Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD4 | Q53EL6 | 3/20 | 0.40 |
| ▸ | GLS2 | Q9UI32 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 7/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294647 | 0.85 | GLS2 (0.44) | PDCD4GLS2PPARGFAAH | |
| SCHEMBL7293046 | 0.85 | GLS2 (0.44) | PDCD4GLS2PPARGFAAH | |
| SCHEMBL7296440 | 0.76 | PDCD4 (0.41) | PDCD4 | |
| SCHEMBL7301215 | 0.76 | PDCD4 (0.45) | PDCD4GLS2TRPV1 | |
| SCHEMBL7294186 | 0.68 | TRPV1 (0.35) | PDCD4GLS2TRPV1FAAH | |
| SCHEMBL9805289 | 0.67 | TRPV1 (0.56) | TRPV1FAAH | |
| SCHEMBL8621126 | 0.67 | ALOX5 (0.44) | PDCD4GLS2FAAH | |
| SCHEMBL8616293 | 0.67 | ALOX5 (0.44) | PDCD4GLS2FAAH | |
| SCHEMBL9550648 | 0.66 | TRPV1 (0.54) | GLS2TRPV1FAAH | |
| SCHEMBL9007930 | 0.66 | TRPV1 (0.50) | GLS2TRPV1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5376676-A | Process of using anti-inflammatory furanones as selective calcium channel inhibitors | ALLERGAN, INC. (US) | 1994-12-27 | — | — | US | disclosed |
| US-5045564-A | Calcium channel antagonists | ALLERGAN, INC. (US) | 1991-09-03 | — | — | US | disclosed |
| EP-0372940-A2 | Anti-inflammatory 2-furanones | ALLERGAN, INC (US) | 1990-06-13 | — | — | EP | disclosed |