Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987838 | 0.81 | ACHE (0.44) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL282155 | 0.80 | EPHX1 (0.44) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL1840802 | 0.80 | EPHX1 (0.44) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL5959811 | 0.80 | EPHX1 (0.44) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL2222653 | 0.79 | EPHX1 (0.45) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL7404539 | 0.79 | ACHE (0.46) | EPHX1ACHEALDH1A1 | |
| SCHEMBL8764308 | 0.79 | EPHX1 (0.43) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL15569273 | 0.78 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2HPGDL3MBTL1CTSK | |
| SCHEMBL9830010 | 0.77 | SMN1; SMN2 (0.42) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL8303799 | 0.77 | EPHX1 (0.42) | EPHX1ACHEALDH1A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951686-A1 | QUINAZOLINE DERIVATIVES AS A MULTIPLEX INHIBITOR AND METHOD FOR THE PREPARATION THEREOF | Hanmi Pharm. Co., Ltd. (KR) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007055514-A1 | QUINAZOLINE DERIVATIVES AS A MULTIPLEX INHIBITOR AND METHOD FOR THE PREPARATION THEREOF | HANMI PHARM. CO., LTD. (KR) | 2007-05-18 | — | — | WO | disclosed |