# NM_006869.4(ADAP1):c.921G>A (p.Thr307=)

https://sugi.bio/variant/adap1-p-thr307

## Summary

**ADAP1 p.Thr307= (c.921G>A)** is classified **Benign** in ADAP1 (ClinVar, Single submitter, 1 submitter; last evaluated 2018-06-18). Common (popmax 9.27%, afr) — too common for a highly-penetrant pathogenic allele.

**At a glance:** Benign · review: Single submitter · rsID rs61995731 · 1 submitter · common (popmax 9.27%, afr) — too common for a highly-penetrant pathogenic allele

## For patients & families {#patients}

This is a change in the ADAP1 gene that is classified as benign — not considered disease-causing, submitted by 1 submitter.

*Reference information, not medical advice, and not a prediction for any individual. A genetic counselor or clinician can interpret what it means for you and your family.*

**Support & next steps:** [Find a genetic counselor (NSGC)](https://findageneticcounselor.nsgc.org/).

## Identity {#identity}

| Field | Value |
| --- | --- |
| Gene | [ADAP1](https://sugi.bio/atlas/gene/ADAP1/) |
| Protein change (HGVS p.) | p.Thr307= |
| Coding change (HGVS c.) | c.921G>A |
| MANE Select transcript | [NM_006869](https://www.ncbi.nlm.nih.gov/nuccore/NM_006869) |
| dbSNP | [rs61995731](https://www.ncbi.nlm.nih.gov/snp/rs61995731/) |
| Variant type | single nucleotide variant |
| Location | chr7:899208-899208 (GRCh38) |
| ClinVar | [VCV776189](https://www.ncbi.nlm.nih.gov/clinvar/variation/776189/) |

**All HGVS expressions:** `NC_000007.13:g.938845C>T`, `NC_000007.14:g.899208C>T`, `NM_001284308.2:c.954G>A`, `NM_001284309.2:c.705G>A`, `NM_001284310.2:c.705G>A`, `NM_001284311.2:c.636G>A`, `NM_006869.4:c.921G>A`

## Computational & population evidence {#evidence}

**Concordance:** Evidence sources **disagree** — common (popmax 9.27%, afr) — too common for a highly-penetrant pathogenic allele.

- **Missense predictors (AlphaMissense/REVEL/SaProt) do not apply** to this variant type — they score amino-acid substitutions only. For non-missense variants the computational signal comes from conservation (below), not from a missing predictor score.
- Conservation: phyloP -1.687, GERP -1.31 — not a conserved position (phyloP < 0.1, ACGS BP7 cut)
- CADD: **PHRED 8.791**. No single ClinGen-calibrated threshold exists and the expert panels that use CADD disagree — GUCY2D/AIPL1 require ≥ 20.0 for an untranslated-region variant, ABCA4 ≥ 28.1 for a synonymous or indel variant, the Pulmonary Hypertension panel imports Pejaver 2022's missense-calibrated numbers, and the Antibody Deficiencies panel declines CADD entirely for PIK3CD. CADD v1.7 also incorporates Zoonomia phyloP, so it partly re-expresses the conservation above. *Descriptive; no threshold applied.*
- SpliceAI: **not assessed** — no allele at this position is in our SpliceAI release, either because it lies outside the scored MANE transcript scope or because every allele is below Δ0.2. We cannot tell which, so this claims neither; absence is not evidence against a splicing effect.
- Population frequency (gnomAD v4.1): grpmax **9.27%** (afr) · FAF95 9.09% · FAF99 9.02% · 6,958/75,034 in the highest group · 8,121/1,612,652 alleles overall — common (popmax 9.27%, afr) — too common for a highly-penetrant pathogenic allele.

| Ancestry group | Allele frequency | 1 in |
| --- | --- | --- |
| African / African-American (grpmax) | 9.27% | 11 |
| Remaining individuals (not grpmax-eligible) | 0.642% | 156 |
| Admixed American | 0.565% | 177 |
| Middle Eastern | 0.429% | 233 |
| European (non-Finnish) | 0.0314% | 3,180 |
| South Asian | 0.0285% | 3,504 |

*Computational predictors are not independent (ClinGen Variant Classification guidance): AlphaMissense (Cheng et al. 2023) carries the ACMG weight for missense and conservation (phyloP/GERP/phastCons) for non-missense; REVEL (Pejaver-2022 calibrated strength bands) and SaProt (Su et al. 2023, structure-aware, ClinVar-independent protein language model, raw LLR) are shown as orthogonal agreement signals, not additive. For frequency, the gnomAD v4.1 grpmax filtering allele frequency (FAF95) is ClinGen's designated BA1/BS1 input (gnomAD v4 guidance v3.0, June 2025); BA1/BS1 thresholds are disease-specific, not a blanket 5%. Predictions, not a clinical determination.*

## Gene constraint & dosage {#gene-context}

**ADAP1** population constraint: LOEUF 0.949, pLI 5.3209e-08, missense-Z -1.2391. *Lower LOEUF and higher pLI indicate a gene that tolerates loss-of-function poorly; ClinGen dosage is the curated haploinsufficiency call.*

## Protein context {#protein}

Residue **307** lies in the ph 2 domain; a β-strand.

AlphaFold model confidence (whole protein): pLDDT 95.96, 93% of residues very-high.

**4 experimental structure(s)** (PDB): [3FEH](https://www.rcsb.org/structure/3FEH), [3FM8](https://www.rcsb.org/structure/3FM8), [3LJU](https://www.rcsb.org/structure/3LJU), [3MDB](https://www.rcsb.org/structure/3MDB).

## What this gene does {#gene-function}

*Describes the biological roles of ADAP1 (the gene this variant disrupts) — not effects measured for this specific variant. A damaging variant is expected to affect these functions and pathways; the degree depends on the variant.*

**How this variant is thought to act:** ADAP1's established molecular role includes GTPase activator activity. p.Thr307= falls in the ph 2 domain.


### Pathways affected {#pathways}

ADAP1 participates in **1 Reactome pathway** (⚕ = disease pathway):

| Pathway (Reactome) | Evidence |
| --- | --- |
| [Nuclear signaling by ERBB4](https://reactome.org/content/detail/R-HSA-1251985) | curated |

### Molecular function & processes (GO — experimentally supported) {#go}

**Molecular function:** GTPase activator activity.

**Biological process:** regulation of GTPase activity.

## Clinical significance {#significance}

**Benign** — review status Single submitter *(criteria provided, single submitter)*, last evaluated 2018-06-18.

**Submitter consensus:** unanimous (1/1 Benign).

### Submitter classifications {#submitters}

| Submitter | Classification | Review | Method | Date |
| --- | --- | --- | --- | --- |
| Labcorp Genetics (formerly Invitae), Labcorp | Benign | criteria provided, single submitter | clinical testing | 2018-06-18 |

**Reported phenotype names (ClinVar):** not provided, RECLASSIFIED - ADRA2C POLYMORPHISM, RECLASSIFIED - ADRB1 POLYMORPHISM, none provided.

## Similar variants {#similar}

Related ADAP1 variant pages (same residue, condition, or type): [ADAP1 p.Ala168Val](/variant/adap1-p-ala168val), [ADAP1 p.Ala182Thr](/variant/adap1-p-ala182thr), [ADAP1 p.Ala243Thr](/variant/adap1-p-ala243thr), [ADAP1 p.Ala26Val](/variant/adap1-p-ala26val), [ADAP1 p.Ala293Val](/variant/adap1-p-ala293val), [ADAP1 p.Ala349Val](/variant/adap1-p-ala349val), [ADAP1 p.Ala81Glu](/variant/adap1-p-ala81glu), [ADAP1 p.Ala81Val](/variant/adap1-p-ala81val).

### Data sources & attribution {#sources}

ClinVar (NCBI — public domain, built 2026-10-11); gnomAD v4.1 (Broad Institute, built 2026-10-06); AlphaMissense (Cheng et al. 2023, © Google DeepMind — CC BY 4.0, built 2026-01-27); REVEL (Ioannidis et al. 2016 — ODbL, built 2026-07-13); SaProt (Su et al. 2023 — MIT, built 2026-07-14); SpliceAI (Illumina — free for non-commercial use, built 2026-10-13); CADD (Rentzsch et al. 2019, University of Washington — free for non-commercial use, built 2026-10-10); Conservation (phyloP/phastCons/GERP) (UCSC hg38 470-way mammal (Hiller Lab) + Ensembl Compara, built 2026-07-12); gnomAD Non-coding Constraint (Gnocchi) (Chen et al. 2024, Broad Institute — CC0, built 2026-10-11); gnomAD Regional Missense Constraint (Broad Institute — CC0, built 2026-10-13); Pangolin (Zeng & Li 2022 — CC BY 4.0, built 2026-10-11); Repeat regions (UCSC — RepeatMasker, TRF, segmental duplications, built 2026-10-11); ClinGen (ClinGen, built 2026-09-22); UniProt (CC BY 4.0); Reactome / GO (CC BY 4.0, built 2026-09-23); MaveDB (per-record license, built 2026-10-11); CIViC (CC0, built 2026-09-22); Orphanet (Orphanet, built 2026-06-12)

*Primary record: NCBI ClinVar (variation 776189). Classifications reflect these databases as of the page's build date and may change. Free reference use — not medical advice; consult the primary submitters and a clinician.*