Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | IDE | P14735 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | UBE2N | P61088 | 1/20 | 0.36 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24256970 | 0.83 | HTT (0.47) | MAPTKDM4EHTTMAPK1IDE | |
| SCHEMBL24256969 | 0.82 | KDM4E (0.46) | MAPTKDM4EHTTMAPK1IDE | |
| SCHEMBL24256356 | 0.79 | NPC1 (0.48) | MAPTKDM4EHTTMAPK1IDE | |
| SCHEMBL24256706 | 0.79 | NPC1 (0.49) | MAPTKDM4EHTTMAPK1IDE | |
| SCHEMBL24256703 | 0.76 | POLB (0.47) | MAPTKDM4EHTTMAPK1IDE | |
| SCHEMBL24256696 | 0.74 | CHRM4 (0.48) | MAPTKDM4EHTTMAPK1IDE | |
| SCHEMBL24256693 | 0.73 | KDM4E (0.46) | MAPTKDM4EHTTMAPK1IDE | |
| SCHEMBL24256615 | 0.73 | KDM4E (0.44) | MAPTKDM4EHTTMAPK1IDE | |
| SCHEMBL24256699 | 0.72 | KDM4E (0.49) | MAPTKDM4EHTTMAPK1IDE | |
| SCHEMBL24256352 | 0.70 | POLB (0.51) | MAPTKDM4EHTTMAPK1IDE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022035806-A1 | FUSED TRICYCLIC PYRIMIDINE-THIENO-PYRIDINE SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |