Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | DEPTOR | Q8TB45 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5552448 | 1.00 | KDM4E (0.46) | KDM4EHSD11B1RECQLHPGDALDH1A1 | |
| SCHEMBL10336149 | 0.79 | HSD11B1 (0.50) | KDM4EHSD11B1RECQLHPGDALDH1A1 | |
| SCHEMBL6317037 | 0.78 | HSD11B1 (0.48) | KDM4EHSD11B1RECQLHPGDALDH1A1 | |
| SCHEMBL25908970 | 0.78 | HSD11B1 (0.48) | KDM4EHSD11B1RECQLHPGDALDH1A1 | |
| SCHEMBL7534584 | 0.78 | HSD11B1 (0.48) | KDM4EHSD11B1RECQLHPGDALDH1A1 | |
| SCHEMBL4585829 | 0.76 | HSD11B1 (0.47) | KDM4EHSD11B1RECQLHPGDALDH1A1 | |
| SCHEMBL14855368 | 0.76 | HSD11B1 (0.47) | KDM4EHSD11B1RECQLHPGDALDH1A1 | |
| SCHEMBL2134534 | 0.76 | AKT1 (0.48) | KDM4EHSD11B1RECQLHPGDALDH1A1 | |
| SCHEMBL18131923 | 0.74 | RECQL (0.48) | KDM4EHSD11B1RECQLHPGDALDH1A1 | |
| SCHEMBL10654856 | 0.74 | KDM4E (0.40) | KDM4ERECQLHPGDALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070259855-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259855-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | ROR1, RORB, RORA | KDM4E 4667/4885HSD11B1 90/4885RECQL 489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.