Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 2/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | METAP1 | P53582 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18843341 | 0.86 | ALOX5 (0.38) | ALOX5EPHX1CTSSCTSKHTR2C | |
| SCHEMBL4780561 | 0.86 | ALOX5 (0.39) | ALOX5EPHX1CTSSCTSKHTR2C | |
| SCHEMBL10648510 | 0.85 | CA14 (0.38) | ALOX5EPHX1CTSSCTSKHTR2C | |
| SCHEMBL8165566 | 0.83 | ALOX5 (0.41) | ALOX5EPHX1CTSSCTSKHTR2C | |
| SCHEMBL6680983 | 0.83 | CTSK (0.37) | ALOX5EPHX1CTSSCTSKHTR2C | |
| SCHEMBL1845039 | 0.83 | SSTR4 (0.38) | ALOX5EPHX1CTSSCTSKHTR2C | |
| SCHEMBL1843886 | 0.83 | EPHX1 (0.38) | ALOX5EPHX1CTSSCTSKHTR2C | |
| SCHEMBL25736665 | 0.82 | ALOX5 (0.36) | ALOX5EPHX1CTSSCTSKHTR2C | |
| SCHEMBL2810316 | 0.81 | CTSS (0.35) | ALOX5EPHX1CTSSCTSKHTR2C | |
| SCHEMBL7329124 | 0.81 | ALOX5 (0.43) | ALOX5EPHX1CTSSCTSKHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6552043-B1 | Useful as Calcitonin Gene-Related Peptide receptors; for therapy of migraine, pain, cardiovascular disorder, inflammation, diabetes, Reynaud's syndrome, peripheral arterial insufficiency, cranial hemorrhage and tumor | MERCK SHARPE & DOHME LTD. (GB) | 2003-04-22 | — | — | US | disclosed |