Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.43 |
| ▸ | LMNA | P02545 | 8/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | UBE2M | P61081 | 1/20 | 0.42 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 6/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8033936 | 0.92 | ALDH1A1 (0.42) | ALDH1A1LMNASMN1; SMN2HTTMAPK1 | |
| SCHEMBL8037043 | 0.91 | SMN1; SMN2 (0.39) | ALDH1A1LMNASMN1; SMN2HTTMAPK1 | |
| SCHEMBL8043905 | 0.89 | KDM4E (0.37) | ALDH1A1LMNASMN1; SMN2HTTMAPK1 | |
| SCHEMBL8043675 | 0.89 | KIT (0.39) | ALDH1A1HTTHSD17B10TDP1GAA | |
| SCHEMBL8043968 | 0.88 | MEN1 (0.45) | ALDH1A1LMNASMN1; SMN2MAPK1KMT2A | |
| SCHEMBL8050838 | 0.88 | KDM4E (0.36) | ALDH1A1LMNASMN1; SMN2HTTMAPK1 | |
| SCHEMBL8041886 | 0.87 | SMN1; SMN2 (0.45) | ALDH1A1LMNASMN1; SMN2HTTMAPK1 | |
| SCHEMBL8047017 | 0.87 | HSP90AA1 (0.44) | ALDH1A1LMNASMN1; SMN2HTTMAPK1 | |
| SCHEMBL8043941 | 0.87 | PTGS2 (0.37) | ALDH1A1LMNASMN1; SMN2HTTMAPK1 | |
| SCHEMBL8046494 | 0.86 | EP300 (0.42) | ALDH1A1LMNASMN1; SMN2HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |