Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.43 |
| ▸ | CDK9 | P50750 | 2/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 5/20 | 0.42 |
| ▸ | CDK1 | P06493 | 4/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772099 | 0.87 | CA2 (0.52) | AURKACDK2CCNT1CCNA2CDK9 | |
| SCHEMBL4763589 | 0.86 | AURKA (0.51) | AURKACDK2CCNT1CCNA2CDK9 | |
| SCHEMBL4768143 | 0.86 | SYK (0.53) | AURKACDK2CCNT1CCNA2CDK9 | |
| SCHEMBL4772198 | 0.86 | AURKA (0.46) | AURKACDK2CCNT1CCNA2CDK9 | |
| SCHEMBL6220297 | 0.85 | RAB9A (0.56) | AURKACDK2CCNT1CCNA2CDK9 | |
| SCHEMBL4766260 | 0.84 | SYK (0.55) | AURKACDK2CCNT1CCNA2CDK9 | |
| SCHEMBL4772264 | 0.84 | AURKA (0.47) | AURKACDK2CCNT1CCNA2CDK9 | |
| SCHEMBL4774317 | 0.84 | AURKA (0.53) | AURKACDK2CCNT1CCNA2CDK9 | |
| SCHEMBL4768983 | 0.84 | AURKA (0.53) | AURKACDK2CCNT1CCNA2CDK9 | |
| SCHEMBL4763519 | 0.83 | AURKA (0.47) | AURKACDK2CCNT1CCNA2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |