Provide a comprehensive cross-database identifier and functional mapping reference for human VEGFA. This should serve as a definitive lookup resource for researchers. ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 1: GENE IDENTIFIERS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Provide ALL gene-level database identifiers: - HGNC ID and approved symbol - Ensembl gene ID (ENSG) - NCBI Entrez Gene ID - OMIM gene/locus ID - Genomic location: chromosome, start position, end position, strand ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 2: TRANSCRIPT IDENTIFIERS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ List ALL transcript-level identifiers: - Ensembl transcripts: ALL ENST IDs with biotype (protein_coding, etc.) How many total transcripts? - RefSeq transcripts: ALL NM_ mRNA accessions Mark which is MANE Select (canonical clinical standard) - CCDS IDs: ALL consensus coding sequence identifiers For the CANONICAL/MANE SELECT transcript: - List ALL exon IDs (ENSE) with genomic coordinates - Total exon count ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 3: PROTEIN IDENTIFIERS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ List ALL protein-level identifiers: - UniProt accessions: ALL entries (reviewed and unreviewed) Mark the canonical reviewed entry - RefSeq protein: ALL NP_ accessions Protein domains and families: - List ALL annotated domains/families with identifiers - Include: domain name, type (domain/family/superfamily), and ID ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 4: STRUCTURE IDENTIFIERS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Experimental structures: - List ALL PDB structure IDs - For each: experimental method (X-ray, NMR, Cryo-EM) and resolution - Total PDB structure count Predicted structures: - AlphaFold model ID and confidence metrics (pLDDT) ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 5: CROSS-SPECIES ORTHOLOGS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ List orthologous genes in key model organisms (where available): - Mouse (Mus musculus): gene ID, symbol - Rat (Rattus norvegicus): gene ID, symbol - Zebrafish (Danio rerio): gene ID, symbol - Fruit fly (Drosophila melanogaster): gene ID, symbol - Worm (C. elegans): gene ID, symbol - Yeast (S. cerevisiae): gene ID, symbol ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 6: CLINICAL VARIANTS & AI PREDICTIONS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Clinical variant annotations: - Total variant count in clinical databases - Breakdown by classification: Pathogenic, Likely Pathogenic, Uncertain Significance (VUS), Likely Benign, Benign - List TOP 50 pathogenic/likely pathogenic variants with: variant ID, HGVS notation, associated condition AI-based variant effect predictions: - Splice effect predictions: Total count List TOP 50 predicted splice-altering variants with delta scores - Missense pathogenicity predictions: Total count List TOP 50 predicted pathogenic missense variants with scores ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 7: BIOLOGICAL PATHWAYS & GENE ONTOLOGY ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Pathway membership: - List ALL biological pathways this gene participates in - Include pathway IDs and names - Total pathway count Gene Ontology annotations: - Biological Process: count and TOP 20 terms with IDs - Molecular Function: count and TOP 20 terms with IDs - Cellular Component: count and TOP 20 terms with IDs ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 8: PROTEIN INTERACTIONS & MOLECULAR NETWORKS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Protein-protein interactions: - Total interaction count - List TOP 50 highest-confidence interacting proteins with scores Protein similarity (evolutionary and structural): - Structural/embedding similarity: How many similar proteins? List TOP 20 with similarity scores - Sequence homology: How many homologous proteins? List TOP 20 with identity/similarity scores ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 9: TRANSCRIPTION FACTOR REGULATORY DATA ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ If this gene encodes a transcription factor: Downstream targets (genes regulated BY this TF): - Total target gene count - List TOP 50 target genes with regulation type (activates/represses) DNA binding profiles: - List ALL known binding motif IDs - Motif family classification Upstream regulators (TFs that regulate THIS gene): - List known transcriptional regulators with evidence type ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 10: DRUG & PHARMACOLOGY DATA ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ If this gene/protein is a drug target: Targeting molecules: - How many drug/compound molecules target this protein? - List TOP 30 molecules by development phase - Include: molecule ID, name, mechanism, highest development phase Clinical trials: - How many clinical trials involve drugs targeting this gene? - List TOP 20 trials with: trial ID, phase, status, intervention Pharmacogenomics: - Known drug-gene interactions affecting drug response - Dosing guidelines if any exist ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 11: EXPRESSION PROFILES ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Tissue expression: - Which tissues express this gene most highly? - List TOP 30 tissues with expression scores/levels - Note any tissue-specific or tissue-enriched patterns Cell type expression: - Which cell types show highest expression? - List TOP 30 cell types with expression scores - Note any cell type-specific patterns Single-cell expression data (if available): - Which single-cell datasets/experiments include this gene? - Notable cell population patterns ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SECTION 12: DISEASE ASSOCIATIONS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Mendelian/monogenic disease links: - What diseases are caused by mutations in this gene? - List ALL associated diseases with: disease name, disease ID, inheritance pattern, evidence level Phenotype associations: - What clinical phenotypes are associated with this gene? - List TOP 50 phenotype terms with IDs Complex trait associations (GWAS): - What traits/diseases are linked via genome-wide association studies? - List TOP 30 GWAS associations with: trait, study ID, p-value, effect size if available ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ FORMATTING REQUIREMENTS ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ - Present each section with clear headers - Use tables for listing multiple items - Always include COUNTS for every category - For lists with 50 items: show total count + TOP 50 - For lists with

Question

Provide a comprehensive cross-database identifier and functional mapping
reference for human VEGFA. This should serve as a definitive
lookup resource for researchers.

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 1: GENE IDENTIFIERS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Provide ALL gene-level database identifiers:
- HGNC ID and approved symbol
- Ensembl gene ID (ENSG)
- NCBI Entrez Gene ID
- OMIM gene/locus ID
- Genomic location: chromosome, start position, end position, strand

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 2: TRANSCRIPT IDENTIFIERS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
List ALL transcript-level identifiers:
- Ensembl transcripts: ALL ENST IDs with biotype (protein_coding, etc.)
  How many total transcripts?
- RefSeq transcripts: ALL NM_ mRNA accessions
  Mark which is MANE Select (canonical clinical standard)
- CCDS IDs: ALL consensus coding sequence identifiers

For the CANONICAL/MANE SELECT transcript:
- List ALL exon IDs (ENSE) with genomic coordinates
- Total exon count

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 3: PROTEIN IDENTIFIERS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
List ALL protein-level identifiers:
- UniProt accessions: ALL entries (reviewed and unreviewed)
  Mark the canonical reviewed entry
- RefSeq protein: ALL NP_ accessions

Protein domains and families:
- List ALL annotated domains/families with identifiers
- Include: domain name, type (domain/family/superfamily), and ID

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 4: STRUCTURE IDENTIFIERS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Experimental structures:
- List ALL PDB structure IDs
- For each: experimental method (X-ray, NMR, Cryo-EM) and resolution
- Total PDB structure count

Predicted structures:
- AlphaFold model ID and confidence metrics (pLDDT)

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 5: CROSS-SPECIES ORTHOLOGS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
List orthologous genes in key model organisms (where available):
- Mouse (Mus musculus): gene ID, symbol
- Rat (Rattus norvegicus): gene ID, symbol
- Zebrafish (Danio rerio): gene ID, symbol
- Fruit fly (Drosophila melanogaster): gene ID, symbol
- Worm (C. elegans): gene ID, symbol
- Yeast (S. cerevisiae): gene ID, symbol

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 6: CLINICAL VARIANTS & AI PREDICTIONS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Clinical variant annotations:
- Total variant count in clinical databases
- Breakdown by classification: Pathogenic, Likely Pathogenic,
  Uncertain Significance (VUS), Likely Benign, Benign
- List TOP 50 pathogenic/likely pathogenic variants with:
  variant ID, HGVS notation, associated condition

AI-based variant effect predictions:
- Splice effect predictions: Total count
  List TOP 50 predicted splice-altering variants with delta scores
- Missense pathogenicity predictions: Total count
  List TOP 50 predicted pathogenic missense variants with scores

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 7: BIOLOGICAL PATHWAYS & GENE ONTOLOGY
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Pathway membership:
- List ALL biological pathways this gene participates in
- Include pathway IDs and names
- Total pathway count

Gene Ontology annotations:
- Biological Process: count and TOP 20 terms with IDs
- Molecular Function: count and TOP 20 terms with IDs
- Cellular Component: count and TOP 20 terms with IDs

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 8: PROTEIN INTERACTIONS & MOLECULAR NETWORKS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Protein-protein interactions:
- Total interaction count
- List TOP 50 highest-confidence interacting proteins with scores

Protein similarity (evolutionary and structural):
- Structural/embedding similarity: How many similar proteins?
  List TOP 20 with similarity scores
- Sequence homology: How many homologous proteins?
  List TOP 20 with identity/similarity scores

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 9: TRANSCRIPTION FACTOR REGULATORY DATA
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
If this gene encodes a transcription factor:

Downstream targets (genes regulated BY this TF):
- Total target gene count
- List TOP 50 target genes with regulation type (activates/represses)

DNA binding profiles:
- List ALL known binding motif IDs
- Motif family classification

Upstream regulators (TFs that regulate THIS gene):
- List known transcriptional regulators with evidence type

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 10: DRUG & PHARMACOLOGY DATA
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
If this gene/protein is a drug target:

Targeting molecules:
- How many drug/compound molecules target this protein?
- List TOP 30 molecules by development phase
- Include: molecule ID, name, mechanism, highest development phase

Clinical trials:
- How many clinical trials involve drugs targeting this gene?
- List TOP 20 trials with: trial ID, phase, status, intervention

Pharmacogenomics:
- Known drug-gene interactions affecting drug response
- Dosing guidelines if any exist

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 11: EXPRESSION PROFILES
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Tissue expression:
- Which tissues express this gene most highly?
- List TOP 30 tissues with expression scores/levels
- Note any tissue-specific or tissue-enriched patterns

Cell type expression:
- Which cell types show highest expression?
- List TOP 30 cell types with expression scores
- Note any cell type-specific patterns

Single-cell expression data (if available):
- Which single-cell datasets/experiments include this gene?
- Notable cell population patterns

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
SECTION 12: DISEASE ASSOCIATIONS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
Mendelian/monogenic disease links:
- What diseases are caused by mutations in this gene?
- List ALL associated diseases with: disease name, disease ID,
  inheritance pattern, evidence level

Phenotype associations:
- What clinical phenotypes are associated with this gene?
- List TOP 50 phenotype terms with IDs

Complex trait associations (GWAS):
- What traits/diseases are linked via genome-wide association studies?
- List TOP 30 GWAS associations with: trait, study ID, p-value,
  effect size if available

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
FORMATTING REQUIREMENTS
━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
- Present each section with clear headers
- Use tables for listing multiple items
- Always include COUNTS for every category
- For lists with >50 items: show total count + TOP 50
- For lists with <50 items: show ALL items
- Always include database identifiers (IDs), not just names
- Mark canonical/primary/reviewed entries where applicable
- If a section has no data available, state "No data available"
  rather than omitting the section

Accepted Answer

VEGFA - Comprehensive Cross-Database Identifier and Functional Mapping Reference Gene: Vascular Endothelial Growth Factor A Date Generated: 2026-03-26
Section 1: Gene Identifiers
AttributeValue HGNC IDHGNC:12680 Approved SymbolVEGFA Approved Namevascular endothelial growth factor A Previous SymbolsVEGF AliasesVEGF-A, VPF Locus Typegene with protein product Gene GroupVEGF family Ensembl Gene IDENSG00000112715 NCBI Entrez Gene ID7422 OMIM ID192240 Chromosome6 Cytogenetic Location6p21.1 Genomic …

Transcript ID	Biotype	Start	End	Strand
ENST00000230480	protein_coding	43771992	43784935	+
ENST00000324450	protein_coding	43770707	43784562	+
ENST00000372055	protein_coding	43770707	43784609	+
ENST00000372064	protein_coding	43770707	43786487	+
ENST00000372067	protein_coding	43770213	43786487	+
ENST00000372077	protein_coding	43770782	43786487	+
ENST00000413642	protein_coding	43770707	43784589	+
ENST00000417285	protein_coding	43770707	43784562	+
ENST00000425836	protein_coding	43770211	43786487	+
ENST00000457104	protein_coding	43771247	43784562	+
ENST00000476772	retained_intron	43770184	43778764	+
ENST00000480614	retained_intron	43773172	43786484	+
ENST00000482630	protein_coding	43770707	43784658	+
ENST00000493786	retained_intron	43778172	43784564	+
ENST00000497139	retained_intron	43777720	43786439	+
ENST00000512683	retained_intron	43771247	43777825	+
ENST00000518538	retained_intron	43771153	43778937	+
ENST00000518689	protein_coding	43771247	43784562	+
ENST00000518824	protein_coding	43771247	43784658	+
ENST00000519767	protein_coding	43770793	43784562	+
ENST00000520265	protein_coding	43774353	43784562	+
ENST00000520948	protein_coding	43771083	43784949	+
ENST00000523125	protein_coding	43771247	43784562	+
ENST00000523873	protein_coding	43771209	43784609	+
ENST00000523950	protein_coding	43771209	43784902	+
ENST00000672860	protein_coding	43770211	43786487	+

Exon ID	Start	End	Strand
ENSE00003998309	43770213	43771312	+
ENSE00003650678	43774341	43774392	+
ENSE00003595535	43777469	43777665	+
ENSE00003501088	43778460	43778536	+
ENSE00003605110	43778889	43778918	+
ENSE00003650262	43781956	43782087	+
ENSE00001431654	43784541	43786487	+

UniProt ID	Status	Name
P15692	Reviewed (Canonical)	Vascular endothelial growth factor A, long form
A0A0A0MR43	Unreviewed	VEGFA isoform
A0A0A0MRQ4	Unreviewed	VEGFA isoform
A0A0A0MSH5	Unreviewed	VEGFA isoform
A0A0A0MSH7	Unreviewed	VEGFA isoform
A0A0A0MSI7	Unreviewed	VEGFA isoform
A0A0A0MTB2	Unreviewed	VEGFA isoform
A0A0Y0IMM4	Unreviewed	VEGFA isoform
A0A5F9ZH41	Unreviewed	VEGFA isoform
A2A2V4	Unreviewed	VEGFA isoform
H0YBI8	Unreviewed	VEGFA isoform
H0YBZ0	Unreviewed	VEGFA isoform
H3BLW8	Unreviewed	VEGFA isoform
J3KPA4	Unreviewed	VEGFA isoform

InterPro ID	Name	Type
IPR000072	PDGF/VEGF_dom	Domain
IPR023581	PD_growth_factor_CS	Conserved_site
IPR027928	VEGF_C	Domain
IPR029034	Cystine-knot_cytokine	Homologous_superfamily
IPR036841	VEGF_C_sf	Homologous_superfamily
IPR050507	PDGF/VEGF_growth_factor	Family

PDB ID	Method	Resolution	Title
1BJ1	X-RAY	2.4 Å	VEGF in complex with neutralizing antibody
1CZ8	X-RAY	2.4 Å	VEGF in complex with affinity matured antibody
1FLT	X-RAY	1.7 Å	VEGF with FLT-1 receptor domain 2
1KAT	NMR	-	VEGF with phage-derived peptide antagonist
1KMX	NMR	-	Heparin-binding domain from VEGF
1MJV	X-RAY	2.1 Å	Disulfide mutant (C51A, C60A)
1MKG	X-RAY	2.5 Å	Disulfide mutant (C57A, C102A)
1MKK	X-RAY	1.32 Å	Disulfide mutant (C61A, C104A)
1QTY	X-RAY	2.7 Å	VEGF with FLT-1 receptor domain 2
1TZH	X-RAY	2.6 Å	Fab YADS1 complexed with VEGF
1TZI	X-RAY	2.8 Å	Fab YADS2 complexed with VEGF
1VGH	NMR	-	Heparin-binding domain
1VPF	X-RAY	2.5 Å	Human VEGF structure
1VPP	X-RAY	1.9 Å	VEGF with receptor blocking peptide
2FJG	X-RAY	2.8 Å	G6 Fab with VEGF
2FJH	X-RAY	3.1 Å	B20-4 Fab with VEGF
2QR0	X-RAY	3.5 Å	VEGF with Fab containing TYR/SER in CDRs
2VGH	NMR	-	Heparin-binding domain (minimized)
2VPF	X-RAY	1.93 Å	VEGF refined structure
3BDY	X-RAY	2.6 Å	Dual specific bH1 Fab with VEGF
3P9W	X-RAY	2.41 Å	Engineered VH domain with VEGF
3QTK	X-RAY	1.85 Å	Chemically synthesized VEGF-A
3S1B	X-RAY	2.9 Å	Peptide-based angiogenesis tools
3S1K	X-RAY	2.55 Å	Peptide-based angiogenesis tools
3V2A	X-RAY	3.2 Å	VEGFR-2/VEGF-A complex
4DEQ	X-RAY	2.65 Å	Neuropilin-1/VEGF-A complex
4GLN	X-RAY	1.6 Å	D-protein antagonist + VEGF-A
4GLS	X-RAY	1.6 Å	D-protein antagonist + VEGF-A
4KZN	X-RAY	1.71 Å	VEGF-A receptor binding domain
4QAF	X-RAY	1.8 Å	Anticalin with VEGF
4WPB	X-RAY	3.11 Å	VEGF with alpha/beta-VEGF-1
4ZFF	X-RAY	2.75 Å	Dual-acting Fab 5A12 with VEGF
5DN2	X-RAY	1.95 Å	NRP2 b1 domain with VEGF-A C-terminus
5FV1	X-RAY	2.7 Å	VEGF with VK domain antibody
5FV2	X-RAY	3.45 Å	VEGF with VH domain antibody
5HHC	X-RAY	2.1 Å	RFX037 + VEGF-A
5HHD	X-RAY	2.1 Å	RFX037 + VEGF-A
5O4E	X-RAY	2.15 Å	VEGF with heterodimeric Fcab
5T89	X-RAY	4.0 Å	VEGF-A with VEGFR-1 domains D1-6
6BFT	X-RAY	2.55 Å	Bevacizumab Fab mutant with VEGF
6D3O	X-RAY	3.1 Å	VEGF with alpha/beta-peptide HH4
6T9D	X-RAY	2.9 Å	Bispecific DutaFab with VEGF121
6V7K	X-RAY	2.5 Å	VEGF with HH4 peptide
6Z13	X-RAY	1.8 Å	VEGF with 3C bicyclic peptide
6Z3F	X-RAY	2.1 Å	VEGF with 2C bicyclic peptide
6ZBR	X-RAY	1.6 Å	VEGF with 4C bicyclic peptide
6ZCD	X-RAY	1.8 Å	VEGF with 1C bicyclic peptide
6ZFL	X-RAY	1.6 Å	High resolution VEGF-A structure
7KEZ	X-RAY	2.31 Å	bH1 Fab variant with VEGF
7KF0	X-RAY	2.32 Å	bH1 Fab variant with VEGF
7KF1	X-RAY	2.45 Å	bH1 Fab variant with VEGF
7LL8	X-RAY	2.31 Å	D-protein RFX-V1 with VEGF-A
7LL9	X-RAY	2.9 Å	D-protein RFX-V2 with VEGF-A
8UWZ	X-RAY	3.5 Å	Raamsizumab with VEGF121
9JU1	X-RAY	1.45 Å	Helix-loop-helix peptide with VEGF-A
9KKU	X-RAY	1.46 Å	M49 peptide with VEGF-A

VEGFA Gene Complete Identifier and Functional Mapping Reference

Structured Data Sources

Attribute	Value
HGNC ID	HGNC:12680
Approved Symbol	VEGFA
Approved Name	vascular endothelial growth factor A
Previous Symbols	VEGF
Aliases	VEGF-A, VPF
Locus Type	gene with protein product
Gene Group	VEGF family
Ensembl Gene ID	ENSG00000112715
NCBI Entrez Gene ID	7422
OMIM ID	192240
Chromosome	6
Cytogenetic Location	6p21.1
Genomic Start (GRCh38)	43,770,184
Genomic End (GRCh38)	43,786,487
Strand	+ (forward)
Biotype	protein_coding

RefSeq ID	Type	MANE Select
NM_003376	mRNA	Yes
NM_001025366	mRNA	No
NM_001025367	mRNA	No
NM_001025368	mRNA	No
NM_001025369	mRNA	No
NM_001025370	mRNA	No
NM_001033756	mRNA	No
NM_001171622	mRNA	No
NM_001171623	mRNA	No
NM_001171624	mRNA	No
NM_001171625	mRNA	No
NM_001171626	mRNA	No
NM_001171627	mRNA	No
NM_001171628	mRNA	No
NM_001171629	mRNA	No
NM_001171630	mRNA	No
NM_001204384	mRNA	No
NM_001204385	mRNA	No
NM_001287044	mRNA	No
NM_001317010	mRNA	No

RefSeq Protein ID	Gene	MANE Select
NP_003367	VEGFA	Yes
NP_001020537	VEGFA	No
NP_001020538	VEGFA	No
NP_001020539	VEGFA	No
NP_001020540	VEGFA	No
NP_001020541	VEGFA	No
NP_001028928	VEGFA	No
NP_001165093	VEGFA	No
NP_001165094	VEGFA	No
NP_001165095	VEGFA	No
NP_001165096	VEGFA	No
NP_001165097	VEGFA	No
NP_001165098	VEGFA	No
NP_001165099	VEGFA	No
NP_001165100	VEGFA	No
NP_001165101	VEGFA	No
NP_001191313	VEGFA	No
NP_001191314	VEGFA	No
NP_001273973	VEGFA	No
NP_001303939	VEGFA	No

Organism	Gene ID	Symbol	Biotype
Mouse (Mus musculus)	ENSMUSG00000023951	Vegfa	protein_coding
Rat (Rattus norvegicus)	ENSRNOG00000019598	Vegfa	protein_coding
Zebrafish (Danio rerio)	ENSDARG00000034700	vegfab	protein_coding
Zebrafish (Danio rerio)	ENSDARG00000103542	vegfaa	protein_coding
Fruit fly (D. melanogaster)	No direct ortholog	-	-
Worm (C. elegans)	No direct ortholog	-	-
Yeast (S. cerevisiae)	No ortholog	-	-

Classification	Count
Pathogenic	0
Likely Pathogenic	1
Uncertain Significance (VUS)	~60
Likely Benign	~15
Benign	~10
Other/No classification	~22

Variant ID	HGVS Notation	Type
1007657	c.7_8dup (p.Asp3fs)	Duplication
1206397	c.64C>T (p.Arg22Trp)	SNV
2227959	c.599A>T (p.His200Leu)	SNV
2261356	c.341G>C (p.Arg114Pro)	SNV
2328107	c.985A>G (p.Lys329Glu)	SNV
2346464	c.89G>A (p.Arg30His)	SNV
2355928	c.214G>T (p.Gly72Trp)	SNV
2478012	c.469A>C (p.Ser157Arg)	SNV
2533592	c.1034+42C>T	SNV
2534725	c.398C>A (p.Ala133Glu)	SNV
2534729	c.511C>G (p.Arg171Gly)	SNV
2551246	c.335G>T (p.Gly112Val)	SNV
2552874	c.692A>C (p.Tyr231Ser)	SNV
290393	c.973C>T (p.Arg325Ter)	SNV
3061283	c.1154A>G (p.Glu385Gly)	SNV
3188428	c.1003C>A (p.Arg335Ser)	SNV
3188429	c.1058G>A (p.Arg353Gln)	SNV
3188430	c.1153G>A (p.Glu385Lys)	SNV
3188431	c.188G>T (p.Arg63Leu)	SNV
3188432	c.595C>T (p.His199Tyr)	SNV
3188434	c.703A>G (p.Ile235Val)	SNV
3188435	c.954A>T (p.Arg318Ser)	SNV
3188436	c.986A>G (p.Lys329Arg)	SNV
3331993	c.946A>G (p.Arg316Gly)	SNV
3331995	c.355T>C (p.Trp119Arg)	SNV
3331996	c.350G>C (p.Gly117Ala)	SNV
3331997	c.1099T>A (p.Cys367Ser)	SNV
3467939	c.1109A>G (p.Lys370Arg)	SNV
3467940	c.368C>A (p.Ala123Glu)	SNV
3467941	c.1036C>T (p.Pro346Ser)	SNV

Variant	Effect	Delta Score
6:43771310:AAGGT:A	donor_loss	0.99
6:43771313:G:GA	donor_loss	0.99
6:43771314:T:G	donor_loss	0.99
6:43771673:G:GT	donor_gain	0.99
6:43771313:G:GG	donor_gain	0.95
6:43771673:G:T	donor_gain	0.94
6:43771311:AG:A	donor_gain	0.93
6:43771312:GG:G	donor_gain	0.93
6:43771010:G:GT	donor_gain	0.88
6:43771716:G:GT	donor_gain	0.88
6:43770948:G:GT	donor_gain	0.78
6:43771664:G:GT	donor_gain	0.78
6:43771707:A:AG	donor_gain	0.77
6:43771708:G:GG	donor_gain	0.78
6:43771598:G:GT	donor_gain	0.76
6:43771048:G:GT	donor_gain	0.76
6:43771675:A:AG	donor_gain	0.75
6:43771676:GTC:G	donor_gain	0.72
6:43771703:GACCA:G	donor_gain	0.70
6:43771310:AAG:A	donor_gain	0.70
6:43771637:G:GT	donor_gain	0.69
6:43771595:G:GT	donor_gain	0.68
6:43771678:C:G	donor_gain	0.67
6:43771309:CAAG:C	donor_gain	0.64
6:43771555:C:G	donor_gain	0.64
6:43771694:G:GT	donor_gain	0.63
6:43771072:G:GT	donor_gain	0.63
6:43771711:G:A	donor_gain	0.60
6:43771556:G:GG	donor_gain	0.60
6:43770998:G:GT	donor_gain	0.59
6:43771560:G:GT	donor_gain	0.59
6:43771741:G:GT	donor_gain	0.59
6:43771690:G:T	donor_gain	0.58
6:43771066:G:A	donor_gain	0.55
6:43771678:C:CG	donor_gain	0.55
6:43771674:A:T	donor_gain	0.54
6:43771073:G:T	donor_gain	0.52
6:43771553:C:T	donor_gain	0.51
6:43771741:G:T	donor_gain	0.51
6:43770789:C:T	donor_gain	0.48
6:43771678:C:A	donor_gain	0.47
6:43771017:A:T	donor_gain	0.47
6:43771308:CCAAG:C	donor_gain	0.46
6:43771552:GCAC:G	donor_gain	0.45
6:43771462:GC:G	donor_gain	0.45
6:43771321:T:TA	donor_gain	0.44
6:43770800:C:T	donor_gain	0.43
6:43771070:G:A	donor_gain	0.43
6:43771607:GGGGC:G	donor_gain	0.42
6:43771461:TGC:T	donor_gain	0.41

Variant	Protein Change	AM Pathogenicity	AM Class
6:43771277:A:C	S11R	0.979	likely_pathogenic
6:43771279:C:A	S11R	0.979	likely_pathogenic
6:43771279:C:G	S11R	0.979	likely_pathogenic
6:43771284:C:A	A13D	0.979	likely_pathogenic
6:43771265:T:A	W7R	0.973	likely_pathogenic
6:43771265:T:C	W7R	0.973	likely_pathogenic
6:43771274:T:A	W10R	0.971	likely_pathogenic
6:43771274:T:C	W10R	0.971	likely_pathogenic
6:43771293:T:C	L16P	0.873	likely_pathogenic
6:43771293:T:G	L16R	0.871	likely_pathogenic
6:43771293:T:A	L16H	0.866	likely_pathogenic
6:43771295:T:G	Y17D	0.854	likely_pathogenic
6:43771281:T:C	L12P	0.927	likely_pathogenic
6:43771281:T:A	L12H	0.925	likely_pathogenic
6:43771281:T:G	L12R	0.923	likely_pathogenic
6:43771253:T:C	F3L	0.912	likely_pathogenic
6:43771255:T:A	F3L	0.912	likely_pathogenic
6:43771255:T:G	F3L	0.912	likely_pathogenic
6:43771290:T:G	L15R	0.892	likely_pathogenic
6:43771290:T:C	L15P	0.875	likely_pathogenic
6:43771252:C:A	N2K	0.820	likely_pathogenic
6:43771252:C:G	N2K	0.820	likely_pathogenic
6:43771269:T:A	V8E	0.820	likely_pathogenic
6:43771283:G:C	A13P	0.805	likely_pathogenic
6:43771251:A:T	N2I	0.754	likely_pathogenic
6:43771290:T:A	L15Q	0.747	likely_pathogenic
6:43771254:T:C	F3S	0.728	likely_pathogenic
6:43771287:T:G	L14W	0.700	likely_pathogenic
6:43771271:C:G	H9D	0.701	likely_pathogenic
6:43771287:T:C	L14S	0.688	likely_pathogenic
6:43771250:A:G	N2D	0.647	likely_pathogenic
6:43771257:T:G	L4R	0.649	likely_pathogenic
6:43771250:A:T	N2Y	0.632	likely_pathogenic
6:43771283:G:A	A13T	0.610	likely_pathogenic
6:43771257:T:C	L4P	0.602	likely_pathogenic
6:43771295:T:A	Y17N	0.585	likely_pathogenic
6:43771254:T:G	F3C	0.572	likely_pathogenic
6:43771284:C:T	A13V	0.564	ambiguous
6:43771278:G:A	S11N	0.556	ambiguous
6:43771295:T:C	Y17H	0.541	ambiguous
6:43771266:G:C	W7S	0.528	ambiguous
6:43771260:T:C	L5P	0.517	ambiguous
6:43771257:T:A	L4Q	0.512	ambiguous
6:43771250:A:C	N2H	0.513	ambiguous
6:43771251:A:C	N2T	0.500	ambiguous
6:43771276:G:C	W10C	0.451	ambiguous
6:43771276:G:T	W10C	0.451	ambiguous
6:43771263:C:A	S6Y	0.411	ambiguous
6:43771269:T:C	V8A	0.409	ambiguous
6:43771253:T:A	F3I	0.403	ambiguous

Pathway ID	Pathway Name	Disease Pathway
R-HSA-194138	Signaling by VEGF	No
R-HSA-4420097	VEGFA-VEGFR2 Pathway	No
R-HSA-194313	VEGF ligand-receptor interactions	No
R-HSA-195399	VEGF binds to VEGFR leading to receptor dimerization	No
R-HSA-5218921	VEGFR2 mediated cell proliferation	No
R-HSA-114608	Platelet degranulation	No
R-HSA-1234158	Regulation of gene expression by Hypoxia-inducible Factor	No
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	No
R-HSA-8866910	TFAP2 family regulates transcription of growth factors	No
R-HSA-9679191	Potential therapeutics for SARS	Yes

GO ID	Term Name
GO:0001525	angiogenesis
GO:0001570	vasculogenesis
GO:0045766	positive regulation of angiogenesis
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0038084	vascular endothelial growth factor signaling pathway
GO:0036324	vascular endothelial growth factor receptor-2 signaling pathway
GO:0002040	sprouting angiogenesis
GO:0001938	positive regulation of endothelial cell proliferation
GO:0010595	positive regulation of endothelial cell migration
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0001666	response to hypoxia
GO:0071456	cellular response to hypoxia
GO:0001946	lymphangiogenesis
GO:0036303	lymph vessel morphogenesis
GO:0043117	positive regulation of vascular permeability
GO:0001569	branching involved in blood vessel morphogenesis
GO:0048844	artery morphogenesis
GO:0060982	coronary artery morphogenesis
GO:0003169	coronary vein morphogenesis
GO:0035767	endothelial cell chemotaxis

CCDS ID
CCDS4907
CCDS34457
CCDS34458
CCDS47432
CCDS47433
CCDS47434
CCDS47435
CCDS55007
CCDS55008
CCDS55009
CCDS55010
CCDS55011
CCDS55012
CCDS55013
CCDS55014
CCDS55015
CCDS69125

GO ID	Term Name
GO:0005172	vascular endothelial growth factor receptor binding
GO:0043183	vascular endothelial growth factor receptor 1 binding
GO:0043184	vascular endothelial growth factor receptor 2 binding
GO:0008083	growth factor activity
GO:0005125	cytokine activity
GO:0048018	receptor ligand activity
GO:0030297	transmembrane receptor protein tyrosine kinase activator activity
GO:0008201	heparin binding
GO:0038191	neuropilin binding
GO:0005161	platelet-derived growth factor receptor binding
GO:0001968	fibronectin binding
GO:0042056	chemoattractant activity
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0050840	extracellular matrix binding

GO ID	Term Name
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0031012	extracellular matrix
GO:0009986	cell surface
GO:0031093	platelet alpha granule lumen
GO:0030141	secretory granule
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005912	adherens junction
GO:0016020	membrane
GO:1990150	VEGF-A complex

Interaction ID	Partner	Interaction Type	Confidence
EBI-1026762	FLT1 (VEGFR1)	direct interaction	0.820
EBI-1028540	FLT1	direct interaction	0.820
EBI-9084618	FLT1	direct interaction	0.820
EBI-9098469	FLT1	physical association	0.820
EBI-54757900	FLT1	physical association	0.820
EBI-8310601	KDR (VEGFR2)	direct interaction	0.810
EBI-8540559	KDR	physical association	0.810
EBI-9098452	KDR	direct interaction	0.810
EBI-9558639	KDR	proximity	0.810
EBI-1187131	NRP1	physical association	0.770
EBI-21347955	NRP1	physical association	0.770
EBI-8540599	NRP1	physical association	0.770
EBI-8540649	NRP1	physical association	0.770
EBI-8540702	NRP1	physical association	0.770
EBI-6902703	VEGFA (homodimer)	direct interaction	0.720
EBI-6902827	VEGFA	direct interaction	0.720
EBI-6902836	VEGFA	direct interaction	0.720
EBI-6902854	VEGFA	direct interaction	0.720
EBI-6902863	VEGFA	direct interaction	0.720
EBI-6902872	VEGFA	direct interaction	0.720
EBI-6902890	VEGFA	direct interaction	0.720
EBI-6902896	VEGFA	direct interaction	0.720
EBI-9683487	VEGFA	direct interaction	0.720
EBI-9098460	KDR-GREM1	physical association	0.640
EBI-54755932	VEGFB	association	0.480
EBI-6594226	VEGFB	proximity	0.480
EBI-15630437	Nrp1 (mouse)	direct interaction	0.440
EBI-15805699	THBS1	physical association	0.400
EBI-3913707	U2AF1	physical association	0.370
EBI-3920510	VPS35	physical association	0.370

Interactor	Experimental System
KDR (VEGFR2)	Co-localization, Biochemical Activity, Reconstituted Complex
FLT1 (VEGFR1)	Affinity Capture-MS, Protein-peptide
NRP1	Affinity Capture-Western
HIF1A	Reconstituted Complex
SP1	Reconstituted Complex
SP3	Reconstituted Complex
TFAP2A	Reconstituted Complex
CLU	Affinity Capture-Western
CTGF	Reconstituted Complex
GPC1	Reconstituted Complex
HSP90AA1	Affinity Capture-Western
HSPA4	Affinity Capture-Western
CRYAB	Affinity Capture-Western
PDIA4	Affinity Capture-Western
USP35	Affinity Capture-Western
VHL	Negative Genetic

UniProt ID	Top Similarity Score	Average Similarity
P09038	0.9998	0.9658
Q5IS69	0.9998	0.9666
Q00731	0.9990	0.9774
Q8NAU1	0.9986	0.9821
Q6DRA6	0.9971	0.9661
B9A064	0.9964	0.9638
O15354 (VEGFB)	0.9949	0.9730
Q8WTX9	0.9910	0.9799
Q2M2W7	0.9900	0.9623
Q8CEZ0	0.9868	0.9762
P49763 (VEGFC)	0.9851	0.9769
O15428 (VEGFD)	0.9740	0.9609
Q5JTJ3	0.9700	0.9642
P21978	0.9644	0.9598

UniProt ID	Identity %	Bit Score
P67964	100.0	416
P67965	100.0	416
P0DW97	99.1	222
P82475	99.1	223
P83942	99.1	223
P15691	99.3	395
P50412	99.3	296
P0DL42	98.2	226
P67861	98.2	266
P67863	99.1	266
B0VXV3	98.7	301
B0VXV4	98.7	301
P16612	98.6	423
Q00731	98.6	576
Q6J936	97.9	296
Q90X23	97.9	295
O35757 (mouse)	97.6	764
P97953 (rat)	97.6	765
P49151	96.8	397
Q9GKR0	96.3	390

TF Symbol	Relationship
HIF1A	up-regulates quantity (transcriptional regulation)
EPAS1 (HIF2A)	major regulator
STAT3	up-regulates quantity by expression
MYC	up-regulates quantity by expression
SP1	transcriptional activator
SP3	transcriptional activator
TFAP2A	transcriptional activator
RUNX2	up-regulates quantity by expression
MYOD1	up-regulates quantity by expression
CREB1	regulator
ATF4	regulator
ATF3	regulator
ATF6	regulator
ARNT	regulator
ESR1	regulator
ESR2	regulator
AR	regulator
EGR1	regulator
ETS1	regulator
ETV4	regulator
ETV6	regulator
E2F1	regulator
E2F3	regulator
E2F7	regulator
E2F8	regulator
FOXO1	regulator
FOXO3	regulator
FOXO4	regulator
FOXC1	regulator
FOXM1	regulator
FOXP3	regulator
FOXQ1	regulator
FOS	regulator
AP1	regulator
GATA4	regulator
GATA6	regulator
CTNNB1	regulator
BMAL1	regulator
BRCA1	regulator
EP300	regulator
ESRRA	regulator
CEBPA	regulator
GABPA	regulator
HLF	regulator
FHL1	regulator
DDIT3	regulator
DLX4	regulator
ELK3	regulator
HIC1	down-regulates quantity by repression
ZMYND8	down-regulates quantity by repression

miRNA	Effect
hsa-miR-30a-3p	down-regulates quantity by repression
hsa-miR-199a-5p	down-regulates quantity by repression
hsa-miR-200b-5p	down-regulates quantity by repression

Entity	Target	Effect	Mechanism
HIF1A	VEGFA	up-regulates	transcriptional regulation
STAT3	VEGFA	up-regulates	transcriptional regulation
MYC	VEGFA	up-regulates	transcriptional regulation
RUNX2	VEGFA	up-regulates	transcriptional regulation
MYOD1	VEGFA	up-regulates	transcriptional regulation
HIC1	VEGFA	down-regulates	transcriptional regulation
ZMYND8	VEGFA	down-regulates	transcriptional regulation

Target	Effect	Mechanism
FLT1	up-regulates	binding
KDR	up-regulates	binding
DLL4	up-regulates quantity	transcriptional regulation
Angiogenesis (phenotype)	up-regulates	-

Target ID	Target Name	Type
CHEMBL1783	Vascular endothelial growth factor A	SINGLE PROTEIN
CHEMBL5482974	VEGFA-NRP1	PROTEIN-PROTEIN INTERACTION
CHEMBL5482995	NRP2-VEGFA	PROTEIN COMPLEX
CHEMBL5482996	VEGFR1-VEGFA	PROTEIN COMPLEX
CHEMBL5482997	VEGFR2-VEGFA	PROTEIN COMPLEX

ChEMBL ID	Drug Name	Type	Phase
CHEMBL3646221	VADADUSTAT	Small molecule	4 (Approved)
CHEMBL4585668	BELZUTIFAN	Small molecule	4 (Approved)

ChEMBL ID	Drug Name	Type	Phase
CHEMBL253969	OSI-632 (CP 547632)	Small molecule	2
CHEMBL3115298	IZILENDUSTAT	Small molecule	2
CHEMBL5314521	IMDATIFAN	Small molecule	2

Drug/Drug Class	Clinical Annotations	Variant Annotations
Bevacizumab (VEGF inhibitor)	24	162
VEGF/VEGFR inhibitors (class)	24	164
Sunitinib	16	138
Sorafenib	40	80
Pazopanib	2	27
Ranibizumab	7	79
Aflibercept	0	1
Pegaptanib	1	2
Cetuximab	15	87
Panitumumab	6	39
Pemetrexed	12	29
Adalimumab	18	118
Anthracyclines (class)	192	731
Taxanes (class)	138	529
Epirubicin	49	175
Lenalidomide	4	23
Thalidomide	26	31
Carfilzomib	0	4
Warfarin	90	1,220
Dexamethasone	14	55
Celecoxib	6	44
Enalapril	10	44
Sildenafil	5	8
Salbutamol	21	59

Drug	Mechanism	Effect
Bevacizumab	binding (antibody)	down-regulates activity
Aflibercept	chemical inhibition (decoy receptor)	down-regulates activity

Attribute	Value
Expression Breadth	Ubiquitous
Total Tissues with Expression	297
Total Absent Calls	1
Max Expression Score	99.59
Average Expression Score	92.05
Gold Quality Measurements	290

Tissue (UBERON ID)	Expression Score	Quality
Right lobe of thyroid gland (UBERON:0001119)	99.59	Gold
Left lobe of thyroid gland (UBERON:0001120)	99.53	Gold
Thyroid gland (UBERON:0002046)	99.51	Gold
Renal glomerulus (UBERON:0000074)	99.25	Gold
Metanephric glomerulus (UBERON:0004736)	99.17	Gold
Pigmented layer of retina (UBERON:0001782)	99.12	Gold
Retina (UBERON:0000966)	99.10	Gold
Cartilage tissue (UBERON:0002418)	98.92	Gold
Right lobe of liver (UBERON:0001114)	98.89	Gold
Apex of heart (UBERON:0002098)	98.88	Gold
Pericardium (UBERON:0002407)	98.79	Gold
Right atrium auricular region (UBERON:0006631)	98.61	Gold
Ventricular zone (UBERON:0003053)	98.58	Gold
Cardiac atrium (UBERON:0002081)	98.55	Gold
Gall bladder (UBERON:0002110)	98.54	Gold
Gastrocnemius (UBERON:0001388)	98.51	Gold
Metanephros (UBERON:0000081)	98.49	Gold
Body of uterus (UBERON:0009853)	98.44	Gold
Lower esophagus mucosa (UBERON:0035834)	98.44	Gold
Mucosa of paranasal sinus (UBERON:0005030)	98.41	Gold
Body of tongue (UBERON:0011876)	98.40	Gold
Islet of Langerhans (UBERON:0000006)	98.38	Gold
Vena cava (UBERON:0004087)	98.37	Gold
Cortex of kidney (UBERON:0001225)	98.34	Gold
Type B pancreatic cell (CL:0000169)	98.33	Gold
Renal medulla (UBERON:0000362)	98.33	Gold
Omental fat pad (UBERON:0010414)	98.32	Gold
Peritoneum (UBERON:0002358)	98.31	Gold
Saphenous vein (UBERON:0007318)	98.29	Gold
Adipose tissue of abdominal region (UBERON:0007808)	98.23	Gold

Dataset ID	Description	Species	Cell Count
E-MTAB-8495	Single-cell RNA-seq of human biliary tree	Homo sapiens	160,459
E-MTAB-9435	Single-cell RNA-seq of IDHwt glioblastoma	Homo sapiens	62,867
E-MTAB-8559	Single-cell RNA-seq of ovarian cancer	Homo sapiens	20,982
E-GEOD-124472	Human embryonic kidney cells	Homo sapiens	18,079
E-GEOD-137537	Human retina - macular degeneration study	Homo sapiens	12,881
E-CURD-135	Kidney organoid vs adult kidney	Homo sapiens	6,192
E-ENAD-27	Human islet cells - type 2 diabetes	Homo sapiens	1,145
E-CURD-7	Adult human breast epithelial cells	Homo sapiens	867
E-ENAD-21	Single-cell RNA-seq breast epithelial	Homo sapiens	867
E-CURD-10	Metastatic renal cell carcinoma	Homo sapiens	118
E-MTAB-6058	Human foetal cone photoreceptors	Homo sapiens	74

Study ID	Trait/Disease	P-value
GCST004422_37	Vascular endothelial growth factor levels	2×10⁻¹⁷¹
GCST004439_21	Interleukin-12p70 levels	3×10⁻¹²⁴
GCST004443_2	Interleukin-13 levels	1×10⁻⁶⁵
GCST004444_26	Interleukin-10 levels	6×10⁻⁶⁷
GCST004451_18	Interleukin-7 levels	7×10⁻³⁹
GCST002782_170	Waist-to-hip ratio (BMI adjusted)	4×10⁻³⁴
GCST004063_94	Waist circumference (BMI adjusted)	4×10⁻³⁰
GCST001155_4	Vascular endothelial growth factor levels	2×10⁻²⁶
GCST000829_2	Waist-hip ratio	6×10⁻²⁵
GCST004064_14	Waist-hip ratio	2×10⁻²⁴
GCST004604_34	Hematocrit	3×10⁻²²
GCST004576_11	Waist-to-hip ratio (BMI adjusted)	3×10⁻²¹
GCST004615_87	Hemoglobin concentration	1×10⁻²⁰
GCST004567_130	WHR adjusted for BMI (physical activity)	1×10⁻²⁰
GCST004601_80	Red blood cell count	3×10⁻¹⁶
GCST001856_29	Thyroid hormone levels	7×10⁻¹⁶
GCST001791_41	Urate levels	8×10⁻¹⁶
GCST004237_40	Triglyceride levels	6×10⁻¹⁶
GCST004063_12	Waist circumference (BMI adjusted)	6×10⁻¹⁵
GCST003372_50	Glomerular filtration rate (creatinine)	3×10⁻¹⁵
GCST002216_9	Triglycerides	3×10⁻¹⁵
GCST003219_22	Advanced age-related macular degeneration	1×10⁻¹⁴
GCST000649_14	Chronic kidney disease	9×10⁻¹⁴
GCST004292_49	Glomerular filtration rate (creatinine)	1×10⁻¹³
GCST004622_33	Reticulocyte count	3×10⁻¹³
GCST005194_228	Coronary artery disease	2×10⁻¹²
GCST004232_58	HDL cholesterol levels	2×10⁻¹²
GCST002223_68	HDL cholesterol	2×10⁻¹¹
GCST002063_2	Sexual dimorphism in anthropometric traits	2×10⁻¹¹
GCST004619_74	Reticulocyte fraction of red cells	7×10⁻¹¹

Category	Associated Traits
Metabolic	Type 2 diabetes, Triglycerides, HDL cholesterol, Urate levels
Anthropometric	Waist-hip ratio, Waist circumference, Body mass index
Cardiovascular	Coronary heart disease, Coronary artery disease
Renal	Chronic kidney disease, Glomerular filtration rate
Ophthalmologic	Age-related macular degeneration
Hematologic	Red blood cell count, Hematocrit, Hemoglobin, Reticulocyte count, White blood cell count
Endocrine	Thyroid hormone levels, Adiponectin levels, Hypothyroidism
Cytokines	VEGF levels, IL-10, IL-12p70, IL-13, IL-7 levels

Category	Count
Gene Identifiers	5 major databases
Transcripts (Ensembl)	26
RefSeq mRNAs (human)	20+
CCDS IDs	17
UniProt Accessions	14
InterPro Domains	6
PDB Structures	56
Orthologs	4 species
ClinVar Variants	108
SpliceAI Predictions	1,191
AlphaMissense Predictions	1,535
Reactome Pathways	10
GO Biological Process	100+
GO Molecular Function	15
GO Cellular Component	13
IntAct Interactions	53
BioGRID Interactions	113+
Upstream TF Regulators	173
PharmGKB Drug Interactions	24
ChEMBL Targeting Molecules	100+
GWAS Associations	260+
Expression Tissues	297
Single-cell Datasets	11