Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1566661 | 0.81 | MAPK1 (0.32) | MAPK1 | |
| SCHEMBL1567042 | 0.81 | SLC6A12 (0.34) | ALDH1A1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL1566243 | 0.73 | MAPK1 (0.33) | ALDH1A1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL12144966 | 0.72 | ALDH1A1 (0.37) | MEN1ALDH1A1TSHRKMT2ANFKB1 | |
| SCHEMBL19927773 | 0.72 | MEN1 (0.33) | MEN1ALDH1A1TSHRKMT2ANFKB1 | |
| SCHEMBL19927772 | 0.72 | MEN1 (0.33) | MEN1ALDH1A1TSHRKMT2ANFKB1 | |
| SCHEMBL19968799 | 0.72 | MEN1 (0.33) | MEN1ALDH1A1TSHRKMT2ANFKB1 | |
| SCHEMBL6513736 | 0.71 | LMNA (0.44) | MEN1ALDH1A1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL12144983 | 0.69 | ALDH1A1 (0.35) | MEN1ALDH1A1TSHRKMT2ANFKB1 | |
| SCHEMBL12144974 | 0.69 | ALDH1A1 (0.35) | MEN1ALDH1A1TSHRKMT2ANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305684-A1 | Poycyloalkylpurines as adenosine receptor antagonists | Biogen Idec MA Inc. (US) | 2011-04-06 | — | — | EP | disclosed |
| US-20090221821-A1 | ADENOSINE RECEPTOR ANTAGONISTS AND METHODS OF MAKING AND USING THE SAME | BIOGEN IDEC MA INC. (US) | 2009-09-03 | — | — | US | disclosed |
| US-7579354-B2 | Adenosine receptor antagonists and methods of making and using the same | KIESMAN WILLIAM F | 2009-08-25 | — | — | US | disclosed |
| EP-2070930-A1 | Polycycloalkylpurines as adenosine receptor antagonists | Biogen Idec MA, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1230243-B1 | POYCYLOALKYLPURINES AS ADENOSINE RECEPTOR ANTAGONISTS | BIOGEN IDEC INC (US) | 2009-03-04 | — | — | EP | disclosed |
| US-20070015732-A1 | Adenosine receptor antagonists and methods of making and using the same | KIESMAN WILLIAM F | 2007-01-18 | — | — | US | disclosed |
| US-20060252730-A1 | Adenosine receptor antagonists and methods of making and using the same | KIESMAN WILLIAM F | 2006-11-09 | — | — | US | disclosed |
| US-6649600-B1 | 2,6-Dioxo or dithioxy-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo derivatives; highly potent and selective diuretics | BIOGEN, INC. | 2003-11-18 | — | — | US | disclosed |
| EP-1230243-A1 | POYCYLOALKYLPURINES AS ADENOSINE RECEPTOR ANTAGONISTS | BIOGEN, INC. (US) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001034610-A1 | POLYCYCLOALKYLPURINES AS ADENOSINE RECEPTOR ANTAGONISTS | BIOGEN, INC. (US) | 2001-05-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221821-A1 | ADENOSINE RECEPTOR ANTAGONISTS AND METHODS OF MAKING AND USING THE SAME | ADORA1, ADORA2A, ADORA3 | MEN1 1711/4885ALDH1A1 72/4885TSHR 437/4885 |
| US-20060252730-A1 | Adenosine receptor antagonists and methods of making and using the same | ADORA1, ADORA2A, ADORA3 | MEN1 1711/4885ALDH1A1 72/4885TSHR 437/4885 |
| US-20070015732-A1 | Adenosine receptor antagonists and methods of making and using the same | ADORA1, ADORA2A, ADORA3 | MEN1 1711/4885ALDH1A1 72/4885TSHR 437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.