SCHEMBL751657

SCHEMBL751657

O=S(=O)(C(Br)(Br)Cc1ccc(F)cc1)C(Br)(Br)Cc1ccc(F)cc1

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CA1 P00915 4/20 0.40
CA2 P00918 4/20 0.40
CA9 Q16790 3/20 0.40
IDO1 P14902 1/20 0.39
LOXL2 Q9Y4K0 1/20 0.39
CA12 O43570 3/20 0.38
CA4 P22748 1/20 0.38
EGFR P00533 3/20 0.37
ERBB2 P04626 3/20 0.37
HPGD P15428 1/20 0.37
TAAR1 Q96RJ0 1/20 0.37
LMNA P02545 2/20 0.36
PLA2G1B P04054 1/20 0.36
ATG4B Q9Y4P1 1/20 0.36
CA7 P43166 1/20 0.36
BCHE P06276 1/20 0.36
ACHE P22303 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL751764 0.80 PLCG1 (0.41) CA1CA2CA9IDO1CA12
SCHEMBL754036 0.78 KMT2A (0.43) CA1CA2CA9IDO1CA12
SCHEMBL753608 0.77 IDO1 (0.38) CA1CA2CA9IDO1LOXL2
SCHEMBL753679 0.74 LOXL2 (0.52) CA1CA2CA9IDO1LOXL2
SCHEMBL754797 0.74 APLNR (0.49) CA1CA2CA9IDO1CA12
SCHEMBL28349122 0.71 ALDH1A1 (0.41) IDO1LOXL2EGFRERBB2HPGD
SCHEMBL9421733 0.70 FAAH (0.62) CA1CA2CA9IDO1LOXL2
SCHEMBL28275711 0.70 PTPN1 (0.42) IDO1LOXL2HPGDLMNA
SCHEMBL755591 0.69 TDP1 (0.38) CA1CA2CA9CA12LMNA
SCHEMBL752230 0.69 FDPS (0.50) IDO1TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2213166-B1 Biocidal compounds containing 2-methylisothiazolin-3-one and a haloalkylsulfone THOR GMBH (DE) 2012-03-21 EP claimed