Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 10/20 | 0.47 |
| ▸ | TERT | O14746 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19012214 | 0.91 | MAPT (0.47) | ALDH1A1HTTMAPTTERTKMT2A | |
| SCHEMBL12136712 | 0.84 | EPHX1 (0.65) | ALDH1A1HTTMAPTKMT2AMEN1 | |
| SCHEMBL16938841 | 0.83 | ALDH1A1 (0.60) | ALDH1A1HTTMAPTKMT2AMEN1 | |
| SCHEMBL23786265 | 0.79 | KDM4E (0.46) | ALDH1A1HTTMAPTKMT2AMEN1 | |
| SCHEMBL11794892 | 0.79 | MCHR1 (0.60) | ALDH1A1HTTMAPTKMT2AMEN1 | |
| SCHEMBL14050284 | 0.78 | MAPT (0.49) | ALDH1A1HTTMAPTKMT2AMEN1 | |
| SCHEMBL16359723 | 0.77 | RXFP1 (0.45) | ALDH1A1HTTMAPTTERTKMT2A | |
| SCHEMBL491614 | 0.75 | EPHX1 (0.66) | ALDH1A1HTTMAPTKMT2AMEN1 | |
| SCHEMBL13918437 | 0.75 | HDAC3 (0.44) | ALDH1A1HTTMAPTKMT2AKDM4E | |
| SCHEMBL12855856 | 0.75 | HDAC3 (0.44) | ALDH1A1HTTMAPTKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372833-B2 | Urea derivative | SHIONOGI & CO., LTD. (JP) | 2013-02-12 | — | — | US | claimed |
| US-20120095231-A1 | UREA DERIVATIVE | YANO TOSHISADA (JP) | 2012-04-19 | — | — | US | claimed |
| US-8088777-B2 | Urea derivative | SHIONOGI & CO., LTD. (JP) | 2012-01-03 | — | — | US | claimed |
| US-20090203712-A1 | Urea Derivative | SHIONOGI &CO., LTD. | 2009-08-13 | — | — | US | claimed |
| EP-2058305-A1 | UREA DERIVATIVE | Shionogi Co., Ltd. (JP) | 2009-05-13 | — | — | EP | claimed |
| US-8372833-B2 | Urea derivative | SHIONOGI & CO., LTD. (JP) | 2013-02-12 | — | — | US | disclosed |
| US-20120095231-A1 | UREA DERIVATIVE | YANO TOSHISADA (JP) | 2012-04-19 | — | — | US | disclosed |
| US-8088777-B2 | Urea derivative | SHIONOGI & CO., LTD. (JP) | 2012-01-03 | — | — | US | disclosed |
| US-20090203712-A1 | Urea Derivative | SHIONOGI &CO., LTD. | 2009-08-13 | — | — | US | disclosed |
| EP-2058305-A1 | UREA DERIVATIVE | Shionogi Co., Ltd. (JP) | 2009-05-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095231-A1 | UREA DERIVATIVE | NPY5R, NPY1R, NPY2R | ALDH1A1 4384/4885HTT 2029/4885MAPT 2307/4885 |
| US-20090203712-A1 | Urea Derivative | NPY5R, NPY1R, NPY2R | ALDH1A1 4390/4885HTT 2033/4885MAPT 2336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.