Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 5/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20158240 | 1.00 | KCNK3 (0.37) | KCNK3ITGB1ITGA4LMNAKCNK9 | |
| SCHEMBL20140636 | 0.88 | ITGB1 (0.47) | KCNK3ITGB1ITGA4LMNAKCNK9 | |
| SCHEMBL20158243 | 0.85 | LMNA (0.39) | KCNK3ITGB1ITGA4LMNAKCNK9 | |
| SCHEMBL20158238 | 0.84 | LMNA (0.39) | KCNK3ITGB1ITGA4LMNAKCNK9 | |
| SCHEMBL6108573 | 0.79 | KCNK3 (0.42) | KCNK3ITGB1ITGA4KCNK9THRB | |
| SCHEMBL6108575 | 0.79 | KCNK3 (0.42) | KCNK3ITGB1ITGA4KCNK9THRB | |
| SCHEMBL20153393 | 0.76 | KCNK3 (0.42) | KCNK3ITGB1ITGA4KCNK9THRB | |
| SCHEMBL23558962 | 0.75 | OXTR (0.39) | KCNK3ITGB1ITGA4KCNK9THRB | |
| SCHEMBL20158259 | 0.74 | ITGB3 (0.46) | KCNK3ITGB1ITGA4KCNK9THRB | |
| SCHEMBL30487495 | 0.74 | ITGB1 (0.41) | KCNK3ITGB1ITGA4LMNAKCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11639353-B2 | Cyclobutanes- and azetidine-containing mono and spirocyclic compounds as αV integrin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11639353-B2 | Cyclobutanes- and azetidine-containing mono and spirocyclic compounds as αV integrin inhibitors | ITGB1, ITGB2, ITGA1 | KCNK3 2064/4885ITGB1 1/4885ITGA4 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.