Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.56 |
| ▸ | ATM | Q13315 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.42 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | HMGCR | P04035 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | CCKAR | P32238 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL557586 | 0.82 | MAPK14 (0.51) | L3MBTL1TDP1MAPK14ALDH1A1LMNA | |
| SCHEMBL246148 | 0.81 | CYP2C9 (0.58) | L3MBTL1TDP1MAPK14ALDH1A1LMNA | |
| SCHEMBL10394285 | 0.77 | MAPK14 (0.42) | L3MBTL1TDP1MAPK14ALDH1A1PTGS2 | |
| SCHEMBL28236134 | 0.77 | L3MBTL1 (0.54) | L3MBTL1TDP1ATMALDH1A1LMNA | |
| SCHEMBL17718403 | 0.74 | TDP1 (0.50) | L3MBTL1TDP1ATMALDH1A1LMNA | |
| SCHEMBL9301103 | 0.73 | MAPK14 (0.56) | TDP1MAPK14ATMALDH1A1LMNA | |
| SCHEMBL9299635 | 0.73 | MAPK14 (0.56) | L3MBTL1TDP1MAPK14ATMALDH1A1 | |
| SCHEMBL31517747 | 0.72 | MAPK14 (0.47) | MAPK14ALDH1A1LMNASMN1; SMN2CYP2C9 | |
| SCHEMBL1092376 | 0.72 | L3MBTL1 (0.55) | L3MBTL1TDP1ATMALDH1A1LMNA | |
| SCHEMBL17883127 | 0.72 | L3MBTL1 (0.53) | L3MBTL1TDP1MAPK14ATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354772-A | Anticholesterol agents | SANDOZ PHARM. CORP. (US) | 1994-10-11 | — | — | US | disclosed |
| US-4739073-A | ANTICHOLESTEROL AGENTS | SANDOZ PHARMACEUTICALS CORP. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0114027-B1 | ANALOGS OF MEVALOLACTONE AND DERIVATIVES THEREOF, PROCESSES FOR THEIR PRODUCTION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS PHARMACEUTICALS | SANDOZ AG (CH) | 1988-01-07 | — | — | EP | disclosed |
| EP-0114027-A1 | Analogs of mevalolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals | SANDOZ AG (CH) | 1984-07-25 | — | — | EP | disclosed |
| WO-1984002131-A1 | ANALOGS OF MEVALOLACTONE AND DERIVATIVES THEREOF, PROCESSES FOR THEIR PRODUCTION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS PHARMACEUTICALS | SANDOZ AG (CH) | 1984-06-07 | — | — | WO | disclosed |