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SCHEMBL2010777

SCHEMBL2010777

Cc1cc(C)c2c(c1)C1(SCCS1)C(=O)N2CC(N)=O

nearest known ligand 0.36

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 1/20 0.36
▸ CYP2C19 P33261 2/20 0.35
▸ POLB P06746 2/20 0.35
▸ CYP1A2 P05177 1/20 0.35
▸ CYP3A4 P08684 1/20 0.35
▸ TP53 P04637 3/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.31
▸ CALCRL Q16602 1/20 0.31
▸ RAB9A P51151 2/20 0.31
▸ NPC1 O15118 1/20 0.31
▸ P2RX7 Q99572 1/20 0.31
▸ MEN1 O00255 1/20 0.31
▸ KMT2A Q03164 1/20 0.31
▸ TDP1 Q9NUW8 1/20 0.31
▸ TSHR P16473 1/20 0.31
▸ ALOX15 P16050 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2008942 0.80 POLB (0.43) CYP2C19POLBCYP1A2CYP3A4TP53
SCHEMBL2006817 0.80 ALDH1A1 (0.36) CYP2C19POLBTP53SMN1; SMN2RAB9A
SCHEMBL2006506 0.72 ANPEP (0.49) CYP2C19CYP1A2TP53
SCHEMBL2009801 0.70 MAPT (0.38) POLBTP53TSHR
SCHEMBL2009399 0.69 ALDH1A1 (0.36) CYP3A4TP53SMN1; SMN2
SCHEMBL663090 0.69 ALDH1A1 (0.39) CYP2C19POLBTP53RAB9AMEN1
SCHEMBL2825476 0.61 TP53 (0.41) CYP2C19POLBTP53SMN1; SMN2MEN1
SCHEMBL662281 0.56 ALDH1A1 (0.38) CYP2C19POLBTP53RAB9AKMT2A
SCHEMBL10584655 0.55 LPAR1 (0.55) SMN1; SMN2TDP1
SCHEMBL28250143 0.55 PGR (0.38) L3MBTL1POLBTP53MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7964593-B2 Indolone-acetamide derivatives, processes for preparing them and their uses UCB PHARMA, S.A. (BE) 2011-06-21 — — US disclosed
EP-1620399-B1 INDOLONE-ACETAMIDE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES UCB PHARMA SA (BE) 2010-09-22 — — EP disclosed
US-20100069375-A1 Indolone-Acetamide Derivatives, Processes for Preparing Them and Their Uses UCB PHARMA, S.A. (BE) 2010-03-18 — — US disclosed
US-7645887-B2 2-(5-iodo-2-oxo-2,3-dihydro-1H-indol-1-yl)acetamide; epilepsy, epileptogenesis, seizure disorders and convulsion; 2-(5-chloro-2-oxo-2,3-dhydro-1H-indol-1-yl)-N-[6-(hydroxymethyl)cyclohex-3-en-1-yl]acetamide UCB PHARMA, S.A. (BE) 2010-01-12 — — US disclosed
US-20070043038-A1 Indolone-acetamide derivatives, processes for preparing them and their uses UCB, S.A. (BE) 2007-02-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100069375-A1 Indolone-Acetamide Derivatives, Processes for Preparing Them and Their Uses AANAT, TPH2, CYP1A2 L3MBTL1 4870/4885CYP2C19 69/4885POLB 3404/4885
US-20070043038-A1 Indolone-acetamide derivatives, processes for preparing them and their uses AANAT, TPH2, CYP1A2 L3MBTL1 4870/4885CYP2C19 69/4885POLB 3404/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.