Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | ACP3 | P15309 | 3/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL424037 | 0.88 | SMN1; SMN2 (0.61) | ADRB2SMN1; SMN2L3MBTL1ATMMEN1 | |
| SCHEMBL1848481 | 0.88 | SMN1; SMN2 (0.61) | ADRB2SMN1; SMN2L3MBTL1ATMMEN1 | |
| SCHEMBL4853220 | 0.88 | SMN1; SMN2 (0.61) | ADRB2SMN1; SMN2L3MBTL1ATMMEN1 | |
| SCHEMBL6472595 | 0.85 | ADRB2 (0.50) | ADRB2SMN1; SMN2L3MBTL1ATMACP3 | |
| SCHEMBL6514671 | 0.83 | ATM (0.66) | ADRB2SMN1; SMN2L3MBTL1ATMMEN1 | |
| Hydrochloric Acid SCHEMBL6473470 | 0.83 | ADRB2 (0.52) | ADRB2SMN1; SMN2L3MBTL1ATMACP3 | |
| SCHEMBL4885769 | 0.83 | CNR2 (0.49) | SMN1; SMN2L3MBTL1ATMMEN1KMT2A | |
| SCHEMBL4885775 | 0.83 | CNR2 (0.49) | SMN1; SMN2L3MBTL1ATMMEN1KMT2A | |
| SCHEMBL4890461 | 0.83 | CNR2 (0.49) | SMN1; SMN2L3MBTL1ATMMEN1KMT2A | |
| SCHEMBL323594 | 0.78 | BCHE (0.55) | ATMMEN1KMT2ANPSR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590954-A1 | BISARYL (THIO)MORPHOLINE DERIVATIVES AS S1P MODULATORS | ABBVIE B.V. (NL) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004375-A1 | BISARYL (THIO)MORPHOLINE DERIVATIVES AS S1P MODULATORS | ABBOTT HEALTHCARE PRODUCTS B.V. (NL) | 2012-01-12 | — | — | WO | disclosed |
| EP-2197877-A1 | 3-METHYL-2- ( (2S) -2- (4- (3-METHYL-L, 2, 4-0XADIAZ0L-5-YL) PHENYL) MORPHOLINO) -6- (PYRIMIDIN-4-YL) PYRIMIDIN-4 (3H) -ONE AS TAU PROTEIN KINASE INHIBITOR | Sanofi-Aventis (FR) | 2010-06-23 | — | — | EP | disclosed |
| EP-2193129-A1 | 6-PYRIMIDINYL-PYRIMID-2-ONE DERIVATIVE | Mitsubishi Tanabe Pharma Corporation (JP) | 2010-06-09 | — | — | EP | disclosed |
| WO-2009035162-A1 | 6-PYRIMIDINYL-PYRIMID-2-ONE DERIVATIVE | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2009-03-19 | — | — | WO | disclosed |
| WO-2009035159-A1 | 3-METHYL-2- ( (2S) -2- (4- (3-METHYL-L, 2, 4-0XADIAZ0L-5-YL) PHENYL) MORPHOLINO) -6- (PYRIMIDIN-4-YL) PYRIMIDIN-4 (3H) -ONE AS TAU PROTEIN KINASE INHIBITOR | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2009-03-19 | — | — | WO | disclosed |