Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | APAF1 | O14727 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | MPI | P34949 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9397263 | 0.81 | CYP1B1 (0.60) | ALDH1A1KDM4EMAPTSMN1; SMN2APAF1 | |
| SCHEMBL9394455 | 0.79 | CYP1B1 (0.58) | ALDH1A1KDM4EMAPTSMN1; SMN2APAF1 | |
| SCHEMBL4803393 | 0.79 | ALDH1A1 (0.46) | ALDH1A1KDM4EMAPTSMN1; SMN2APAF1 | |
| SCHEMBL4370950 | 0.75 | MEN1 (0.61) | ALDH1A1KDM4EMAPTSMN1; SMN2APAF1 | |
| SCHEMBL29437345 | 0.74 | ALDH1A1 (0.60) | ALDH1A1KDM4EMAPTSMN1; SMN2APAF1 | |
| SCHEMBL29649695 | 0.71 | CES1 (0.71) | ALDH1A1PARK7HSD17B10ALDH2ALDH3A1 | |
| SCHEMBL5114051 | 0.71 | CES1 (0.71) | ALDH1A1PARK7HSD17B10ALDH2ALDH3A1 | |
| SCHEMBL31528039 | 0.69 | PARK7 (0.45) | ALDH1A1KDM4EMAPTSMN1; SMN2APAF1 | |
| SCHEMBL28840295 | 0.68 | ALDH1A1 (0.43) | ALDH1A1KDM4EMAPTSMN1; SMN2APAF1 | |
| SCHEMBL31528258 | 0.67 | PARK7 (0.50) | ALDH1A1KDM4EMAPTSMN1; SMN2APAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5151518-A | N-arylation of isatins | ABBOTT LABORATORIES (US) | 1992-09-29 | — | — | US | disclosed |