Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 3/20 | 0.43 |
| ▸ | TYMS | P04818 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.34 |
| ▸ | XIAP | P98170 | 1/20 | 0.34 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | PDE6D | O43924 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2780205 | 0.78 | ASIC3 (0.39) | PLAUNCF1KDM4EMAPTNOS3 | |
| SCHEMBL20557225 | 0.78 | MEN1 (0.45) | PLAUNCF1KDM4EMAPTNOS3 | |
| SCHEMBL8151882 | 0.77 | NOS3 (0.42) | PLAUNCF1KDM4EMAPTNOS3 | |
| SCHEMBL28533610 | 0.76 | PARP1 (0.43) | TYMSTHRBTHRAPDE6DEGFR | |
| SCHEMBL4707883 | 0.74 | XIAP (0.45) | PLAUNCF1KDM4EMAPTNOS3 | |
| SCHEMBL6305713 | 0.73 | KMT2A (0.50) | PLAUNCF1KDM4EMAPTMEN1 | |
| SCHEMBL11031958 | 0.72 | MGAM (0.44) | KDM4EMAPTPDE6DMEN1ALDH1A1 | |
| SCHEMBL22556890 | 0.72 | ACHE (0.41) | KDM4EMAPTNOS3NOS2MCHR1 | |
| SCHEMBL28211013 | 0.71 | THRB (0.41) | TYMSTHRBKDM4ENOS3NOS2 | |
| SCHEMBL1056117 | 0.71 | THRB (0.41) | TYMSTHRBKDM4ENOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3956322-A1 | JAK1 SELECTIVE KINASE INHIBITOR | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2022-02-23 | — | — | EP | disclosed |
| WO-2020211839-A1 | JAK1 SELECTIVE KINASE INHIBITOR | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2020-10-22 | — | — | WO | disclosed |