Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 11/20 | 0.62 |
| ▸ | BRD4 | O60885 | 9/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17680682 | 0.85 | BRD4 (0.67) | CREBBPBRD4MAPTRAB9ALMNA | |
| SCHEMBL17680709 | 0.76 | CREBBP (1.00) | CREBBPBRD4 | |
| SCHEMBL22368597 | 0.76 | CREBBP (0.61) | CREBBPBRD4NPC1MAPTMEN1 | |
| SCHEMBL4484367 | 0.73 | NPC1 (0.41) | CREBBPBRD4NPC1MAPTMEN1 | |
| SCHEMBL15964658 | 0.73 | CREBBP (0.55) | CREBBPBRD4NPC1MAPTRAB9A | |
| SCHEMBL22368721 | 0.71 | CREBBP (0.69) | CREBBPBRD4NPC1MAPTRAB9A | |
| (Z)-1,2-Diphenylethene SCHEMBL10997053 | 0.71 | CRBN (0.50) | CREBBPBRD4NPC1MAPTMEN1 | |
| (Z)-1,2-Diphenylethene SCHEMBL10997055 | 0.71 | CRBN (0.50) | CREBBPBRD4NPC1MAPTMEN1 | |
| SCHEMBL27060152 | 0.71 | BRD4 (0.39) | CREBBPBRD4NPC1MAPTMEN1 | |
| SCHEMBL22368946 | 0.70 | CREBBP (0.57) | CREBBPBRD4NPC1MAPTMAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204360-B1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2020-08-26 | — | — | EP | disclosed |