Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 12/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 12/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCND2 | P30279 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1662581 | 0.96 | BTK (0.44) | PLK4USP30IDO1TDO2JAK3 | |
| SCHEMBL1662847 | 0.83 | JAK3 (0.45) | USP30JAK3JAK2PTK2BTK | |
| SCHEMBL1662580 | 0.80 | JAK3 (0.44) | USP30JAK3JAK2PTK2BTK | |
| SCHEMBL1662386 | 0.80 | PLK4 (0.50) | PLK4JAK3JAK2PTK2BTK | |
| SCHEMBL1662994 | 0.78 | PLK4 (0.53) | PLK4JAK3JAK2BTKTTK | |
| SCHEMBL1662604 | 0.78 | PLK4 (0.47) | PLK4JAK3JAK2BTKTTK | |
| SCHEMBL12002573 | 0.77 | PLK4 (0.51) | PLK4JAK3JAK2BTKTTK | |
| SCHEMBL1662699 | 0.74 | PLK4 (0.43) | PLK4JAK3PTK2BTKTTK | |
| SCHEMBL27885779 | 0.71 | JAK3 (0.46) | JAK3JAK2BTKCDK4CCND1 | |
| SCHEMBL27233602 | 0.69 | USP30 (0.58) | USP30TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491039-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | Cellzome Limited (GB) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011048082-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2011-04-28 | — | — | WO | disclosed |