Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 5/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.49 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.40 |
| ▸ | RNF4 | P78317 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3656769 | 0.87 | TSHR (0.51) | KDM4ENPC1ALDH1A1MAPTHPGD | |
| SCHEMBL6717574 | 0.87 | TSHR (0.49) | TRPM8KDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL11866005 | 0.85 | ALDH1A1 (0.43) | KDM4ENPC1ALDH1A1MAPTHPGD | |
| SCHEMBL7455182 | 0.82 | LTB4R2 (0.45) | KDM4EALDH1A1MAPTMAPK1LTB4R2 | |
| SCHEMBL7771243 | 0.82 | TSHR (0.51) | KDM4ENPC1ALDH1A1MAPK1RAB9A | |
| SCHEMBL4686880 | 0.80 | NPC1 (0.50) | KEAP1NFE2L2KDM4ENPC1ALDH1A1 | |
| SCHEMBL5967202 | 0.80 | KEAP1 (0.51) | KEAP1NFE2L2TRPM8NPC1ALDH1A1 | |
| SCHEMBL7106756 | 0.77 | KEAP1 (0.55) | KEAP1NFE2L2SMN1; SMN2TSHRRNF4 | |
| SCHEMBL3660817 | 0.77 | KEAP1 (0.49) | KEAP1NFE2L2TRPM8TSHRBCL2A1 | |
| SCHEMBL9686344 | 0.77 | CHRM1 (0.52) | KEAP1NFE2L2TRPM8RNF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2219600-A1 | TOPICAL COSMETIC SKIN LIGHTENING COMPOSITIONS AND METHODS OF USE THEREOF | STIEFEL LABORATORIES, INC. (US) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009067095-A1 | TOPICAL COSMETIC SKIN LIGHTENING COMPOSITIONS AND METHODS OF USE THEREOF | STIEFEL LABORATORIES, INC. (US) | 2009-05-28 | — | — | WO | disclosed |