Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | ALB | P02768 | 1/20 | 0.32 |
| ▸ | LDHB | P07195 | 1/20 | 0.32 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.32 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | PRNP | P04156 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689482 | 0.89 | ALDH1A1 (0.34) | ALDH1A1RAB9ASMN1; SMN2KDM4EMAP3K5 | |
| SCHEMBL9689940 | 0.87 | TDP1 (0.40) | ALDH1A1SMN1; SMN2KDM4EGPR139HPGD | |
| SCHEMBL9688895 | 0.86 | KDM4E (0.43) | ALDH1A1RAB9AKDM4EMAP3K5GPR139 | |
| SCHEMBL9690657 | 0.82 | NPSR1 (0.38) | POLBMAPT | |
| SCHEMBL9690031 | 0.80 | TDP1 (0.40) | ALDH1A1RAB9ASMN1; SMN2KDM4EGPR139 | |
| SCHEMBL9689969 | 0.75 | HDAC3 (0.39) | ALDH1A1RAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL9689975 | 0.74 | GPR139 (0.37) | ALDH1A1RAB9ASMN1; SMN2KDM4EMAP3K5 | |
| SCHEMBL9688515 | 0.73 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2NPC1KDM4EHPGD | |
| SCHEMBL9689439 | 0.71 | KDM4E (0.45) | ALDH1A1RAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL9688521 | 0.71 | SIGMAR1 (0.38) | ALDH1A1RAB9AKDM4EMAP3K5HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506011-A1 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1992-09-30 | — | — | EP | disclosed |