Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 11/20 | 0.82 |
| ▸ | ACHE | P22303 | 10/20 | 0.82 |
| ▸ | APP | P05067 | 2/20 | 0.82 |
| ▸ | BACE1 | P56817 | 2/20 | 0.82 |
| ▸ | GABRP | O00591 | 1/20 | 0.82 |
| ▸ | GABRD | O14764 | 1/20 | 0.82 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.82 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.82 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.82 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.82 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.82 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.82 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.82 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.82 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.82 |
| ▸ | GABRE | P78334 | 1/20 | 0.82 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.82 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.82 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.82 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38658735 | 1.00 | BCHE (0.82) | BCHEACHEAPPBACE1GABRP | |
| SCHEMBL8520784 | 0.95 | ACHE (0.88) | BCHEACHEAPPBACE1GABRP | |
| SCHEMBL38658907 | 0.95 | ACHE (0.88) | BCHEACHEAPPBACE1GABRP | |
| SCHEMBL8523735 | 0.92 | BCHE (0.78) | BCHEACHEAPPBACE1GABRP | |
| SCHEMBL24000133 | 0.92 | BCHE (0.97) | BCHEACHEAPPBACE1GABRP | |
| SCHEMBL13480729 | 0.92 | BCHE (0.92) | BCHEACHEAPPBACE1GABRP | |
| SCHEMBL12059555 | 0.91 | ACHE (1.00) | BCHEACHEAPPBACE1GABRP | |
| SCHEMBL15168191 | 0.91 | ACHE (1.00) | BCHEACHEAPPBACE1GABRP | |
| SCHEMBL29486236 | 0.91 | ACHE (1.00) | BCHEACHEAPPBACE1GABRP | |
| SCHEMBL24164216 | 0.91 | ACHE (1.00) | BCHEACHEAPPBACE1GABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200087648-A1 | PARKIN LIGASE ACTIVATION METHODS AND COMPOSITIONS | NYSNOBIO IRELAND DAC (IE) | 2020-03-19 | — | — | US | disclosed |
| US-10155936-B2 | Parkin ligase activation methods and compositions | An2H Discovery Limited (IE) | 2018-12-18 | — | — | US | disclosed |
| US-20160160205-A1 | PARKIN LIGASE ACTIVATION METHODS AND COMPOSITIONS | An2H Discovery Limited (IE) | 2016-06-09 | — | — | US | disclosed |
| US-20160160205-A1 | PARKIN LIGASE ACTIVATION METHODS AND COMPOSITIONS | An2H Discovery Limited (IE) | 2016-06-09 | — | — | US | disclosed |
| US-20160160205-A1 | PARKIN LIGASE ACTIVATION METHODS AND COMPOSITIONS | An2H Discovery Limited (IE) | 2016-06-09 | — | — | US | disclosed |
| WO-2012065527-A1 | COMPOUDS AND USES AS L-TYPE CALCIUM CHANNEL BLOCKER AND/OR ACETYLCHOLINESTERASE INHIBITOR THEREOF | 江苏先声药物研究有限公司 (CN) | 2012-05-24 | — | — | WO | disclosed |
| WO-2007122274-A1 | ACETYLCHOLINESTERASE-INHIBITING COMPOUNDS FOR TREATING ALZHEIMER'S DISEASE | UNIVERSIDAD DE BARCELONA (ES) | 2007-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10155936-B2 | Parkin ligase activation methods and compositions | PINK1, XIAP, STUB1 | BCHE 1669/4885ACHE 1722/4885APP 720/4885 |
| US-20200087648-A1 | PARKIN LIGASE ACTIVATION METHODS AND COMPOSITIONS | PINK1, XIAP, STUB1 | BCHE 1669/4885ACHE 1722/4885APP 720/4885 |
| US-20160160205-A1 | PARKIN LIGASE ACTIVATION METHODS AND COMPOSITIONS | PINK1, XIAP, STUB1 | BCHE 1669/4885ACHE 1722/4885APP 720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.