Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5237366 | 0.84 | AKR1C3 (0.52) | GAASMN1; SMN2FAAHALDH1A1 | |
| SCHEMBL5239273 | 0.84 | ALDH1A1 (0.60) | TSHRL3MBTL1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5236897 | 0.81 | ALDH1A1 (0.53) | GAASMN1; SMN2TSHRCYP3A4CYP2C9 | |
| SCHEMBL5237576 | 0.81 | KMT2A (0.53) | GAASMN1; SMN2TSHRL3MBTL1CYP2C9 | |
| SCHEMBL7961982 | 0.81 | L3MBTL1 (0.51) | GAASMN1; SMN2ADRA1DADRA1AADRA1B | |
| SCHEMBL5232433 | 0.79 | ALDH1A1 (0.59) | GAASMN1; SMN2TSHRFAAHALDH1A1 | |
| SCHEMBL5235199 | 0.79 | GAA (0.53) | GAASMN1; SMN2TSHRFAAHALDH1A1 | |
| SCHEMBL5240191 | 0.79 | L3MBTL1 (0.49) | GAASMN1; SMN2ADRA1DADRA1AADRA1B | |
| SCHEMBL5235922 | 0.77 | HTR1A (0.51) | GAASMN1; SMN2FAAHALDH1A1 | |
| SCHEMBL5233076 | 0.77 | GAA (0.50) | GAASMN1; SMN2FAAHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |