9933	LCK
Q01621	0.9999	0.9933	Src-family kinase
Q04736	0.9998	0.9943	YES1
P63185	0.9998	0.9948	Src homolog
P50545	0.9998	0.9928	Tyrosine kinase
P06239	0.9997	0.9928	LCK (human)
Q5PXS1	0.9997	0.9936	Src-family kinase
Q95KR7	0.9997	0.9936	Src homolog
P07947	0.9996	0.9943	YES proto-oncogene
P07948	0.9996	0.9906	LYN
P13115	0.9996	0.9952	Src-family kinase
P13116	0.9996	0.9940	Src-family kinase
F1RDG9	0.9995	0.9952	Src homolog
P00523	0.9994	0.9957	v-Src (viral)
P14234	0.9994	0.9943	Src-family kinase

UniProt ID	Identity (%)	Bitscore	Protein
P00523	100.0	1068	v-Src viral oncogene
P15054	100.0	1067	PP60-SRC
P04049	100.0	1303	RAF proto-oncogene
P10533	100.0	720	Src family
A0JNB0	99.6	1114	SRC homolog
P06241	99.6	1114	FYN
P05480	99.4	1077	c-Src (Gallus)
A1Y2K1	99.4	1115	SRC homolog
O15197	99.3	2024	Ephrin B3
P00519	99.3	1866	ABL1
P06240	99.2	1056	LCK
P14084	99.6	1065	Src homolog
P14085	99.8	1057	Src homolog
P00524	99.0	1060	v-Src
P00525	99.0	1060	v-Src
P00526	99.0	1061	v-Src
P00527	98.9	1048	pp60v-src
P09324	98.9	1046	Src-related
P00520	98.9	1871	ABL proto-oncogene
O08644	98.4	2010	Ephrin type-B

TF Gene	Regulation	Confidence
JUN	Activation	High
HNF1A	Activation	High
SP1	Unknown	High
GTF2I	-	High
JDP2	-	High
SP3	-	High
AR	-	High
ESR1	Unknown	High
AP1	Activation	Low
EGR1	-	Low
FOXO3	-	Low
HIF1A	-	Low
HNF4A	-	Low
NCOA1	-	Low
NCOA2	-	Low
NCOA3	Activation	Low
NFATC1	Activation	Low
NFKB	-	Low
RBPJ	Activation	Low
RELA	-	Low
RELB	-	Low
STAT5A	-	Low
THRA	-	Low
ARNT	-	Low
ESR2	-	Low
HHEX	-	Low
IER2	-	Low
JUNB	-	Low
KAT7	-	Low
MAFB	-	Low
NFIC	-	Low
TAF1	Unknown	-

Target	Effect	Mechanism	Score
BCAR1	up-regulates activity	phosphorylation	0.80
CTNNB1	up-regulates activity	phosphorylation	0.76
CTNNB1	down-regulates activity	phosphorylation	0.76
CAV1	down-regulates activity	phosphorylation	0.76
STAT5A	up-regulates	phosphorylation	0.75
PTPRA	up-regulates activity	phosphorylation	0.74
CDC42	up-regulates	phosphorylation	0.69
ARRB1	down-regulates	phosphorylation	0.68
CAV2	down-regulates	phosphorylation	0.68
RAPGEF1	up-regulates	phosphorylation	0.67
TIAM1	up-regulates	phosphorylation	0.66
PTK2	up-regulates	phosphorylation	0.65
EZR	up-regulates	phosphorylation	0.65
SH3GL1	down-regulates	phosphorylation	0.64
PTK2B	up-regulates	phosphorylation	0.62
RAC1	up-regulates	phosphorylation	0.61
HSP90AB1	up-regulates	phosphorylation	0.59
GJA1	down-regulates	phosphorylation	0.59
RRAS	down-regulates activity	phosphorylation	0.58
PDPK1	up-regulates activity	phosphorylation	0.58
CDH5	up-regulates	phosphorylation	0.57
SPRY2	up-regulates	phosphorylation	0.56
ANXA2	up-regulates	phosphorylation	0.55
DAG1	down-regulates	phosphorylation	0.55
PTEN	down-regulates	phosphorylation	0.54
CBLC	up-regulates	phosphorylation	0.54
PRKCI	up-regulates	phosphorylation	0.53
PTPN6	up-regulates	phosphorylation	0.53
FLT4	up-regulates	phosphorylation	0.51
CDKN1B	down-regulates	phosphorylation	0.50
WWOX	up-regulates	phosphorylation	0.48
PLSCR1	up-regulates activity	phosphorylation	0.48
MPZL1	up-regulates	phosphorylation	0.47
DGKA	up-regulates	phosphorylation	0.46
CASP8	down-regulates	phosphorylation	0.45
MMP14	unknown	phosphorylation	0.43
TERT	down-regulates	phosphorylation	0.42
WASF1	up-regulates	phosphorylation	0.41
NOXA1	up-regulates	phosphorylation	0.41
PRKD1	up-regulates	phosphorylation	0.41
ARHGDIA	down-regulates	phosphorylation	0.40
CDH2	down-regulates	phosphorylation	0.40
LRP1	up-regulates activity	phosphorylation	0.39
KIT	up-regulates activity	phosphorylation	0.39
DDR2	up-regulates	phosphorylation	0.38
HCN4	up-regulates	phosphorylation	0.37
IKBKB	up-regulates activity	phosphorylation	0.36
RPS6KA3	up-regulates	phosphorylation	0.35
VAV3	up-regulates	phosphorylation	0.33
FBXO5	up-regulates	phosphorylation	0.32

ChEMBL ID	Type	Description
CHEMBL267	SINGLE PROTEIN	Proto-oncogene tyrosine-protein kinase Src
CHEMBL2363074	PROTEIN FAMILY	SRC
CHEMBL2111336	SELECTIVITY GROUP	VEGF-receptor 2 and tyrosine-protein kinase SRC
CHEMBL4523978	SELECTIVITY GROUP	Src/Lck kinase
CHEMBL3885535	PROTEIN-PROTEIN INTERACTION	Calmodulin/SRC
CHEMBL4523733	PROTEIN-PROTEIN INTERACTION	VHL/SRC
CHEMBL4630728	PROTEIN-PROTEIN INTERACTION	Cereblon/SRC

ChEMBL ID	Drug Name	Type	Phase
CHEMBL1421/CHEMBL5416410	DASATINIB	Small molecule	4
CHEMBL288441	BOSUTINIB	Small molecule	4
CHEMBL255863	NILOTINIB	Small molecule	4
CHEMBL941	IMATINIB	Small molecule	4
CHEMBL1336	SORAFENIB	Small molecule	4
CHEMBL535	SUNITINIB	Small molecule	4
CHEMBL477772	PAZOPANIB	Small molecule	4
CHEMBL24828	VANDETANIB	Small molecule	4
CHEMBL939	GEFITINIB	Small molecule	4
CHEMBL553	ERLOTINIB	Small molecule	4
CHEMBL554	LAPATINIB	Small molecule	4
CHEMBL1173655	AFATINIB	Small molecule	4
CHEMBL180022	NERATINIB	Small molecule	4
CHEMBL2110732	DACOMITINIB	Small molecule	4
CHEMBL1873475	IBRUTINIB	Small molecule	4
CHEMBL2403108	CERITINIB	Small molecule	4
CHEMBL3545311	BRIGATINIB	Small molecule	4
CHEMBL1983268	ENTRECTINIB	Small molecule	4
CHEMBL4298138	REPOTRECTINIB	Small molecule	4
CHEMBL601719	CRIZOTINIB	Small molecule	4
CHEMBL2105717	CABOZANTINIB	Small molecule	4
CHEMBL1171837	PONATINIB	Small molecule	4
CHEMBL608533	MIDOSTAURIN	Small molecule	4
CHEMBL502835	NINTEDANIB	Small molecule	4
CHEMBL1287853	FEDRATINIB	Small molecule	4
CHEMBL1289494	TIVOZANIB	Small molecule	4
CHEMBL1834657/1852688	INFIGRATINIB	Small molecule	4
CHEMBL571546	TIRBANIBULIN	Small molecule	4
CHEMBL1448	NICLOSAMIDE	Small molecule	4

ChEMBL ID	Drug Name	Type	Phase
CHEMBL217092	SARACATINIB	Small molecule	3
CHEMBL1908391	MASITINIB	Small molecule	3
CHEMBL223360	LINIFANIB	Small molecule	3
CHEMBL31965	CANERTINIB	Small molecule	3
CHEMBL3544983	TESEVATINIB	Small molecule	3
CHEMBL377300	BRIVANIB	Small molecule	3
CHEMBL428690	ALVOCIDIB	Small molecule	3
CHEMBL483158	ALISERTIB	Small molecule	3
CHEMBL491473	CEDIRANIB	Small molecule	3
CHEMBL50	QUERCETIN	Small molecule	3
CHEMBL522892	DOVITINIB	Small molecule	3
CHEMBL276711	SEMAXANIB	Small molecule	3
CHEMBL599552	INDIGO	Small molecule	3
CHEMBL603469	LESTAURTINIB	Small molecule	3
CHEMBL103667	DORAMAPIMOD	Small molecule	2

Attribute	Value
PharmGKB ID	PA36111
Gene Symbol	SRC
VIP Gene	Yes
Has CPIC Guideline	No
Chromosome	chr20

Attribute	Value
Expression Breadth	Ubiquitous
Total Present Calls	236
Total Absent Calls	50
Total Conditions Tested	286
Max Expression Score	95.98
Average Expression Score	81.10
Gold Quality Annotations	242

Rank	Tissue	Score	Quality
1	Body of stomach	95.98	Gold
2	Gall bladder	95.89	Gold
3	Rectum	95.58	Gold
4	Body of pancreas	95.45	Gold
5	Lower esophagus mucosa	95.36	Gold
6	Transverse colon	95.11	Gold
7	Ganglionic eminence	94.92	Gold
8	Cortical plate	94.65	Gold
9	Stomach	94.25	Gold
10	Ectocervix	94.18	Gold
11	Small intestine Peyer's patch	94.16	Gold
12	Body of uterus	93.98	Gold
13	Muscle layer of sigmoid colon	93.83	Gold
14	Mucosa of transverse colon	93.62	Gold
15	Mucosa of stomach	93.52	Gold
16	Ascending aorta	93.25	Gold
17	Small intestine	93.15	Gold
18	Thoracic aorta	93.12	Gold
19	Right testis	92.96	Gold
20	Endocervix	92.93	Gold
21	Esophagus mucosa	92.91	Gold
22	Ventricular zone	92.88	Gold
23	Metanephros cortex	92.86	Gold
24	Left testis	92.75	Gold
25	Right adrenal gland cortex	92.73	Gold
26	Right adrenal gland	92.60	Gold
27	Right ovary	92.56	Gold
28	Left uterine tube	92.48	Gold
29	Left adrenal gland	92.48	Gold
30	Left adrenal gland cortex	92.40	Gold

Disease	Classification	Inheritance	Source
Thrombocytopenia 6 (OMIM:616937)	Strong	Autosomal dominant	PanelApp Australia
Thrombocytopenia 6 (OMIM:616937)	Limited	Autosomal dominant	Labcorp Genetics
Thrombocytopenia 6 (Orphanet:480851)	Supportive	Autosomal dominant	Orphanet
Colorectal cancer (OMIM:114500)	No Known Disease Relationship	Unknown	Labcorp Genetics

HPO ID	Phenotype
HP:0000006	Autosomal dominant inheritance
HP:0001442	Typified by somatic mosaicism
HP:0001873	Thrombocytopenia
HP:0001892	Abnormal bleeding
HP:0004406	Spontaneous, recurrent epistaxis
HP:0011974	Myelofibrosis
HP:0031020	Bone marrow hypercellularity
HP:0000939	Osteoporosis
HP:0000490	Deeply set eye
HP:0000601	Hypotelorism
HP:0002003	Large forehead
HP:0003003	Colon cancer
HP:0005584	Renal cell carcinoma
HP:0006716	Hereditary nonpolyposis colorectal carcinoma
HP:0006740	Transitional cell carcinoma of the bladder
HP:0006753	Neoplasm of the stomach
HP:0002891	Uterine leiomyosarcoma

Study ID	Trait/Disease	P-value	Mapped Genes
GCST007843	Rheumatoid arthritis	4.0e-13	SRC - RPL7AP14
GCST003422	Squamous cell carcinoma	1.0e-06	SRC
GCST001854	Retinopathy in non-diabetics	4.0e-06	SRC - RPL7AP14
GCST012488	L1-L4 bone mineral density x serum urate interaction	3.0e-06	SRC

Category	Count
Gene Identifiers	5 databases
Transcripts (Ensembl)	29
RefSeq mRNAs (Human)	2 (reviewed)
CCDS IDs	1
Exons (canonical)	14
UniProt Accessions	2
Protein Domains (InterPro)	11
PDB Structures	79
Orthologs	3 (key model organisms)
Paralogs	32
ClinVar Variants	111+
SpliceAI Predictions	3,484
AlphaMissense Predictions	3,468
Reactome Pathways	69
GO Annotations	121
STRING Interactions	9,720+
IntAct Interactions	801+
SIGNOR Signaling Entries	560+
Regulatory TFs	32
Approved Drugs (Phase 4)	29
Phase 3 Candidates	15
BindingDB Compounds	4,955+
Expression Tissues	236 (ubiquitous)
HPO Phenotypes	17
GWAS Associations	4